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Cited by 452

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

An ingestible self-orienting system for oral delivery of macromolecules

Open access
Abramson, Alex, Caffarel-Salvador, Ester, Khang, Minsoo, Dellal, David, Silverstein, David, Gao, Yuan, Frederiksen, Morten Revsgaard, Vegge, Andreas, Hubálek, František, Water, Jorrit J., Friderichsen, Anders V., Fels, Johannes, Kirk, Rikke Kaae, Cleveland, Cody, Collins, Joy, Tamang, Siddartha, Hayward, Alison, Landh, Tomas, Buckley, Stephen T., Roxhed, Niclas, Rahbek, Ulrik, Langer, Robert, Traverso, Giovanni·2019·Science

Abstract

Delivering fragile drugs to the gut: Oral delivery is the simplest and least invasive way to deliver many pharmaceuticals, but many drugs and medications, including insulin, cannot survive passage through the stomach or the gastrointestinal tract. Abramson et al. developed an ingestible delivery vehicle that could self-reorient from any starting position so as to attach to the gastric wall. Encapsulation of a spring in a sugar casing allowed for triggered actuation for the delivery of biomolecules. The approach successfully provided active insulin delivery in pigs. Science , this issue p. 611

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Crossref · 10.1126/science.aau2277

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Metadata

Authors
Abramson, A., Caffarel-Salvador, E., Khang, M., Dellal, D., Silverstein, D., Gao, Y., Frederiksen, M. R., Vegge, A., Hubálek, F., Water, J. J., Friderichsen, A. V., Fels, J., Kirk, R. K., Cleveland, C., Collins, J., Tamang, S., Hayward, A., Landh, T., Buckley, S. T., Roxhed, N., Rahbek, U., Langer, R., & Traverso, G.
Venue
Science
Published
2019-02-08
Volume
363
Issue
6427
Pages
611-615
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2913582983
Cited by
452
References
28
FWCI
20.10
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: An ingestible self-orienting system for oral delivery of macromolecules. https://app.cochat.ai/papers/10.1126/science.aau2277
The paper
Abramson, A., Caffarel-Salvador, E., Khang, M., Dellal, D., Silverstein, D., Gao, Y., Frederiksen, M. R., Vegge, A., Hubálek, F., Water, J. J., Friderichsen, A. V., Fels, J., Kirk, R. K., Cleveland, C., Collins, J., Tamang, S., Hayward, A., Landh, T., Buckley, S. T., . . . Traverso, G. (2019). An ingestible self-orienting system for oral delivery of macromolecules. Science. https://doi.org/10.1126/science.aau2277

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.