The Rise of Molecular Glues

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116 · see citing works

The mechanism of action of cyclosporin A and FK506

Schreiber, S. L., & Crabtree, G. R. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90111-j · Cited by 2,127 · see citing works

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

Di Stasi, A., Tey, S.-K., Dotti, G., Fujita, Y., Kennedy-Nasser, A., Martinez, C., Straathof, K., Liu, E., Durett, A. G., Grilley, B., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1106152 · Cited by 1,512 · see citing works

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Schreiber, S. L. (1991) · Science · doi:10.1126/science.1702904 · Cited by 1,494 · see citing works

Chemically induced proximity in biology and medicine

Stanton, B. Z., Chory, E. J., & Crabtree, G. R. (2018) · Science · doi:10.1126/science.aao5902 · Cited by 475 · see citing works

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

Sabatini, D. (2017) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1716173114 · Cited by 448 · see citing works

Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

Bierer, B. E., Somers, P. K., Wandless, T. J., Burakoff, S. J., & Schreiber, S. L. (1990) · Science · doi:10.1126/science.1700475 · Cited by 351 · see citing works

Immunophilin-sensitive protein phosphatase action in cell signaling pathways

Schreiber, S. L. (1992) · Cell · doi:10.1016/0092-8674(92)90158-9 · Cited by 344 · see citing works

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

Haggarty, S. J., Mayer, T. U., Miyamoto, D. T., Fathi, R., King, R. W., Mitchison, T. J., & Schreiber, S. L. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00101-0 · Cited by 251 · see citing works

Unifying principles of bifunctional, proximity-inducing small molecules

Gerry, C. J., & Schreiber, S. L. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0469-1 · Cited by 199 · see citing works

Prime time for PROTACs

Deshaies, R. J. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1887 · Cited by 162 · see citing works

Cereblon modulators: Low molecular weight inducers of protein degradation

Chamberlain, P. P., & Cathers, B. E. (2019) · Drug Discovery Today: Technologies · doi:10.1016/j.ddtec.2019.02.004 · Cited by 106 · see citing works

SnapShot: Ca2+-Calcineurin-NFATSignaling

Crabtree, G. R., & Schreiber, S. L. (2009) · Cell · doi:10.1016/j.cell.2009.06.026 · Cited by 105 · see citing works

A Chemical Biology View of Bioactive Small Molecules and a Binder‐Based Approach to Connect Biology to Precision Medicines

Schreiber, S. L. (2018) · Israel Journal of Chemistry · doi:10.1002/ijch.201800113 · Cited by 76 · see citing works

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

Quancard, J., Klein, T., Fung, S.-Y., Renatus, M., Hughes, N., Israël, L., Priatel, J. J., Kang, S., Blank, M. A., Viner, R. I., et al. (2019) · Nature Chemical Biology · doi:10.1038/s41589-018-0222-1 · Cited by 72 · see citing works

PROTAC targeted protein degraders: the past is prologue

Békés, M., Langley, D. R., & Crews, C. M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00371-6 · Cited by 3,395 · see citing works

The current state of the art and future trends in RAS-targeted cancer therapies

Punekar, S. R., Velcheti, V., Neel, B. G., & Wong, K.-K. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00671-9 · Cited by 549 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery

Dong, G., Ding, Y., He, S., & Sheng, C. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00895 · Cited by 369 · see citing works

Chemistries of bifunctional PROTAC degraders

Cao, C., He, M., Wang, L., He, Y., & Rao, Y. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00220e · Cited by 313 · see citing works

Chasing molecular glue degraders: screening approaches

Domostegui, A., Nieto-Barrado, L., Perez-Lopez, C., & Mayor-Ruiz, C. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00197g · Cited by 200 · see citing works

Reimagining Druggability Using Chemoproteomic Platforms

Spradlin, J. N., Zhang, E., & Nomura, D. K. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.1c00065 · Cited by 176 · see citing works

Defining molecular glues with a dual-nanobody cannabidiol sensor

Cao, S., Kang, S., Mao, H., Yao, J., Gu, L., & Zheng, N. (2022) · Nature Communications · doi:10.1038/s41467-022-28507-1 · Cited by 125 · see citing works

Ligandability of E3 Ligases for Targeted Protein Degradation Applications

Belcher, B. P., Ward, C. C., & Nomura, D. K. (2023) · Biochemistry · doi:10.1021/acs.biochem.1c00464 · Cited by 132 · see citing works

Molecular glues and bifunctional compounds: Therapeutic modalities based on induced proximity

Schreiber, S. L. (2024) · Cell Chemical Biology · doi:10.1016/j.chembiol.2024.05.004 · Cited by 112 · see citing works

Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs

Nussinov, R., Zhang, M., Maloney, R., Liu, Y., Tsai, C.-J., & Jang, H. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167569 · Cited by 66 · see citing works

Development of MDM2 degraders based on ligands derived from Ugi reactions: Lessons and discoveries

Wang, B., Liu, J., Tandon, I., Wu, S., Teng, P., Liao, J., & Tang, W. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113425 · Cited by 67 · see citing works

Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216

Teng, M., Lu, W., Donovan, K. A., Sun, J., Krupnick, N. M., Nowak, R. P., Li, Y.-D., Sperling, A. S., Zhang, T., Ebert, B. L., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01832 · Cited by 63 · see citing works

UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

Yeo, M. J. R., Zhang, O., Xie, X., Nam, E., Payne, N. C., Gosavi, P. M., Kwok, H. S., Iram, I., Lee, C., Li, J., et al. (2025) · Nature · doi:10.1038/s41586-024-08532-4 · Cited by 58 · see citing works

Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders

Gosavi, P. M., Ngan, K. C., Yeo, M. J. R., Su, C., Li, J., Lue, N. Z., Hoenig, S. M., & Liau, B. B. (2022) · ACS Central Science · doi:10.1021/acscentsci.1c01603 · Cited by 56 · see citing works

Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library

Razumkov, H., Jiang, Z., Baek, K., You, I., Geng, Q., Donovan, K. A., Tang, M. T., Metivier, R. J., Mageed, N., Seo, P., et al. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c06127 · Cited by 53 · see citing works

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations

Xie, X., Zhang, O., Yeo, M. J. R., Lee, C., Tao, R., Harry, S. A., Payne, N. C., Nam, E., Paul, L., Li, Y., et al. (2025) · Nature · doi:10.1038/s41586-024-08533-3 · Cited by 50 · see citing works

Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence

Duran-Frigola, M., Cigler, M., & Winter, G. E. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c11098 · Cited by 50 · see citing works

Unifying Catalysis Framework to Dissect Proteasomal Degradation Paradigms

Rodriguez-Rivera, F. P., & Levi, S. M. (2021) · ACS Central Science · doi:10.1021/acscentsci.1c00389 · Cited by 30 · see citing works

Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha

Jiang, S., Liu, K., Jiang, T., Li, H., Wei, X., Wan, X., Zhong, C., Gong, R., Chen, Z., Zou, C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62288-7 · Cited by 23 · see citing works

From serendipity to strategy: molecular glue degraders in cancer therapeutics

Darling, S., Bajrami, I., & West, S. C. (2025) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2025.2564068 · Cited by 10 · see citing works

A comprehensive kinetic model for ternary complex catalysis

Douglass Jr., E. F., & Miller, C. J. (2022) · doi:10.26434/chemrxiv-2021-wgn82-v2 · Cited by 7 · see citing works

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

Book Review: I. Biblical Studies: The Revelation of Jesus Christ, Interpreting Revelation, the Book of Revelation

Adam, W. W. (1958) · Review & Expositor · doi:10.1177/003463735805500325

Two Accounts of Qur'anic Revelation

Völker, K. (2015) · Islam and Christian–Muslim Relations · doi:10.1080/09596410.2015.1040240 · Cited by 8 · see citing works

Revelation

Hebblethwaite, B. L. (2005) · doi:10.1002/9780470775714.ch2

Gerald O’Collins, Revelation. Towards a Christian Interpretation of God’s Self-Revelation in Jesus Christ, Oxford University Press, Oxford 2016, ss. 247, ISBN 978-0-19-108700-3.

Bergel, Ł. (2019) · Biblica et Patristica Thoruniensia · doi:10.12775/bpth.2019.010