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Single-stranded DNA and RNA origami
Open accessAbstract
Large origami from a single strand: Nanostructures created by origami-like folding of nucleic acids are usually formed by base-pairing interactions between multiple strands. Han et al. show that large origami (up to 10,000 nucleotides for DNA and 6000 nucleotides for RNA) can be created in simple shapes, such as a rhombus or a heart. A single strand can be folded smoothly into structurally complex but knot-free structures by using partially complemented double-stranded DNA and the cohesion of parallel crossovers. The use of single strands also enables in vitro synthesis of these structures. Science , this issue p. eaao2648
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“As three-dimensional nucleic acid nanostructures have also successfully been produced inside cells,154 there is potentially important synergy between in vitro/in vivo DNA nanotechnology and data storage, which remains, as of yet, unexplored.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [154]
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“As three-dimensional nucleic acid nanostructures have also successfully been produced inside cells,154 there is potentially important synergy between in vitro/in vivo DNA nanotechnology and data storage, which remains, as of yet, unexplored.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [154]
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Programmable Assembly of Higher‐Order DNA Nanostructures from Microbial ssDNA Staple Libraries
Yen, M. H., Kesama, M. R., Du, Y., Choi, J. H., & Solomon, K. (2026) · Small · doi:10.1002/smll.75880
Tools For Building Artificial Biological Nanostructures
Bradford, T. S., Hutchings, S., Liston, J. D., Pakosz, Z., Sanderson, A., Shaukat, A., Bentham, A. R., Lin, T., Stępień, P., & Heddle, J. G. (2026) · ACS Nano · doi:10.1021/acsnano.5c14315
From Blueprint to Breakthrough: How Far Can We Fold DNA Origami for Nano-Enabled Technologies?
Yadav, A. K., Verma, D., & Bhatia, D. D. (2026) · JACS Au · doi:10.1021/jacsau.5c01315 · Cited by 1
The Synthetic Double-Helical Polyelectrolyte PBDT: From Molecular Conformation to Advanced Materials
Zheng, H., & Men, Y. (2026) · ACS Applied Polymer Materials · doi:10.1021/acsapm.6c01398
Prospects of DNA nanotechnology in stroke repair and regeneration
Kansara, K., Jantrania, K., Chokshi, S., Bhatia, D. D., & Kumar, A. (2026) · Communications Biology · doi:10.1038/s42003-026-10617-x
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Programmable Edge-to-Edge Assembly of RNA Nanostructures
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Iterative Selection of DNA Nanostructures for Cellular Uptake
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Programmable Self-Assembly of RNA Nanostructures with >100 Unique ComponentsPreprint
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Metadata
- Authors
- Han, D., Qi, X., Myhrvold, C., Wang, B., Dai, M., Jiang, S., Bates, M., Liu, Y., An, B., Zhang, F., Yan, H., & Yin, P.
- Affiliations
- Harvard University (US)
- Arizona State University (US)
- University of Science and Technology of China (CN)
- Autodesk (United States) (US)
- Corresponding author
- Han, Dongran
- Qi, Xiaodong
- An, Byoungkwon
- Zhang, Fei
- Yan, Hao
- Yin, Peng
- ORCID
- Venue
- Science
- Published
- 2017-12-15
- Volume
- 358
- Issue
- 6369
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6384012
- OpenAlex
- W2775235705
- Cited by
- 300
- References
- 67
- Citations by year
- 2026: 23 · 2025: 35 · 2024: 31 · 2023: 30 · 2022: 41 · 2021: 39 · 2020: 48 · 2019: 24 · 2018: 29
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
- Funders
- National Science Foundation (award355762, 1360635, award355763, 1563799, award355764, 1334109)
- Office of Naval Research (award355757, N000141010827, award355758, N000141310593, award355759, N000141410610, award355761, N000141512689)
- China Scholarship Council (award355765, 201506340048)
- Army Research Office (award355760, W911NF1210238)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Mathematics › Theoretical Computer Science › DNA and Biological Computing
- Keywords
- DNA origami, RNA origami, single-stranded DNA, single-stranded RNA, nucleic acid nanostructures, self-assembly, in vitro replication, in vivo replication, bottom-up nanotechnology
- MeSH terms
- DNA Replication, DNA, Single-Stranded, Escherichia coli, Nucleotides, RNA, Nanotechnology, Nanostructures, RNA Folding
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