The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Gut microbiota utilize immunoglobulin A for mucosal colonization
Open accessAbstract
Benign colonization of the gut: Microbial communities in the gut can be highly individual. What engenders this specificity? The gut characteristically produces gram quantities of immunoglobulin A (IgA) antibody, which is presumed to protect the gut from pathogen attack. Donaldson et al. engineered strains of Bacteroides fragilis , a common human commensal, to modify its surface capsule, which affects its ability to colonize the germ-free mouse gut. Capsule changes altered the capacity of IgA to bind to the different mutants. It seems that this commensal species exploits IgA sticking power specifically to give it a competitive edge and to promote its establishment in the gut. Science , this issue p. 795
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Cited by
Swanson, K. S., Gibson, G. R., Hutkins, R., Reimer, R. A., Reid, G., Verbeke, K., Scott, K. P., Holscher, H. D., Azad, M. B., Delzenne, N. M., et al. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0344-2 · Cited by 2,196
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Wypych, T. P., Wickramasinghe, L. C., & Marsland, B. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0451-9 · Cited by 611
Yoon, H. S., Cho, C. H., Yun, M. S., Jang, S. J., You, H. J., Kim, J.-H., Han, D., Cha, K. H., Moon, S. H., Lee, K., et al. (2021) · Nature Microbiology · doi:10.1038/s41564-021-00880-5 · Cited by 602
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Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders
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Metadata
- Authors
- Donaldson, G. P., Ladinsky, M. S., Yu, K. B., Sanders, J. G., Yoo, B. B., Chou, W.-C., Conner, M. E., Earl, A. M., Knight, R., Bjorkman, P. J., & Mazmanian, S. K.
- Venue
- Science
- Published
- 2018-05-18
- Volume
- 360
- Issue
- 6390
- Pages
- 795-800
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2800593054
- Cited by
- 643
- References
- 19
- FWCI
- 21.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Donaldson, G. P., Ladinsky, M. S., Yu, K. B., Sanders, J. G., Yoo, B. B., Chou, W.-C., Conner, M. E., Earl, A. M., Knight, R., Bjorkman, P. J., & Mazmanian, S. K. (2018). Gut microbiota utilize immunoglobulin A for mucosal colonization. Science. https://doi.org/10.1126/science.aaq0926
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