Plasma cell survival in the absence of B cell memory
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Pre-existing serum antibodies play an important role in vaccine-mediated protection against infection but the underlying mechanisms of immune memory are unclear. Clinical studies indicate that antigen-specific antibody responses can be maintained for many years, leading to theories that reactivation/differentiation of memory B cells into plasma cells is required to sustain long-term antibody production. Here, we present a decade-long study in which we demonstrate site-specific survival of bone marrow-derived plasma cells and durable antibody responses to multiple virus and vaccine antigens in rhesus macaques for years after sustained memory B cell depletion. Moreover, BrdU + cells with plasma cell morphology can be detected for 10 years after vaccination/BrdU administration, indicating that plasma cells may persist for a prolonged period of time in the absence of cell division. On the basis of these results, long-lived plasma cells represent a key cell population responsible for long-term antibody production and serological memory.
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Rapid early antibody decay is due to the short half-life of serum antibodies and short-lived antibody-secreting cells, leaving long-lived plasma cells with half-lives of months to years.
“This pattern of rapid early decay is due to the short half-life of serum antibodies and to short-lived antibody-secreting cells, which decay with a half-life of weeks to leave a population of long-lived plasma cells with half-lives of months to years21.”
From Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection (2021) · cites this paper as [21]
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- Authors
- Hammarlund, E., Thomas, A., Amanna, I. J., Holden, L. A., Slayden, O. D., Park, B., Gao, L., & Slifka, M. K.
- Affiliations
- Oregon National Primate Research Center (US)
- Najít Technologies (United States) (US)
- Portland State University (US)
- OHSU Knight Cancer Institute (US)
- Corresponding author
- Slifka, Mark K.
- ORCID
- Venue
- Nature Communications
- Published
- 2017-11-24
- Volume
- 8
- Issue
- 1
- Pages
- 1781-1781
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5701209
- OpenAlex
- W2770797413
- Cited by
- 210
- References
- 67
- Citations by year
- 2026: 20 · 2025: 20 · 2024: 15 · 2023: 23 · 2022: 28 · 2021: 36 · 2020: 32 · 2019: 22 · 2018: 14
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PDXScholar (Portland State University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (P51OD011092)
- Genentech
- Oregon National Primate Research Center
- National Institute on Aging (P01AG023664)
- National Institute of Allergy and Infectious Diseases (U01AI082196)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Keywords
- long-lived plasma cells, plasma cell survival, memory B cells, long-term antibody response, vaccine immunity, rhesus monkeys, BrdU labeling, bone marrow plasma cells
- MeSH terms
- Animals, Antibodies, Bacterial, Antibody Formation, B-Lymphocytes, Bacterial Vaccines, Cell Survival, Immunologic Memory, Macaca mulatta, Male, Plasma Cells, Vaccination
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