Chemically induced proximity in biology and medicine

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SH2 domains recognize specific phosphopeptide sequences

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TAC‐tics for Leveraging Proximity Biology in Drug Discovery

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Pairwise Proximity‐Differentiated Visualization of Single‐Cell DNA Epigenetic Marks

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Structural basis for chemically-induced homodimerization of a single domain antibody

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Modular Thermal Control of Protein Dimerization

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Using antibodies to control DNA-templated chemical reactions

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A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in Alzheimer’s disease

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The present and the future of protein biosensor engineering

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A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation

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Lenalidomide Stabilizes Protein–Protein Complexes by Turning Labile Intermolecular H-Bonds into Robust Interactions

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Optogenetic Approaches for the Spatiotemporal Control of Signal Transduction Pathways

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Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices

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Proximity-Dependent Biotinylation Approaches to Explore the Dynamic Compartmentalized Proteome

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Unifying Catalysis Framework to Dissect Proteasomal Degradation Paradigms

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Remote control of cellular immunotherapy

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SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues

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High-throughput ligand diversification to discover chemical inducers of proximity

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Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs

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A Chemically Disrupted Proximity System for Controlling Dynamic Cellular Processes

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T herapeutic targeting of chromatin: status and opportunities

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Phage-Assisted Continuous Evolution and Selection of Enzymes for Chemical Synthesis

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Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets

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Directions for research and training in plant omics: Big Questions and Big Data

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Templated chemistry for bioorganic synthesis and chemical biology

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Transformable DNA Nanorobots Reversibly Regulating Cell Membrane Receptors for Modulation of Cellular Migrations

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The size matters? A computational tool to design bivalent ligands

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Recent advances in induced proximity modalities

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In vivo protein-based biosensors: seeing metabolism in real time

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A Split CRISPR/Cas13b System for Conditional RNA Regulation and Editing

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Advancing protein therapeutics through proximity-induced chemistry

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O-GlcNAcylation in tumorigenesis and its implications for cancer therapy

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Biological impact of mutually exclusive exon switching

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Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches

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ARVib suppresses growth of advanced prostate cancer via inhibition of androgen receptor signaling

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Blank spots on the map: some current questions on nuclear organization and genome architecture

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Epigenetic Control of a Local Chromatin Landscape

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Heterobivalent Ligand for the Adenosine A2A–Dopamine D2 Receptor Heteromer

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Design and engineering of genetically encoded protein biosensors for small molecules

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IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors

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Engineering receptors in the secretory pathway for orthogonal signalling control

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Sonogenetic control of multiplexed genome regulation and base editing

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Dynamic Metabolons Using Stimuli-Responsive Protein Cages

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The First‐In‐Class Deubiquitinase‐Targeting Chimera Stabilizes and Activates cGAS

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Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins

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Chemically induced proximity reveals a Piezo-dependent meiotic checkpoint at the oocyte nuclear envelope

Liu, C., & Dernburg, A. F. (2024) · Science · doi:10.1126/science.adm7969 · Cited by 23

Chemical and Light Inducible Epigenome Editing

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Natural and Designed Proteins Inspired by Extremotolerant Organisms Can Form Condensates and Attenuate Apoptosis in Human Cells

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CREB3L2-ATF4 heterodimerization defines a transcriptional hub of Alzheimer’s disease gene expression linked to neuropathology

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Targeted protein degradation in mammalian cells: A promising avenue toward future

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Targeted Degradation of Structured RNAs via Ribonuclease-Targeting Chimeras (RiboTacs)

Haj-Yahia, S., Nandi, A., & Benhamou, R. I. (2023) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2224960 · Cited by 25

Quantitative control of subcellular protein localization with a photochromic dimerizer

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Pooled endogenous protein tagging and recruitment for systematic profiling of protein function

Serebrenik, Y. V., Mani, D. R., Maujean, T., Burslem, G. M., & Shalem, O. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100651 · Cited by 21

Induced proximity at the cell surface

Till, N. A., Ramanathan, M., & Bertozzi, C. R. (2025) · Nature Biotechnology · doi:10.1038/s41587-025-02592-1 · Cited by 21

Facilitating the development of molecular glues: Opportunities from serendipity and rational design

Jiang, W., Jiang, Y., Luo, Y., Qiao, W., & Yang, T. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115950 · Cited by 22

A nanobody-based molecular toolkit provides new mechanistic insight into clathrin-coat initiation

Traub, L. M. (2019) · eLife · doi:10.7554/elife.41768 · Cited by 20

Repurposing salicylic acid as a versatile inducer of proximity

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ATNC: Versatile Nanobody Chimeras for Autophagic Degradation of Intracellular Unligandable and Undruggable Proteins

He, H., Zhou, C., & Chen, X. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c08843 · Cited by 20

A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins

Gama-Brambila, R. A., Chen, J., Dabiri, Y., Tascher, G., Němec, V., Münch, C., Song, G., Knapp, S., & Cheng, X. (2021) · JACS Au · doi:10.1021/jacsau.1c00007 · Cited by 21

Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective

Chang, X., Qu, F., Li, C., Zhang, J., Zhang, Y., Xie, Y., Fan, Z., Bian, J., Wang, J., Li, Z., et al. (2024) · Medicinal Research Reviews · doi:10.1002/med.22024 · Cited by 21

Molecular Epigenetics: Chemical Biology Tools Come of Age

Bagert, J. D., & Muir, T. W. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-080120-021109 · Cited by 21

Small molecule-induced degradation of the full length and V7 truncated variant forms of human androgen receptor

Dalal, K., Morin, H., Ban, F., Shepherd, A., Fernández, M., Tam, K. J., Li, H., Leblanc, E., Lack, N. A., Prinz, H., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.08.059 · Cited by 18

Proximity-Dependent Switchable ATP Aptasensors Utilizing a High-Performance FRET Reporter

Wang, Q., Fang, T., Zheng, J., Shi, L., Shi, L., & Li, T. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c15543 · Cited by 19

RIPTACs for Precision Cancer Therapy: A Novel Modality with the Inspiration of HLD-0915 as the First Candidate in Clinical Trials

Ma, Z., Zhang, C., Shen, Q., & Zhou, J. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01250 · Cited by 19

Targeted protein modification as a paradigm shift in drug discovery

Amirian, R., Azadi Badrbani, M., Izadi, Z., Samadian, H., Bahrami, G., Sarvari, S., Abdolmaleki, S., Nabavi, S. M., Derakhshankhah, H., & Jaymand, M. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115765 · Cited by 18

A chemically induced proximity system engineered from the plant auxin signaling pathway

Zhao, W., Nguyen, H., Zeng, G., Gao, D., Yan, H., & Liang, F. (2018) · Chemical Science · doi:10.1039/c8sc02353k · Cited by 17

Gigavalent Display of Proteins on Monodisperse Polyacrylamide Hydrogels as a Versatile Modular Platform for Functional Assays and Protein Engineering

Fryer, T., Rogers, J. D., Mellor, C., Kohler, T. N., Minter, R., & Hollfelder, F. (2022) · ACS Central Science · doi:10.1021/acscentsci.2c00576 · Cited by 18

Targeted Degradation of Androgen Receptor by VNPP433-3β in Castration-Resistant Prostate Cancer Cells Implicates Interaction with E3 Ligase MDM2 Resulting in Ubiquitin-Proteasomal Degradation

Thomas, E. B., Thankan, R. S., Purushottamachar, P., Weber, D. J., & Njar, V. C. O. (2023) · Cancers · doi:10.3390/cancers15041198 · Cited by 20

Identification of Actionable Targeted Protein Degradation Effector Sites through Site-Specific Ligand Incorporation-Induced Proximity (SLIP)

Xiao, Z., Gavriil, E.-S., Cao, F., Zhang, X., Li, S. X., Kotelnikov, S., Michalska, P., Marte, F., Huang, C., Lu, Y., et al. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c01420 · Cited by 17

Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders

Zhuang, Z., Byun, W. S., Kozicka, Z., Donovan, K. A., Dwyer, B. G., Thornhill, A. M., Jones, H. M., Jiang, Z., Zhu, X., Fischer, E. S., et al. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202508427 · Cited by 17

Caffeine‐Operated Synthetic Modules for Chemogenetic Control of Protein Activities by Life Style

Wang, T., He, L., Ji, J., Lan, T., Hong, T., Wang, F., Huang, Y., Ma, G., & Zhou, Y. (2020) · Advanced Science · doi:10.1002/advs.202002148 · Cited by 17

A Closed Form Model for Molecular Ratchet-Type Chemically Induced Dimerization Modules

Steiner, P. J., Swift, S. D., Bedewitz, M. A., Wheeldon, I. R., Cutler, S. R., Nusinow, D. A., & Whitehead, T. A. (2022) · Biochemistry · doi:10.1021/acs.biochem.2c00172 · Cited by 16

A single-component, light-assisted uncaging switch for endoproteolytic release

Cui, M., Lee, S.-H., Ban, S. H., Ryu, J. R., Shen, M., Yang, S. H., Kim, J. Y., Choi, S. K., Han, J., Kim, Y., et al. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01480-6 · Cited by 17

Lighting Up Single-mRNA Translation Dynamics in Living Cells

Cialek, C., Koch, A. L., Galindo, G., & Stasevich, T. (2020) · Current Opinion in Genetics and Development · doi:10.1016/j.gde.2020.04.003 · Cited by 14

Harnessing Effective Molarity to Design an Electrochemical DNA‐based Platform for Clinically Relevant Antibody Detection

Rossetti, M., Brannetti, S., Mocenigo, M., Marini, B., Ippodrino, R., & Porchetta, A. (2020) · Angewandte Chemie · doi:10.1002/ange.202005124 · Cited by 17

A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death

Nix, M. N., Gourisankar, S. P., Bowman, K., Nettles, S. A., Yang, H. H., Dwyer, B. G., Sarott, R. C., Abuzaid, H. Z., Martinez, M. M., Phillips, N. A., et al. (2026) · Cell · doi:10.1016/j.cell.2026.06.037 · Cited by 16

CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly

Schwaemmle, H., Soldati, H., Lykoskoufis, N. M. R., Docquier, M., Hainard, A., & Braun, S. M. G. (2025) · Nature Communications · doi:10.1038/s41467-025-60424-x · Cited by 17

Uncoupling the distinct functions of HP1 proteins during heterochromatin establishment and maintenance

Seman, M., Levashkevich, A., Larkin, A., Huang, F., & Ragunathan, K. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113428 · Cited by 16

Proximity-Enhanced Electrochemiluminescence Sensing Platform for Effective Capturing of Exosomes and Probing Internal MicroRNAs Involved in Cancer Cell Apoptosis

Shi, L., Cai, H., Wang, H., Wang, Q., Shi, L., & Li, T. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c03412 · Cited by 16

Molecular glue degrader for tumor treatment

Hu, Y., Yan, Y., Wang, J., Hou, J., & Lin, Q. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1512666 · Cited by 17

Cancer drug resistance as learning of signaling networks

Keresztes, D., Kerestély, M., Szarka, L., Kovács, B. M., Schulc, K., Veres, D. V., & Csermely, P. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117880 · Cited by 17

Synthetic chemical ligands and cognate antibodies for biorthogonal drug targeting and cell engineering

Monge, P., Søgaard, A. B., Andersen, D. G., Chandrawati, R., & Zelikin, A. N. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.010 · Cited by 16

Luciferase Controlled Protein Interactions

Chang, D., Feng, S., Girik, V., Riezman, H., & Winssinger, N. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.0c11016 · Cited by 16

Cross‐Linking Profiling of Molecular Glue Degrader‐Induced E3 Ligase Interactome to Expand Target Space

Xu, Y., Zhao, W., Nie, H., Wang, J., Fu, J., Hu, H., Liu, Z., Tao, S., Zhang, M., Zhou, Y., et al. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202505053 · Cited by 17

De Novo Design of High-Performance Cortisol Luminescent Biosensors

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CeO2/CoNiP Heterojunction as Excellent OER Electrocatalysts in Alkaline Seawater Effectively Suppresses Chloride Corrosion and Cobalt Leaching

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