Neutrophils and NETS in modulating acute and chronic inflammation
Open accessAbstract
Neutrophils are an absolutely essential part of the innate immune system, playing an essential role in the control of infectious diseases but more recently are also being viewed as important players in tissue repair. Neutrophils are able to counteract an infection through phagocytosis and/or the release of neutrophil extracellular traps (NETs). By contrast, neutrophils help repair damaged tissues, limiting NET production but still phagocytosing debris. However, when inflammation is recurrent, or the inciting agent persists, neutrophils through a frustrated inability to resolve the problem can release NETs to exacerbate tissue damage during inappropriate inflammation. In this review, we discuss the mechanisms of NET formation, as well as the apparent paradoxical role of neutrophils and NETs in host defense, chronic inflammation, and tissue disrepair.
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Proteins typically associated with NET structures (elastase, cathepsin G, myeloperoxidase, and histones) could interact and bind directly with collagen and other ECM proteins to form complex interlinked structures that alter matrix architecture.
“the proteins [90] that are typically associated with the NET structures (elastase, cathepsin G, myeloperoxidase, and histones) could interact and bind directly with the collagen and other proteins present within the ECM, to form complex interlinked structures that result in altered properties of the matrix architecture”
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Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659 · see citing works
Neutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472 · see citing works
Self-citationNeutrophil extracellular traps in immunity and disease
Papayannopoulos, V. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.105 · Cited by 3,428 · see citing works
Novel cell death program leads to neutrophil extracellular traps
Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197 · see citing works
Neutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971 · see citing works
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Clark, S. R., Ma, A. C., Tavener, S. A., McDonald, B., Goodarzi, Z., Kelly, M. M., Patel, K. D., Chakrabarti, S., McAvoy, E., Sinclair, G. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1565 · Cited by 2,309 · see citing works
Self-citationNeutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103 · see citing works
Urban, C. F., Ermert, D., Schmid, M., Abed, U. A., Goosmann, C., Nacken, W. K. F., Brinkmann, V., Jungblut, P. R., & Zychlinsky, A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000639 · Cited by 1,677 · see citing works
Lood, C., Blanco, L. P., Purmalek, M. M., Carmona-Rivera, C., De Ravin, S. S., Smith, C. K., Malech, H. L., Ledbetter, J. A., Elkon, K. B., & Kaplan, M. J. (2016) · Nature Medicine · doi:10.1038/nm.4027 · Cited by 1,570 · see citing works
Extracellular histones are major mediators of death in sepsis
Xu, J., Zhang, X., Pelayo, R., Monestier, M., Ammollo, C. T., Semeraro, F., Taylor, F. B., Esmon, N. L., Lupu, F., & Esmon, C. T. (2009) · Nature Medicine · doi:10.1038/nm.2053 · Cited by 1,547 · see citing works
Wang, Y., Li, M., Stadler, S. C., Correll, S., Li, P., Wang, D., Hayama, R., Leonelli, L., Han, H., Grigoryev, S. A., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200806072 · Cited by 1,532 · see citing works
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
Li, P., Li, M., Lindberg, M. R., Kennett, M. J., Xiong, N., & Wang, Y. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100239 · Cited by 1,495 · see citing works
Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis
Hakkim, A., Fürnrohr, B. G., Amann, K., Laube, B., Abed, U. A., Brinkmann, V., i, M. H., Voll, R. E., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909927107 · Cited by 1,473 · see citing works
García-Romo, G. S., Caielli, S., Vega, B., Connolly, J., Allantaz, F., Xu, Z., Punaro, M., Baisch, J. M., Guiducci, C., Coffman, R. L., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001201 · Cited by 1,387 · see citing works
Saffarzadeh, M., Jünemann, C., Queisser, M. A., Lochnit, G., Barreto, G., Galuska, S. P., Lohmeyer, J., & Preissner, K. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032366 · Cited by 1,343 · see citing works
Khandpur, R., Carmona‐Rivera, C., Vivekanandan‐Giri, A., Gizinski, A. M., Yalavarthi, S., Knight, J. S., Friday, S. C., Li, S., Patel, R. M., Subramanian, V., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005580 · Cited by 1,342 · see citing works
Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
Warnatsch, A., Ιωάννου, Μ., Wang, Q., & Papayannopoulos, V. (2015) · Science · doi:10.1126/science.aaa8064 · Cited by 1,280 · see citing works
Diabetes primes neutrophils to undergo NETosis, which impairs wound healing
Wong, S. L., Demers, M., Martinod, K., Gallant, M., Wang, Y., Goldfine, A. B., Kahn, C. R., & Wagner, D. D. (2015) · Nature Medicine · doi:10.1038/nm.3887 · Cited by 1,264 · see citing works
An emerging role for neutrophil extracellular traps in noninfectious disease
Jorch, S. K., & Kubes, P. (2017) · Nature Medicine · doi:10.1038/nm.4294 · Cited by 1,244 · see citing works
Self-citationInfection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo
Yipp, B. G., Petri, B., Salina, D., Jenne, C. N., Scott, B. N. V., Zbytnuik, L. D., Pittman, K., Asaduzzaman, M., Wu, K., Meijndert, H. C., et al. (2012) · Nature Medicine · doi:10.1038/nm.2847 · Cited by 1,169 · see citing works
Self-citationPilsczek, F. H., Salina, D., Poon, K. K. H., Fahey, C., Yipp, B. G., Sibley, C. D., Robbins, S. M., Green, F. H. Y., Surette, M. G., Sugai, M., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000675 · Cited by 1,114 · see citing works
Self-citationBranzk, N., Lubojemska, A., Hardison, S. E., Wang, Q., Gutierrez, M. G., Brown, G. D., & Papayannopoulos, V. (2014) · Nature Immunology · doi:10.1038/ni.2987 · Cited by 1,037 · see citing works
Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps
Yousefi, S., Mihalache, C., Kozlowski, E., Schmid, I., & Simon, H. U. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.96 · Cited by 1,036 · see citing works
Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
Urban, C. F., Reichard, U., Brinkmann, V., & Zychlinsky, A. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00659.x · Cited by 1,014 · see citing works
Yipp, B. G., & Kubes, P. (2013) · Blood · doi:10.1182/blood-2013-04-457671 · Cited by 998 · see citing works
Self-citationAggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines
Schauer, C., Janko, C., Munoz, L. E., Zhao, Y., Kienhöfer, D., Frey, B., Lell, M., Manger, B., Rech, J., Naschberger, E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3547 · Cited by 998 · see citing works
Semeraro, F., Ammollo, C. T., Morrissey, J. H., Dale, G. L., Friese, P., Esmon, N. L., & Esmon, C. T. (2011) · Blood · doi:10.1182/blood-2011-03-343061 · Cited by 870 · see citing works
Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation
Hakkim, A., Fuchs, T. A., Martinez, N. E., Hess, S., Prinz, H., Zychlinsky, A., & Waldmann, H. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.496 · Cited by 793 · see citing works
Metzler, K. D., Fuchs, T. A., Nauseef, W. M., Reumaux, D., Roesler, J., Schulze, I., Wahn, V., Papayannopoulos, V., & Zychlinsky, A. (2010) · Blood · doi:10.1182/blood-2010-06-290171 · Cited by 775 · see citing works
Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis
McDonald, B., Urrutia, R., Yipp, B. G., Jenne, C. N., & Kubes, P. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.06.011 · Cited by 772 · see citing works
Self-citationGasdermin D plays a vital role in the generation of neutrophil extracellular traps
Sollberger, G., Choidas, A., Burn, G. L., Habenberger, P., Lucrezia, R. D., Kordes, S., Menninger, S., Eickhoff, J., Nußbaumer, P., Klebl, B., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aar6689 · Cited by 761 · see citing works
Metzler, K. D., Goosmann, C., Lubojemska, A., Zychlinsky, A., & Papayannopoulos, V. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.044 · Cited by 741 · see citing works
Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1
Saitoh, T., Komano, J. A., Saitoh, Y., Misawa, T., Takahama, M., Kozaki, T., Uehata, T., Iwasaki, H., Omori, H., Yamaoka, S., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.05.015 · Cited by 731 · see citing works
Douda, D. N., Khan, M. A., Grasemann, H., & Palaniyar, N. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414055112 · Cited by 696 · see citing works
Buchanan, J. T., Simpson, A. J., Aziz, R. K., Liu, G. Y., Kristian, S. A., Kotb, M., Feramisco, J. R., & Nizet, V. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.039 · Cited by 683 · see citing works
McDonald, B., Davis, R. P., Kim, S., Tse, M., Esmon, C. T., Kołaczkowska, E., & Jenne, C. N. (2017) · Blood · doi:10.1182/blood-2016-09-741298 · Cited by 666 · see citing works
Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps
Chen, K. W., Monteleone, M. M., Boucher, D., Sollberger, G., Ramnath, D., Condon, N. D., von Pein, J. B., Brož, P., Sweet, M. J., & Schroder, K. (2018) · Science Immunology · doi:10.1126/sciimmunol.aar6676 · Cited by 640 · see citing works
Neutrophils in tissue injury and repair
Wang, J. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2785-7 · Cited by 628 · see citing works
Host DNases prevent vascular occlusion by neutrophil extracellular traps
Jiménez-Alcázar, M., Rangaswamy, C., Panda, R., Bitterling, J., Simsek, Y., Long, A. T., Bilyy, R. O., Krenn, V., Renné, C., Renné, T., et al. (2017) · Science · doi:10.1126/science.aam8897 · Cited by 597 · see citing works
Restoration of NET formation by gene therapy in CGD controls aspergillosis
Bianchi, M., Hakkim, A., Brinkmann, V., Siler, U., Seger, R. A., Zychlinsky, A., & Reichenbach, J. (2009) · Blood · doi:10.1182/blood-2009-05-221606 · Cited by 593 · see citing works
Kolaczkowska, E., Jenne, C. N., Surewaard, B. G. J., Thanabalasuriar, A., Lee, W.-Y., Sanz, M.-J., Mowen, K., Opdenakker, G., & Kubes, P. (2015) · Nature Communications · doi:10.1038/ncomms7673 · Cited by 584 · see citing works
Self-citationVisualizing the function and fate of neutrophils in sterile injury and repair
Wang, J., Hossain, M., Thanabalasuriar, A., Gunzer, M., Meininger, C. J., & Kubes, P. (2017) · Science · doi:10.1126/science.aam9690 · Cited by 511 · see citing works
Self-citationMaladaptive role of neutrophil extracellular traps in pathogen-induced lung injury
Lefrançais, E., Mallavia, B., Zhuo, H., Calfee, C. S., & Looney, M. R. (2018) · JCI Insight · doi:10.1172/jci.insight.98178 · Cited by 472 · see citing works
The role of neutrophils and NETosis in autoimmune and renal diseases
Gupta, S., & Kaplan, M. J. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.71 · Cited by 433 · see citing works
Parker, H., Dragunow, M., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1211601 · Cited by 430 · see citing works
Bruns, S., Kniemeyer, O., Hasenberg, M., Aimanianda, V., Nietzsche, S., Thywißen, A., Jeron, A., Latgé, J., Brakhage, A. A., & Gunzer, M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000873 · Cited by 422 · see citing works
Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death
Kambara, H., Liu, F., Zhang, X., Liu, P., Bajrami, B., Teng, Y., Zhao, L., Zhou, S., Yu, H., Zhou, W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.067 · Cited by 418 · see citing works
Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis
Czaikoski, P. G., Mota, J. M., Nascimento, D. C., Sônego, F., Castanheira, F. V. S., Melo, P. H., Scortegagna, G. T., Silva, R. L., Barroso‐Sousa, R., Souto, F. O., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148142 · Cited by 400 · see citing works
Self-citationPeptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus
Knight, J. S., Zhao, W., Luo, W., Subramanian, V., O’Dell, A. A., Yalavarthi, S., Hodgin, J. B., Eitzman, D. T., Thompson, P. R., & Kaplan, M. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67390 · Cited by 388 · see citing works
BACTERICIDAL ACTION OF HISTONE
Hirsch, J. G. (1958) · The Journal of Experimental Medicine · doi:10.1084/jem.108.6.925 · Cited by 365 · see citing works
Chowdhury, C. S., Giaglis, S., Walker, U. A., Buser, A. S., Hahn, S., & Hasler, P. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4579 · Cited by 352 · see citing works
Neutrophil Extracellular Traps: The Biology of Chromatin Externalization
Sollberger, G., Tilley, D. O., & Zychlinsky, A. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.019 · Cited by 346 · see citing works
Neutrophil elastase targets virulence factors of enterobacteria
Weinrauch, Y., Drujan, D., Shapiro, S. D., Weiss, J. P., & Zychlinsky, A. (2002) · Nature · doi:10.1038/417091a · Cited by 334 · see citing works
Unconventional Roles of the NADPH Oxidase: Signaling, Ion Homeostasis, and Cell Death
Steinberg, B. E., & Grinstein, S. (2007) · Science s STKE · doi:10.1126/stke.3792007pe11 · Cited by 319 · see citing works
Neutrophil Extracellular Traps in the Second Decade
Brinkmann, V. (2018) · Journal of Innate Immunity · doi:10.1159/000489829 · Cited by 315 · see citing works
Byrd, A. S., O’Brien, X. M., Johnson, C. M., Lavigne, L. M., & Reichner, J. S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202671 · Cited by 311 · see citing works
Dicker, A., Crichton, M. L., Pumphrey, E., Cassidy, A., Suárez-Cuartín, G., Sibila, O., Furrie, E., Fong, C. J., Ibrahim, W., Brady, G., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.04.022 · Cited by 298 · see citing works
CD177+ neutrophils as functionally activated neutrophils negatively regulate IBD
Zhou, G., Lin, Y., Fang, L., Yang, W., Yu, T., Miao, Y., Chen, M., Wu, K., Chen, F., Cong, Y., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313535 · Cited by 278 · see citing works
Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps
Amulic, B., Knackstedt, S. L., Abed, U. A., Deigendesch, N., Harbort, C. J., Caffrey, B. E., Brinkmann, V., Heppner, F. L., Hinds, P. W., & Zychlinsky, A. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.10.013 · Cited by 269 · see citing works
Guglietta, S., Chiavelli, A., Zagato, E., Krieg, C., Gandini, S., Ravenda, P. S., Bazolli, B., Lu, B., Penna, G., & Rescigno, M. (2016) · Nature Communications · doi:10.1038/ncomms11037 · Cited by 257 · see citing works
Papayannopoulos, V., Staab, D., & Zychlinsky, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028526 · Cited by 252 · see citing works
NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus
Campbell, A. M., Kashgarian, M. J., & Shlomchik, M. J. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004801 · Cited by 246 · see citing works
Inflammation in cystic fibrosis: An update
Roesch, E. A., Nichols, D. P., & Chmiel, J. F. (2018) · Pediatric Pulmonology · doi:10.1002/ppul.24129 · Cited by 242 · see citing works
Damage-Associated Molecular Patterns Control Neutrophil Recruitment
Pittman, K., & Kubes, P. (2013) · Journal of Innate Immunity · doi:10.1159/000347132 · Cited by 241 · see citing works
Self-citationPAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock
Martinod, K., Fuchs, T. A., Zitomersky, N. L., Wong, S. L., Demers, M., Gallant, M., Wang, Y., & Wagner, D. D. (2015) · Blood · doi:10.1182/blood-2014-07-587709 · Cited by 237 · see citing works
Mouse Neutrophil Extracellular Traps in Microbial Infections
Ermert, D., Urban, C. F., Laube, B., Goosmann, C., Zychlinsky, A., & Brinkmann, V. (2009) · Journal of Innate Immunity · doi:10.1159/000205281 · Cited by 236 · see citing works
Krishnamoorthy, N., Douda, D. N., Brüggemann, T. R., Ricklefs, I., Duvall, M. G., Abdulnour, R.-E. E., Martinod, K., Tavares, L. P., Wang, X., Cernadas, M., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aao4747 · Cited by 234 · see citing works
Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious
Sônego, F., Castanheira, F. V. S., Ferreira, R. G., Kanashiro, A., Leite, C. A., Nascimento, D. C., Colón, D. F., Borges, V. D. F., Alves-Filho, J. C., & Cunha, F. Q. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00155 · Cited by 231 · see citing works
Self-citationFunctional activity of enucleated human polymorphonuclear leukocytes.
Roos, D., Voetman, A., & Meerhof, L. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.368 · Cited by 225 · see citing works
NEUTROPHIL PARALYSIS IN SEPSIS
Alves-Filho, J. C., Spiller, F., & Cunha, F. Q. (2010) · Shock · doi:10.1097/shk.0b013e3181e7e61b · Cited by 222 · see citing works
Impaired efferocytosis and neutrophil extracellular trap clearance by macrophages in ARDS
Grégoire, M., Uhel, F., Lesouhaitier, M., Gacouin, A., Guirriec, M., Mourcin, F., Dumontet, E., Chalin, A., Samson, M., Berthelot, L., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.02590-2017 · Cited by 219 · see citing works
Neutrophil extracellular traps are associated with inflammation in chronic airway disease
Wright, T. K., Gibson, P. G., Simpson, J. L., McDonald, V. M., Wood, L. G., & Baines, K. J. (2016) · Respirology · doi:10.1111/resp.12730 · Cited by 214 · see citing works
Dwyer, M., Shan, Q., D'Ortona, S., Maurer, R., Mitchell, R. A., Olesen, H. V., Thiel, S., Hüebner, J., & Gadjeva, M. G. (2014) · Journal of Innate Immunity · doi:10.1159/000363242 · Cited by 212 · see citing works
Grabcanovic-Musija, F., Obermayer, A., Stoiber, W., Krautgartner, W.-D., Steinbacher, P., Winterberg, N., Bathke, A. C., Klappacher, M., & Studnicka, M. (2015) · Respiratory Research · doi:10.1186/s12931-015-0221-7 · Cited by 211 · see citing works
Neutrophil extracellular traps promote macrophage pyroptosis in sepsis
Chen, L., Zhao, Y., Lai, D., Zhang, P., Yang, Y., Li, Y., Fei, K., Jiang, G., & Fan, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0538-5 · Cited by 211 · see citing works
Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis
Gray, R. D., Hardisty, G. R., Regan, K., Smith, M. P., Robb, C. T., Duffin, R., Mackellar, A., Felton, J. M., Paemka, L., McCullagh, B. N., et al. (2017) · Thorax · doi:10.1136/thoraxjnl-2017-210134 · Cited by 203 · see citing works
Thanabalasuriar, A., Scott, B., Peiseler, M., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.02.007 · Cited by 203 · see citing works
Zhou, G. X., & Liu, Z. (2017) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12540 · Cited by 202 · see citing works
Meng, W., Paunel‐Görgülü, A., Flohé, S., Hoffmann, A., Witte, I., MacKenzie, C. R., Baldus, S. E., Windolf, J., & Lögters, T. T. (2012) · Critical Care · doi:10.1186/cc11442 · Cited by 200 · see citing works
Bhattacharya, M., Berends, E. T. M., Chan, R., Schwab, E. R., Roy, S., Sen, C. K., Torres, V. J., & Wozniak, D. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721949115 · Cited by 200 · see citing works
Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production
Amini, P., Stojkov, D., Felser, A., Jackson, C. B., Courage, C., Schaller, A., Gelman, L., Soriano, M. E., Nuoffer, J., Scorrano, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05387-y · Cited by 184 · see citing works
Nicotine induces neutrophil extracellular traps
Hosseinzadeh, A., Thompson, P. R., Segal, B. H., & Urban, C. F. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ab0815-379rr · Cited by 169 · see citing works
Tanaka, K., Koike, Y., Shimura, T., Okigami, M., Ide, S., Toiyama, Y., Okugawa, Y., Inoue, Y., Araki, T., Uchida, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111888 · Cited by 156 · see citing works
Neutrophil heterogeneity: Bona fide subsets or polarization states?
Deniset, J., & Kubes, P. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ri0917-361r · Cited by 152 · see citing works
Self-citationMaugeri, N., Rovere, P. Q., Evangelista, V., Covino, C., Capobianco, A., Bertilaccio, M. T. S., Piccoli, A. L., Jr., Totani, L., Cianflone, D., Maseri, A., et al. (2009) · Blood · doi:10.1182/blood-2008-09-180794 · Cited by 150 · see citing works
Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin
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Imaging the dynamic platelet‐neutrophil response in sterile liver injury and repair in mice
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Self-citationClaushuis, T. A. M., van der Donk, L. E. H., Luitse, A. L., van Veen, H. A., van der Wel, N. N., van Vught, L. A., Roelofs, J. J. T. H., de Boer, O. J., Lankelma, J. M., Boon, L., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800314 · Cited by 110 · see citing works
Welin, A., Amirbeagi, F., Christenson, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069575 · Cited by 109 · see citing works
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Increased levels of serum myeloperoxidase in patients with active rheumatoid arthritis
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Flagged first, then by citations
Research works printed but not linked: 1
- Kolaczkowska E, Kubes P. Neutrophil re- cruitment and function in health and in- flammation. Nat Rev Immunol. 2013;13(3): 159-175.
Cited by
Sorted by citations
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How neutrophils meet their end
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Self-citation
- Authors
- Castanheira, F. V. S., & Kubes, P.
- Affiliations
- University of Calgary (CA)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2019-05-16
- Volume
- 133
- Issue
- 20
- Pages
- 2178-2185
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2925230746
- Cited by
- 792
- References
- 99
- Citations by year
- 2026: 94 · 2025: 173 · 2024: 144 · 2023: 103 · 2022: 119 · 2021: 97 · 2020: 45 · 2019: 17
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of Canada
- Canada Research Chairs
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- neutrophils, neutrophil extracellular traps, NETosis, acute inflammation, chronic inflammation, innate immunity, phagocytosis, tissue repair, host defense, tissue damage
- MeSH terms
- Acute Disease, Animals, Chronic Disease, Humans, Inflammation, Neutrophils, Phagocytosis, Extracellular Traps
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