The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases
Open accessAbstract
Chronic stress as a survival tactic: Most patients with pancreatic ductal adenocarcinoma (PDA) develop liver metastases after surgical removal of their primary tumor. These metastases are thought to potentially arise from quiescent disseminated cancer cells, likely present at the time of surgery, which evade elimination by the immune system. Pommier et al. explored how these quiescent cells survive by analyzing mouse models and tissue samples from patients with PDA. They found that disseminated cancer cells do not express a cell surface molecule that triggers killing by T cells. This phenotypic feature is linked to their inability to resolve endoplasmic reticulum stress. When this stress is resolved, the disseminated cells begin proliferating and form metastases. Science , this issue p. eaao4908
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Molecular principles of metastasis: a hallmark of cancer revisited
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Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice
Albrengues, J., Shields, M. A., Ng, D., Park, C. G., Ambrico, A., Poindexter, M. E., Upadhyay, P., Uyeminami, D. L., Pommier, A., Küttner, V., et al. (2018) · Science · doi:10.1126/science.aao4227 · Cited by 1,476
Self-citationThe Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer
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Endoplasmic reticulum stress signals in the tumour and its microenvironment
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Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I
Yamamoto, K., Venida, A., Yano, J., Biancur, D. E., Kakiuchi, M., Gupta, S., Sohn, A. S. W., Mukhopadhyay, S., Lin, E. Y., Parker, S. J., et al. (2020) · Nature · doi:10.1038/s41586-020-2229-5 · Cited by 1,240
Self-citation
Metadata
- Authors
- Pommier, A., Anaparthy, N., Memos, N., Kelley, Z. L., Gouronnec, A., Yan, R., Auffray, C., Albrengues, J., Egeblad, M., Iacobuzio-Donahue, C. A., Lyons, S. K., & Fearon, D. T.
- Venue
- Science
- Published
- 2018-06-15
- Volume
- 360
- Issue
- 6394
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2804317605
- Cited by
- 271
- References
- 7
- FWCI
- 11.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Pommier, A., Anaparthy, N., Memos, N., Kelley, Z. L., Gouronnec, A., Yan, R., Auffray, C., Albrengues, J., Egeblad, M., Iacobuzio-Donahue, C. A., Lyons, S. K., & Fearon, D. T. (2018). Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases. Science. https://doi.org/10.1126/science.aao4908
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