The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Pervasive functional translation of noncanonical human open reading frames
Open accessAbstract
Expanding the human proteome: Using mass spectrometry, ribosome profiling, and several CRISPR-based screens, Chen et al. identified hundreds of previously uncharacterized functional micropeptides in the human genome (see the Perspective by Wei and Guo). Protein translation outside of annotated open reading frames (ORFs) in messenger RNAs and within ORFs in long noncoding RNAs is pervasive. A functional screen using CRISPR-Cas9 with single-cell transcriptomics suggested critical roles for hundreds of micropeptides. Micropeptides encoded by multiple short, upstream ORFs form stable protein complexes with the downstream canonical proteins encoded on the same messenger RNAs. Science , this issue p. 1140 ; see also p. 1074
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Structured elements drive extensive circular RNA translation
Chen, C.-K., Cheng, R., Demeter, J., Chen, J., Weingarten-Gabbay, S., Jiang, L., Snyder, M. P., Weissman, J. S., Segal, E., Jackson, P. K., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.07.042 · Cited by 316
Self-citationUnannotated proteins expand the MHC-I-restricted immunopeptidome in cancer
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Identification of tumor antigens with immunopeptidomics
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Metadata
- Authors
- Chen, J., Brunner, A.-D., Cogan, J. Z., Nuñez, J. K., Fields, A. P., Adamson, B., Itzhak, D. N., Li, J. Y., Mann, M., Leonetti, M. D., & Weissman, J. S.
- Venue
- Science
- Published
- 2020-03-06
- Volume
- 367
- Issue
- 6482
- Pages
- 1140-1146
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3010073072
- Cited by
- 655
- References
- 70
- FWCI
- 25.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, J., Brunner, A.-D., Cogan, J. Z., Nuñez, J. K., Fields, A. P., Adamson, B., Itzhak, D. N., Li, J. Y., Mann, M., Leonetti, M. D., & Weissman, J. S. (2020). Pervasive functional translation of noncanonical human open reading frames. Science. https://doi.org/10.1126/science.aay0262
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