The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
Open accessAbstract
Why is ketamine an antidepressant?: A better understanding of the mechanisms underlying the action of antidepressants is urgently needed. Moda-Sava et al. explored a possible mode of action for the drug ketamine, which has recently been shown to help patients recover from depression (see the Perspective by Beyeler). Ketamine rescued behavior in mice that was associated with depression-like phenotypes by selectively reversing stress-induced spine loss and restoring coordinated multicellular ensemble activity in prefrontal microcircuits. The initial induction of ketamine's antidepressant effect on mouse behavior occurred independently of effects on spine formation. Instead, synaptogenesis in the prefrontal region played a critical role in nourishing these effects over time. Interventions aimed at enhancing the survival of restored synapses may thus be useful for sustaining the behavioral effects of fast-acting antidepressants. Science , this issue p. eaat8078 ; see also p. 129
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Activation of AS-PaRac1 three hours post-treatment did not impact tail suspension test behavior 48 hours post-treatment, which is prior to the onset of spine formation by ketamine 12 hours post-treatment.”
From Mechanisms of ketamine and its metabolites as antidepressants (2022) · cites this paper as Moda-Sava et al., 2019
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Using a chronic (21 day) corticosterone (CORT) exposure model of depression in mice, this study demonstrated that CORT induces dendritic spine elimination in the mPFC which is rescued 24 hours following a single ketamine treatment (10 mg/kg i.p.).”
From Mechanisms of ketamine and its metabolites as antidepressants (2022) · cites this paper as Moda-Sava et al., 2019
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The rapidity and magnitude of ketamine's effects have been attributed to its ability to rapidly reverse neuroplasticity deficits in animal models 3,4,10,34 .”
From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Impairments of neuroplasticity often characterize disorders of negative affect including depression 3,4 and multiple efficacious therapies often reverse such deficits 10,148-151 .”
From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Ketamine and other fast-acting antidepressant candidates all produce a rapid restoration of dendritic spine density in the PFC in stressed and unstressed animals with the same rapid time course as its behavioral actions [145, 187, 202, 203], implying the restoration of synaptic and circuit function, too.”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [145]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Ketamine and psychedelics modulate cortical neuron function by increasing dendritic spine and synapse density in the PFC (129, 146–149)”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [129]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“While animal studies show that ketamine-induced increases in synaptic proteins and density 14 67 40”
From Imaging the effect of ketamine on synaptic density (SV2A) in the living brain (2022) · cites this paper as [40]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Chronic exposure to uncontrollable stress causes loss of spines and dendrites in the prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of thought, action, and emotion.”
From Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes. (2021) · cites this paper as [77]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“ketamine rescued the increase in immobility produced by CORT exposure during the tail suspension test starting at three hours to one-week post-treatment.”
From Mechanisms of ketamine and its metabolites as antidepressants (2022) · cites this paper as Moda-Sava et al., 2019
The cited source says what the claim attributes to it.
In the citing paper
“specific deletion of the newly formed spines 24 hours post-treatment via activated synapse-targeting photoactivatable Rac1 (AS-PaRac1), which collapses newly formed spines through light stimulation, reversed the effects of ketamine in the tail suspension test 48 hours post-treatment.”
From Mechanisms of ketamine and its metabolites as antidepressants (2022) · cites this paper as Moda-Sava et al., 2019
The cited source says what the claim attributes to it.
In the citing paper
“Ketamine restored dendritic spines that were specifically lost during the CORT exposure.”
From Mechanisms of ketamine and its metabolites as antidepressants (2022) · cites this paper as Moda-Sava et al., 2019
The cited source says what the claim attributes to it.
In the citing paper
“An elegant recent study provided further evidence that new synapse formation is causally related to the antidepressant actions of ketamine 10 .”
From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“As an example, we discuss the potential for ketamine-which exhibits both rapid plasticity-enhancing effects in animal models 4,10 and rapid clinical effects in human patients 11,12 -to provide a test of the predictions of this integrative model, including simultaneous and correlated reversals of multiple plasticity-related deficits across levels of analysis.”
From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [10]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“These structural changes are accompanied by depressive phenotypes related to motivation (129), anxiety (122), and anhedonia (122, 129).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [129]
The cited source says what the claim attributes to it.
In the citing paper
“Liston et al. recently used a photoactivatable Rac1 to demonstrate that ketamine-induced spine growth in the PFC was causally related to long-lasting antidepressant effects of the drug in rodents (129).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [129]
The cited source says what the claim attributes to it.
In the citing paper
“In both humans and rodents, the antidepressant responses of ketamine appear to last for about 1 week.”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [129]
The cited source says what the claim attributes to it.
In the citing paper
“Indeed, recent in vivo work indicates that ketamine regrows the dendritic spines lost to stress in a targeted manner.”
From Imaging the effect of ketamine on synaptic density (SV2A) in the living brain (2022) · cites this paper as [40]
The cited source says what the claim attributes to it.
In the citing paper
“With chronic stress exposure, there is architectural loss of mPFC spines and dendrites (Moda-Sava et al., 2019, Radley et al., 2006) that correlates with impaired PFC cognitive functioning (Hains et al., 2009, Hains et al., 2015, Liston et al., 2006).”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Moda-Sava et al., 2019
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Computational tools that integrate fMRI and EEG already recover predictive signatures of response and can propose dose and timing schedules aligned to individual network states [14,37,181].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [181]
Experimental — accuracy not yet measuredIn the citing paper
“Similarly to observation in MDD, CORT mice showed spine loss in prefrontal microcircuit and altered neuronal brain-derived neurotrophic factor (BDNF) signaling and neurogenesis with a reduced progenitor cell proliferation in hippocampal and cortical structures.6,7”
From Synaptic Vesicle 2A (SV2A) Positron Emission Tomography (PET) Imaging as a Marker of Therapeutic Response in a Mouse Model of Depression (2025) · cites this paper as [7]
In the citing paper
“Second, another study demonstrated that the induction of antidepressant behavioral effects occurs in vivo independently of (and before) actual spine formation. However, glutamate-induced synaptogenesis in their study played a critical role in sustaining the effects over the subsequent week [80].”
From Pharmacotherapies Targeting GABA-Glutamate Neurotransmission for Treatment-Resistant Depression (2023) · cites this paper as [80]
In the citing paper
“Multiple studies have reported similar occurrences with ketamine increasing dendritic spine density within 12–24 h of administration (Li et al., 2010; Liu et al., 2013; Moda-Sava et al., 2019).”
From A single subanaesthetic dose of the rapid-acting antidepressant S-ketamine raises presynaptic SV2A density in limbic regions of the Wistar Kyoto rat model of depression (2024) · cites this paper as Moda-Sava et al., 2019
In the citing paper
“Moda-Sava, et al. [145] used longitudinal imaging to demonstrate that the induction of depression-related behavior by chronic stress in mice, simulated by chronic corticosterone (CORT) exposure, correlated with targeted dendritic spine elimination within prefrontal cortex micro-circuits.”
From Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression (2025) · cites this paper as [145]
In the citing paper
“while these studies found that ketamine treatment selectively restored spines eliminated during CORT exposure”
From Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression (2025) · cites this paper as [145]
In the citing paper
“suggesting that spinogenesis may be important for the long-term maintenance of these behavioral effects”
From Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression (2025) · cites this paper as [145]
In the citing paper
“the authors observed a relationship between the degree to which ketamine was able to restore spines eliminated during CORT exposure and the sustained (2 days -1 week) antidepressant response”
From Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression (2025) · cites this paper as [145]
In the citing paper
“the effect of ketamine on antidepressant behavior preceded its effects on spine formation”
From Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression (2025) · cites this paper as [145]
In the citing paper
“suggesting spinogenesis is not required for inducing ketamine's effects on behavior”
From Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression (2025) · cites this paper as [145]
In the citing paper
“Ketamine and other fast-acting antidepressant candidates all produce a rapid restoration of dendritic spine density in the PFC in stressed and unstressed animals with the same rapid time course as its behavioral actions [145, 187, 202, 203], implying the restoration of synaptic and circuit function, too.”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [145]
In the citing paper
“Ketamine and other fast-acting antidepressant candidates all produce a rapid restoration of dendritic spine density in the PFC in stressed and unstressed animals with the same rapid time course as its behavioral actions [145, 187, 202, 203], implying the restoration of synaptic and circuit function, too.”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [145]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881
Cited by
Sorted by citations
Items 101–200 of 644
Kopelman, J., Keller, T. A., Panny, B., Griffo, A., Degutis, M., Spotts, C., Cruz, N., Bell, E., Do-Nguyen, K., Wallace, M. L., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02451-0 · Cited by 60
Serial Prefrontal Pathways Are Positioned to Balance Cognition and Emotion in Primates
Joyce, M. K. P., García‐Cabezas, M. Á., John, Y. J., & Barbas, H. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0860-20.2020 · Cited by 61
Rodent ketamine depression-related research: Finding patterns in a literature of variability
Polis, A. J., Fitzgerald, P. J., Hale, P. J., & Watson, B. O. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112153 · Cited by 63
Molecular insights into psychedelic drug action
Slocum, S. T., DiBerto, J. F., & Roth, B. L. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15540 · Cited by 59
Zhao, X., Du, Y., Yao, Y., Dai, W., Yin, Y., Wang, G., Li, Y., & Zhang, L. (2024) · Journal of Psychopharmacology · doi:10.1177/02698811241249436 · Cited by 64
Subanesthetic Ketamine Reactivates Adult Cortical Plasticity to Restore Vision from Amblyopia
Grieco, S. F., Qiao, X., Zheng, X., Liu, Y., Chen, L., Zhang, H., Yu, Z., Gavornik, J. P., Lai, C., Gandhi, S. P., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.07.008 · Cited by 60
Kaul, D., Schwab, S. G., Mechawar, N., & Matosin, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.025 · Cited by 58
Arnsten, A. F. T., Joyce, M. K. P., & Roberts, A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.105000 · Cited by 64
5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice
Jefferson, S. J., Gregg, I., Dibbs, M., Liao, C., Wu, H., Davoudian, P. A., Woodburn, S. C., Wehrle, P. H., Sprouse, J. S., Sherwood, A. M., et al. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01572-w · Cited by 57
Zhang, J., Qu, Y., Chang, L., Pu, Y., & Hashimoto, K. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz048 · Cited by 55
Ponton, E., Turecki, G., & Nagy, C. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab082 · Cited by 59
Kim, J., & Monteggia, L. M. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112378 · Cited by 56
Neurobiology of the rapid-acting antidepressant effects of ketamine: impact and opportunities
Shinohara, R., Aghajanian, G. K., & Abdallah, C. G. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.006 · Cited by 54
Psychedelics as Transformative Therapeutics
Roth, B. L., & Gumpper, R. H. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230172 · Cited by 57
Mechanisms of Action of TMS in the Treatment of Depression
Downar, J. H., Siddiqi, S., Mitra, A., Williams, N., & Liston, C. M. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_483 · Cited by 59
Self-citationSex differences in resilience: Experiential factors and their mechanisms
Fallon, I. P., Tanner, M. K., Greenwood, B. N., & Baratta, M. V. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14639 · Cited by 62
Muscat, S.-A., Hartelius, G., Crouch, C., & Morin, K. W. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.710338 · Cited by 59
Chen, T., Cheng, L., Ma, J., Yuan, J., Pi, C., Xiong, L., Chen, J., Liu, H., Tang, J., Zhong, Y., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106837 · Cited by 59
Enhanced ERK activity extends ketamine’s antidepressant effects by augmenting synaptic plasticity
Ma, Z., Guzikowski, N. J., Kim, J., Kavalali, E. T., & Monteggia, L. M. (2025) · Science · doi:10.1126/science.abb6748 · Cited by 54
Regulatory mechanisms of major depressive disorder risk variants
Li, S., Li, Y., Li, X., Liu, J., Huo, Y., Wang, J., Liu, Z., Li, M., & Luo, X. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0715-7 · Cited by 51
Bączyńska, E., Pels, K. K., Basu, S., Włodarczyk, J., & Ruszczycki, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084053 · Cited by 49
Uncovering the Underlying Mechanisms of Ketamine as a Novel Antidepressant
Xu, S., Yao, X., Li, B., Cui, R., Zhu, C., Wang, Y., & Yang, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.740996 · Cited by 53
Habenula Connectivity and Intravenous Ketamine in Treatment-Resistant Depression
Rivas-Grajales, A. M., Salas, R., Robinson, M. E., Qi, K., Murrough, J. W., & Mathew, S. J. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa089 · Cited by 52
Wu, M., Minkowicz, S., Dumrongprechachan, V., Hamilton, P., Xiao, L., & Kozorovitskiy, Y. (2021) · eLife · doi:10.7554/elife.64041 · Cited by 54
Schumacher, F., Edwards, M. J., Mühle, C., Carpinteiro, A., Wilson, G. C., Wilker, B., Soddemann, M., Keitsch, S., Scherbaum, N., Müller, B. W., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102185 · Cited by 52
Sarrazin, D. H., Gardner, W., Marchese, C., Balzinger, M., Ramanathan, C., Schott, M., Rozov, S. V., Veleanu, M., Vestring, S., Normann, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51716-9 · Cited by 50
Tillmon, H., Soteros, B. M., Shen, L., Cong, Q., Wollet, M., General, J., Chin, H., Lee, J. B., Carreno, F. R., Morilak, D. A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54007-5 · Cited by 58
Siegel, J. S., Palanca, B. J. A., Ances, B. M., Kharasch, E. D., Schweiger, J. A., Yingling, M. D., Snyder, A. Z., Nicol, G. E., Lenze, E. J., & Farber, N. B. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05762-6 · Cited by 50
Kajitani, N., Iwata, M., Miura, A., Tsunetomi, K., Yamanashi, T., Matsuo, R., Nishiguchi, T., Fukuda, S., Nagata, M., Shibushita, M., et al. (2020) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12099 · Cited by 49
Pharmacotherapies Targeting GABA-Glutamate Neurotransmission for Treatment-Resistant Depression
Vecera, C. M., C. Courtes, A., Jones, G., Soares, J. C., & Machado-Vieira, R. (2023) · Pharmaceuticals · doi:10.3390/ph16111572 · Cited by 48
“However, glutamate-induced synaptogenesis in their study played a critical role in sustaining the effects over the subsequent week [80].”
BackgroundThe role of the excitation:inhibition functional balance in the mPFC in the onset of antidepressants
Yin, Y., Wang, Y., Liu, W., Yao, J.-Q., Yuan, J., Li, Z.-H., Ran, Y., Zhang, L., & Li, Y. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108573 · Cited by 51
Pardossi, S., Fagiolini, A., & Cuomo, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313098 · Cited by 51
Rantamäki, T., & Kohtala, S. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018697 · Cited by 45
Kohtala, S., Alitalo, O., Rosenholm, M., Rozov, S. V., & Rantamäki, T. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107741 · Cited by 47
Advancing preclinical models of psychiatric disorders with human brain organoid cultures
Dixon, T. A., & Muotri, A. R. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01708-2 · Cited by 49
Deyama, S., & Kaneda, K. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109335 · Cited by 46
Agnorelli, C., Spriggs, M. J., Godfrey, K., Sawicka, G., Bohl, B., Douglass, H. M., Fagiolini, A. M., Parastoo, H., Carhart-Harris, R. L., Nutt, D. J., et al. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106132 · Cited by 65
Peng, B., Xu, Q., Liu, J., Guo, S., Borgland, S. L., & Liu, S. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2533-20.2020 · Cited by 53
The impact of adult neurogenesis on affective functions: of mice and men
Alonso, M., Petit, A., & Lledo, P. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02504-w · Cited by 60
Zhang, B., Yang, X., Ye, L., Liu, R., Ye, B., Du, W., Shen, F., Li, Q., Guo, F., Liu, J., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108382 · Cited by 47
Ketamine for a Boost of Neural Plasticity: How, but Also When?
Wu, H., Savalia, N. K., & Kwan, A. C. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.03.014 · Cited by 45
Abe, R., Okada, S., Nakayama, R., Ikegaya, Y., & Sasaki, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-45833-5 · Cited by 47
Deyama, S., Kondo, M., Shimada, S., & Kaneda, K. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01943-9 · Cited by 44
Neural plasticity and depression treatment
Wang, Y., Song, N., Ding, Y., & Zhang, L. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.09.001 · Cited by 48
Elhussiny, M. E. A., Carini, G., Mingardi, J., Tornese, P., Sala, N., Bono, F., Fiorentini, C., Via, L. L., Popoli, M., Musazzi, L., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110033 · Cited by 42
Qin, X., Shan, Q., Fang, H., Wang, Y., Chen, P., Xiong, Z., Swaab, D. F., & Zhou, J. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02371-7 · Cited by 42
Ketamine metabolite pilot study in a suicidal depression trial
Grunebaum, M. F., Galfalvy, H. C., Choo, T.-H., Parris, M. S., Burke, A. K., Suckow, R. F., Cooper, T. B., & Mann, J. J. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.08.005 · Cited by 41
Antidepressant mechanisms of ketamine: Focus on GABAergic inhibition
Lüscher, B., Feng, M., & Jefferson, S. J. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.03.002 · Cited by 41
Bortolozzi, A., Manashirov, S., Chen, A., & Artigas, F. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107873 · Cited by 37
Plasticity of synapses and reward circuit function in the genesis and treatment of depression
Thompson, S. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01422-1 · Cited by 40
Neuroplasticity, the Prefrontal Cortex, and Psychopathology-Related Deviations in Cognitive Control
Luciana, M. M., & Collins, P. F. (2022) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-081219-111203 · Cited by 46
Zhao, Y.-T., Deng, J. F., Liu, H.-M., Wei, J., Fan, H.-T., Liu, M., Xu, T., Chen, T., He, J., Sun, W., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02503-0 · Cited by 40
Oughli, H. A., Gebara, M. A., Ciarleglio, A., Lavretsky, H., Brown, P. J., Flint, A. J., Farber, N. B., Karp, J. F., Mulsant, B. H., Reynolds, C. F., et al. (2022) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2022.11.013 · Cited by 40
Sala, N., Paoli, C., Bonifacino, T., Mingardi, J., Schiavon, E., Via, L. L., Milanese, M., Tornese, P., Datusalia, A. K., Rosa, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.759626 · Cited by 38
Engineering Safer Psychedelics for Treating Addiction
Peters, J., & Olson, D. E. (2021) · Neuroscience Insights · doi:10.1177/26331055211033847 · Cited by 42
Mingardi, J., La Via, L., Tornese, P., Carini, G., Trontti, K., Seguini, M., Tardito, D., Bono, F., Fiorentini, C., Elia, L., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100381 · Cited by 36
Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation
Prévot, T. D., Sumitomo, A., Tomoda, T., Knutson, D. E., Li, G., Mondal, P., Banasr, M., Cook, J. M., & Sibille, E. L. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa310 · Cited by 41
Catalysts for change: the cellular neurobiology of psychedelics
Banks, M. I., Zahid, Z., Jones, N., Sultan, Z. W., & Wenthur, C. J. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e20-05-0340 · Cited by 45
Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disorders
Göver, T., & Ślęzak, M. (2024) · Pharmacological Reports · doi:10.1007/s43440-024-00654-w · Cited by 45
Purohit, M. P., Yu, B. J., Roy, K. S., Xiang, Y., Ewbank, S. N., Azadian, M. M., Hart, A. R., Muwanga, G. P. B., Martinez, P. J., Wang, J. B., et al. (2025) · Nature Nanotechnology · doi:10.1038/s41565-025-01990-5 · Cited by 39
Adenosine signalling drives antidepressant actions of ketamine and ECT
Yue, C., Wang, N., Zhai, H., Yuan, Z., Cui, Y., Jing, Q., Zhou, Y., Fan, X., Wang, H., Wu, Z., et al. (2025) · Nature · doi:10.1038/s41586-025-09755-9 · Cited by 46
Ketamine and Calcium Signaling—A Crosstalk for Neuronal Physiology and Pathology
Lisek, M., Żylińska, L., & Boczek, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218410 · Cited by 40
Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice
Xu, W., Li, H., Wang, L., Zhang, J., Liu, C., Wan, X., Liu, X., Hu, Y., Fang, Q., Xiao, Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19780-z · Cited by 37
The paraventricular thalamus input to central amygdala controls depression-related behaviors
Zhao, D., Liu, C., Cui, M., Liu, J., Meng, F., Lian, H., Wang, D., Hu, F., Liu, D., & Li, C. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113744 · Cited by 41
Kwon, D. Y., Xu, B., Zhao, Y.-T., Beagan, J. A., Beagan, J. A., Cui, Y., Xu, B., Zaitseva, D., Phillips‐Cremins, J. E., Blendy, J. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27571-3 · Cited by 39
Dendritic spine remodeling and plasticity under general anesthesia
Granak, S., Höschl, C., & Ovsepian, S. V. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02308-6 · Cited by 37
Garel, N., Drury, J., Lévesque, J. T., Goyette, N., Lehmann, A., Looper, K. J., Erritzøe, D., Dames, S., Turecki, G., Rej, S., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1268832 · Cited by 39
Yao, X., Yang, C., Jia, X., Yu, Z., Wang, C., Zhao, J., Chen, Y., Xie, B., Zhuang, H., Sun, C., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.04.005 · Cited by 38
Souza‐Marques, B., Santos‐Lima, C., Araújo-de-Freitas, L., Vieira, F., Jesus‐Nunes, A. P., Quarantini, L. C., & Sampaio, A. S. (2021) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000312 · Cited by 40
Artin, H., Bentley, S., Mehaffey, E., Liu, F. X., Sojourner, K., Bismark, A. W., Printz, D., Lee, E., Martis, B., Peralta, S. D., et al. (2022) · EClinicalMedicine · doi:10.1016/j.eclinm.2022.101439 · Cited by 38
Hughes, B. W., Siemsen, B. M., Tsvetkov, E., Berto, S., Kumar, J., Cornbrooks, R. G., Akiki, R. M., Cho, J. Y., Carter, J. S., Snyder, K. K., et al. (2023) · eLife · doi:10.7554/elife.75631 · Cited by 35
Gan, S.-L., Long, Y.-Q., Wang, Q., Feng, C.-D., Lai, C.-X., Liu, C., Ding, Y.-Y., Liu, H., Peng, K., & Ji, F. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1128406 · Cited by 37
Ugarte, G., Piña, R., Contreras, D., Godoy, F., Rubio, D., Rozas, C., Zeise, M. L., Vidal, R., Escobar, J., & Morales, B. (2023) · Biology · doi:10.3390/biology12091241 · Cited by 35
Sex dependence of opioid-mediated responses to subanesthetic ketamine in rats
Ianni, T. D., Ewbank, S. N., Levinstein, M. R., Azadian, M. M., Budinich, R. C., Michaelides, M., & Airan, R. D. (2024) · Nature Communications · doi:10.1038/s41467-024-45157-7 · Cited by 33
Kim, H., Kim, H., Suh, H. J., & Choi, H. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c07260 · Cited by 36
Furuyashiki, T., & Kitaoka, S. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12901 · Cited by 35
Odland, A. U., Jessen, L., Kristensen, J. L., Fitzpatrick, C. M., & Andreasen, J. T. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107838 · Cited by 35
Wilkowska, A., Włodarczyk, A., Gałuszko‐Węgielnik, M., Wiglusz, M. S., & Cubała, W. J. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s325000 · Cited by 38
Höflich, A., Kraus, C., Pfeiffer, R. M., Seiger, R., Rujescu, D., Zarate, C. A., Kasper, S., Winkler, D., & Lanzenberger, R. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01318-6 · Cited by 34
Pan, H., Steixner-Kumar, A. A., Seelbach, A., Deutsch, N. R., Ronnenberg, A., Tapken, D., von Ahsen, N., Mitjans, M., Worthmann, H., Trippe, R., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0672-1 · Cited by 36
Zhang, X., Zhao, Y., Du, Y., Sun, H., Zhang, W., Wang, A., Li, Q., Li, C., Wang, Y., Du, Z., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.02.058 · Cited by 34
Zhang, Y., Li, J., Wang, H., Niu, W.-P., Zhang, C., Zhang, Y., Wang, X., Si, T., & Su, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105571 · Cited by 34
Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity
Ren, F., & Guo, R. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s268012 · Cited by 32
Neurobiological Underpinnings of Hyperarousal in Depression: A Comprehensive Review
Xie, M., Huang, Y., Cai, W., Zhang, B., Huang, H. D., Li, Q., Qin, P., & Han, J. (2024) · Brain Sciences · doi:10.3390/brainsci14010050 · Cited by 36
Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase Signaling
Duncan, B. W., Mohan, V., Wade, S. D., Truong, Y. K.-N., Kampov-Polevoi, A., Temple, B. R. S., & Maness, P. F. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02373-2 · Cited by 32
Liu, T., Lu, J., Łukasiewicz, K., Pan, B., & Zuo, Y. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100342 · Cited by 32
Liang, X., Tang, J., Qi, Y., Luo, Y., Yang, C., Dou, X., Jiang, L. H., Xiao, Q., Zhang, L., Chao, F., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114103 · Cited by 32
Ketamine in Bipolar Disorder: A Review
Wilkowska, A., Szałach, Ł. P., & Cubała, W. J. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s282208 · Cited by 35
Xia, B., Huang, X., Sun, G., & Tao, W. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113665 · Cited by 31
Schumacher, F., Carpinteiro, A., Edwards, M. J., Wilson, G. C., Keitsch, S., Soddemann, M., Wilker, B., Kleuser, B., Becker, K. A., Müller, C. P., et al. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02250-y · Cited by 32
Chenani, A., Weston, G., Ulivi, A. F., Castello-Waldow, T. P., Huettl, R.-E., Chen, A., & Attardo, A. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02107-5 · Cited by 34
Troppoli, T. A., Zanos, P., Georgiou, P., Gould, T. D., Rudolph, U., & Thompson, S. M. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.024 · Cited by 29
Dawson, M., Terstege, D. J., Jamani, N. F., Tsutsui, M., Pavlov, D., Bugescu, R., Epp, J. R., Leinninger, G. M., & Sargin, D. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112815 · Cited by 34
Aarrestad, I. K., Cameron, L. P., Fenton, E. M., Casey, A. B., Rijsketic, D. R., Patel, S. D., Sambyal, R., Johnson, S. B., Ly, C., Viswanathan, J., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02021-1 · Cited by 33
Self-citationWang, X., Bai, X., Su, D., Zhang, Y., Li, P., Lu, S., Gong, Y., Zhang, W., & Tang, B. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05771 · Cited by 31
Serotonergic Psychedelics in Neural Plasticity
Łukasiewicz, K., Baker, J. J., Zuo, Y., & Lu, J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.748359 · Cited by 37
Averbeck, B. B. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121331119 · Cited by 37
Li, Y., Fan, C., Wang, C., Wang, L., Yi, Y., Mao, X., Chen, X., Lan, T., Wang, W., & Yu, S. Y. (2022) · Science Advances · doi:10.1126/sciadv.add7063 · Cited by 27
Esmethadone-HCl (REL-1017): a promising rapid antidepressant
D, M. F. M., Stahl, S. M., Martin, S. D., Mattarei, A., Bettini, E., Comai, S., Alimonti, A., Bifari, F., Pani, L., Folli, F. B., et al. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01571-4 · Cited by 32
Wei, M.-D., Wang, Y., Lu, K., Lv, B.-J., Wang, Y., & Chen, W. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112342 · Cited by 30
Metadata
- Authors
- Moda-Sava, R. N., Murdock, M. H., Parekh, P. K., Fetcho, R. N., Huang, B. S., Huynh, T. N., Witztum, J., Shaver, D. C., Rosenthal, D. L., Alway, E. J., Lopez, K., Meng, Y., Nellissen, L., Grosenick, L., Milner, T. A., Deisseroth, K., Bito, H., Kasai, H., & Liston, C.
- Affiliations
- Weill Cornell Medicine (US)
- Stanford University (US)
- The University of Tokyo (JP)
- Center for Disease Biology and Integrative Medicine, The University of Tokyo (JP)
- Corresponding author
- Moda-Sava, R. N.
- Murdock, M. H.
- Parekh, P. K.
- Liston, C.
- ORCID
- Venue
- Science
- Published
- 2019-04-12
- Volume
- 364
- Issue
- 6436
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6785189
- OpenAlex
- W2935995671
- Cited by
- 643
- References
- 96
- Citations by year
- 2026: 64 · 2025: 92 · 2024: 91 · 2023: 91 · 2022: 91 · 2021: 96 · 2020: 84 · 2019: 34
- FWCI
- 47.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Institute of Mental Health (R00 MH097822, R01 MH109685)
- Simons Foundation (429965)
- Whitehall Foundation
- Rita Allen Foundation
- KAKENHI (Grant 17H06312)
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science, and Technology
- Hartwell Foundation
- One Mind Institute
- Klingenstein-Simons Fellowship in Brain Science
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- depression, antidepressant effects, ketamine, dendritic spine formation, medial prefrontal cortex, postsynaptic neurons
- MeSH terms
- Animals, Antidepressive Agents, Corticosterone, Depressive Disorder, Disease Models, Animal, Escape Reaction, Ketamine, Mice, Inbred C57BL, Mice, Transgenic, Neuronal Plasticity, Stress, Psychological, Synapses, Prefrontal Cortex, Dendritic Spines, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
