The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Single-stranded DNA and RNA origami
Open accessAbstract
Large origami from a single strand: Nanostructures created by origami-like folding of nucleic acids are usually formed by base-pairing interactions between multiple strands. Han et al. show that large origami (up to 10,000 nucleotides for DNA and 6000 nucleotides for RNA) can be created in simple shapes, such as a rhombus or a heart. A single strand can be folded smoothly into structurally complex but knot-free structures by using partially complemented double-stranded DNA and the cohesion of parallel crossovers. The use of single strands also enables in vitro synthesis of these structures. Science , this issue p. eaao2648
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As three-dimensional nucleic acid nanostructures have also successfully been produced inside cells,154 there is potentially important synergy between in vitro/in vivo DNA nanotechnology and data storage, which remains, as of yet, unexplored.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [154]
In the citing paper
“As three-dimensional nucleic acid nanostructures have also successfully been produced inside cells,154 there is potentially important synergy between in vitro/in vivo DNA nanotechnology and data storage, which remains, as of yet, unexplored.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [154]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Folding DNA to create nanoscale shapes and patterns
Rothemund, P. W. K. (2006) · Nature · doi:10.1038/nature04586 · Cited by 7,474 · cited 8×
“Despite its fundamental importance and practical desirability, as well as the aforementioned promising early efforts (3, 41–45), it remains challenging to develop a general strategy for the design and synthesis of an ssDNA or ssRNA that can fold into a user-prescribed complex, arbitrary shape [for example, comparable…”
BackgroundMethodInfluentialDesign and self-assembly of two-dimensional DNA crystals
Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C. (1998) · Nature · doi:10.1038/28998 · Cited by 2,857 · cited 2×
“A typical PCR reaction was as follows: (1) Initial denaturation at 98°C for 30 s; (2) 25 to 35 cycles of 10 s at 98°C (strand separation stage), 30 s at 65°C (annealing stage), and 1 min at 72°C (polymerase extension stage); (3) final extension for 10 min at 72°C; (4) hold at 4°C after reaction.”
MethodSelf-assembly of DNA into nanoscale three-dimensional shapes
Douglas, S. M., Dietz, H., Liedl, T., Högberg, B., Graf, F., & Shih, W. M. (2009) · Nature · doi:10.1038/nature08016 · Cited by 2,617 · cited 2×
“However, whereas multikilobase, megadalton-size discrete DNA nanostructures have been demonstrated [for example, via scaffolded origami (4, 8) and DNA bricks (14, 15)], synthetic RNA nanostructures remain comparatively simple: The largest discrete structure demonstrated is the aforementioned 660-nt ssRNA tile (44).”
BackgroundDNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response
Kuzyk, A., Schreiber, R., Fan, Z., Pardatscher, G., Roller, E.-M., Högele, A., Simmel, F. C., Govorov, A. O., & Liedl, T. (2012) · Nature · doi:10.1038/nature10889 · Cited by 2,235
A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
Douglas, S. M., Bachelet, I., & Church, G. M. (2012) · Science · doi:10.1126/science.1214081 · Cited by 2,187
Self-assembly of a nanoscale DNA box with a controllable lid
Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Subramani, R., Mamdouh, W., Golas, M. M., Sander, B. O., Stark, H., Oliveira, C. L. P., et al. (2009) · Nature · doi:10.1038/nature07971 · Cited by 1,650
Synthesis from DNA of a molecule with the connectivity of a cube
Chen, J., & Seeman, N. C. (1991) · Nature · doi:10.1038/350631a0 · Cited by 1,394 · cited 3×
“More formally, previous scaffolded origami work and the DNA brick work demonstrate the construction of a size n object using O(n) number of components; the unimolecular ssOrigami demonstrates the construction of a size n object using one component; the two-strand case represents its construction using O(1) components;…”
MethodFolding DNA into Twisted and Curved Nanoscale Shapes
Dietz, H., Douglas, S. M., & Shih, W. M. (2009) · Science · doi:10.1126/science.1174251 · Cited by 1,361
Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra
He, Y., Ye, T., Su, M., Zhang, C., Ribbe, A. E., Jiang, W., & Mao, C. (2008) · Nature · doi:10.1038/nature06597 · Cited by 1,326
Three-Dimensional Structures Self-Assembled from DNA Bricks
Ke, Y., Ong, L. L., Shih, W. M., & Yin, P. (2012) · Science · doi:10.1126/science.1227268 · Cited by 1,249
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- W. B. R. Lickorish An Introduction to Knot Theory (Springer Science and Business Media 2012) vol. 175.
Cited by
Sorted by citations
Items 101–200 of 299
Cumberworth, A., & Reinhardt, A. (2025) · Chemical Society Reviews · doi:10.1039/d4cs01095g · Cited by 14
Aptamers as target-specific recognition elements in drug delivery
Vydaline, A. O. E., Rozhkov, S., Sosa, G., & Mallikaratchy, P. R. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115685 · Cited by 23
Liu, C., & Sun, J. (2021) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-091520-091450 · Cited by 23
Isothermal folding of a light-up bio-orthogonal RNA origami nanoribbon
Torelli, E., Kozyra, J., Gu, J.-Y., Stimming, U., Piantanida, L., Voı̈tchovsky, K., & Krasnogor, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-25270-6 · Cited by 22
Framework Nucleic Acids in Nuclear Medicine Imaging: Shedding Light on Nano–Bio Interactions
Wang, H., Liu, Q., Lan, X., & Jiang, D. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202111980 · Cited by 22
High-order structures from nucleic acids for biomedical applications
Hill, A. C., & Hall, J. (2020) · Materials Chemistry Frontiers · doi:10.1039/c9qm00638a · Cited by 22
Topology of Folded Molecular Chains: From Single Biomolecules to Engineered Origami
Scalvini, B., Sheikhhassani, V., Woodard, J. C., Aupič, J., Dame, R. T., Jerala, R., & Mashaghi, A. (2020) · Trends in Chemistry · doi:10.1016/j.trechm.2020.04.009 · Cited by 21
Immunomodulation with Nucleic Acid Nanodevices
Ding, F., Zhang, S., Chen, Q., Feng, H., Ge, Z., Zuo, X., Fan, C., Li, Q., & Xia, Q. (2023) · Small · doi:10.1002/smll.202206228 · Cited by 21
Addressing the in vivo delivery of nucleic-acid nanostructure therapeutics
Alexander, S., Moghadam, M. G., Rothenbroker, M., & Chou, L. Y. T. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114898 · Cited by 24
Barcoding chemical modifications into nucleic acids improves drug stability in vivo
Sago, C. D., Kalathoor, S., Fitzgerald, J. P., Lando, G. N., Djeddar, N., Bryksin, A. V., & Dahlman, J. E. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01642a · Cited by 23
Genetically encoded RNA nanodevices for cellular imaging and regulation
Yu, Q., Ren, K., & You, M. (2021) · Nanoscale · doi:10.1039/d0nr08301a · Cited by 20
Dai, K., Xu, Y. Y., Yang, Y., Shen, J., Liu, X., Tu, X., Lu, Y., Qi, X., Li, J., Wang, L., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c03477 · Cited by 20
Self-citationCircular Single-Stranded DNA: Discovery, Biological Effects, and Applications
Cao, X., Tang, L., & Song, J. (2024) · ACS Synthetic Biology · doi:10.1021/acssynbio.4c00040 · Cited by 20
Atomic structures of RNA nanotubes and their comparison with DNA nanotubes
Naskar, S., Joshi, H., Chakraborty, B., Seeman, N. C., & Maiti, P. K. (2019) · Nanoscale · doi:10.1039/c9nr00786e · Cited by 20
Lu, J., Hu, P., Cao, L., Wei, Z., Xiao, F., Chen, Z., Li, Y., & Tian, L. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202012916 · Cited by 21
Engineering a DNAzyme-Based Operon System for the Production of DNA Nanoscaffolds in Living Bacteria
Alon, D. M., Voigt, C. A., & Elbaz, J. (2020) · ACS Synthetic Biology · doi:10.1021/acssynbio.9b00415 · Cited by 19
An RNA Paranemic Crossover Triangle as A 3D Module for Cotranscriptional Nanoassembly
Vallina, N. S., McRae, E. K. S., Geary, C. W., & Andersen, E. S. (2022) · Small · doi:10.1002/smll.202204651 · Cited by 20
Out-of-Plane Aptamer Functionalization of RNA Three-Helix Tiles
Chopra, A., Sagredo, S., Grossi, G., Andersen, E. S., & Simmel, F. C. (2019) · Nanomaterials · doi:10.3390/nano9040507 · Cited by 18
Synthetic bionanotechnology: synthetic biology finds a toehold in nanotechnology
Green, A. A. (2019) · Emerging Topics in Life Sciences · doi:10.1042/etls20190100 · Cited by 19
Zhu, G., Song, P., Wu, J., Luo, M., Chen, Z., & Chen, T. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.792489 · Cited by 20
Ghosal, S., Bag, S., & Bhowmik, S. (2023) · Polymers · doi:10.3390/polym15081850 · Cited by 18
Wang, R., Zhang, G., & Liu, H. (2018) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2018.09.006 · Cited by 18
In silico modelling of DNA nanostructures
Kekić, T., & Barišić, I. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.05.016 · Cited by 18
“1) [21–24].”
MethodCotranscriptional Folding of a Bio-orthogonal Fluorescent Scaffolded RNA Origami
Torelli, E., Kozyra, J., Shirt‐Ediss, B., Piantanida, L., Voı̈tchovsky, K., & Krasnogor, N. (2020) · ACS Synthetic Biology · doi:10.1021/acssynbio.0c00009 · Cited by 19
Elango, R., Vishnubalaji, R., Shaath, H., & Alajez, N. M. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02213-2 · Cited by 17
Toward a comprehensive catalog of regulatory elements
Fan, K., Pfister, E. L., & Weng, Z. (2023) · Human Genetics · doi:10.1007/s00439-023-02519-3 · Cited by 19
DNA nanotechnology-based nucleic acid delivery systems for bioimaging and disease treatment
Sun, Z., Ren, Y., Zhu, W., Xiao, Y., & Wu, H. (2023) · The Analyst · doi:10.1039/d3an01871g · Cited by 17
Jeon, H., Nam, H., & Lee, J. B. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11080387 · Cited by 17
DNA Origami Nanostructures with Scaffolds Obtained from Rolling Circle Amplification
Xu, M., Zhang, C., Zhang, C., Zhao, Y., Qi, Z., Fan, C., Chao, J., & Wei, B. (2020) · ACS Materials Letters · doi:10.1021/acsmaterialslett.9b00484 · Cited by 17
Biomedical Micro/nanomotors: Driven mechanism, preparation and physiological barriers breakthrough
Guo, Q., Wang, J., Guo, J., Wu, Q., Li, S., Wang, H., Sun, Y., & Liu, H. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216441 · Cited by 16
Biomolecule-Based Optical Metamaterials: Design and Applications
Torres‐Huerta, A. L., Pérez, A. A., García-Huante, Y., Alcázar-Ramírez, N. J., & Rueda-Silva, J. C. (2022) · Biosensors · doi:10.3390/bios12110962 · Cited by 16
Programmable all-DNA hydrogels based on rolling circle and multiprimed chain amplification products
Hanif, W., Yadav, I., Hasan, E. A., & Sulaiman, D. A. (2023) · APL Bioengineering · doi:10.1063/5.0169063 · Cited by 16
“3 Indeed, the field of DNA nanotechnology has made significant advancements using DNA to form nanorobots 4 as well as 0D, 1D, and multidimensional structures 5 assembled via tile assembly 6,7 and DNA origami, 8 among other strategies.”
BackgroundNucleoCraft: The Art of Stimuli-Responsive Precision in DNA and RNA Bioengineering
Lu, Y., Chen, L., Satyabola, D., Prasad, A., & Yan, H. (2024) · BME Frontiers · doi:10.34133/bmef.0050 · Cited by 17
“Unlike sticky ends, these interactions occur between closed strands and permit the design and self-assembly of single-stranded RNA nanostructures [28,38].”
BackgroundMethodSelf-citationStereochemical conversion of nucleic acid circuits via strand displacement
Hsieh, W., Rama, G., Wang, A. R., Wu, S. F., Chamdia, R., & Ly, D. H. (2018) · Communications Chemistry · doi:10.1038/s42004-018-0089-9 · Cited by 16
Biomimetic Compartments Scaffolded by Nucleic Acid Nanostructures
Fu, J., Oh, S. W., Monckton, K., Arbuckle-Keil, G. A., Ke, Y., & Zhang, T. (2019) · Small · doi:10.1002/smll.201900256 · Cited by 17
Framework Nucleic Acids for Cell Imaging and Therapy
Ge, Z., Li, Q., & Fan, C. (2019) · Chemical Research in Chinese Universities · doi:10.1007/s40242-019-9249-4 · Cited by 16
DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials
Xu, X., Winterwerber, P., Ng, D. Y. W., & Wu, Y. (2020) · Topics in Current Chemistry · doi:10.1007/s41061-020-0292-x · Cited by 16
Single-Stranded RNA Origami-Based Epigenetic Immunomodulation
Dai, K., Chen, G., Xu, Y., Ding, F., Qi, X., Tu, X., Lu, Y., Liu, X., Li, J., Fan, C., et al. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c02185 · Cited by 15
Self-citationMarpaung, D. S. S., Sinaga, A. O. Y., Damayanti, D., & Taharuddin, T. (2024) · Analytical Sciences · doi:10.1007/s44211-024-00566-y · Cited by 15
“Han et al. [52] created self-complementary single-stranded DNA scaffolds of varying sizes from E.coli plasmid, spanning from 966 to 10,682 nucleotides, tailored to achieve a user-defined shape.”
DNA origami: an outstanding platform for functions in nanophotonics and cancer therapy
Dai, L., Liu, P., Hu, X., Zhao, X., Shao, G., & Tian, Y. (2021) · The Analyst · doi:10.1039/d0an02160a · Cited by 15
Programming ultrasensitive threshold response through chemomechanical instability
Kim, Y., Park, J., Lee, J. Y., & Kim, D. (2021) · Nature Communications · doi:10.1038/s41467-021-25406-9 · Cited by 15
Therapeutic applications of RNA nanostructures
Yip, T., Qi, X., Yan, H., & Chang, Y. (2024) · RSC Advances · doi:10.1039/d4ra03823a · Cited by 15
“12 Qi, et al. demonstrated that this ssRNA molecule could self-assemble e ffi ciently into its dsRNA rectangular conformation in the absence of divalent cations, eliminating the dependence on Mg 2+ for folding.”
BackgroundMethodInfluentialSelf-citationDynamically regulating metabolic fluxes with synthetic metabolons
Zhang, Y., & Fernie, A. R. (2022) · Trends in biotechnology · doi:10.1016/j.tibtech.2022.06.005 · Cited by 14
Zheng, M., Li, Z., Liu, L., Li, M., Paluzzi, V. E., Choi, J. H., & Mao, C. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c09925 · Cited by 15
In Vivo Production of RNA Aptamers and Nanoparticles: Problems and Prospects
Shanaa, O. A., Rumyantsev, A. M., Sambuk, E. V., & Padkina, M. V. (2021) · Molecules · doi:10.3390/molecules26051422 · Cited by 12
Asymmetry in Polymer–Solvent Interactions Yields Complex Thermoresponsive Behavior
Dhamankar, S., & Webb, M. A. (2024) · ACS Macro Letters · doi:10.1021/acsmacrolett.4c00178 · Cited by 13
Algorithmic Design of 3D Wireframe RNA Polyhedra
Elonen, A., Natarajan, A. K., Kawamata, I., Oesinghaus, L., Mohammed, A., Seitsonen, J. J. T., Suzuki, Y., Simmel, F. C., Kuzyk, A., & Orponen, P. (2022) · ACS Nano · doi:10.1021/acsnano.2c06035 · Cited by 17
“…also the work of Afonin et al., 22 where RNA cubes are constructed from a small number of intertwined short RNA strands, and that of Han et al., 23 where 2D RNA tiles of various shapes are created by locking antiparallel overlays of partially complemented regions together with cohesive…”
Wang, Z., Iago-Mcrae, E. S., Ebrahimimojarad, A., Oh, S. W., & Fu, J. (2022) · Langmuir · doi:10.1021/acs.langmuir.2c02064 · Cited by 13
Stable DNA Sequence Over Close-Ending and Pairing Sequences Constraint
Li, X., Wei, Z., Wang, B., & Song, T. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.644484 · Cited by 13
“Han et al. (2017) developed a new strategy called single-stranded origami (ssOrigami), which uses a single-stranded DNA or RNA as long as thin as a noodle to implement a self-folding structure without a topological junction, which could allow drugs to travel directly to the site of injury within…”
BackgroundSelf-citationKöhler, J. M. (2021) · Encyclopedia · doi:10.3390/encyclopedia1030051 · Cited by 13
“The simple construction principle, the availability of enzymes as natural tools for processing of DNA fragments, and the principle of molecular recognition by base-pairing allowing for manipulation of DNA in the artificial molecular construction is an impressive example for the realization of a bottom-up approach [15,…”
BackgroundDynamics of flexible multi-stable origami with bio-inspired creases
Han, H., Yu, B., Tang, L., Zhao, N., Cao, D., & Wang, Y. (2025) · International Journal of Mechanical Sciences · doi:10.1016/j.ijmecsci.2025.110488 · Cited by 12
Zhao, Z. G., Zheng, X., Li, Y., Yao, X., Wang, H., & Song, X. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202409050 · Cited by 12
DNA interfaces with dimensional materials for biomedical applications
Asefifeyzabadi, N., Das, P. K., Onorimuo, A. H., Durocher, G., & Shamsi, M. H. (2021) · RSC Advances · doi:10.1039/d1ra04917h · Cited by 12
Single-stranded templates as railroad tracks for hierarchical assembly of DNA origami
Rahbani, J. F., Hsu, J. C. C., Chidchob, P., & Sleiman, H. F. (2018) · Nanoscale · doi:10.1039/c8nr03185a · Cited by 12
DNA origami directed fabrication of shape-controllable nanomaterials
Liu, F., Shang, Y., Wang, Z., Jiao, Y., Li, N., & Ding, B. (2020) · APL Materials · doi:10.1063/5.0025776 · Cited by 12
Bioinspired Photonic Systems Directed by Designer DNA Nanostructures
Satyabola, D., Prasad, A., Yan, H., & Zhou, X. (2024) · ACS Applied Optical Materials · doi:10.1021/acsaom.4c00103 · Cited by 11
Self-citationRecent Advances in DNA Origami-Enabled Optical Biosensors for Multi-Scenario Application
Hao, Z., Kong, L., Ruan, L., & Deng, Z. (2024) · Nanomaterials · doi:10.3390/nano14231968 · Cited by 11
“In addition, to fully integrate DNA folding with biological systems, Yan et al. came up with a single-strand origami [11], where ssDNA can be cloned into Escherichia coli for replication and amplification.”
A single strand: A simplified approach to DNA origami
Yang, M., Bakker, D., Raghu, D., & Li, I. T. S. (2023) · Frontiers in Chemistry · doi:10.3389/fchem.2023.1126177 · Cited by 11
Inhomogeneity-Induced Casimir Transport of Nanoparticles
Bao, F., Shi, K., Cao, G., Evans, J. S., & He, S. (2018) · Physical Review Letters · doi:10.1103/physrevlett.121.130401 · Cited by 11
Self-assembled Nucleic Acid Nanostructures for Biomedical Applications
Chang, X., Yang, Q., Lee, J., & Zhang, F. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026622666220321140729 · Cited by 10
Self-citationProgrammable in vitro and in vivo folding of single-stranded nucleic-acid wireframe origami
Zhang, T., Qian, X., Cui, H., Li, Q., Du, X., Fu, X., Gu, H., Zeng, W., & Wei, B. (2024) · Chem · doi:10.1016/j.chempr.2024.04.023 · Cited by 11
Expanding DNA Origami Design Freedom with De Novo Synthesized Scaffolds
Wu, H., Zhang, T., Qin, Y., Xia, X., Bai, T., Gu, H., & Wei, B. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c03148 · Cited by 10
DNA origami-based nano-vaccines for cancer immunotherapy
Ahmed, T. (2024) · Nano Trends · doi:10.1016/j.nwnano.2024.100060 · Cited by 10
Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis
Caldwell, B. A., Ie, S., Lucas, A., & Li, L. (2025) · Scientific Reports · doi:10.1038/s41598-025-86103-x · Cited by 10
Diverse applications of DNA origami as a cross-disciplinary tool
Xiao, L., Hu, X., Zhou, Z., Xie, X., Huang, S., Ji, M., Xu, A., & Tian, Y. (2025) · Nanoscale · doi:10.1039/d4nr04490h · Cited by 10
DNA-programmed responsive microorganism assembly with controlled patterns and behaviors
Kong, Y., Du, Q., Zhao, D., Wen, Y., Zhang, T., Geng, Z.-W., Ying, M., Wei, B., Si, T., Tian, Y., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads8651 · Cited by 10
mRNA folding algorithms for structure and codon optimization
Ward, M., Richardson, M. O. G., & Metkar, M. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf386 · Cited by 12
“These include CRISPR guide RNA design [28],inverse RNA folding (also called RNA structure design) [29, 30], RNA (and DNA) origami [31], and more.”
Li, X., Dai, X., Pan, Y., Sun, Y., Yang, B., Chen, K., Wang, Y., Xu, J., Dong, Y., Yang, Y. R., et al. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c08930 · Cited by 9
Conformational Control of DNA Origami by DNA Oligomers, Intercalators and UV Light
Li, R., Chen, H., Lee, H., & Choi, J. H. (2021) · Methods and Protocols · doi:10.3390/mps4020038 · Cited by 9
“DNA origami may form complex one-dimensional (1-D), 2-D and 3-D nanostructures of arbitrary geometries, including smiley faces [7,9], multi-tooth gears [10], nanorobots [11,12], polyhedral [13], and auxetic structures [14,15].”
BackgroundWalker-Gibbons, R., Xin, Z., Behjatian, A., Bennett, T. J. D., & Krishnan, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-70641-x · Cited by 9
RNA–DNA Hybrid Nanoshape Synthesis by Facile Module Exchange
Chen, S., & Hermann, T. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c09739 · Cited by 9
A Comparison of Methods for the Production of Kilobase-Length Single-Stranded DNA
Oh, C. Y., & Henderson, E. R. (2022) · DNA · doi:10.3390/dna2010005 · Cited by 9
“Identification and isolation of the desired strand post-denaturation can be accomplished by, for example, asymmetric biotin modification using a variety of streptavidin (or avidin) selection systems [21,25,26] or agarose gel electrophoresis (AGE) [24,26,27].”
BackgroundMethodZhang, J., Lin, B., Wu, L., Huang, M., Li, X., Zhang, H., Song, J. T., Wang, W., Zhao, G., Song, Y., et al. (2020) · Angewandte Chemie · doi:10.1002/ange.202005974 · Cited by 9
Duplex-forming oligocarbamates with tunable nonbonding sites
Weigel, R. K., & Alabi, C. A. (2024) · Chemical Science · doi:10.1039/d4sc00242c · Cited by 8
DNA-templated fabrication of metal nanostructures with special shapes
Ren, S., Ren, L., Wei, B., Liu, Y., Yang, J., Li, J., & Wang, L. (2024) · Advanced Sensor and Energy Materials · doi:10.1016/j.asems.2024.100133 · Cited by 8
Self-citationLoescher, S., Groeer, S., & Walther, A. (2018) · Angewandte Chemie · doi:10.1002/ange.201801700 · Cited by 8
DNA-based plasmonic nanostructures and their optical and biomedical applications
Liu, S., Shang, Y., Jiao, Y., Li, N., & Ding, B. (2021) · Nanotechnology · doi:10.1088/1361-6528/ac0d1c · Cited by 8
ExpertRNA: A New Framework for RNA Secondary Structure Prediction
Liu, M., Pedrielli, G., Poppleton, E., Šulc, P., & Bertsekas, D. P. (2022) · INFORMS journal on computing · doi:10.1287/ijoc.2022.1188 · Cited by 7
RNA Nanostructures: From Structure to Function
Wilner, O. I., Yesodi, D., & Weizmann, Y. (2022) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.2c00417 · Cited by 10
Guo, Y., Xiong, T., Yan, H., & Zhang, R. (2025) · Discover Nano · doi:10.1186/s11671-025-04188-9 · Cited by 7
Self-citationZhou, X., Wang, N., Zhao, B., Liu, Z., & Yu, P. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125694 · Cited by 7
A DNA Origami‐Based Gene Editing System for Efficient Gene Therapy in Vivo
Tang, W., Tong, T., Wang, H., Lu, X., Yang, C., Wu, Y., Wang, Y., Liu, J., & Ding, B. (2023) · Angewandte Chemie · doi:10.1002/ange.202315093 · Cited by 7
ANNaMo: Coarse-grained modeling for folding and assembly of RNA and DNA systems
Guerra, F. T., Poppleton, E., Šulc, P., & Rovigatti, L. (2024) · The Journal of Chemical Physics · doi:10.1063/5.0202829 · Cited by 7
Genetically Encoded Nucleic Acid Nanostructures for Biological Applications
Yang, C., Fan, J., Zhu, H., Wang, H., He, Y., Liu, J., & Ding, B. (2025) · ChemBioChem · doi:10.1002/cbic.202400991 · Cited by 7
Recent Advances in Origins of Life Research by Biophysicists in Japan
Jia, T. Z., & Kuruma, Y. (2019) · Challenges · doi:10.3390/challe10010028 · Cited by 8
“This time-resolution could allow further elucidation into the assembly dynamics and topology of primitive self-assembling systems, such as fiber-forming tripeptides [20], lipid layers on mineral surfaces [156], or complex-folded RNA origamis [157].”
BackgroundDesigning libraries for pooled CRISPR functional screens of long noncoding RNAs
Pulido-Quetglas, C., & Johnson, R. (2021) · Mammalian Genome · doi:10.1007/s00335-021-09918-9 · Cited by 7
Aliev, T. A., Timralieva, A. A., Kurakina, T. A., Кацуба, К. Е., Egorycheva, Y. A., Dubovichenko, M. V., Kutyrev, M. A., Shilovskikh, V. V., Orekhov, N., Kondratyuk, N., et al. (2022) · Nano Select · doi:10.1002/nano.202200092 · Cited by 7
Implementing Arbitrary CRNs Using Strand Displacing Polymerase
Shah, S., Song, T., Song, X., Yang, M., & Reif, J. H. (2019) · Lecture notes in computer science · doi:10.1007/978-3-030-26807-7_2 · Cited by 7
Biotechnological and Therapeutic Applications of Natural Nucleic Acid Structural Motifs
Duan, J., Wang, X., & Kizer, M. E. (2020) · Topics in Current Chemistry · doi:10.1007/s41061-020-0290-z · Cited by 8
Folding molecular origami from ribosomal RNA
Shapiro, A., Joseph, N., Mellul, N., Abu-Horowitz, A., Mizrahi, B., & Bachelet, I. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02489-2 · Cited by 7
“In DNA origami, the folding of a single DNA scaffold is usually mediated by hybridization of many short DNA oligonucleotides termed staples [7], although unimolecular folding has also been demonstrated [6, 13, 19–21].”
BackgroundMethodDNA/RNA Origami Based on Different Scaffolds and Their Biomedical Applications
Fan, J., Yang, C., Zhu, H., Wang, H., Li, X., Liu, J., & Ding, B. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00154 · Cited by 6
A long-staple design approach towards the scalable production of scaffolded DNA origami
Lee, C., Kim, Y., Jeon, K., Ryu, T., & Kim, D. (2025) · Nanoscale Horizons · doi:10.1039/d5nh00357a · Cited by 6
Revolutionizing tumor diagnosis and treatment: the promise of DNA nanotechnology
Zhou, Y., & Wang, N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1637539 · Cited by 6
PyFuRNAce: an integrated design engine for RNA origami
Monari, L., Braun, I., Verstraeten, W., Poppleton, E., & Göpfrich, K. (2025) · Nature Communications · doi:10.1038/s41467-025-66290-x · Cited by 6
“To accomplish these feats of rational design, the field has developed three RNA design pardigms: RNA architectonics (tectoRNA) [9, 10], co-transcriptional RNA origami [4, 11], and paranemic cohesion (PX) RNA origami [12], each with their advantages and disadvantages.”
Proximity-enhanced synthesis of DNA–peptide–DNA triblock molecules
MacCulloch, T., Novacek, A., & Stephanopoulos, N. (2022) · Chemical Communications · doi:10.1039/d1cc04970d · Cited by 6
Molecularly or atomically precise nanostructures for bio-applications: how far have we come?
Wang, J., Li, P., Wang, C., Liu, N., & Xing, D. (2023) · Materials Horizons · doi:10.1039/d3mh00574g · Cited by 6
Xie, W., & Pedrielli, G. (2022) · Winter Simulation Conference · doi:10.1109/wsc57314.2022.10015464 · Cited by 7
DNA Computing Model for Satisfiability Problem Based on Hybridization Chain Reaction
Yin, Z., Yang, J., Zhang, Q., Tang, Z., Wang, G., & Zheng, Z. (2020) · International Journal of Pattern Recognition and Artificial Intelligence · doi:10.1142/s0218001421590102 · Cited by 6
Brightwell, D. F., Samanta, K., Watts, J. A., Fay, M. W., & Palma, A. (2024) · Nanoscale Advances · doi:10.1039/d4na00762j · Cited by 5
A review of advances in in vitro RNA preparation by ssRNAP
Shen, Y., Yang, D.-Q., Liu, Y., Lao, J.-E., Liu, C., Gao, X., He, Y.-R., & Xia, H. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141002 · Cited by 5
Self-citation
Metadata
- Authors
- Han, D., Qi, X., Myhrvold, C., Wang, B., Dai, M., Jiang, S., Bates, M., Liu, Y., An, B., Zhang, F., Yan, H., & Yin, P.
- Affiliations
- Harvard University (US)
- Arizona State University (US)
- University of Science and Technology of China (CN)
- Autodesk (United States) (US)
- Corresponding author
- Han, Dongran
- Qi, Xiaodong
- An, Byoungkwon
- Zhang, Fei
- Yan, Hao
- Yin, Peng
- ORCID
- Venue
- Science
- Published
- 2017-12-15
- Volume
- 358
- Issue
- 6369
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6384012
- OpenAlex
- W2775235705
- Cited by
- 300
- References
- 67
- Citations by year
- 2026: 23 · 2025: 35 · 2024: 31 · 2023: 30 · 2022: 41 · 2021: 39 · 2020: 48 · 2019: 24 · 2018: 29
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
- Funders
- National Science Foundation (award355762, 1360635, award355763, 1563799, award355764, 1334109)
- Office of Naval Research (award355757, N000141010827, award355758, N000141310593, award355759, N000141410610, award355761, N000141512689)
- China Scholarship Council (award355765, 201506340048)
- Army Research Office (award355760, W911NF1210238)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Mathematics › Theoretical Computer Science › DNA and Biological Computing
- Keywords
- DNA origami, RNA origami, single-stranded DNA, single-stranded RNA, nucleic acid nanostructures, self-assembly, in vitro replication, in vivo replication, bottom-up nanotechnology
- MeSH terms
- DNA Replication, DNA, Single-Stranded, Escherichia coli, Nucleotides, RNA, Nanotechnology, Nanostructures, RNA Folding
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
