The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Effects of microbiota-directed foods in gnotobiotic animals and undernourished children
Open accessAbstract
To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.
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“Supplementing children with moderate acute malnutrition with a microbiota-directed complementary food prototype shifted the microbiota as well as markers of neurodevelopment toward that of healthy children, indicating that the immature microbiota is causally linked to unhealthy growth and development, but can be rescued by microbiota-targeted food therapy (282).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [282]
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- MAL-ED Network Investigators, The Malnutrition and Enteric Disease Study (MAL-ED): Understanding the Consequences for Child Health and Development. Clin. Infect. Dis. 59, S193–S206 (2014).
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Metadata
- Authors
- Gehrig, J. L., Venkatesh, S., Chang, H.-W., Hibberd, M. C., Kung, V. L., Cheng, J., Chen, R. Y., Subramanian, S., Cowardin, C. A., Meier, M. F., O’Donnell, D., Talcott, M., Spears, L. D., Semenkovich, C. F., Henrissat, B., Giannone, R. J., Hettich, R. L., Ilkayeva, O., Muehlbauer, M., Newgard, C. B., Sawyer, C., Head, R. D., Rodionov, D. A., Arzamasov, A. A., Leyn, S. A., Osterman, A. L., Hossain, M. I., Islam, M., Choudhury, N., Sarker, S. A., Huq, S., Mahmud, I., Mostafa, I., Mahfuz, M., Barratt, M. J., Ahmed, T., & Gordon, J. I.
- Affiliations
- Washington University in St. Louis (US)
- Centre National de la Recherche Scientifique (FR)
- Oak Ridge National Laboratory (US)
- Duke Medical Center (US)
- Russian Academy of Sciences (RU)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- International Centre for Diarrhoeal Disease Research (BD)
- Corresponding author
- Gehrig, Jeanette L.
- Venkatesh, Siddarth
- Chang, Hao-Wei
- Gordon, Jeffrey I.
- ORCID
- Gehrig, Jeanette L.
- Venkatesh, Siddarth
- Chang, Hao-Wei
- Hibberd, Matthew C.
- Kung, Vanderlene L.
- Cheng, Jiye
- Chen, Robert Y.
- Subramanian, Sathish
- Cowardin, Carrie A.
- O’Donnell, David
- Talcott, Michael
- Spears, Larry D.
- Semenkovich, Clay F.
- Henrissat, Bernard
- Giannone, Richard J.
- Hettich, Robert L.
- Ilkayeva, Olga
- Muehlbauer, Michael
- Newgard, Christopher B.
- Sawyer, Christopher
- Head, Richard D.
- Rodionov, Dmitry A.
- Arzamasov, Aleksandr A.
- Leyn, Semen A.
- Osterman, Andrei L.
- Hossain, Md Iqbal
- Islam, Munirul
- Choudhury, Nuzhat
- Sarker, Shafiqul Alam
- Huq, Sayeeda
- Mahmud, Imteaz
- Mostafa, Ishita
- Mahfuz, Mustafa
- Barratt, Michael J.
- Ahmed, Tahmeed
- Gordon, Jeffrey I.
- Venue
- Science
- Published
- 2019-07-12
- Volume
- 365
- Issue
- 6449
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6683325
- OpenAlex
- W2959398154
- Cited by
- 431
- References
- 120
- Citations by year
- 2026: 38 · 2025: 51 · 2024: 56 · 2023: 57 · 2022: 72 · 2021: 82 · 2020: 56 · 2019: 16
- FWCI
- 18.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion, cc-by)
- HAL (submittedVersion, cc-by)
- Bristol Research (University of Bristol) (submittedVersion, other-oa)
- Greater South Information System
- Funders
- National Institutes of Health (GM007200, P30AR057235)
- Bill and Melinda Gates Foundation (OPP1134649)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Child Nutrition and Water Access
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- gut microbiota, child undernutrition, severe acute malnutrition, moderate acute malnutrition, gnotobiotic mice, gnotobiotic pigs, plasma biomarkers, bone formation, brain development, immune function, Bangladeshi children
- MeSH terms
- Gastrointestinal Microbiome, Host Microbial Interactions, Animals, Bangladesh, Blood Proteins, Child, Preschool, Germ-Free Life, Humans, Infant, Infant Nutritional Physiological Phenomena, Child Nutrition Disorders
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