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Placebo and nocebo effects: from observation to harnessing and clinical application

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Placebo effects and the molecular biological components involved

Cai, L., & He, L. (2019) · General Psychiatry · doi:10.1136/gpsych-2019-100089 · Cited by 32 · see citing works

Expectation and dyspnoea: the neurobiological basis of respiratory nocebo effects

Vlemincx, E., Sprenger, C., & Büchel, C. (2021) · European Respiratory Journal · doi:10.1183/13993003.03008-2020 · Cited by 33 · see citing works

Pain, from perception to action: A computational perspective

Chen, Z. S., & Wang, J. (2022) · iScience · doi:10.1016/j.isci.2022.105707 · Cited by 35 · see citing works

Open-Label Placebo Injection for Chronic Back Pain With Functional Neuroimaging

Ashar, Y. K., Sun, M. M. C., Knight, K., Flood, T. F., Anderson, Z. G., Kaptchuk, T. J., & Wager, T. D. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.32427 · Cited by 32 · see citing works

The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects

Wei, H., Zhou, L., Zhang, H., Chen, J., Lu, X., & Hu, L. (2018) · Pain Research and Management · doi:10.1155/2018/8459429 · Cited by 30 · see citing works

A test of positive suggestions about side effects as a way of enhancing the analgesic response to NSAIDs

Fernandez, A., Kirsch, I., Noël, L., Rodondi, P., Kaptchuk, T. J., Suter, M. R., Décosterd, I., & Berna, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0209851 · Cited by 30 · see citing works

Another's pain in my brain: No evidence that placebo analgesia affects the sensory-discriminative component in empathy for pain

Hartmann, H., Rütgen, M., Riva, F., & Lamm, C. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117397 · Cited by 28 · see citing works

Distinct networks of periaqueductal gray columns in pain and threat processing

Wang, S., Veinot, J., Goyal, A., Khatibi, A., Lazar, S. W., & Hashmi, J. A. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.118936 · Cited by 30 · see citing works

Reattribution to Mind-Brain Processes and Recovery From Chronic Back Pain

Ashar, Y. K., Lumley, M. A., Perlis, R. H., Liston, C. M., Gunning, F. M., & Wager, T. D. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.33846 · Cited by 30 · see citing works

Prefrontal expectancy and reinforcement-driven antidepressant placebo effects

Peciña, M., Heffernan, J., Wilson, J., Zubieta, J., & Dombrovski, A. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0263-y · Cited by 28 · see citing works

Distinct neural networks subserve placebo analgesia and nocebo hyperalgesia

Fu, J., Wu, S.-Y., Liu, C., Camilleri, J., Eickhoff, S., & Yu, R. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.117833 · Cited by 18 · see citing works

Opioid analgesia alters corticospinal coupling along the descending pain system in healthy participants

Tinnermann, A., Sprenger, C., & Büchel, C. (2022) · eLife · doi:10.7554/elife.74293 · Cited by 30 · see citing works

Super Placebos: A Feasibility Study Combining Contextual Factors to Promote Placebo Effects

Olson, J. A., Lifshitz, M., Raz, A., & Veissière, S. P. L. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.644825 · Cited by 28 · see citing works

Review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS)

Leszczyński, D. (2021) · Reviews on Environmental Health · doi:10.1515/reveh-2021-0038 · Cited by 26 · see citing works

Translating knowledge on placebo and nocebo effects into clinical practice

Caliskan, E. B., Bingel, U., & Kunkel, A. (2024) · PAIN Reports · doi:10.1097/pr9.0000000000001142 · Cited by 26 · see citing works

Social communication pathways to COVID-19 vaccine side-effect expectations and experience

Clemens, K. S., Faasse, K., Tan, W., Colagiuri, B., Colloca, L., Webster, R., Vase, L., Jason, E. C., & Geers, A. L. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.111081 · Cited by 26 · see citing works

The Power of Labeling in Nocebo Effects

Faasse, K., & Martin, L. R. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.016 · Cited by 24 · see citing works

Nocebo hyperalgesia can be induced by classical conditioning without involvement of expectancy

Bajcar, E. A., Adamczyk, W. M., Wiercioch‐Kuzianik, K., & Bąbel, P. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232108 · Cited by 19 · see citing works

Towards a Real-Life Understanding of the Altered Functional Behaviour of the Default Mode and Salience Network in Chronic Pain: Are People with Chronic Pain Overthinking the Meaning of Their Pain?

Johansson, E., Xiong, H.-Y., Polli, A., Coppieters, I., & Nijs, J. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13061645 · Cited by 21 · see citing works

How Negative Experience Influences the Brain: A Comprehensive Review of the Neurobiological Underpinnings of Nocebo Hyperalgesia

Thomaidou, M. A., Peerdeman, K. J., Koppeschaar, M. I., Evers, A. W. M., & Veldhuijzen, D. S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.652552 · Cited by 22 · see citing works

Gentle stroking elicits somatosensory ERP that differentiates between hairy and glabrous skin

Schirmer, A., Lai, O., McGlone, F. P., Cham, C., & Lau, D. (2022) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsac012 · Cited by 20 · see citing works

Hippocampus mediates nocebo impairment of opioid analgesia through changes in functional connectivity

Bingel, U., Wiech, K., Ritter, C., Wanigasekera, V., Mhuircheartaigh, R. N., Lee, M., Ploner, M., & Tracey, I. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15687 · Cited by 22 · see citing works

The beneficial effect of positive treatment expectations on pharmacological migraine prophylaxis

Schmidt, K., Berding, T., Kleine‐Borgmann, J., Engler, H., Holle, D., Gaul, C., & Bingel, U. (2021) · Pain · doi:10.1097/j.pain.0000000000002341 · Cited by 21 · see citing works

Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico‐spinal fMRI study

Braaß, H., Feldheim, J. F., Chu, Y., Tinnermann, A., Finsterbusch, J., Büchel, C., Schulz, R., & Gerloff, C. P. (2023) · Human Brain Mapping · doi:10.1002/hbm.26523 · Cited by 17 · see citing works

Association of nocebo hyperalgesia and basic somatosensory characteristics in a large cohort

Feldhaus, M. H., Horing, B., Sprenger, C., & Büchel, C. (2021) · Scientific Reports · doi:10.1038/s41598-020-80386-y · Cited by 18 · see citing works

Automated slice‐specific z‐shimming for functional magnetic resonance imaging of the human spinal cord

Kaptan, M., Vannesjo, S. J., Mildner, T., Horn, U., Hartley‐Davies, R., Oliva, V., Brooks, J. C. W., Weiskopf, N., Finsterbusch, J., & Eippert, F. (2022) · Human Brain Mapping · doi:10.1002/hbm.26018 · Cited by 18 · see citing works

The focus of spatial attention during the induction of central sensitization can modulate the subsequent development of secondary hyperalgesia

Filbrich, L., van den Broeke, E. N., Legrain, V., & Mouraux, A. (2019) · Cortex · doi:10.1016/j.cortex.2019.11.014 · Cited by 16 · see citing works

Microstructural plasticity in nociceptive pathways after spinal cord injury

Kyathanahally, S. P., Azzarito, M., Rösner, J., Calhoun, V. D., Blaiotta, C., Ashburner, J., Weiskopf, N., Wiech, K., Friston, K. J., Ziegler, G., et al. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-325580 · Cited by 17 · see citing works

Nocebo effects: more investigation is needed

Benedetti, F., & Shaibani, A. I. (2018) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2018.1474199 · Cited by 17 · see citing works

Are neural pathways processing airway inputs sensitized in patients with cough hypersensitivity?

Farrell, M. J., & Mazzone, S. B. (2019) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2019.101806 · Cited by 16 · see citing works

Learned Nocebo Effects on Cutaneous Sensations of Pain and Itch: A Systematic Review and Meta-analysis of Experimental Behavioral Studies on Healthy Humans

Thomaidou, M. A., Blythe, J. S., Peerdeman, K. J., van Laarhoven, A. I. M., van Schothorst, M. M. E., Veldhuijzen, D. S., & Evers, A. W. M. (2023) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001194 · Cited by 15 · see citing works

A comparison of the effectiveness of functional MRI analysis methods for pain research: The new normal

Stroman, P. W., Warren, H. J. M., Ioachim, G., Powers, J. M., & McNeil, K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243723 · Cited by 16 · see citing works

Distraction and cognitive control independently impact parietal and prefrontal response to pain

Silvestrini, N., & Corradi‐Dell’Acqua, C. (2023) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsad018 · Cited by 16 · see citing works

Abnormal intrinsic brain functional network dynamics in patients with cervical spondylotic myelopathy

Zhao, G., Zhan, Y., Zha, J., Cao, Y., Zhou, F., & He, L. (2022) · Cognitive Neurodynamics · doi:10.1007/s11571-022-09807-0 · Cited by 15 · see citing works

Decoding cerebro-spinal signatures of human behavior: Application to motor sequence learning

Kinany, N., Khatibi, A., Lungu, O., Finsterbusch, J., Büchel, C., Marchand‐Pauvert, V., Ville, D. V. D., Vahdat, S., & Doyon, J. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120174 · Cited by 15 · see citing works

Placebo effects in pain

Colloca, L. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.04.001 · Cited by 14 · see citing works

Human ventromedial prefrontal cortex lesions enhance the effect of expectations on pain perception

Motzkin, J. C., Hiser, J., Carroll, I. C., Wolf, R. C., Başkaya, M. K., Koenigs, M. R., & Atlas, L. Y. (2023) · Cortex · doi:10.1016/j.cortex.2023.04.017 · Cited by 16 · see citing works

Investigation of the neural basis of expectation-based analgesia in the human brainstem and spinal cord by means of functional magnetic resonance imaging

Stroman, P. W., Powers, J. M., Ioachim, G., Warren, H. J. M., & McNeil, K. (2021) · Neurobiology of Pain · doi:10.1016/j.ynpai.2021.100068 · Cited by 14 · see citing works

Placebo induced expectations of mood enhancement generate a positivity effect in emotional processing

Baker, J., Gamer, M., Rauh, J., & Brassen, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-09342-2 · Cited by 13 · see citing works

Integration of prior expectations and suppression of prediction errors during expectancy-induced pain modulation: the influence of anxiety and pleasantness

Tsai, H.-Y., Lapanan, K., Lin, Y., Huang, C., Lin, W., Lin, M., Lu, Z., Lin, F.-S., & Tseng, M. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1627-23.2024 · Cited by 14 · see citing works

The impact of generic labels on the consumption of and adherence to medication: a randomized controlled trial

Goldszmidt, R. B., Buttendorf, A. R., Filho, G. S., de Souza, J. M., & Bianchini, M. A. (2018) · European Journal of Public Health · doi:10.1093/eurpub/cky183 · Cited by 13 · see citing works

Pharmaceutical “New Prior Knowledge”: Twenty-First Century Assurance of Therapeutic Equivalence

Hussain, A. S., Gurvich, V. J., & Morris, K. R. (2019) · AAPS PharmSciTech · doi:10.1208/s12249-019-1347-6 · Cited by 13 · see citing works

Nocebo phenomena may be enhanced in aging: Implications for clinical practice

Kravvariti, E., Kotsani, M., Mitsikostas, D. D., & Sfikakis, P. P. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.07.011 · Cited by 13 · see citing works

Coordinated Human Brainstem and Spinal Cord Networks during the Expectation of Pain Have Elements Unique from Resting-State Effects

Ioachim, G., Powers, J. M., Warren, H. J. M., & Stroman, P. W. (2020) · Brain Sciences · doi:10.3390/brainsci10090568 · Cited by 13 · see citing works

The role of the Nocebo effect in the use of biosimilars in routine rheumatology clinical practice

Kravvariti, E., & Kitas, G. D. (2019) · Mediterranean Journal of Rheumatology · doi:10.31138/mjr.30.1.63 · Cited by 13 · see citing works

The causal role of brain circuits in osteoarthritis pain

Barroso, J., Branco, P., & Apkarian, A. V. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01234-9 · Cited by 11 · see citing works

Application of electroacupuncture for postoperative pain management after total knee arthroplasty: a study protocol for a single-blinded, randomised placebo-controlled trial

Zhong, S., Huang, H. M., Xie, J., Zhao, L., Song, X., Chen, Y., & Xiao, L. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-026084 · Cited by 13 · see citing works

The Context of Values in Pain Control: Understanding the Price Effect in Placebo Analgesia

Lee, Y., Jung, W.-M., Bingel, U., & Chae, Y. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.11.005 · Cited by 12 · see citing works

New insights into managing symptoms during statin therapy

Robinson, J. G. (2019) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2019.10.005 · Cited by 12 · see citing works

Observation of others’ painful heat stimulation involves responses in the spinal cord

Tinnermann, A., Büchel, C., & Haaker, J. (2021) · Science Advances · doi:10.1126/sciadv.abe8444 · Cited by 12 · see citing works

Improving T2*-weighted human cortico-spinal acquisitions with a dedicated algorithm for region-wise shimming

Chu, Y., Fricke, B., & Finsterbusch, J. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.119868 · Cited by 11 · see citing works

Harnessing placebo effects and mitigating nocebo effects: implications for clinical practice in psychiatry and medicine

Burke, M. J., Sandra, D. A., Peciña, M., Olson, J. A., Mollica, A., Butler, M., Moss, J. H., Nicholson, T. R., Wager, T. D., & Kaptchuk, T. J. (2026) · The Lancet Psychiatry · doi:10.1016/s2215-0366(25)00340-2 · Cited by 12 · see citing works

What is the relative contribution of biological and psychosocial factors to the generation of hypoxia headache?

Barbiani, D., Camerone, E. M., & Benedetti, F. (2018) · Canadian Journal of Pain · doi:10.1080/24740527.2018.1478224 · Cited by 10 · see citing works

Statistical learning shapes pain perception and prediction independently of external cues

Onysk, J., Gregory, N., Whitefield, M., Jain, M., Turner, G., Seymour, B., & Mancini, F. (2023) · eLife · doi:10.7554/elife.90634 · Cited by 14 · see citing works

Forebrain networks driving brainstem pain modulatory circuits during nocebo hyperalgesia in healthy humans

Crawford, L. S., Yang, S., Meylakh, N., Sattarov, L., Ramachandran, A., Macefield, V. G., Keay, K. A., & Henderson, L. A. (2025) · Pain · doi:10.1097/j.pain.0000000000003604 · Cited by 4 · see citing works

Facilitation of Pain in the Human Spinal Cord by Nocebo Treatment

Geuter, S., & Büchel, C. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2191-13.2013 · Cited by 152 · see citing works

The Context of Values in Pain Control: Understanding the Price Effect in Placebo Analgesia

Lee, Y., Jung, W.-M., Bingel, U., & Chae, Y. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.11.005 · Cited by 12 · see citing works

P271 In anticipation of pain: Corticospinal inhibition during nocebo hyperalgesia

Barnes, K., McNair, N. A., Harris, J. A., & Colagiuri, B. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.12.381

The downside to choice: instrumental control increases conditioned nocebo hyperalgesia

Tang, B., Livesey, E. J., & Colagiuri, B. (2024) · Pain · doi:10.1097/j.pain.0000000000003251 · Cited by 6 · see citing works