Cited by 461Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Space and Time: The Hippocampus as a Sequence Generator

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Buzsáki, György, Tingley, David·2018·Trends in Cognitive Sciences

Abstract

Neural computations are often compared to instrument-measured distance or duration, and such relationships are interpreted by a human observer. However, neural circuits do not depend on human-made instruments but perform computations relative to an internally defined rate-of-change. While neuronal correlations with external measures, such as distance or duration, can be observed in spike rates or other measures of neuronal activity, what matters for the brain is how such activity patterns are utilized by downstream neural observers. We suggest that hippocampal operations can be described by sequential activity of neuronal assemblies and their internally defined rate of change without resorting to the concept of space or time.

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Crossref · 10.1016/j.tics.2018.07.006

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  • Anomalies have been accumulating over the simple view that place cells represent just locations.

    “However, anomalies have been accumulating over the simple view that place cells represent just locations (8, 9, 32, 45, 46).”

    From Space is a latent sequence: A theory of the hippocampus (2024) · cites this paper as [45]

  • The sequence-centric paradigm developed in this paper resolves these anomalies by re-interpreting space as a sequence.

    “In contrast, the sequence-centric paradigm (45) we develop in this paper resolves these anomalies by re-interpreting space as a sequence.”

    From Space is a latent sequence: A theory of the hippocampus (2024) · cites this paper as [45]

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Research works printed but not linked: 3

  1. [3]Borges JL (1994) Ficciones, Grove Press.
  2. [6]Kant I (1781) Critique of pure reason, Penguin.
  3. [22]Amaral DG and Lavenex P (2006) Hippocampal Neuroanatomy. In The Hippocampus Book pp. 45– 66

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Authors
Buzsáki, G., & Tingley, D.
Affiliations
NYU Langone Health (US)
Corresponding author
Buzsáki, György
Venue
Trends in Cognitive Sciences
Publisher
Elsevier BV
Published
2018-10
Volume
22
Issue
10
Pages
853-869
ISSN
1364-6613 (ISSN-L)
OpenAlex
W2893325263
Cited by
461
References
138
Citations by year
2026: 57 · 2025: 77 · 2024: 50 · 2023: 62 · 2022: 63 · 2021: 52 · 2020: 44 · 2019: 51 · 2018: 4
FWCI
5.06
Type
journal article
Language
en
Open access
Locations
  • Trends in Cognitive Sciences (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • US National Institute of Health (MH107396, NS099705, NS104590)
  • Mathers Foundation
  • Simons Foundation
  • US National Science Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
hippocampus, sequence generation, neural computation, rate of change, cell assemblies, spike frequency, time and space, neural observer
MeSH terms
Animals, Hippocampus, Humans, Neurons, Space Perception, Theta Rhythm, Time Perception

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