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Triggered recruitment of ESCRT machinery promotes endolysosomal repair
Abstract
A quick fix for leaky endosomes: Cells internalize diverse material through various forms of endocytosis into an extensive endolysosomal network. Protecting the integrity of endolysosomal membranes in both physiological and pathophysiological contexts is critical to cell health. Skowyra et al. describe a role for the ESCRT (endosomal sorting complex required for transport) machinery on endolysosomal organelles during membrane repair (see the Perspective by Gutierrez and Carlton). The ESCRTs act as first responders to repair limited membrane damage and thereby restore compartmental integrity and function. This ESCRT activity is distinct from organelle disposal pathways. These findings will be important in understanding cellular responses to invading pathogens and potentially disruptive proinflammatory particulates. Science , this issue p. eaar5078 ; see also p. 33
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“For example, translocation of ESCRT to lysosomes in response to LLOMe is triggered by the efflux of lysosomal Ca2+ and subsequent recruitment of ALIX, which in turn brings other ESCRT-III components42.”
From TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress (2024) · cites this paper as [42]
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Metadata
- Authors
- Skowyra, M. L., Schlesinger, P. H., Naismith, T. V., & Hanson, P. I.
- Venue
- Science
- Published
- 2018-04-06
- Volume
- 360
- Issue
- 6384
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC6195421
- Cited by
- 578
- References
- 6
- Language
- en
- Funders
- National Institute of General Medical Sciences (R01 GM122434)
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