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Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases
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Dementia is a rapidly rising global health crisis that silently disables families and ends lives and livelihoods around the world. To date, however, no early biomarkers or effective therapies exist. It is now clear that brain microglia are more than mere bystanders or amyloid phagocytes; they can act as governors of neuronal function and homeostasis in the adult brain. Here, we highlight the fundamental role of microglia as tissue-resident macrophages in neuronal health. Then, we suggest how chronic impairment in microglia-neuron cross-talk may secure the permanence of the failure of synaptic and neuronal function and health in Alzheimer’s and Parkinson’s diseases. Understanding how to assess and modulate microglia-neuron interactions critical for brain health will be key to developing effective therapies for dementia.
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“The uptake and processing of non-toxic α-syn by glia could lead to the generation of toxic strains specific to the disease through autophagy and impaired lysosomal degradation250”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [250]
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Metadata
- Authors
- Bartels, T., De Schepper, S., & Hong, S.
- Affiliations
- UK Dementia Research Institute (GB)
- UK Dementia Research Institute, Institute of Neurology, University College London, London WC1E 6BT, UK.
- Corresponding author
- Hong, Soyon
- Venue
- Science
- Published
- 2020-10-02
- Volume
- 370
- Issue
- 6512
- Pages
- 66-69
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3090922258
- Cited by
- 412
- References
- 70
- Citations by year
- 2026: 48 · 2025: 85 · 2024: 68 · 2023: 69 · 2022: 75 · 2021: 66 · 2020: 1
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke
- Michael J. Fox Foundation for Parkinson's Research
- Parkinson's Disease Foundation
- Chan Zuckerberg Initiative
- Dementia Research UK
- UK Medical Research Council
- Alzheimer's Research UK
- Alzheimer's Society UK
- Eisai
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microglia, neurodegeneration, Alzheimer's disease, Parkinson's disease, dementia, microglia-neuron interaction, tissue-resident macrophages, synaptic dysfunction, neuronal health, neuroinflammation
- MeSH terms
- Alzheimer Disease, Amyloid, Animals, Cell Communication, Humans, Macrophages, Neurons, Parkinson Disease, Synapses, Synaptosomes, Microglia, Mice, alpha-Synuclein
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