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Detection and localization of surgically resectable cancers with a multi-analyte blood test
Open accessAbstract
SEEK and you may find cancer earlier: Many cancers can be cured by surgery and/or systemic therapies when detected before they have metastasized. This clinical reality, coupled with the growing appreciation that cancer's rapid genetic evolution limits its response to drugs, have fueled interest in methodologies for earlier detection of the disease. Cohen et al. developed a noninvasive blood test, called CancerSEEK that can detect eight common human cancer types (see the Perspective by Kalinich and Haber). The test assesses eight circulating protein biomarkers and tumor-specific mutations in circulating DNA. In a study of 1000 patients previously diagnosed with cancer and 850 healthy control individuals, CancerSEEK detected cancer with a sensitivity of 69 to 98% (depending on cancer type) and 99% specificity. Science , this issue p. 926 ; see also p. 866
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Metadata
- Authors
- Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C. L., Goggins, M. G., Dal Molin, M., Wang, T.-L., Roden, R., Klein, A. P., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H.-L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Lennon, A. M., & Papadopoulos, N.
- Affiliations
- Howard Hughes Medical Institute (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- University of Pittsburgh (US)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Mayo Clinic (US)
- The University of Texas MD Anderson Cancer Center (US)
- IRCCS Ospedale San Raffaele (IT)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Diaz, Luis A.
- Tomasetti, Cristian
- Kinzler, Kenneth W.
- Vogelstein, Bert
- Lennon, Anne Marie
- Papadopoulos, Nickolas
- ORCID
- Cohen, Joshua D.
- Li, Lu
- Wang, Yuxuan
- Thoburn, Christopher
- Afsari, Bahman
- Danilova, Ludmila
- Douville, Christopher
- Javed, Ammar A.
- Wong, Fay
- Mattox, Austin
- Hruban, Ralph H.
- Wolfgang, Christopher L.
- Goggins, Michael G.
- Wang, Tian-Li
- Roden, Richard
- Klein, Alison P.
- Ptak, Janine
- Dobbyn, Lisa
- Schaefer, Joy
- Silliman, Natalie
- Popoli, Maria
- Vogelstein, Joshua T.
- Schoen, Robert E.
- Brand, Randall E.
- Tie, Jeanne
- Gibbs, Peter
- Wong, Hui-Li
- Mansfield, Aaron S.
- Jen, Jin
- Hanash, Samir M.
- Falconi, Massimo
- Allen, Peter J.
- Zhou, Shibin
- Bettegowda, Chetan
- Diaz, Luis A.
- Tomasetti, Cristian
- Kinzler, Kenneth W.
- Vogelstein, Bert
- Lennon, Anne Marie
- Papadopoulos, Nickolas
- Venue
- Science
- Published
- 2018-02-23
- Volume
- 359
- Issue
- 6378
- Pages
- 926-930
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6080308
- OpenAlex
- W2783674487
- Cited by
- 2,783
- References
- 37
- Citations by year
- 2026: 244 · 2025: 343 · 2024: 300 · 2023: 341 · 2022: 301 · 2021: 377 · 2020: 324 · 2019: 317 · 2018: 232
- FWCI
- 96.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- National Institutes of Health (P50-CA62924, P50-CA102701, CA06973, GM-07309, U01CA152753)
- Doris Duke Charitable Foundation (2014107)
- Commonwealth Fund
- John Templeton Foundation
- Lustgarten Foundation
- Virginia and D.K. Ludwig Fund for Cancer Research
- Billi and Bernie Marcus Foundation
- Mayo Clinic Clinomics Program, Center for Individualized Medicine
- Defense Sciences Office, DARPA (N66001-15-C-4041)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Health Sciences › Medicine › Oncology › Cancer Diagnosis and Treatment
- Keywords
- early cancer detection, cancer screening, circulating proteins, tumor localization, ovarian cancer, liver cancer, gastric cancer, pancreatic cancer, esophageal cancer, colorectal cancer, lung cancer, breast cancer, sensitivity and specificity
- MeSH terms
- Circulating Tumor DNA, Costs and Cost Analysis, Hematologic Tests, Humans, Mutation, Neoplasm Proteins, Neoplasms, Polymerase Chain Reaction, Early Detection of Cancer
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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