Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search.

Keller, A., Nesvizhskii, A., Kolker, E., & Aebersold, R. (2002) · Analytical Chemistry · doi:10.1021/ac025747h · Cited by 4,970 · see citing works

A statistical model for identifying proteins by tandem mass spectrometry.

Nesvizhskii, A., Keller, A., Kolker, E., & Aebersold, R. (2003) · Analytical Chemistry · doi:10.1021/ac0341261 · Cited by 4,902 · see citing works

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176 · see citing works

Role of the gut microbiota in immunity and inflammatory disease

Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256 · see citing works

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

Chang, C.-H., Curtis, J. D., Maggi, L. B., Faubert, B., Villarino, A. V., O’Sullivan, D., Huang, S. C.-C., van der Windt, G. J. W., Blagih, J., Qiu, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.016 · Cited by 2,204 · see citing works

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · see citing works

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

Kelly, B., & O'Neill, L. A. (2015) · Cell Research · doi:10.1038/cr.2015.68 · Cited by 1,876 · see citing works

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803 · see citing works

Metabolic Pathways in Immune Cell Activation and Quiescence

Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692 · see citing works

Linking genome and proteome by mass spectrometry: Large-scale identification of yeast proteins from two dimensional gels

Shevchenko, A., Jensen, O. N., Podtelejnikov, A. V., Sagliocco, F. A., Wilm, M. S., Vorm, O., Mortensen, P. M., Shevchenko, A., Boucherie, H., & Mann, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14440 · Cited by 1,429 · see citing works

Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation

Vats, D., Mukundan, L., Odegaard, J. I., Zhang, L., Smith, K. L., Morel, C. R., Greaves, D. R., Murray, P. J., & Chawla, A. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.011 · Cited by 1,369 · see citing works

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

Linker, R. A., Lee, D.-H., Ryan, S., van Dam, A. M., Conrad, R., Bista, P., Zeng, W., Hronowsky, X., Buko, A., Chollate, S., et al. (2011) · Brain · doi:10.1093/brain/awq386 · Cited by 1,155 · see citing works

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

Macintyre, A. N., Gerriets, V. A., Nichols, A., Michalek, R. D., Rudolph, M. C., Deoliveira, D., Anderson, S. M., Abel, E. D., Chen, B. J., Hale, L. P., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.004 · Cited by 1,129 · see citing works

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

Hara, M. R., Agrawal, N., Kim, S. F., Cascio, M. B., Fujimuro, M., Ozeki, Y., Takahashi, M., Cheah, J. H., Tankou, S. K., Hester, L. D., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1268 · Cited by 1,071 · see citing works

Vitamin C selectively kills <i>KRAS</i> and <i>BRAF</i> mutant colorectal cancer cells by targeting GAPDH

Yun, J., Mullarky, E., Lu, C., Bosch, K. N., Kavalier, A., Rivera, K., Roper, J., Chio, I. I. C., Giannopoulou, E. G., Rago, C., et al. (2015) · Science · doi:10.1126/science.aaa5004 · Cited by 913 · see citing works

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

Gerriets, V. A., Kishton, R. J., Nichols, A., Macintyre, A. N., Inoue, M., Ilkayeva, O., Winter, P. S., Liu, X., Priyadharshini, B., Slawinska, M. E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76012 · Cited by 729 · see citing works

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8⁺ T cells

Cham, C. M., Driessens, G., O'Keefe, J. P., & Gajewski, T. F. (2008) · European Journal of Immunology · doi:10.1002/eji.200838289 · Cited by 388 · see citing works

Glyceraldehyde-3-phosphate Dehydrogenase Selectively Binds AU-rich RNA in the NAD+-binding Region (Rossmann Fold)

Nagy, E., & Rigby, W. F. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.6.2755 · Cited by 361 · see citing works

Glucose Availability Regulates IFN-γ Production and p70S6 Kinase Activation in CD8+ Effector T Cells

Cham, C. M., & Gajewski, T. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4670 · Cited by 359 · see citing works

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

Shestov, A. A., Liu, X., Ser, Z., Cluntun, A. A., Hung, Y. P., Huang, L., Kim, D.-S., Le, A., Yellen, G., Albeck, J. G., et al. (2014) · eLife · doi:10.7554/elife.03342 · Cited by 315 · see citing works

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

Schulze‐Topphoff, U., Varrin‐Doyer, M., Pekarek, K. L., Spencer, C. M., Shetty, A., Sagan, S. A., Cree, B., Sobel, R. A., Wipke, B. T., Steinman, L., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603907113 · Cited by 292 · see citing works

A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product

Liberti, M. V., Dai, Z., Wardell, S. E., Baccile, J. A., Liu, X., Gao, X., Baldi, R. M., Mehrmohamadi, M., Johnson, M. O., Madhukar, N. S., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.017 · Cited by 196 · see citing works

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

Blewett, M. M., Xie, J., Zaro, B. W., Backus, K. M., Altman, A., Teijaro, J. R., & Cravatt, B. F. (2016) · Science Signaling · doi:10.1126/scisignal.aaf7694 · Cited by 194 · see citing works

Reduction of CD8 + T lymphocytes in multiple sclerosis patients treated with dimethyl fumarate

Spencer, C. M., Crabtree‐Hartman, E., Lehmann‐Horn, K., et al. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000076 · Cited by 189 · see citing works

Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer

van der Windt, G. J. W., Chang, C., & Pearce, E. L. (2016) · Current Protocols in Immunology · doi:10.1002/0471142735.im0316bs113 · Cited by 186 · see citing works

Pharmacokinetics of oral fumarates in healthy subjects

Litjens, N. H. R., Burggraaf, J., van Strijen, E., et al. (2004) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2004.02145.x · Cited by 142 · see citing works

Dimethyl fumarate treatment alters circulating T helper cell subsets in multiple sclerosis

Groß, C. C., Schulte‐Mecklenbeck, A., Klinsing, S., Posevitz‐Fejfár, A., Wiendl, H., & Klotz, L. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000183 · Cited by 142 · see citing works

Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase by Fumarate in Diabetes

Blatnik, M., Frizzell, N., Thorpe, S. R., & Baynes, J. (2007) · Diabetes · doi:10.2337/db07-0838 · Cited by 140 · see citing works

Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy

Linker, R. A., & Haghikia, A. (2016) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622316653307 · Cited by 134 · see citing works

Detection of metabolites of fumaric acid esters in human urine: implications for their mode of action.

Rostami‐Yazdi, M., Clement, B., Schmidt, T., Schinor, D., & Mrowietz, U. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.197 · Cited by 76 · see citing works

Effects of fumarates on circulating and CNS myeloid cells in multiple sclerosis

Michell‐Robinson, M. A., Moore, C. S., Healy, L. M., Osso, L. A., Garbajs, N. Z., Grouza, V., Touil, H., Poliquin‐Lasnier, L., Trudelle, A., Giacomini, P. S., et al. (2015) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.270 · Cited by 74 · see citing works

Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder

Piyarathna, D. W. B., Rajendiran, T. M., Putluri, V., et al. (2017) · European Urology Focus · doi:10.1016/j.euf.2017.04.005 · Cited by 65 · see citing works

Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments

Peng, H., Huo, L., Sheehy, A. M., Cullen, P. F., Allaire, N., & Scannevin, R. H. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.08.006 · Cited by 53 · see citing works

Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer

Vantaku, V., Donepudi, S. R., Ambati, C. R., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21038 · Cited by 52 · see citing works

Identification of koningic acid (heptelidic acid)-modified site in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase

Sakai, K., Hasumi, K., & Endo, A. (1991) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(91)90058-8 · Cited by 42 · see citing works

Redox Regulation of Protein Tyrosine Phosphatases

Parsons, Z. D., & Gates, K. S. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-405881-1.00008-2 · Cited by 32 · see citing works

Kinetics of CCR7 expression differ between primary activation and effector memory states of TH1 and TH2 cells

Calabresi, P. A., Allie, R., Mullen, K. M., Yun, S. H., Georgantas, R. W., & Whartenby, K. A. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00127-9 · Cited by 14 · see citing works

Mitochondrial TCA cycle metabolites control physiology and disease

Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813 · see citing works

Metabolism of immune cells in cancer

Leone, R. D., & Powell, J. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-020-0273-y · Cited by 877 · see citing works

Krebs cycle Reborn in macrophage immunometabolism

Ryan, D. G., & O'Neill, L. A. J. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-081619-104850 · Cited by 444 · see citing works

Coupling Krebs cycle metabolites to signalling in immunity and cancer

Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0014-7 · Cited by 398 · see citing works

HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron

Singhal, R., Mitta, S. R., Das, N. K., Kerk, S. A., Sajjakulnukit, P., Solanki, S., Andren, A., Kumar, R., Olive, K. P., Banerjee, R., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143691 · Cited by 215 · see citing works

Microglia in multiple sclerosis: protectors turn destroyers

Yong, V. W. (2022) · Neuron · doi:10.1016/j.neuron.2022.06.023 · Cited by 185 · see citing works

Reactive-cysteine profiling for drug discovery

Maurais, A. J., & Weerapana, E. (2019) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2019.02.010 · Cited by 167 · see citing works

Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis

Kaushik, D. K., Bhattacharya, A., Mirzaei, R., Rawji, K. S., Ahn, Y., Rho, J. M., & Yong, V. W. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124012 · Cited by 136 · see citing works

Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4–MyD88 Complex

Zaro, B. W., Vinogradova, E. V., Lazar, D. C., Blewett, M. M., Suciu, R. M., Takaya, J., Studer, S., de la Torre, J. C., Casanova, J.-L., Cravatt, B. F., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801627 · Cited by 68 · see citing works

Disrupting pro-survival and inflammatory pathways with dimethyl fumarate sensitizes chronic lymphocytic leukemia to cell death

Mantione, M. E., Meloni, M., Sana, I., Bordini, J., Del Nero, M., Riba, M., Ranghetti, P., Perotta, E., Ghia, P., Scarfò, L., et al. (2024) · Cell Death &amp; Disease · doi:10.1038/s41419-024-06602-z · Cited by 57 · see citing works

Reprogramming of mitochondrial metabolism by innate immunity

Garaude, J. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.09.010 · Cited by 33 · see citing works

Dimethyl fumarate: targeting glycolysis to treat MS

Angiari, S., & O’Neill, L. A. (2018) · Cell Research · doi:10.1038/s41422-018-0045-3 · Cited by 27 · see citing works

Mildly Oxidized Glyceraldehyde‐3‐Phosphate Dehydrogenase as a Possible Regulator of Glycolysis

Danshina, P. V., Schmalhausen, E. V., Avetisyan, A. V., et al. (2001) · IUBMB Life · doi:10.1080/152165401317190824 · Cited by 59 · see citing works

Aerobic Glycolysis and Its Role in Maintenance of High O2 Tensions in the Teleost Retina

Baeyens, D. A., Hoffert, J. R., & Fromm, P. O. (1971) · Experimental Biology and Medicine · doi:10.3181/00379727-137-35657 · Cited by 9 · see citing works

[Involvement of K+ in anerobic glycolysis of E. coli].

Puchkov, E. O., Nv, K., & Nm, P. (1982) · PubMed · Cited by 2 · see citing works

Oncogenic virus-induced aerobic glycolysis and tumorigenesis

Yu, L., Chen, X., Wang, L., & Chen, S. (2018) · Journal of Cancer · doi:10.7150/jca.27279 · Cited by 40 · see citing works

Engineering glyceraldehyde‐3‐phosphate dehydrogenase for switching control of glycolysis in Escherichia coli

Cho, H., Seo, S. W., Kim, Y. M., et al. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24532 · Cited by 34 · see citing works