Cited by 1,087Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 240 of the 240 references it cites were found in a registry or an index.

Memory engrams: Recalling the past and imagining the future

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Abstract

The neural substrate of memory: The ability to form memory is an essential trait that allows learning and the accumulation of knowledge. But what is a memory? There has been a long history of searching for the neuronal substrate that forms memory in the brain, and the emerging view is that ensembles of engram cells explain how memories are formed and retrieved. In a Review, Josselyn and Tonegawa discuss the evidence for engram cells as a substrate of memory, particularly in rodents; what we have learned so far about the features of memory, including memory formation, retrieval over time, and loss; and future directions to understand how memory becomes knowledge. Science , this issue p. eaaw4325

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  1. K. S. Lashley in Society of Experimental Biology Symposium No. 4: Psychological Mechanisms in Animal Behavior J. F. Danielli R. Brown Eds. (Academic Press 1950) pp. 454–482.
  2. M. Moscovitch in Science of Memory: Concepts H. L. I. Roediger Y. Dudai S. M. Fitzpatrick Eds. (Oxford Univ. Press 2007) pp. 17–29.
  3. M. S. Fanselow L. S. Lester in Evolution and Learning R. C. Bolles M. D. Beecher Eds. (Lawrence Erlbaum Associates Inc. 1988) pp. 185–212.
  4. P. M. Milner, Cell assemblies: Whose idea? Psycholoquy 10, 1 (1999).
  5. I. Pavlov Conditioned Reflexes (Oxford Univ. Press 1927).
  6. 10.1016/j.cub.2012.11.019 · DOI
  7. H. B. Barlow in The Cognitive Neurosciences M. S. Gazzaniga Ed. (MIT Press 1995) pp. 415–435.

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Metadata

Authors
Josselyn, S. A., & Tonegawa, S.
Affiliations
  • Canadian Institute for Advanced Research (CA)
  • Howard Hughes Medical Institute (US)
Corresponding author
  • Josselyn, Sheena A.
  • Tonegawa, Susumu
Venue
Science
Published
2020-01-03
Volume
367
Issue
6473
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2998470023
Cited by
1,087
References
240
Citations by year
2026: 165 · 2025: 224 · 2024: 199 · 2023: 159 · 2022: 157 · 2021: 111 · 2020: 70
FWCI
16.83
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
Funders
  • Howard Hughes Medical Institute
  • JPB Foundation
  • Canadian Institute for Advanced Research
  • RIKEN Brain Science Institute
  • Canadian Institutes of Health Research (FDN-388455)
  • NIMH (1 R01 MH119421-01)
  • NSERC
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
memory engrams, engram cells, memory storage, memory retrieval, intrinsic excitability, synaptic plasticity, single-unit recording, memory reconsolidation
MeSH terms
Animals, Brain, Brain Chemistry, Humans, Memory Disorders, Neurons, Mental Recall

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