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Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation
Open accessAbstract
Tubulin carboxypeptidase identity revealed: Enzymes of the α-tubulin detyrosination/tyrosination cycle create landmarks on microtubules that are essential for their multiple cellular functions and are altered in disease. Tubulin carboxypeptidases (TCPs) responsible for detyrosination have remained elusive for 40 years (see the Perspective by Akhmanova and Maiato). Aillaud et al. identified vasohibins as enzymes that perform the TCP function and found that their small interacting partner SBVP was essential for their activity. Vasohibin/SVBP complexes were involved in neuron polarization and brain cortex development. The authors also developed an inhibitor targeting this family of enzymes. Using a completely different strategy, Nieuwenhuis et al. also showed that vasohibins can remove the C-terminal tyrosine of α-tubulin. Science , this issue p. 1448 , p. 1453 ; see also p. 1381
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“Induction of microtubule detyrosination (removal of the C-terminal tyrosine of α-tubulin), another modification associated with microtubule stability 31 , by overexpressing the detyrosinating enzymes VASH2-SVBP or MATCAP 56-58 , either did not impact the localization of GEF-H1 to microtubules or showed a slight increase in binding (Extended Data Fig. 4b-e).”
From Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling (2026) · cites this paper as [56]
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Metadata
- Authors
- Aillaud, C., Bosc, C., Peris, L., Bosson, A., Heemeryck, P., Van Dijk, J., Le Friec, J., Boulan, B., Vossier, F., Sanman, L. E., Syed, S., Amara, N., Couté, Y., Lafanechère, L., Denarier, E., Delphin, C., Pelletier, L., Humbert, S., Bogyo, M., Andrieux, A., Rogowski, K., & Moutin, M.-J.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Grenoble Institut des Neurosciences (GIN), Université Grenoble Alpes, F-38000 Grenoble, France.
- Stanford Medicine (US)
- Team Regulation and Pharmacology of the Cytoskeleton, Institute for Advanced Biosciences, INSERM U 1209, CNRS UMR 5309, Université Grenoble Alpes, 38000 Grenoble, France.
- Corresponding author
- Andrieux, Annie
- Rogowski, Krzysztof
- Moutin, Marie-Jo
- ORCID
- Aillaud, Chrystelle
- Bosc, Christophe
- Peris, Leticia
- Bosson, Anouk
- Heemeryck, Pierre
- Van Dijk, Juliette
- Le Friec, Julien
- Boulan, Benoit
- Vossier, Frédérique
- Sanman, Laura E.
- Syed, Salahuddin
- Amara, Neri
- Couté, Yohann
- Lafanechère, Laurence
- Denarier, Eric
- Delphin, Christian
- Pelletier, Laurent
- Humbert, Sandrine
- Bogyo, Matthew
- Andrieux, Annie
- Rogowski, Krzysztof
- Moutin, Marie-Jo
- Venue
- Science
- Published
- 2017-12-15
- Volume
- 358
- Issue
- 6369
- Pages
- 1448-1453
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2769672674
- Cited by
- 293
- References
- 37
- Citations by year
- 2026: 24 · 2025: 40 · 2024: 33 · 2023: 31 · 2022: 38 · 2021: 35 · 2020: 40 · 2019: 33 · 2018: 16 · 2017: 3
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- National Institutes of Health (EB005011)
- Association pour la Recherche sur le Cancer (SFI20111204053, DOC20120605000, 20151203348)
- Agence Nationale de la Recherche (ANR-10-INBS-08-01, ANR-13-JSV2-0002/TYRTUB)
- Institut national de la santé et de la recherche médicale
- Centre National de la Recherche Scientifique
- Commissariat à l"Énergie Atomique et aux Énergies Alternatives
- Université Grenoble Alpes
- La Ligue contre le Cancer, comités Isère et Savoie
- Fondation pour la Recherche Médicale (FDT20160435356)
- Institut National Du Cancer (2016-165)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- vasohibin-1, vasohibin-2, microtubule dynamics, neuronal differentiation, neuronal migration, neocortex development, chemoproteomics, irreversible enzyme inhibitors
- MeSH terms
- Animals, Carboxypeptidases, Carrier Proteins, Cell Movement, Female, Humans, Male, Neurons, Tubulin, Tyrosine, Cell Cycle Proteins, Neocortex, Proteomics, Angiogenic Proteins, Mice, Neurogenesis, Gene Knockdown Techniques, HEK293 Cells
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