The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of Pathology

Alzheimer's disease: the amyloid cascade hypothesis

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Neuroinflammation in Alzheimer's disease

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

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A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

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ATP mediates rapid microglial response to local brain injury in vivo

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Complement and microglia mediate early synapse loss in Alzheimer mouse models

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The Classical Complement Cascade Mediates CNS Synapse Elimination

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

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Identification of a unique TGF-β–dependent molecular and functional signature in microglia

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Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

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TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

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Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

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Resting Microglia Directly Monitor the Functional State of Synapses <i>In Vivo</i> and Determine the Fate of Ischemic Terminals

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

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Microglial interactions with synapses are modulated by visual experience

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The P2Y12 receptor regulates microglial activation by extracellular nucleotides

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Control of microglial neurotoxicity by the fractalkine receptor

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The microglial sensome revealed by direct RNA sequencing

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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

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Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

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Alzheimer’s disease β-amyloid peptides are released in association with exosomes

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Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

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Activation of microglial cells by β-amyloid protein and interferon-γ

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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

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Microglial brain region-dependent diversity and selective regional sensitivities to aging

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Systemic inflammation and disease progression in Alzheimer disease

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Activated microglia mediate neuronal cell injury via a nitric oxide mechanism

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Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2

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Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200)

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Trans-Synaptic Spread of Tau Pathology In Vivo

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

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Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

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Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

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Microglia in Alzheimer's disease

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Exosomes are released by cultured cortical neurones

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Metabolic Regulation of Brain Aβ by Neprilysin

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Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

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Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

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The pathological process underlying Alzheimer’s disease in individuals under thirty

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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Inflammatory processes in Alzheimer's disease

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Layer V cortical neurons require microglial support for survival during postnatal development

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Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

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Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

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Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

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Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

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Turnover of resident microglia in the normal adult mouse brain

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Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

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Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression

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Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

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Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease

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Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

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Microglia Modulate Wiring of the Embryonic Forebrain

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Regulation of Tau Pathology by the Microglial Fractalkine Receptor

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Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

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Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

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Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

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Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

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Microglial response to amyloid plaques in APPsw transgenic mice.

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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

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Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease.

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The “quad‐partite” synapse: Microglia‐synapse interactions in the developing and mature CNS

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Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

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CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

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Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

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TREM2 sustains microglial expansion during aging and response to demyelination

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Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

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The Indispensable Roles of Microglia and Astrocytes during Brain Development

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Cytokine Induction in Fetal Rat Brains and Brain Injury in Neonatal Rats after Maternal Lipopolysaccharide Administration

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Microglia in Prion Diseases: Angels or Demons?

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Alzheimer’s disease basics: we all should know

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Nanotherapeutic Modulation of Human Neural Cells and Glioblastoma in Organoids and Monocultures

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Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis

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Transcriptomic alterations in APP/PS1 mice astrocytes lead to early postnatal axon initial segment structural changes

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The Inflammatory Gene PYCARD of the Entorhinal Cortex as an Early Diagnostic Target for Alzheimer’s Disease

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Spreading of Tau Protein Does Not Depend on Aggregation Propensity

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Chromogranin A Analysis in the Differential Diagnosis Across Lewy Body Disorders

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Research Progress of Lipid Metabolism-Mediated Neuroinflammation in Alzheimer’s Disease

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E2F4-Based Gene Therapy Mitigates the Phenotype of the Alzheimer's Disease Mouse Model 5xFAD

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Effect of scutellarin on BV-2 microglial-mediated apoptosis in PC12 cells via JAK2/STAT3 signalling pathway

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Repurposing Artemisinin-Based Drugs from Antimalarial to Pan-Therapeutic: Pharmacological Promise and Therapeutic Challenges

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A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice

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A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity

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E2F4DN Transgenic Mice: A Tool for the Evaluation of E2F4 as a Therapeutic Target in Neuropathology and Brain Aging

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Biomechanics of Sport-Related Neurological Injury

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Aging Microglia and Their Impact in the Nervous System

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TLR7 is expressed by support cells, but not sensory neurons, in ganglia

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The P38MAPK/ATF2 signaling pathway is involved in PND in mice

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Editorial for the Special Issue: Microglia-Neuron interactions in health and disease - novel perspectives for translational research

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Profiling Brain Trauma in Professional American-style Football and the Implications to Developing Neurological Injury

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Neuroinflammation in Alzheimer’s and Parkinson’s diseases: pathogenic mechanisms and therapeutic strategies

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Repression of lysosomal transcription factors Tfeb and Tfe3 is essential for the migration and function of microgliaPreprint

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Microglial Cell Dysregulation in the Aged Brain and Neurodegeneration

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Microglial Cell Dysregulation in the Aged Brain and Neurodegeneration

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E2F4 as a single multifactorial target against Alzheimer’s diseasePreprint

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Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microgliaPreprint

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Tβ4 and PDTC displayed recovery on the glial and neuronal alterations in an early Alzheimer’s disease modelPreprint

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"In vitro" evaluation of anti-inflammatory, anti-lipogenic, estrogenic, and neuroprotective potential of biotransformed soy extracts

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TLR7 Is Expressed by Support Cells, but Not Sensory Neurons, in GangliaPreprint

Proskocil, B. J., Wai, K., Lebold, K. M., Norgard, M. A., Michaelis, K. A., Marks, D. L., Fryer, A. D., Jacoby, D. B., & Drake, M. G. (2021) · Research Square · doi:10.21203/rs.3.rs-136876/v1

Visualization of Hocl in Pc12 Cells and Brains of Alzheimer's Disease Models by a Two-Photon Activatable Fluorogenic ProbePreprint

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The influence of ferroptosis on the in vitro OGD/R model in rat microgliaPreprint

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Neurodegenerative Disorders

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Comparison of microglial cell population expansion in the Tg344-AD rat and APP SWE /PS1 ΔE9 mouse model of Alzheimer's disease

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Age-Related Changes in Neuron–Microglia Interaction Mediated by Fractalkine Under Inflammatory Conditions

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Additional file 2 of TLR7 is expressed by support cells, but not sensory neurons, in ganglia

Proskocil, B. J., Wai, K., Lebold, K. M., Norgard, M. A., Michaelis, K. A., Torre, U. D. L., Cook, M. M., Marks, D. L., Fryer, A. D., Jacoby, D. B., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16632995

Additional file 1 of TLR7 is expressed by support cells, but not sensory neurons, in ganglia

Proskocil, B. J., Wai, K., Lebold, K. M., Norgard, M. A., Michaelis, K. A., Torre, U. D. L., Cook, M. M., Marks, D. L., Fryer, A. D., Jacoby, D. B., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16632992

Minocycline differentially modulates human spatial memory systemsPreprint

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BindingDB Entry 50011128: Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.

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Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention

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Microglia in Alzheimer’s Disease: A Double-Edged Sword Guided by Neuroimmune Dynamics

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Microglial Therapeutic Potential in Alzheimer’s Disease: From Phenotypic Diversity to Targeted Interventions

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Microglia in Alzheimer’s Disease

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