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Chemically induced proximity in biology and medicine
Open accessAbstract
Regulating molecule proximity: The physical distance, or proximity, between molecules often directs biological events. The development of membrane-permeable small molecules that reversibly regulate proximity has enabled advances in fields such as synthetic biology, signal transduction, transcription, protein degradation, epigenetic memory, and chromatin dynamics. This “induced proximity” can also be applied to the development of new therapeutics. Stanton et al. review the wide range of advances and speculate on future applications of this fundamental approach. Science , this issue p. eaao5902
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“Molecular glues are a class of small molecule drugs that induce or stabilise protein-protein interactions1.”
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Cites
THE CONSTITUTION AND FUNDAMENTAL PROPERTIES OF SOLIDS AND LIQUIDS. PART I. SOLIDS.
Langmuir, I. (1916) · Journal of the American Chemical Society · doi:10.1021/ja02268a002 · Cited by 10,017
The new frontier of genome engineering with CRISPR-Cas9
Doudna, J. A., & Charpentier, E. (2014) · Science · doi:10.1126/science.1258096 · Cited by 7,062
Reaction-rate theory: fifty years after Kramers
Hänggi, P., Talkner, P., & Borkovec, M. (1990) · Reviews of Modern Physics · doi:10.1103/revmodphys.62.251 · Cited by 6,154
Selective inhibition of BET bromodomains
Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W. B., Fedorov, O., Morse, E. M., Keates, T., Hickman, T. T., Felletar, I., et al. (2010) · Nature · doi:10.1038/nature09504 · Cited by 4,262
The constitution and fundamental properties of solids and liquids
Langmuir, I. (1917) · Journal of the Franklin Institute · doi:10.1016/s0016-0032(17)90938-x · Cited by 3,787
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 2×
“This CIP “suicideswitch” strategy was extended to a senescent cell–clearing mouse to study age-related pathologies (94).”
BackgroundAbscisic Acid: Emergence of a Core Signaling Network
Cutler, S. R., Rodrı́guez, P. L., Finkelstein, R. R., & Abrams, S. R. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112122 · Cited by 3,227
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.017 · Cited by 2,888
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,876
SH2 domains recognize specific phosphopeptide sequences
Songyang, Z. (1993) · Cell · doi:10.1016/0092-8674(93)90404-e · Cited by 2,620
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Cui, Z., Guo, Z., Liew, Y. J., Caputo, A. T., Fiorito, M. M., Ayva, C. E., Mutschler, R., Leguarca, M. B., Newton, S., Lam, G. N., et al. (2026) · Angewandte Chemie · doi:10.1002/ange.9707369
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BindingDB Entry 50002775: Inducing protein-protein interactions with molecular glues.
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Herzog, L. K., & Wu, Y.-W. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5687-7_15
Metadata
- Authors
- Stanton, B. Z., Chory, E. J., & Crabtree, G. R.
- Affiliations
- Stanford Medicine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Stanton, Benjamin Z.
- Chory, Emma J.
- Crabtree, Gerald R.
- Venue
- Science
- Published
- 2018-03-09
- Volume
- 359
- Issue
- 6380
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6417506
- OpenAlex
- W2789732912
- Cited by
- 475
- References
- 104
- Citations by year
- 2026: 75 · 2025: 92 · 2024: 59 · 2023: 64 · 2022: 55 · 2021: 39 · 2020: 45 · 2019: 30 · 2018: 15
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- National Institutes of Health (NIH Javits Neuroscience Investigator Award R37 NS046789-12, F31 CA203228-02)
- Howard Hughes Medical Institute
- U.S. Department of Energy (CDMRP Breast Cancer Research Breakthrough Award)
- National Cancer Institute (NIH 5R01CA163915-04)
- Simons Foundation Autism Research Initiative
- Simons Foundation
- NSF Office of the Director
- Ruth L. Kirschstein National Research Service Award (F31 CA203228-02)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
- Keywords
- protein-protein interaction, post-translational modification, transcriptional regulation, signaling pathways, chromatin regulation, protein folding, protein degradation, CRISPR, synthetic biology, gene therapy, cancer therapy
- MeSH terms
- Biological Mimicry, Animals, Chromatin, Humans, Ligands, Protein Processing, Post-Translational, Proteins, Transcription, Genetic, Genetic Therapy, Signal Transduction, Tacrolimus, Protein Folding, Proteolysis, CRISPR-Cas Systems, Cell- and Tissue-Based Therapy
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