The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Partitioning of cancer therapeutics in nuclear condensates
Open accessAbstract
Drug partitioning in nuclear condensates: There is increasing interest in the function of phase-separated biomolecular condensates in cells because of their distinct properties and expanding roles in important biological processes. Klein et al. considered the fate of small-molecule therapeutics in the context of nuclear condensates (see the Perspective by Viny and Levine). They show that certain antineoplastic drugs have physicochemical properties that cause them to concentrate preferentially in condensates, both in vitro and in cancer cells. This property influences drug activity, and protein mutations that alter condensate formation can lead to drug resistance. Optimizing condensate partitioning may be valuable in developing improved therapeutics. Science , this issue p. 1386 ; see also p. 1314
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Metadata
- Authors
- Klein, I. A., Boija, A., Afeyan, L. K., Hawken, S. W., Fan, M., Dall'Agnese, A., Oksuz, O., Henninger, J. E., Shrinivas, K., Sabari, B. R., Sagi, I., Clark, V. E., Platt, J. M., Kar, M., McCall, P. M., Zamudio, A. V., Manteiga, J. C., Coffey, E. L., Li, C. H., Hannett, N. M., Guo, Y. E., Decker, T.-M., Lee, T. I., Zhang, T., Weng, J.-K., Taatjes, D. J., Chakraborty, A., Sharp, P. A., Chang, Y. T., Hyman, A. A., Gray, N. S., & Young, R. A.
- Venue
- Science
- Published
- 2020-06-19
- Volume
- 368
- Issue
- 6497
- Pages
- 1386-1392
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3035864988
- Cited by
- 499
- References
- 67
- FWCI
- 18.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Klein, I. A., Boija, A., Afeyan, L. K., Hawken, S. W., Fan, M., Dall'Agnese, A., Oksuz, O., Henninger, J. E., Shrinivas, K., Sabari, B. R., Sagi, I., Clark, V. E., Platt, J. M., Kar, M., McCall, P. M., Zamudio, A. V., Manteiga, J. C., Coffey, E. L., Li, C. H., . . . Young, R. A. (2020). Partitioning of cancer therapeutics in nuclear condensates. Science. https://doi.org/10.1126/science.aaz4427
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
