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Aptamers for mycotoxin recognition in food: Recent advances and future considerations

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Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage DisplayPreprint

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Fluorogenic RNA-Based Biosensors of Small Molecules: Current Developments, Uses, and Perspectives

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Nuclease‐Resistant L‐DNA Tension Probes Enable Long‐Term Force Mapping of Single Cells and Cell Consortia

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Illuminating Substrate Preferences of Promiscuous F 420 H 2 -Dependent Dehydroamino Acid Reductases with 4-Track mRNA Display

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Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor

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The clinical potential of l -oligonucleotides: challenges and opportunities

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Chemically Synthetic d -Sortase Enables Enzymatic Ligation of d -Peptides

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How scientists are hacking the genetic code to give proteins new powers

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[CuII( l -Phe)2–H]+ Complex: A Versatile Selector for Wide Enantiomeric Excess Determination and Chiral Recognition in Complicated Matrices by Post-column Infusion LC–Energy-resolved MS/MS

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Serine Octamer Clusters Direct the Chirality of Peptides Formed in Water Microdroplets

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The Use of CRISPR-Cas Systems for Viral Detection: A Bibliometric Analysis and Systematic Review

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Mirror Life: Bridging Chirality, Ethics, and the Foundations of Life Creation

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Chemical Synthesis of Proteins Using an o-Nitrobenzyl Group as a Robust Temporary Protective Group for N-Terminal Cysteine Protection

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Engineering Bacteria for Environmental Release: Regulatory Challenges and Design StrategiesPreprint

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Stereoselective RNA reaction with chiral 2′-OH acylating agents

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Mirror of the unknown: should research on mirror-image molecular biology be stopped?

Zhu, T. F. (2025) · Nature · doi:10.1038/d41586-025-02912-0 · Cited by 5 · see citing works

Chemical Synthesis, Refolding, and Characterization of Mirror-Image Cyclophilin A

Yeşilçimen, A., Gandhesiri, S., Travaline, T. L., Callahan, A. J., Tokareva, O. S., Loas, A., McGee, J. H., & Pentelute, B. L. (2025) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.4c03049 · Cited by 4 · see citing works

Cross-chiral exponential amplification of an RNA enzyme

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Homochiral ligations of amino acids by N-phosphorylation in water

Zhang, Y., Zhou, L., Chen, C., Wang, X., Liu, Y., Tang, G., Zhao, Y., & Gao, X. (2025) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2025.102495 · Cited by 3 · see citing works

An expanded substrate scope for cross-chiral ligation enables efficient synthesis of long l -RNAs

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Chiral Gold Nanopropellers: Engineering Plasmonic Chirality for Enantioselective Recognition Through Stereoselective Binding

Haroon, M. Y., Huang, L., Hayat, A., Chen, H., & You, X. (2025) · Advanced Optical Materials · doi:10.1002/adom.202501589 · Cited by 2 · see citing works

Chiral biomaterials for promoting wound healing: Fabrication strategies, therapeutic applications, and future prospects

Duan, Y., Chen, S., Wang, Y., Liu, Z., Wei, L., Luo, B., Liu, W., & Gao, H. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115328 · Cited by 2 · see citing works

Sanger Sequencing of Xeno‐Nucleic Acid

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Protein engineering: status report

Ai, H., Arnold, F. H., Barrick, D., Bayley, H., Brownless, A.-L. R., Campbell, R. E., Castells‐Graells, R., Chaiyen, P., Chica, R. A., Chisholm, L. O., et al. (2026) · Protein Engineering Design and Selection · doi:10.1093/protein/gzag020 · Cited by 2 · see citing works

Selective Activation of Peptide‐Thioester Precursors for Templated Native Chemical Ligations

Spaltenstein, P., Giesler, R. J., Scherer, S. R., Erickson, P. W., & Kay, M. S. (2024) · Angewandte Chemie · doi:10.1002/ange.202413644 · Cited by 2 · see citing works

Efficient chemical synthesis of mirror-image DNA polymerase Dpo4 assisted by one-pot multi-segment condensation

Wang, M., Cui, T., Huang, S., Han, D., Deng, X., Liu, Y., & Shi, C. (2025) · Organic & Biomolecular Chemistry · doi:10.1039/d5ob00243e · Cited by 2 · see citing works

Reconstituting alternative life using the test-bed of cell-free systems

Hofmann, M., Abdo, F., Borkowski, O., & Kushwaha, M. (2025) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2024.0293 · Cited by 2 · see citing works

Automated Flow Synthesis of Artificial Heme Enzymes for Enantioselective BiocatalysisPreprint

Fittolani, G., Kutateladze, D. A., Loas, A., Buchwald, S. L., & Pentelute, B. L. (2024) · ChemRxiv · doi:10.26434/chemrxiv-2024-k0wkb · Cited by 2 · see citing works

Making Sense of Helices: Right and Wrong Models in Science and Art

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Silicon Is the Next Frontier in Plant Synthetic Biology

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Oa AEP1-Mediated Ligation of Mirror-Image Peptides via Acyl Donor Substrate Engineering

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Spiegelmer Aptamers: Innovative Approach in Breast Cancer

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Automated Flow Synthesis of Nature-Derived, Engineered, and De Novo -Designed Functional Luciferases

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Nucleoside modification-based flexizymes with versatile activity for tRNA aminoacylation

Zhang, X.-D., Wang, Y.-S., Xiang, H., Bai, L., Cheng, P., Li, K., Huang, R. T., Wang, X., & Lei, X. (2024) · Chemical Communications · doi:10.1039/d3cc05673b · Cited by 1 · see citing works

BracketMaker : Visualization and optimization of chemical protein synthesis

Evangelista, J. L., & Kay, M. S. (2024) · Protein Science · doi:10.1002/pro.5174 · Cited by 1 · see citing works

Review of major scientific research achievements on the 40th Anniversary of the Re-establishment of Department of Biology at Tsinghua University

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Functional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain

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Chiral Single Molecule Localization Microscopy (chiralSMLM)Preprint

Aravinth, S., Pant, N., & Mondal, P. P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.10.637296 · Cited by 1 · see citing works

How should ‘mirror life’ research be restricted? Debate heats up

Peplow, M. (2025) · Nature · doi:10.1038/d41586-025-02902-2 · Cited by 1 · see citing works

Design and synthesis of mirror image fluorescent nucleotide reversible terminator, (L)-3ʹ-O-azidomethyl-dGTP-N 3 -fluorophore and (D)-9°N mutant DNA polymerase for mirror image (L)-DNA sequencing by synthesisPreprint

Kim, D. H., Huang, B.-S., Yik, E. J., Baker, J. R., Rajasekaran, G., Jangili, P., Zhou, G., Sismour, A. M., Medina, E. L., & Lee, J. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.03.692211 · Cited by 1 · see citing works

Biological Catalysis and Information Storage Have Relied on N-Glycosyl Derivatives of β-D-Ribofuranose since the Origins of Life

Woźniak, K., & Brzeziński, K. (2023) · Biomolecules · doi:10.3390/biom13050782

Nuclease‐Resistant L‐DNA Tension Probes Enable Long‐Term Force Mapping of Single Cells and Cell Consortia

Sethi, S., Xu, T., Sarkar, A., Drees, C., Jacob, C., & Walther, A. (2024) · Angewandte Chemie · doi:10.1002/ange.202413983

Theoretical Framework for Novel Catalytic Biomolecules Composed of Multiple Peptides

Ambo, A., Ohno, S., Yamaguchi, Y., & Seki, M. (2024) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c24-00155

POLETicians in the Mud: Preprokaryotic Organismal Lifeforms Existing Today (POLET) Hypothesis

Ruden, D. M., & Hood, G. R. (2025) · Bacteria · doi:10.3390/bacteria4030042

Les bactéries miroirs pourraient conquérir la vie sur Terre : et si ce fantasme de scientifiques devenait une dangereuse réalité

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Leveraging protein representations to explore uncharted fold spaces with generative modelsPreprint

Miao, Y., Pačesa, M., Georgeon, S., Schmidt, J. H., Lu, T., Huang, P., & Correia, B. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.10.681606

Leveraging protein representations to explore uncharted fold spaces with generative modelsPreprint

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Theory of conferred hyper-Raman optical activity

Andrews, D. L., & Valev, V. K. (2025) · Journal of Optics · doi:10.1088/2040-8986/ae248d

Mirror life is a scientific fantasy leading to a dangerous reality − a synthetic biologist explains how mirror bacteria could conquer life on Earth

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Fourier Helicity Spectra as Quantifiers of Multiscale ChiralityPreprint

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Metabolic diversity of microorganisms toward atypical sugar enantiomersPreprint

Nishijima, H., Igarashi, K., Kitagawa, W., Tabata, H., Nakanishi, S., & Kato, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.17.700050

Sanger Sequencing of Xeno‐Nucleic Acid

Wang, Y., Zhang, Z., Chen, L., Zhu, J., Qin, S., Wei, D., Zhang, J., Han, F., Wang, F., Lin, Q., et al. (2026) · Angewandte Chemie · doi:10.1002/ange.202516617

Recent instrumental developments in chiral mass spectrometry

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Second-harmonic chiroptical scattering spectroscopy from plasmonic nanohelices

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Face au spectre de la vie miroir

Cooper, V. S. (2026) · Pour la Science · doi:10.3917/pls.581.0028

Total chemical synthesis of pentameric cholera toxin subunit B

Spaltenstein, P., Scherer, S. R., Jones, T. E., Giesler, R. J., & Kay, M. S. (2026) · Chemical Communications · doi:10.1039/d5cc06935a

Development of synthetic RNA using ultrahigh-throughput microfluidic screening

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Mirror-image biology: perspectives and challenges

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Xenonucleic Acids and Their Applications

Abdi, G., Dave, K., Gautam, S., & Panchal, U. (2026) · Springer eBooks · doi:10.1007/978-981-95-3957-4_12

Engineered Template-Dependent DNA Polymerases with an Expanded Substrate Scope

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Recent advances in chemoselective protein desulfurization: from VA-044 to emerging boron, photochemical, iron-catalyzed, and ultrasound methods

Ding, X., Li, C., Wang, X., & Liang, L.-J. (2026) · Organic & Biomolecular Chemistry · doi:10.1039/d6ob00780e

Tracking Chirality Evolution in Tellurium Nanocrystals Via Polarization-Resolved Second-Harmonic Scattering

Ji, R., Reuven, B., Kerrigan, B., Markovich, G., & Valev, V. K. (2026) · Nano Letters · doi:10.1021/acs.nanolett.6c01271

Soil Moisture and Nutrients Regulate Bacterial Communities in Chromite Mining Restoration Areas on the Qinghai–Tibet Plateau

Wang, J., Wang, G., Li, J., & Zhu, B. (2026) · Applied Sciences · doi:10.3390/app16147008

From mRNA stabilisation to mirror life: Biological orthogonality, incremental risk, and anticipatory governance

Lean, C. H., Vincent, R. M., Lynch, K. E., Jamrozik, E., & Jaschke, P. R. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1833212

In Vitro Selection of Functional Neoproteins Containing Highly Fluorinated Cores

Beattie, A. T., Vinogradov, A. A., Okada, C., Sengoku, T., Katoh, T., & Suga, H. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.5293145

In Vitro Selection of Functional Neoproteins Containing Highly Fluorinated Cores

Beattie, A. T., Vinogradov, A. A., Okada, C., Sengoku, T., Katoh, T., & Suga, H. (2026) · Angewandte Chemie · doi:10.1002/ange.5293145

Genetically Expanded Fluorescent SSBT7 RNA Polymerase in Action: Intriguing Photophysics with Enhanced RNA Production

Bag, S. S., Banerjee, A., & Barman, S. (2026) · ACS Omega · doi:10.1021/acsomega.6c07950

Mirror‐Image 5S Ribonucleoprotein Complexes

Ling, J., Fan, C., Qin, H., Wang, M., Ji, C., Wittung-Stafshede, P. E., & Zhu, T. F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201914799 · Cited by 34 · see citing works

Mirror-Image Gene Transcription and Reverse Transcription

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Compatibility and Fidelity of Mirror-Image Thymidine in Transcription Events by T7 RNA Polymerase

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A synthetic molecular system capable of mirror-image genetic replication and transcription

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ChemInform Abstract: Improvements in the Synthesis of L‐Ribonucleotides for the Preparation of Mirror‐Image Oligoribonucleotides

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