The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ionic liquids for oral insulin delivery
Open accessAbstract
Significance: Insulin is currently available as an injectable formulation, but an oral product would enjoy higher patient compliance and would significantly improve the quality of life of diabetic patients worldwide. However, oral delivery of proteins such as insulin is challenging due to various gastrointestinal barriers to oral absorption of macromolecules. We have developed a safe and highly effective ionic liquid-based oral insulin formulation that significantly enhanced oral insulin absorption by efficiently circumventing the gastrointestinal barriers. Besides, the formulation demonstrated good stability at room temperature and under refrigeration. Evidence from cell and animal studies supports a promising prospect of development of the formulation into a clinical product.
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Cites
Choline: an essential nutrient for public health
Zeisel, S. H., & da Costa, K.-A. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00246.x · Cited by 1,062
Correlates of Insulin Injection Omission
Peyrot, M., Rubin, R. R., Kruger, D. F., & Travis, L. B. (2010) · Diabetes Care · doi:10.2337/dc09-1348 · Cited by 407
Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles
Chalasani, K. B., Russell-Jones, G. J., Jain, A. K., Diwan, P. V., & Jain, S. K. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.019 · Cited by 257
Cited by
An ingestible self-orienting system for oral delivery of macromolecules
Abramson, A., Caffarel-Salvador, E., Khang, M., Dellal, D., Silverstein, D., Gao, Y., Frederiksen, M. R., Vegge, A., Hubálek, F., Water, J. J., et al. (2019) · Science · doi:10.1126/science.aau2277 · Cited by 452
Biocompatible ionic liquids and their applications in pharmaceutics
Md Moshikur, R., Chowdhury, M. R., Moniruzzaman, M., & Goto, M. (2020) · Green Chemistry · doi:10.1039/d0gc02387f · Cited by 268
Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches
Brayden, D. J., Hill, T. A., Fairlie, D. P., Maher, S., & Mrsny, R. J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.05.007 · Cited by 253
Treatment strategies against diabetes: Success so far and challenges ahead.
Khursheed, R., Singh, S. K., Wadhwa, S., Kapoor, B., Gulati, M., Kumar, R., Ramanunny, A. K., Awasthi, A., & Dua, K. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172625 · Cited by 239
Lipid nanoparticle-mediated drug delivery to the brain
Khare, P., Edgecomb, S. X., Hamadani, C. M., Tanner, E. E. L., & S Manickam, D. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114861 · Cited by 187
Metadata
- Authors
- Banerjee, A., Ibsen, K., Brown, T., Chen, R., Agatemor, C., & Mitragotri, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-06-25
- Volume
- 115
- Issue
- 28
- Pages
- 7296-7301
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2810098751
- Cited by
- 378
- References
- 3
- FWCI
- 17.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Banerjee, A., Ibsen, K., Brown, T., Chen, R., Agatemor, C., & Mitragotri, S. (2018). Ionic liquids for oral insulin delivery. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1722338115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
