The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Space and time in the brain
Open accessAbstract
Nothing is more intuitive, yet more complex, than the concepts of space and time. In contrast to spacetime in physics, space and time in neuroscience remain separate coordinates to which we attach our observations. Investigators of navigation and memory relate neuronal activity to position, distance, time point, and duration and compare these parameters to units of measuring instruments. Although spatial-temporal sequences of brain activity often correlate with distance and duration measures, these correlations may not correspond to neuronal representations of space or time. Neither instruments nor brains sense space or time. Neuronal activity can be described as a succession of events without resorting to the concepts of space or time. Instead of searching for brain representations of our preconceived ideas, we suggest investigating how brain mechanisms give rise to inferential, model-building explanations.
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“Treating space as a sequence is a necessity for humans and other animals because they lack a global positioning system that enables direct sensing of location coordinates.”
From Space is a latent sequence: A theory of the hippocampus (2024) · cites this paper as [9]
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“However, anomalies have been accumulating over the simple view that place cells represent just locations (8, 9, 32, 45, 46).”
From Space is a latent sequence: A theory of the hippocampus (2024) · cites this paper as [9]
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Citations
Cites
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Cited by
Sorted by citations
Viewpoints: how the hippocampus contributes to memory, navigation and cognition
Lisman, J., Buzsáki, G., Eichenbaum, H., Nadel, L., Ranganath, C., & Redish, A. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4661 · Cited by 851
Self-citationSpace and Time: The Hippocampus as a Sequence Generator
Buzsáki, G., & Tingley, D. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.07.006 · Cited by 461
“If distance and duration are defined and understood with the help of human-made measuring instruments, one may wonder how space and time are computed and comprehended by other animals who cannot read those instruments [9].”
BackgroundInfluentialSelf-citationIntegrating time from experience in the lateral entorhinal cortex
Tsao, A., Sugar, J., Lu, L., Wang, C., Knierim, J. J., Moser, M.-B., & Moser, E. I. (2018) · Nature · doi:10.1038/s41586-018-0459-6 · Cited by 490
The Neural Basis of Timing: Distributed Mechanisms for Diverse Functions
Paton, J. J., & Buonomano, D. V. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.045 · Cited by 469
“It is increasingly well accepted that the ability to tell time, to predict when events will happen, and to process and represent temporal patterns are among the brain’s most important and basic functions (Meck and Ivry, 2016; Buzsáki and Llinás, 2017).”
BackgroundNorthoff, G., Wainio‐Theberge, S., & Evers, K. (2019) · Physics of Life Reviews · doi:10.1016/j.plrev.2019.05.002 · Cited by 272
Metadata
- Authors
- Buzsáki, G., & Llinás, R.
- Affiliations
- New York University (US)
- Corresponding author
- Buzsáki, György
- ORCID
- Buzsáki, György
- Venue
- Science
- Published
- 2017-10-27
- Volume
- 358
- Issue
- 6362
- Pages
- 482-485
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5998813
- OpenAlex
- W2766264103
- Semantic Scholar
- 492d4fdcadcc502d185bd3924176dbf422cf451a
- Cited by
- 175
- References
- 53
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 19 · 2023: 18 · 2022: 17 · 2021: 32 · 2020: 25 · 2019: 23 · 2018: 16 · 2017: 1
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (award343774, NS 090583, award343775, NS090526, award343777, NS074015)
- National Institute of Mental Health (award343773, MH54671)
- Simons Foundation (award343778)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
- Keywords
- spatial representation, representation of time, neuronal activity, navigation, memory, model development, inference
- MeSH terms
- Animals, Brain, Humans, Neurons, Space Perception, Time Perception, Rats, Memory, Episodic, Spatial Navigation
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