The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Comprehensive quantification of fuel use by the failing and nonfailing human heart
Open accessAbstract
The heart consumes circulating nutrients to fuel lifelong contraction, but a comprehensive mapping of human cardiac fuel use is lacking. We used metabolomics on blood from artery, coronary sinus, and femoral vein in 110 patients with or without heart failure to quantify the uptake and release of 277 metabolites, including all major nutrients, by the human heart and leg. The heart primarily consumed fatty acids and, unexpectedly, little glucose; secreted glutamine and other nitrogen-rich amino acids, indicating active protein breakdown, at a rate ~10 times that of the leg; and released intermediates of the tricarboxylic acid cycle, balancing anaplerosis from amino acid breakdown. Both heart and leg consumed ketones, glutamate, and acetate in direct proportionality to circulating levels, indicating that availability is a key driver for consumption of these substrates. The failing heart consumed more ketones and lactate and had higher rates of proteolysis. These data provide a comprehensive and quantitative picture of human cardiac fuel use.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The process of breaking down fatty acids to produce acetyl-CoA, known as β-oxidation, supplies the majority of acetyl-CoA for TCA cycle oxidation in certain tissues such as the heart (62).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [62]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
DrugBank 5.0: a major update to the DrugBank database for 2018
Wishart, D. S., Feunang, Y. D., Guo, A. C., Lo, E. J., Marcu, A., Grant, J. R., Sajed, T., Johnson, D., Li, C., Sayeeda, Z., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1037 · Cited by 8,404
HMDB 4.0: the human metabolome database for 2018
Wishart, D. S., Feunang, Y. D., Marcu, A., Guo, A. C., Liang, K., Vázquez-Fresno, R., Sajed, T., Johnson, D., Li, C., Karu, N., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1089 · Cited by 3,438
The Failing Heart — An Engine Out of Fuel
Neubauer, S. (2007) · New England Journal of Medicine · doi:10.1056/nejmra063052 · Cited by 2,465
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., et al. (2013) · Nature · doi:10.1038/nature12138 · Cited by 1,683
Self-citationAcetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome
Perry, R. J., Peng, L., Barry, N. A., Cline, G. W., Zhang, D., Cardone, R. L., Petersen, K. F., Kibbey, R. G., Goodman, A. L., & Shulman, G. I. (2016) · Nature · doi:10.1038/nature18309 · Cited by 1,299
Bedi, K. C., Snyder, N. W., Brandimarto, J., Aziz, M. K., Mesaros, C., Worth, A. J., Wang, L. L., Javaheri, A., Blair, I. A., Margulies, K. B., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.017545 · Cited by 654
Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts
Allard, M., Schönekess, B. O., Henning, S. L., English, D. R., & Lopaschuk, G. D. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.2.h742 · Cited by 576
Hutchins, G. D., Schwaiger, M., Rosenspire, K. C., Krivokapich, J., Schelbert, H. R., & Kuhl, D. E. (1990) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(90)90237-j · Cited by 552
Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure
Sun, H., Olson, K. C., Gao, C., Prosdocimo, D. A., Zhou, M., Wang, Z., Jeyaraj, D., Youn, J. Y., Ren, S. V., Liu, Y., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.020226 · Cited by 544
Nielsen, R. R., Møller, N., Gormsen, L. C., Tolbod, L. P., Hansson, N. H., Sorensen, J., Harms, H. J., Frøkiær, J., Eiskjær, H., Jespersen, N. R., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.036459 · Cited by 528
Flagged first, then by citations
Cited by
Sorted by citations
Cancer metabolism: looking forward
Martínez‐Reyes, I., & Chandel, N. S. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00378-6 · Cited by 1,877
Cardiac Energy Metabolism in Heart Failure
Lopaschuk, G. D., Karwi, Q. G., Tian, R., Wende, A. R., & Abel, E. D. (2021) · Circulation Research · doi:10.1161/circresaha.121.318241 · Cited by 1,458
PPAR control of metabolism and cardiovascular functions
Montaigne, D., Butruille, L., & Staels, B. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00569-6 · Cited by 981
Small molecule metabolites: discovery of biomarkers and therapeutic targets
Qiu, S., Cai, Y., Yao, H., Lin, C., Xie, Y., Tang, S., & Zhang, A. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01399-3 · Cited by 993
Short-chain fatty acids in diseases
Zhang, D., Jian, Y., Zhang, Y., Li, Y., Gu, L.-T., Sun, H.-H., Liu, M., Zhou, H., Wang, Y., & Xu, Z. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01219-9 · Cited by 813
Regulation and function of the mammalian tricarboxylic acid cycle
Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535
“The process of breaking down fatty acids to produce acetyl-CoA, known as βoxidation, supplies the majority of acetyl-CoA for TCA cycle oxidation in certain tissues such as the heart (62).”
BackgroundKetone bodies: from enemy to friend and guardian angel
Kolb, H., Kempf, K., Röhling, M., Lenzen-Schulte, M., Schloot, N. C., & Martin, S. (2021) · BMC Medicine · doi:10.1186/s12916-021-02185-0 · Cited by 389
L-Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine
McCann, M. R., la Rosa, M. V. G. D., Rosania, G. R., & Stringer, K. A. (2021) · Metabolites · doi:10.3390/metabo11010051 · Cited by 328
Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction
Hahn, V. S., Petucci, C. J., Kim, M., Bedi, K. C., Wang, H., Mishra, S., Koleini, N., Yoo, E., Margulies, K. B., Arany, Z. P., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.061846 · Cited by 305
Self-citationSlow TCA flux and ATP production in primary solid tumours but not metastases
Bartman, C. R., Weilandt, D. R., Shen, Y., Lee, W. D., Han, Y., TeSlaa, T., Jankowski, C. S. R., Samarah, L., Park, N. R., da Silva-Diz, V., et al. (2023) · Nature · doi:10.1038/s41586-022-05661-6 · Cited by 299
Self-citationZhang, N., Zhang, Y., Xu, J., Wang, P., Wu, B., Lu, S., Lu, X., You, S., Huang, X., Li, M., et al. (2023) · Cell Research · doi:10.1038/s41422-023-00844-w · Cited by 307
Metabolic and Signaling Roles of Ketone Bodies in Health and Disease
Puchalska, P., & Crawford, P. A. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-111120-111518 · Cited by 304
Branched-chain amino acids in cardiovascular disease
McGarrah, R. W., & White, P. J. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00760-3 · Cited by 296
Cardiac lipid metabolism, mitochondrial function, and heart failure
Dalt, L. D., Cabodevilla, A. G., Goldberg, I. J., & Norata, G. D. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad100 · Cited by 264
Ritterhoff, J., & Tian, R. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00887-x · Cited by 265
Therapeutic Potential of Ketone Bodies for Patients With Cardiovascular Disease
Yurista, S. R., Chong, C., Badimón, J. J., Kelly, D. P., de Boer, R. A., & Westenbrink, B. D. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.12.065 · Cited by 230
Spatially resolved isotope tracing reveals tissue metabolic activity
Wang, L., Xing, X., Zeng, X., Jackson, S. R., TeSlaa, T. A., Al‐Dalahmah, O., Samarah, L. Z., Goodwin, K., Yang, L., McReynolds, M. R., et al. (2022) · Nature Methods · doi:10.1038/s41592-021-01378-y · Cited by 191
Self-citationIns and outs of the TCA cycle: the central role of anaplerosis
Inigo, M., Deja, S., & Burgess, S. C. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-120420-025558 · Cited by 189
SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism
Packer, M. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00824-4 · Cited by 196
Ketones and the Heart: Metabolic Principles and Therapeutic Implications
Matsuura, T. R., Puchalska, P., Crawford, P. A., & Kelly, D. P. (2023) · Circulation Research · doi:10.1161/circresaha.123.321872 · Cited by 191
Advances in myocardial energy metabolism: metabolic remodelling in heart failure and beyond
Sun, Q., Karwi, Q. G., Wong, N. K. P., & Lopaschuk, G. D. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae231 · Cited by 164
Cardiac metabolism in HFpEF: from fuel to signalling
Capone, F., Sotomayor-Flores, C., Bode, D., Wang, R., Rodolico, D., Strocchi, S., & Schiattarella, G. G. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac166 · Cited by 145
Short-Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart
Carley, A. N., Maurya, S. K., Fasano, M. J., Wang, Y., Selzman, C. H., Drakos, S. G., & Lewandowski, E. D. (2021) · Circulation · doi:10.1161/circulationaha.120.052671 · Cited by 137
The emerging role of protein l-lactylation in metabolic regulation and cell signalling
Ren, H., Tang, Y., & Zhang, D. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01259-0 · Cited by 159
Immunometabolic mechanisms of heart failure with preserved ejection fraction
Schiattarella, G. G., Alcaide, P., Condorelli, G., Gillette, T. G., Heymans, S. R. B., Jones, E. A. V., Kallikourdis, M., Lichtman, A. H., Marelli‐Berg, F. M., Shah, S. J., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00032-w · Cited by 137
Hundertmark, M., Adler, A., Antoniades, C. A., Coleman, R. L., Griffin, J. L., Holman, R. R., Lamlum, H., Lee, J., Massey, D., Miller, J. J. J. J., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.062021 · Cited by 129
Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer
Karlstaedt, A., Moslehi, J. J., & de Boer, R. A. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00698-6 · Cited by 130
Cardiorenal protection of SGLT2 inhibitors—Perspectives from metabolic reprogramming
Gao, Y.-M., Feng, S., Wen, Y., Tang, T., Wang, B., & Liu, B. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104215 · Cited by 125
Metabolic Messengers: ketone bodies
Nelson, A. B., Queathem, E. D., Puchalska, P., & Crawford, P. A. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00935-3 · Cited by 118
Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure
Ghazal, R., Wang, M., Liu, D., Tschumperlin, D. J., & Pereira, N. L. (2025) · Circulation Research · doi:10.1161/circresaha.124.325402 · Cited by 128
Defects in the Proteome and Metabolome in Human Hypertrophic Cardiomyopathy
Previs, M. J., O’Leary, T. S., Morley, M. P., Morley, M. P., Palmer, B., Lewinter, M., Pagani, F. D., Pagani, F. D., Petucci, C., Kim, M., et al. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.121.009521 · Cited by 108
Self-citationDato, V. A., Lange, S., & Cho, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021211 · Cited by 117
Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure
Murashige, D., Jung, J. W., Neinast, M. D., Levin, M. G., Chu, Q., Lambert, J. P., Garbincius, J. F., Kim, B., Hoshino, A., Martí-Pàmies, Í., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.008 · Cited by 111
Self-citationSelvaraj, S., Fu, Z., Jones, P. G., Kwee, L. C., Windsor, S. L., Ilkayeva, O., Newgard, C. B., Margulies, K. B., Husain, M., Inzucchi, S. E., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.060402 · Cited by 104
The Ketogenic Diet and Cardiovascular Diseases
Dyńka, D., Kowalcze, K., Charuta, A., & Paziewska, A. (2023) · Nutrients · doi:10.3390/nu15153368 · Cited by 127
Therapeutic Manipulation of Myocardial Metabolism
Honka, H., Solis‐Herrera, C., Triplitt, C. L., Norton, L., Butler, J., & DeFronzo, R. A. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.02.057 · Cited by 101
Deranged Myocardial Fatty Acid Metabolism in Heart Failure
Yamamoto, T., & Sano, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020996 · Cited by 107
Myocardial ketone body utilization in patients with heart failure: The impact of oral ketone ester
Monzo, L., Sedláček, K., Hromaníková, K., Tomanova, L., Borlaug, B. A., Jabor, A., Kautzner, J., & Melenovský, V. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154452 · Cited by 99
Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
Walejko, J. M., Christopher, B. A., Crown, S. B., Zhang, G., Pickar‐Oliver, A., Yoneshiro, T., Foster, M. W., Page, S. C., van Vliet, S., Ilkayeva, O., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21962-2 · Cited by 102
Ma, X. M., Geng, K., Wang, P., Jiang, Z., Law, B. Y. K., & Xu, Y. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02178-2 · Cited by 101
The Role of Oxidative Stress in the Aging Heart
Pagan, L. U., Gomes, M. J., Gatto, M., Mota, G. A. F., Okoshi, K., & Okoshi, M. P. (2022) · Antioxidants · doi:10.3390/antiox11020336 · Cited by 99
Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy
Flam, E. L., Jang, C., Murashige, D., Yang, Y., Morley, M. P., Jung, S., Kantner, D. S., Pepper, H. L., Bedi, K. C., Brandimarto, J., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00117-6 · Cited by 96
Self-citationInsulin signaling in the heart
Abel, E. D. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00158.2021 · Cited by 94
SGLT2 Inhibitors and Ketone Metabolism in Heart Failure
Saucedo‐Orozco, H., Voorrips, S. N., Yurista, S. R., de Boer, R. A., & Westenbrink, B. D. (2022) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2022.11.1.1 · Cited by 101
Roca, M., Alcoriza‐Balaguer, M. I., García‐Cañaveras, J. C., & Lahoz, A. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.12.025 · Cited by 102
Metabolism and Chronic Inflammation: The Links Between Chronic Heart Failure and Comorbidities
Li, Z., Zhao, H., & Wang, J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.650278 · Cited by 102
Type 2 Diabetes Mellitus: A Pathophysiologic Perspective
Westman, E. C. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.707371 · Cited by 110
Sun, Q., Güven, B., Wagg, C. S., de Oliveira, A. A., Silver, H. L., Zhang, L., Chen, B., Wei, K., Ketema, E. B., Karwi, Q. G., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae006 · Cited by 92
Bornstein, M. R., Tian, R., & Arany, Z. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.06.003 · Cited by 98
Self-citationCarpentier, A. C. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00620.2020 · Cited by 93
Yan, W., Xia, Y., Zhao, H., Xu, X., Ma, X., & Tao, L. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.12.009 · Cited by 83
Cardiac metabolic remodelling in chronic kidney disease
Patel, N., Yaqoob, M. M., & Aksentijević, D. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00576-x · Cited by 80
Hansen, K. B., Gopalasingam, N., Christensen, K. H., Ladefoged, B. T., Andersen, M. J., Poulsen, S. H., Borlaug, B. A., Nielsen, R. R., Møller, N., & Wiggers, H. (2024) · Circulation · doi:10.1161/circulationaha.123.067971 · Cited by 81
Zhao, D., Zhuo, J., Chen, Z., Wu, J., Ma, R., Zhang, X., Zhang, Y., Wang, X., Wei, X., Liu, L., et al. (2021) · Nano Energy · doi:10.1016/j.nanoen.2021.106580 · Cited by 76
Endothelial cell metabolism in cardiovascular physiology and disease
Pasut, A., Lama, E., Van Craenenbroeck, A. H., Kroon, J., & Carmeliet, P. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01162-x · Cited by 74
Lactate and Myocardiac Energy Metabolism
Dong, S., Qian, L., Cheng, Z., Chen, C., Wang, K., Hu, S., Zhang, X., & Wu, T. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.715081 · Cited by 76
Gut butyrate-producers confer post-infarction cardiac protection
Chen, H.-C., Liu, Y.-W., Chang, K., Wu, Y., Chen, Y., Chao, Y.-K., You, M.-Y., Lundy, D. J., Lin, C., Hsieh, M. L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43167-5 · Cited by 81
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis
Park, G. S. H., Haley, J. A., Le, J., Jung, S. M., Fitzgibbons, T. P., Korobkina, E. D., Li, H., Fluharty, S. M., Chen, Q., Spinelli, J. B., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00825-8 · Cited by 74
Self-citationPathophysiology and risk factors of peripartum cardiomyopathy
Hoes, M. F., Arany, Z., Bauersachs, J., Hilfiker-Kleiner, D., Petrie, M. C., Sliwa, K. S., & van der Meer, P. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00664-8 · Cited by 75
Self-citationQuantitative flux analysis in mammals
Bartman, C., TeSlaa, T. A., & Rabinowitz, J. D. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00419-2 · Cited by 73
Self-citationVuckovic, S., Dinani, R., Nollet, E. E., Kuster, D. W. D., Buikema, J. W., Houtkooper, R. H., Nabben, M., van der Velden, J., & Goversen, B. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03021-9 · Cited by 78
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
Stacpoole, P. W., & McCall, C. E. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.02.007 · Cited by 70
Sources and Sinks of Serine in Nutrition, Health, and Disease
Handzlik, M. K., & Metallo, C. M. (2023) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-061021-022648 · Cited by 75
Metabolic switches during development and regeneration
Mahmoud, A. I. (2023) · Development · doi:10.1242/dev.202008 · Cited by 65
Myocardial Metabolism in Heart Failure
Ng, S. M., Neubauer, S., & Rider, O. J. (2023) · Current Heart Failure Reports · doi:10.1007/s11897-023-00589-y · Cited by 67
GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration
Fajardo, V. M., Feng, I., Chen, B. Y., Perez-Ramirez, C. A., Shi, B., Clark, P. M., Tian, R., Lien, C., Pellegrini, M. A., Christofk, H. R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-88159-x · Cited by 69
The Contribution of Cardiac Fatty Acid Oxidation to Diabetic Cardiomyopathy Severity
Karwi, Q. G., Sun, Q., & Lopaschuk, G. D. (2021) · Cells · doi:10.3390/cells10113259 · Cited by 68
Gopalasingam, N., Hansen, K. B., Christensen, K. H., Ladefoged, B. T., Poulsen, S. H., Andersen, M. J., Borlaug, B. A., Nielsen, R. R., Møller, N., & Wiggers, H. (2024) · Circulation · doi:10.1161/circulationaha.124.069732 · Cited by 70
Ketone bodies for the failing heart: fuels that can fix the engine?
Yurista, S. R., Nguyen, C. T., Rosenzweig, A., de Boer, R. A., & Westenbrink, B. D. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.07.006 · Cited by 70
Beneficial Effects of Ketone Ester in Patients With Cardiogenic Shock
Hansen, K. B., Christensen, K. H., Gopalasingam, N., Nielsen, R. R., Eiskjær, H., Møller, N., Birkelund, T., Christensen, S., & Wiggers, H. (2023) · JACC Heart Failure · doi:10.1016/j.jchf.2023.05.029 · Cited by 67
Mitochondrial redox and TCA cycle metabolite signaling in the heart
Vujić, A., Koo, A., Prag, H. A., & Krieg, T. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.041 · Cited by 62
Branched-Chain Amino Acid Metabolism in the Failing Heart
Karwi, Q. G., & Lopaschuk, G. D. (2022) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-022-07320-4 · Cited by 65
Decoding the Liver-Heart Axis in Cardiometabolic Diseases
Capone, F., Vacca, A., Bidault, G., Sarver, D. C., Kamińska, D., Strocchi, S., Vidal‐Puig, A., Greco, C. M., Lusis, A. J., & Schiattarella, G. G. (2025) · Circulation Research · doi:10.1161/circresaha.125.325492 · Cited by 76
Mericskay, M., Zuurbier, C. J., Heather, L. C., Karlstaedt, A., Inserte, J., Bertrand, L., Kararigas, G., Ruiz‐Meana, M., Maack, C., & Schiattarella, G. G. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01166-7 · Cited by 68
Translation of New and Emerging Therapies for Genetic Cardiomyopathies
Helms, A. S., Thompson, A. D., & Day, S. M. (2021) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.07.012 · Cited by 68
Short-Chain Fatty Acids in the Metabolism of Heart Failure – Rethinking the Fat Stigma
Palm, C. L., Nijholt, K. T., Bakker, B. M., & Westenbrink, B. D. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.915102 · Cited by 64
Short-Chain Fatty Acids in Gut–Heart Axis: Their Role in the Pathology of Heart Failure
Iwashita, M., Nagatomo, Y., Kawai, A., Taruoka, A., Yumita, Y., Kagami, K., Yasuda, R., Toya, T., Ikegami, Y., Masaki, N., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12111805 · Cited by 68
Thirunavukarasu, S., Jex, N., Chowdhary, A., Hassan, I. U., Straw, S., Craven, T. P., Gorecka, M. M., Broadbent, D. A., Swoboda, P., Witte, K. K., et al. (2021) · Diabetes · doi:10.2337/db21-0270 · Cited by 60
Metabolic characterization of hypertrophic cardiomyopathy in human heart
Wang, W., Wang, J., Yao, K., Wang, S., Nie, M., Zhao, Y., Wang, B., Pang, H., Xu, J., Wu, G., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00057-1 · Cited by 58
Chong, D., Gu, Y., Zhang, T., Xu, Y., Bu, D., Chen, Z., Xu, N., Li, L., Zhu, X., Wang, H., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00447-6 · Cited by 58
Goedeke, L., Ma, Y., Gaspar, R. C., Nasiri, A. R., Lee, J., Zhang, D., Galsgaard, K. D., Hu, X., Zhang, J., Guerrera, N. M., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci176708 · Cited by 60
Proteome characterisation of extracellular vesicles isolated from heart
Claridge, B., Rai, A., Fang, H., Matsumoto, A., Luo, J., McMullen, J. R., & Greening, D. W. (2021) · PROTEOMICS · doi:10.1002/pmic.202100026 · Cited by 58
Role of the Heart in Lactate Shuttling
Brooks, G. A. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.663560 · Cited by 56
Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
Prag, H. A., Murphy, M. P., & Krieg, T. (2023) · Basic Research in Cardiology · doi:10.1007/s00395-023-01002-4 · Cited by 58
Zhuang, L., Ye, M., Liu, Z., Li, C., Jin, Q., Lu, L., Tao, R., Yan, X., & Chen, K. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.722908 · Cited by 53
Ketone Bodies and Cardiovascular Disease: An Alternate Fuel Source to the Rescue
Manolis, A. S., Manolis, T. A., & Manolis, A. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043534 · Cited by 56
Mechano-energetic uncoupling in heart failure
Aksentijević, D., Sedej, S., Fauconnier, J., Paillard, M., Abdellatif, M., Streckfuß‐Bömeke, K., Ventura‐Clapier, R., van der Velden, J., de Boer, R. A., Bertero, E., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01167-6 · Cited by 55
Acute Echocardiographic Effects of Exogenous Ketone Administration in Healthy Participants
Selvaraj, S., Hu, R., Vidula, M. K., Dugyala, S., Tierney, A. M., Ky, B., Margulies, K. B., Shah, S. H., Kelly, D. P., & Bravo, P. E. (2021) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2021.10.017 · Cited by 56
Jhanji, M., Rao, C. N., Massey, J. C., Hope, M. C., Zhou, X., Keene, C. D., Ma, T., Wyatt, M. D., Stewart, J. A., & Sajish, M. (2022) · Nature Communications · doi:10.1038/s41467-022-30785-8 · Cited by 55
Glutamine uptake and catabolism is required for myofibroblast formation and persistence
Gibb, A., Huynh, A. T., Gaspar, R. B., Ploesch, T. L., Lombardi, A. A., Lorkiewicz, P., Lazaropoulos, M. P., Bedi, K., Arany, Z. P., Margulies, K. B., et al. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.08.002 · Cited by 55
Self-citationInsulin–Heart Axis: Bridging Physiology to Insulin Resistance
Caturano, A., Galiero, R., Vetrano, E., Sardu, C., Rinaldi, L., Russo, V., Monda, M., Marfella, R., & Sasso, F. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158369 · Cited by 57
Cancer Therapy-Induced Cardiotoxicity—A Metabolic Perspective on Pathogenesis, Diagnosis and Therapy
Choksey, A., & Timm, K. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010441 · Cited by 76
Double-side role of short chain fatty acids on host health via the gut-organ axes
Gao, Y., Yao, Q., Meng, L., Wang, J., & Zheng, N. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.05.001 · Cited by 58
Mitochondrial heterogeneity and adaptations to cellular needs
Granath-Panelo, M., & Kajimura, S. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01410-1 · Cited by 50
Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy
Nakamura, M. (2024) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2024.12568 · Cited by 53
Sakamoto, T., & Kelly, D. P. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.12.008 · Cited by 50
Ewoldt, J. K., DePalma, S. J., Jewett, M. E., Karakan, M. Ç., Lin, Y.-M., Hashemian, P. M., Gao, X., Lou, L., McLellan, M. A., Tabares, J., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02480-7 · Cited by 57
Walls, S. M., Diop, S. B., Birse, R. T., Elmeń, L., Gan, Z., Kalvakuri, S., Pineda, S. B., Reddy, C. P., Taylor, E., Trinh, B., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108445 · Cited by 46
Flores-Guerrero, J. L., Westenbrink, B. D., Connelly, M. A., Otvos, J. D., Groothof, D., SHALAUROVA, I. Y., Garcia, E., Navis, G. J., de Boer, R. A., Bakker, S. J. L., et al. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13468 · Cited by 46
Emerging role for branched-chain amino acids metabolism in fibrosis
Wu, T., Wang, M., Ning, F., Zhou, S., Hu, X., Xin, H., Reilly, S. N., & Zhang, X. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106604 · Cited by 47
Metadata
- Authors
- Murashige, D., Jang, C., Neinast, M., Edwards, J. J., Cowan, A., Hyman, M. C., Rabinowitz, J. D., Frankel, D. S., & Arany, Z.
- Affiliations
- University of Pennsylvania (US)
- Princeton University (US)
- Children's Hospital of Philadelphia (US)
- Perelman School of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
- ORCID
- Venue
- Science
- Published
- 2020-10-16
- Volume
- 370
- Issue
- 6514
- Pages
- 364-368
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7871704
- OpenAlex
- W3092932642
- Cited by
- 580
- References
- 47
- Citations by year
- 2026: 84 · 2025: 120 · 2024: 121 · 2023: 100 · 2022: 77 · 2021: 71 · 2020: 7
- FWCI
- 39.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (1DP1DK113643)
- American Diabetes Association (1-17-PDF-076)
- National Heart, Lung, and Blood Institute (HL126797, 5T32HL007915, HL142186-01A1)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK114103)
- Diabetes Research Center (P30 DK019525)
- Blavatnik Family Foundation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- heart failure, human heart, myocardial metabolism, fatty acid uptake, glucose uptake, amino acid catabolism, TCA cycle, anaplerosis, ketone bodies, lactate, acetate, glutamate, metabolomics
- MeSH terms
- Acetates, Aged, Blood Glucose, Citric Acid Cycle, Fatty Acids, Female, Glutamine, Heart Failure, Humans, Ketones, Leg, Male, Middle Aged, Myocardial Contraction, Myocardium, Glutamic Acid, Metabolomics, Proteolysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
