The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Potassium channel dysfunction in human neuronal models of Angelman syndrome
Open accessAbstract
Hyperexcitable neurons in brain organoids: Individuals with Angelman syndrome experience intellectual disability and seizures throughout their lives. In this condition, ubiquitin-mediated degradation of a key potassium channel is disrupted, allowing for the neuronal excitability and network synchronization that leads to seizure. Sun et al. used brain organoid technology to study what happens in human neurons with a mutation in a ubiquitin ligase that is implicated in Angelman syndrome. In these in vitro models and in a mouse model of Angelman syndrome, antagonists for the potassium channel normalized neuronal excitability. Science , this issue p. 1486
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Autism-associated SHANK3 haploinsufficiency causes I h channelopathy in human neurons
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Cited by
Identification of neural oscillations and epileptiform changes in human brain organoids
Samarasinghe, R. A., Miranda, O. A., Buth, J. E., Mitchell, S., Ferando, I., Watanabe, M., Allison, T. F., Kurdian, A., Fotion, N. N., Gandal, M. J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00906-5 · Cited by 281
Organoids: The current status and biomedical applications
Yang, S., Hu, H., Kung, H., Zou, R., Dai, Y., Hu, Y., Wang, T., Lv, T., Yu, J., & Li, F. (2023) · MedComm · doi:10.1002/mco2.274 · Cited by 266
Recent advances in gene therapy for neurodevelopmental disorders with epilepsy
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Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs.
Brighi, C., Salaris, F., Soloperto, A., Cordella, F., Ghirga, S., de Turris, V., Rosito, M., Porceddu, P. F., D’Antoni, C., Reggiani, A., et al. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-03776-8 · Cited by 56
The sociability spectrum: evidence from reciprocal genetic copy number variations
López-Tobón, A., Trattaro, S., & Testa, G. (2020) · Molecular Autism · doi:10.1186/s13229-020-00347-0 · Cited by 20
Metadata
- Authors
- Sun, A. X., Yuan, Q., Fukuda, M., Yu, W., Yan, H., Lim, G. G. Y., Nai, M. H., D’Agostino, G. A., Tran, H.-D., Itahana, Y., Wang, D., Lokman, H., Itahana, K., Lim, S. W. L., Tang, J., Chang, Y. Y., Zhang, M., Cook, S. A., Rackham, O. J. L., Lim, C. T., Tan, E. K., Ng, H. H., Lim, K. L., Jiang, Y.-H., & Je, H. S.
- Venue
- Science
- Published
- 2019-12-20
- Volume
- 366
- Issue
- 6472
- Pages
- 1486-1492
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2996359755
- Cited by
- 178
- References
- 11
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Sun, A. X., Yuan, Q., Fukuda, M., Yu, W., Yan, H., Lim, G. G. Y., Nai, M. H., D’Agostino, G. A., Tran, H.-D., Itahana, Y., Wang, D., Lokman, H., Itahana, K., Lim, S. W. L., Tang, J., Chang, Y. Y., Zhang, M., Cook, S. A., Rackham, O. J. L., . . . Je, H. S. (2019). Potassium channel dysfunction in human neuronal models of Angelman syndrome. Science. https://doi.org/10.1126/science.aav5386
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
