A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

Wang, Jing; Kubes, Paul

doi:10.1016/j.cell.2016.03.009

Cited by 537Immune cells in cancerWound Healing and TreatmentsPhagocytosis and Immune Regulation

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

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Wang, Jing, Kubes, Paul·2016·Cell

DOI 10.1016/j.cell.2016.03.009

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Abstract

A key feature of inflammation is the timely recruitment of leukocytes, including monocytes, from blood into tissues, the latter maturing into macrophages over a period of 2-3 days. Using multi-channel spinning disk microscopy, we identified a rapid pathway of macrophage recruitment into an injured organ via a non-vascular route requiring no maturation from monocytes. In response to a sterile injury in liver, a reservoir of fully mature F4/80(hi)GATA6(+) peritoneal cavity macrophages rapidly invaded into afflicted tissue via direct recruitment across the mesothelium. The invasion was dependent on CD44 and DAMP molecule ATP and resulted in rapid replication and switching of macrophage toward an alternatively activated phenotype. These macrophages dismantled the nuclei of necrotic cells releasing DNA and forming a cover across the injury site. Rapid invasion of mature macrophages from body cavity with capacity for induction of reparative phenotype may impact altered tissues ranging from trauma to infections to cancer. VIDEO ABSTRACT.

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Authors: Wang, J., & Kubes, P.
Affiliations: University of Calgary (CA)
Corresponding author: Kubes, Paul
ORCID: Wang, Jing
Kubes, Paul
Venue: Cell
Publisher: Elsevier BV
Published: 2016-04
Volume: 165
Issue: 3
Pages: 668-678
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2016.03.009
OpenAlex: W2321369117
Cited by: 537
References: 43
Citations by year: 2026: 32 · 2025: 46 · 2024: 48 · 2023: 51 · 2022: 55 · 2021: 77 · 2020: 61 · 2019: 45 · 2018: 52 · 2017: 47 · 2016: 23
FWCI: 33.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: University of Calgary
Alberta Innovates - Health Solutions
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: peritoneal macrophages, macrophage recruitment, mesothelium, tissue repair, alternative activation, CD44, ATP, GATA6, F4/80, necrotic cell clearance, DNA release, inflammation, monocyte maturation
MeSH terms: Animals, Cell Movement, Disease Models, Animal, Inflammation, Leukocytes, Liver, Specific Pathogen-Free Organisms, Wound Healing, Macrophages, Peritoneal, Mice, Knockout, GATA6 Transcription Factor, Mice

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A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

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