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Cited by 643

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Gut microbiota utilize immunoglobulin A for mucosal colonization

Open access
Donaldson, G. P., Ladinsky, M. S., Yu, K. B., Sanders, J. G., Yoo, B. B., Chou, W.-C., Conner, M. E., Earl, A. M., Knight, R., Bjorkman, P. J., Mazmanian, S. K.·2018·Science

Abstract

Benign colonization of the gut: Microbial communities in the gut can be highly individual. What engenders this specificity? The gut characteristically produces gram quantities of immunoglobulin A (IgA) antibody, which is presumed to protect the gut from pathogen attack. Donaldson et al. engineered strains of Bacteroides fragilis , a common human commensal, to modify its surface capsule, which affects its ability to colonize the germ-free mouse gut. Capsule changes altered the capacity of IgA to bind to the different mutants. It seems that this commensal species exploits IgA sticking power specifically to give it a competitive edge and to promote its establishment in the gut. Science , this issue p. 795

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Crossref · 10.1126/science.aaq0926

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Metadata

Authors
Donaldson, G. P., Ladinsky, M. S., Yu, K. B., Sanders, J. G., Yoo, B. B., Chou, W.-C., Conner, M. E., Earl, A. M., Knight, R., Bjorkman, P. J., & Mazmanian, S. K.
Venue
Science
Published
2018-05-18
Volume
360
Issue
6390
Pages
795-800
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2800593054
Cited by
643
References
19
FWCI
21.74
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Gut microbiota utilize immunoglobulin A for mucosal colonization. https://app.cochat.ai/papers/10.1126/science.aaq0926
The paper
Donaldson, G. P., Ladinsky, M. S., Yu, K. B., Sanders, J. G., Yoo, B. B., Chou, W.-C., Conner, M. E., Earl, A. M., Knight, R., Bjorkman, P. J., & Mazmanian, S. K. (2018). Gut microbiota utilize immunoglobulin A for mucosal colonization. Science. https://doi.org/10.1126/science.aaq0926

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.