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Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases
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Dementia is a rapidly rising global health crisis that silently disables families and ends lives and livelihoods around the world. To date, however, no early biomarkers or effective therapies exist. It is now clear that brain microglia are more than mere bystanders or amyloid phagocytes; they can act as governors of neuronal function and homeostasis in the adult brain. Here, we highlight the fundamental role of microglia as tissue-resident macrophages in neuronal health. Then, we suggest how chronic impairment in microglia-neuron cross-talk may secure the permanence of the failure of synaptic and neuronal function and health in Alzheimer’s and Parkinson’s diseases. Understanding how to assess and modulate microglia-neuron interactions critical for brain health will be key to developing effective therapies for dementia.
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“The uptake and processing of non-toxic α-syn by glia could lead to the generation of toxic strains specific to the disease through autophagy and impaired lysosomal degradation250”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [250]
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A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
Cognitive reserve in ageing and Alzheimer's disease
Stern, Y. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70191-6 · Cited by 3,557
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343
Self-citationAlzheimer Disease Genetics Consortium (ADGC), Kunkle, B. W., The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, P. A. E. R. F. A. D. C. (., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0358-2 · Cited by 2,946
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599
Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
Sidransky, E., Nalls, M. A., Aasly, J. O., Aharon-Peretz, J., Annesi, G., Barbosa, E. R., Bar-Shira, A., Berg, D., Bras, J., Brice, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901281 · Cited by 2,135
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.049 · Cited by 1,736
Molecular diversity and specializations among the cells of the adult mouse brain
Saunders, A., Macosko, E. Z., Wysoker, A., Goldman, M., Krienen, F. M., de Rivera, H., Bien, E., Baum, M., Bortolin, L., Wang, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.028 · Cited by 1,531
Kim, S., Kwon, S.-H., Kam, T.-I., Panicker, N., Karuppagounder, S. S., Lee, S., Lee, J. H., Kim, W. R., Kook, M., Foss, C. A., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.035 · Cited by 1,397
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Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616
The neuroimmune axis of Alzheimer’s disease
Jorfi, M., Maaser‐Hecker, A., & Tanzi, R. E. (2023) · Genome Medicine · doi:10.1186/s13073-023-01155-w · Cited by 313
Hussain, B., Fang, C., & Chang, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.688090 · Cited by 255
Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology
Rahman, M. M., & Lendel, C. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00465-0 · Cited by 260
Meftah, S., & Gan, J. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2023.1129036 · Cited by 205
Microglia-containing human brain organoids for the study of brain development and pathology
Zhang, W., Jiang, J., Xu, Z., Yan, H., Tang, B., Liu, C., Chen, C., & Meng, Q. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01892-1 · Cited by 195
Genetics of the human microglia regulome refines Alzheimer’s disease risk loci
Kosoy, R., Fullard, J. F., Zeng, B., Bendl, J., Dong, P., Rahman, S., Kleopoulos, S. P., Shao, Z., Girdhar, K., Humphrey, J., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01149-1 · Cited by 168
Zhong, G., Long, H., Zhou, T., Liu, Y., Zhao, J., Han, J., Yang, X., Yin, Y., Chen, F., & Shi, S. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121690 · Cited by 155
Xie, J., Cools, L., Imschoot, G. V., Wonterghem, E. V., Pauwels, M. J., Vlaeminck, I., Witte, C. D., Andaloussi, S. E., Wierda, K. D. B., Groef, L. D., et al. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12306 · Cited by 161
Liu, P., Zhang, T., Chen, Q., Li, C., Chu, Y., Guo, Q., Zhang, Y., Zhou, W., Chen, H., Zhou, Z., et al. (2021) · Advanced Materials · doi:10.1002/adma.202100746 · Cited by 140
Rueda‐Carrasco, J., Sokolova, D., Lee, S., Childs, T., Jurčáková, N., Crowley, G., Schepper, S. D., Ge, J. Z., Lachica, J., Toomey, C. E., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022113246 · Cited by 125
Self-citationCentral role of microglia in sepsis-associated encephalopathy: From mechanism to therapy
Yan, X., Yang, K., Xiao, Q., Hou, R., Pan, X., & Zhu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.929316 · Cited by 127
Bao, C., Ma, Q., Ying, X., Wang, F., Hou, Y., Wang, D., Zhu, L., Huang, J., & He, C. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105502 · Cited by 135
Schlepckow, K., Morenas‐Rodríguez, E., Hong, S. Y., & Haass, C. (2023) · The Lancet Neurology · doi:10.1016/s1474-4422(23)00247-8 · Cited by 122
Self-citationPeripheral immunity is associated with the risk of incident dementia
Zhang, Y.-R., Wang, J.-J., Chen, S.-F., Wang, H.-F., Li, Y.-Z., Ou, Y.-N., Huang, S.-Y., Chen, S.-D., Cheng, W., Feng, J.-F., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01446-5 · Cited by 114
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Wu, K., Zhang, Y.-R., Huang, Y., Dong, Q., Tan, L., & Yu, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101409 · Cited by 119
Que, R., Zheng, J., Chang, Z., Zhang, W., Li, H., Xie, Z., Huang, Z., Wang, H., Xu, J., Jin, D., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.794770 · Cited by 107
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Yang, H., Zhou, Q. X., Fang, Z., Li, W., Zheng, Y., Ma, J., Wang, Z., Zhao, L., Liu, S., Shen, Y., et al. (2021) · Chem · doi:10.1016/j.chempr.2021.06.010 · Cited by 104
Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease
Tan, Y., Zheng, Y., Xu, D., Sun, Z., Yang, H., & Yin, Q. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00592-7 · Cited by 100
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Deng, Q., Wu, C., Parker, E., Liu, T. C.-Y., Duan, R., & Yang, L. (2023) · Aging and disease · doi:10.14336/ad.2023.0907 · Cited by 102
Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity
Zhao, J., Andreev, I., & Silva, H. M. (2024) · Science Immunology · doi:10.1126/sciimmunol.add1967 · Cited by 109
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Yu, Y., Li, T., Ou, M., Luo, R., Chen, H., Ren, H., Li, Z., Sun, J., Zhang, H., Peng, S., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.11.051 · Cited by 99
Cai, M., Zhuang, W., Lv, E., Liu, Z., Wang, Y., Zhang, W., & Fu, W. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105221 · Cited by 97
Feng, Q., Zhang, X., Zhao, X., Liu, J., Wang, Q., Yao, Y., Xiao, H., Zhu, Y., Zhang, W., & Wang, L. (2024) · Small · doi:10.1002/smll.202405781 · Cited by 98
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Wicks, E. E., Ran, K. R., Kim, J. E., Xu, R., Lee, R. P., & Jackson, C. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.897022 · Cited by 92
Glucose metabolism, neural cell senescence and Alzheimer's disease
Wang, Q., Duan, L., Li, X., Wang, Y., Guo, W., Guan, F., & Ma, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084351 · Cited by 90
Shen, Q., Jv, X.-H., Ma, X., Li, C., Liu, L., Jia, W., Qu, L., Chen, L., & Xie, J. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01153-z · Cited by 90
Zhang, X., Tang, L., Yang, J., Meng, L., Chen, J., Zhou, L., Wang, J., Xiong, M., & Zhang, Z. (2023) · Nature Communications · doi:10.1038/s41467-023-42505-x · Cited by 91
Extracellular vesicles in neuroinflammation: Pathogenesis, diagnosis, and therapy
Ruan, J., Miao, X., Schlüter, D., Li, L., & Wang, X. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.04.020 · Cited by 87
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Han, J., Zhang, Z., Zhang, P., Yu, Q., Cheng, Q., Lu, Z., & Zong, S. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1575453 · Cited by 97
The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
Alexaki, V. I. (2021) · Cells · doi:10.3390/cells10071584 · Cited by 84
Dhaynaut, M., Sprugnoli, G., Cappon, D., Macone, J., Sanchez, J. S., Normandin, M. D., Guehl, N. J., Koch, G., Paciorek, R., Connor, A., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215072 · Cited by 81
Da, Z., Yang, K., Guo, H., Zeng, J., Wang, S., Xu, H., Ge, A., Zeng, L., Chen, S., & Ge, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114312 · Cited by 77
Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING
Gao, D., Hao, J.-P., Li, B., Zheng, C.-C., Miao, B.-B., Zhang, L., Li, Y., Li, L., Li, X., & Zhang, L. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175809 · Cited by 82
Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease
Chao, Z., Mei, Q., Yang, C., Luo, J., Liu, P., Peng, H., Guo, X., Yin, Z., Li, L., & Wang, Z. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02332-6 · Cited by 96
Kaempferol: Unveiling its anti-inflammatory properties for therapeutic innovation
Herrera, T. E. S., Tello, I. P. S., Mustafa, M. A., Jamil, N. Y., Alaraj, M., Altameemi, K. K. A., Alasheqi, M. Q., Hamoody, A.-H. M., Alkhafaji, A. T., Shakir, M. N., et al. (2025) · Cytokine · doi:10.1016/j.cyto.2024.156846 · Cited by 83
Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts
Cullinane, P. W., Pablo‐Fernández, E. D., König, A., Outeiro, T. F., Jaunmuktane, Z., & Warner, T. T. (2022) · Movement Disorders · doi:10.1002/mds.29298 · Cited by 78
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Margiotta, A. (2021) · Cells · doi:10.3390/cells10050991 · Cited by 70
Prowse, N. A., & Hayley, S. P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.018 · Cited by 72
Wei, Y., Xia, X., Wang, X., Yang, W., He, S., Wang, L., Chen, Y., Zhou, Y., Chen, F., Li, H., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.01.015 · Cited by 73
Xie, J., Gorlé, N., Vandendriessche, C., Imschoot, G. V., Wonterghem, E. V., Cauwenberghe, C. V., Parthoens, E., Hamme, E. V., Lippens, S., Hoecke, L. V., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01253-z · Cited by 69
Aron, L., Zullo, J., & Yankner, B. A. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.09.009 · Cited by 70
Zhao, K., Zheng, Q., Dyrba, M., Rittman, T., Li, A., Che, T., Chen, P., Sun, Y., Kang, X., Li, Q., et al. (2022) · Advanced Science · doi:10.1002/advs.202104538 · Cited by 67
Associations Between Diabetes Mellitus and Neurodegenerative Diseases
Szablewski, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020542 · Cited by 80
Gong, Y., Huang, A., Guo, X., Zhi, J., Chen, X., Zhu, X., Xia, Y., Liu, J., Xu, Y., & Qin, X. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.129345 · Cited by 63
Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics
Yadav, D., & Kumar, P. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105327 · Cited by 63
Glia in Neurodegeneration: The Housekeeper, the Defender and the Perpetrator
Sheeler, C. A., Rosa, J. S., Ferro, A., McAdams, B. D., Borgenheimer, E., & Cvetanović, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239188 · Cited by 61
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Casali, B. T., & Reed-Geaghan, E. G. (2021) · Cells · doi:10.3390/cells10040957 · Cited by 70
Microglia Heterogeneity in Alzheimer’s Disease: Insights From Single-Cell Technologies
Wang, H. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.773590 · Cited by 62
Troutman, T. D., Kofman, E. R., & Glass, C. K. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.08.004 · Cited by 62
Infantino, R., Schiano, C., Luongo, L., Paino, S., Mansueto, G., Boccella, S., Guida, F., Ricciardi, F., Iannotta, M., Belardo, C., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105611 · Cited by 61
Dhandapani, R., Neri, M., Bernhard, M., Brzak, I., Schweizer, T., Rudin, S., Joller, S., Berth, R., Kernen, J., Neuhaus, A., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110883 · Cited by 60
Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders
Zhang, L., Wang, Y., Liu, T., Mao, Y. Q., & Peng, B. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-022-01013-6 · Cited by 59
Aβ promotes CD38 expression in senescent microglia in Alzheimer’s disease
Hu, Y., Huang, Y., Xing, S., Chen, C., Shen, D., & Chen, J. (2022) · Biological Research · doi:10.1186/s40659-022-00379-1 · Cited by 58
Lee, Y. Z., Cheng, S.-H., Chang, M.-Y., Lin, Y., Wu, C.-C., & Tsai, Y.-C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076794 · Cited by 59
Adult neurogenesis in Alzheimer's disease
Choi, S. H., & Tanzi, R. E. (2023) · Hippocampus · doi:10.1002/hipo.23504 · Cited by 54
Wang, Y., Zhou, Y., Jiang, L. H., Wang, S., Zhu, L., Zhang, S., Yang, H., He, Q., Liu, L., Xie, Y., et al. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114371 · Cited by 56
Raghavan, K., Dedeepiya, V. D., Yamamoto, N., Ikewaki, N., Sonoda, T., Iwasaki, M., Kandaswamy, R. S., Senthilkumar, R., Preethy, S., & Abraham, S. J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220388 · Cited by 49
Dong, Y., Li, T., Ma, Z., Zhou, C., Wang, X., & Li, J. (2022) · Disease Markers · doi:10.1155/2022/9480398 · Cited by 57
Association of Glial Activation and α-Synuclein Pathology in Parkinson’s Disease
Wang, R., Ren, H., Kaznacheyeva, E. V., Lu, X., & Wang, G. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00957-z · Cited by 51
Zhang, W., Ding, L., Chen, H., Zhang, M., Ma, R., Zheng, S., Gong, J., Zhang, Z., Xu, H., Xu, P., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05807-y · Cited by 55
Spinozzi, E., Pavela, R., Bonacucina, G., Perinelli, D. R., Cespi, M., Petrelli, R., Cappellacci, L., Fiorini, D., Scortichini, S., Garzoli, S., et al. (2021) · Industrial Crops and Products · doi:10.1016/j.indcrop.2021.114027 · Cited by 50
Pike, A. F., Szabó, I., Veerhuis, R., & Bubacco, L. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00293-z · Cited by 50
Sphingolipid metabolism in brain insulin resistance and neurological diseases
Mei, M., Liu, M., Mei, Y., Zhao, J., & Li, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1243132 · Cited by 52
Li, L., Yang, C., Jia, M., Wang, Y., Zhao, Y., Li, Q., Gong, J., He, Y., Xu, K., Liu, X., et al. (2024) · Food & Function · doi:10.1039/d4fo00886c · Cited by 52
Lv, X., Lü, Z., Tao, Y., Xie, H., Chen, Z., Lin, Y., Cai, X., Yang, W., Liao, X., Liu, J., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111116 · Cited by 50
Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice
Gu, H., Yang, X., Mao, X., Xu, E., Qi, C., Wang, H., Brahmachari, S., York, B., Sriparna, M., Li, A., et al. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.656426 · Cited by 49
Shao, Y., Chen, C., Zhu, T., Sun, Z., Li, S., Gong, L., Dong, X., Shen, W., Zeng, L., Xie, Y., et al. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105534 · Cited by 48
Li, C., Ren, J., Zhang, M., Wang, H., Fang, Y., Wu, J., & Tang, Y. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04536-3 · Cited by 52
Nanomaterials as Microglia Modulators in the Treatment of Central Nervous System Disorders
Battaglini, M., Marino, A., Montorsi, M., Carmignani, A., Ceccarelli, M. C., & Ciofani, G. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202304180 · Cited by 54
Fetal-Derived Immune Cells at the Roots of Lifelong Pathophysiology
Mass, E., & Gentek, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.648313 · Cited by 47
Angeloni, S., Freschi, M., Marrazzo, P., Hrelia, S., Beghelli, D., Juan-García, A., Juan, C., Caprioli, G., Sagratini, G., & Angeloni, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6620913 · Cited by 50
Microglial dynamics and neuroinflammation in prodromal and early Parkinson’s disease
Mogensen, F. L., Seibler, P., Grünewald, A., & Michelucci, A. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03462-y · Cited by 60
Xiong, F., Gong, K., Xu, H., Tu, Y., Lu, J., Zhou, Y., He, W., Li, W., Li, C., Zhao, L., et al. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.02.011 · Cited by 47
Ghosh, S., Won, S., Wang, J.-J., Fong, R., Butler, N. J. M., Moss, A., Wong, C., Pan, J., Sanchez, J., Huynh, A., et al. (2021) · Progress in neurobiology · doi:10.1016/j.pneurobio.2021.102070 · Cited by 40
Li, S., Bi, G., Han, S., & Huang, R. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.744942 · Cited by 45
Liu, J., Wang, Z., Liang, W., Zhang, Z., Deng, Y., Chen, X., Hou, Z., Xie, Y., Wang, Q., Li, Y., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.018 · Cited by 47
Galvani, G., Mottolese, N., Gennaccaro, L., Loi, M., Medici, G., Tassinari, M., Fuchs, C., Ciani, E., & Trazzi, S. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02204-0 · Cited by 44
Yang, H., Su, Y., Sun, Z., Ma, B., Liu, F., Kong, Y., Sun, C., Li, B., Sang, Y., Wang, S., et al. (2022) · Advanced Science · doi:10.1002/advs.202202376 · Cited by 42
LilrB3 is a putative cell surface receptor of APOE4
Zhou, J., Wang, Y., Huang, G., Yang, M., Zhu, Y., Jin, C., Jing, D., Ji, K., & Shi, Y. (2023) · Cell Research · doi:10.1038/s41422-022-00759-y · Cited by 44
Lan, L., Wang, H., Zhang, X., Shen, Q., Li, X., He, L., Rong, X., Peng, J., Mo, J., & Peng, Y. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114061 · Cited by 40
Neuroinflammaging: A Tight Line Between Normal Aging and Age-Related Neurodegenerative Disorders
Soraci, L., Corsonello, A., Paparazzo, E., Montesanto, A., Piacenza, F., Olivieri, F., Gambuzza, M. E., Savedra, E. V., Marino, S., Lattanzio, F., et al. (2024) · Aging and Disease · doi:10.14336/ad.2023.1001 · Cited by 49
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Metadata
- Authors
- Bartels, T., De Schepper, S., & Hong, S.
- Affiliations
- UK Dementia Research Institute (GB)
- UK Dementia Research Institute, Institute of Neurology, University College London, London WC1E 6BT, UK.
- Corresponding author
- Hong, Soyon
- Venue
- Science
- Published
- 2020-10-02
- Volume
- 370
- Issue
- 6512
- Pages
- 66-69
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3090922258
- Cited by
- 412
- References
- 70
- Citations by year
- 2026: 48 · 2025: 85 · 2024: 68 · 2023: 69 · 2022: 75 · 2021: 66 · 2020: 1
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke
- Michael J. Fox Foundation for Parkinson's Research
- Parkinson's Disease Foundation
- Chan Zuckerberg Initiative
- Dementia Research UK
- UK Medical Research Council
- Alzheimer's Research UK
- Alzheimer's Society UK
- Eisai
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microglia, neurodegeneration, Alzheimer's disease, Parkinson's disease, dementia, microglia-neuron interaction, tissue-resident macrophages, synaptic dysfunction, neuronal health, neuroinflammation
- MeSH terms
- Alzheimer Disease, Amyloid, Animals, Cell Communication, Humans, Macrophages, Neurons, Parkinson Disease, Synapses, Synaptosomes, Microglia, Mice, alpha-Synuclein
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