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Chemically induced proximity in biology and medicine
Open accessAbstract
Regulating molecule proximity: The physical distance, or proximity, between molecules often directs biological events. The development of membrane-permeable small molecules that reversibly regulate proximity has enabled advances in fields such as synthetic biology, signal transduction, transcription, protein degradation, epigenetic memory, and chromatin dynamics. This “induced proximity” can also be applied to the development of new therapeutics. Stanton et al. review the wide range of advances and speculate on future applications of this fundamental approach. Science , this issue p. eaao5902
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“Molecular glues are a class of small molecule drugs that induce or stabilise protein-protein interactions1.”
From The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K (2020) · cites this paper as [1]
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“Molecular glue compounds induce protein-protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation.1”
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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Słabicki, M., Kozicka, Z., Petzold, G., Li, Y.-D., Manojkumar, M., Bunker, R. D., Donovan, K. A., Sievers, Q. L., Koeppel, J., Suchyta, D., et al. (2020) · Nature · doi:10.1038/s41586-020-2374-x · Cited by 433
Metadata
- Authors
- Stanton, B. Z., Chory, E. J., & Crabtree, G. R.
- Affiliations
- Stanford Medicine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Stanton, Benjamin Z.
- Chory, Emma J.
- Crabtree, Gerald R.
- Venue
- Science
- Published
- 2018-03-09
- Volume
- 359
- Issue
- 6380
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6417506
- OpenAlex
- W2789732912
- Cited by
- 475
- References
- 104
- Citations by year
- 2026: 75 · 2025: 92 · 2024: 59 · 2023: 64 · 2022: 55 · 2021: 39 · 2020: 45 · 2019: 30 · 2018: 15
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- National Institutes of Health (NIH Javits Neuroscience Investigator Award R37 NS046789-12, F31 CA203228-02)
- Howard Hughes Medical Institute
- U.S. Department of Energy (CDMRP Breast Cancer Research Breakthrough Award)
- National Cancer Institute (NIH 5R01CA163915-04)
- Simons Foundation Autism Research Initiative
- Simons Foundation
- NSF Office of the Director
- Ruth L. Kirschstein National Research Service Award (F31 CA203228-02)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
- Keywords
- protein-protein interaction, post-translational modification, transcriptional regulation, signaling pathways, chromatin regulation, protein folding, protein degradation, CRISPR, synthetic biology, gene therapy, cancer therapy
- MeSH terms
- Biological Mimicry, Animals, Chromatin, Humans, Ligands, Protein Processing, Post-Translational, Proteins, Transcription, Genetic, Genetic Therapy, Signal Transduction, Tacrolimus, Protein Folding, Proteolysis, CRISPR-Cas Systems, Cell- and Tissue-Based Therapy
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