Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids
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LFA-1 expression allows liver-resident CD8 + T cells to patrol hepatic sinusoids yet remain in the liver.
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CD103 may not be fully responsible for the retention of intrahepatic Trm cells in mice.
“Furthermore, it has been reported that CD103 may not be fully responsible for the retention of intrahepatic Trm cells in mice28,34, suggesting another molecular mechanism underlying the global localization of CD8+ Trm cells in the liver sinusoids.”
From CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells (2021) · cites this paper as [34]
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works
A global double-fluorescent Cre reporter mouse
Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491 · see citing works
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · see citing works
The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
Mackay, L. K., Rahimpour, A., Ma, J. Z., Collins, N., Stock, A. T., Hafon, M.-L., Vega-Ramos, J., Lauzurica, P., Mueller, S. N., Stefanovic, T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2744 · Cited by 1,331 · cited 2× · see citing works
“CD103 is highly expressed on epithelial TRM cells, such as those found in the skin and the gut, and has been shown to be required for T cell residence in the skin (2, 3, 13).”
BackgroundSelf-citationGebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157 · see citing works
Self-citationHobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
Mackay, L. K., Minnich, M., Kragten, N. A. M., Liao, Y., Nota, B., Seillet, C., Zaid, A., Man, K., Preston, S., Freestone, D., et al. (2016) · Science · doi:10.1126/science.aad2035 · Cited by 1,010 · see citing works
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
Koller, B. H., Marrack, P., Kappler, J. W., & Smithies, O. (1990) · Science · doi:10.1126/science.2112266 · Cited by 884 · see citing works
Resident memory CD8 T cells trigger protective innate and adaptive immune responses
Schenkel, J. M., Fraser, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. (2014) · Science · doi:10.1126/science.1254536 · Cited by 731 · see citing works
Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance
Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D. (2015) · Cell · doi:10.1016/j.cell.2015.03.031 · Cited by 685 · see citing works
Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A. E., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K. A., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200402 · Cited by 642 · see citing works
Dynamic T cell migration program provides resident memory within intestinal epithelium
Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20090858 · Cited by 628 · see citing works
Mackay, L. K., Wynne-Jones, E., Freestone, D., Pellicci, D. G., Mielke, L. A., Newman, D. M., Braun, A., Masson, F., Kallies, A., Belz, G. T., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.008 · Cited by 597 · see citing works
Different patterns of peripheral migration by memory CD4+ and CD8+ T cells
Gebhardt, T., Whitney, P. G., Zaid, A., Mackay, L. K., Brööks, A. G., Heath, W. R., Carbone, F. R., & Mueller, S. N. (2011) · Nature · doi:10.1038/nature10339 · Cited by 529 · see citing works
Self-citationLiver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection
Fernandez-Ruiz, D., Ng, W. Y., Holz, L. E., Ma, J. Z., Zaid, A., Wong, Y. C., Lau, L. S., Mollard, V., Cozijnsen, A., Collins, N., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.011 · Cited by 438 · see citing works
Self-citationObservation of Antigen-Dependent CD8+ T-Cell/ Dendritic Cell Interactions in Vivo
Schaefer, B. C., Schaefer, M. L., Kappler, J. W., Marrack, P., & Kedl, R. M. (2001) · Cellular Immunology · doi:10.1006/cimm.2001.1895 · Cited by 394 · see citing works
Laidlaw, B. J., Zhang, N., Marshall, H. D., Staron, M. M., Guan, T., Hu, Y., Cauley, L. S., Craft, J. E., & Kaech, S. M. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.007 · Cited by 366 · see citing works
Cutting Edge: Gut Microenvironment Promotes Differentiation of a Unique Memory CD8 T Cell Population
Masopust, D., Vezys, V., Wherry, E. J., Barber, D. L., & Ahmed, R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2079 · Cited by 357 · see citing works
Warren, A., Le Couteur, D. G., Fraser, R., Bowen, D. G., McCaughan, G. W., & Bertolino, P. (2006) · Hepatology · doi:10.1002/hep.21378 · Cited by 347 · see citing works
Self-citationImmunosurveillance of the Liver by Intravascular Effector CD8 + T Cells
Guidotti, L. G., Inverso, D., Sironi, L., Di Lucia, P., Fioravanti, J., Ganzer, L., Fiocchi, A., Vacca, M., Aiolfi, R., Sammicheli, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.03.005 · Cited by 323 · see citing works
The liver as a site of T-cell apoptosis: graveyard, or killing field?
Crispe, I. N., Dao, T., Klugewitz, K., Mehal, W. Z., & Metz, D. P. (2000) · Immunological Reviews · doi:10.1034/j.1600-0528.2002.017412.x · Cited by 321 · see citing works
Intravascular staining redefines lung CD8 T cell responses
Anderson, K., Sung, H., Skon, C. N., Lefrançois, L., Deisinger, A., Vezys, V., & Masopust, D. (2012) · Journal of Immunology · doi:10.4049/jimmunol.1201682 · Cited by 309 · see citing works
Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity
Slütter, B., Budimir, N., Abboud, G., Varga, S. M., Salek‐Ardakani, S., & Harty, J. T. (2017) · Science Immunology · doi:10.1126/sciimmunol.aag2031 · Cited by 297 · see citing works
Selective Retention of Activated CD8+ T Cells by the Normal Liver
Mehal, W. Z., Juedes, A. E., & Crispe, I. N. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.6.3202 · Cited by 253 · see citing works
Smith, A. M., Bracke, M., Leitinger, B., Porter, J. C., & Hogg, N. (2003) · Journal of Cell Science · doi:10.1242/jcs.00606 · Cited by 245 · see citing works
Wakim, L. M., Gupta, N., Mintern, J. D., & Villadangos, J. A. (2013) · Nature Immunology · doi:10.1038/ni.2525 · Cited by 214 · see citing works
PLZF induces an intravascular surveillance program mediated by long-lived LFA-1–ICAM-1 interactions
Thomas, S. Y., Scanlon, S. T., Griewank, K., Constantinides, M. G., Savage, A. K., Barr, K., Meng, F., Luster, A. D., & Bendelac, A. S. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102630 · Cited by 202 · see citing works
Memory T Cell Populations in the Lung Airways Are Maintained by Continual Recruitment
Ely, K. H., Cookenham, T. S., Roberts, A. D., & Woodland, D. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.1.537 · Cited by 187 · see citing works
Passive and Active Mechanisms Trap Activated CD8+ T Cells in the Liver
John, B., & Crispe, I. N. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5222 · Cited by 157 · see citing works
In vivo imaging of CD8 + T cell-mediated elimination of malaria liver stages
Cockburn, I. A., Amino, R., Kelemen, R. K., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303858110 · Cited by 132 · see citing works
Self-citationIntermittence of blood flow in liver sinusoids, studied by high-resolution in vivo microscopy
MacPhee, P. J., Schmidt, E. E., & Groom, A. C. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.269.5.g692 · Cited by 127 · see citing works
Boutet, M., Gauthier, L., Leclerc, M., Gros, G., de Montpréville, V., Théret, N., Donnadieu, E., & Mami‐Chouaib, F. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1545 · Cited by 104 · see citing works
LFA-1 is required for retention of effector CD8 T cells in mouse lungs
Thatte, J., Dabak, V. S., Williams, M. B., Braciale, T. J., & Ley, K. F. (2003) · Blood · doi:10.1182/blood-2002-10-3159 · Cited by 82 · see citing works
ENU-mutagenesis: insight into immune function and pathology
Cook, M., Vinuesa, C. G., & Goodnow, C. C. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.07.011 · Cited by 62 · see citing works
Self-citationBertolino, P., Schrage, A., Bowen, D. G., Klugewitz, K., Ghani, S., Eulenburg, K., Holz, L. E., Hogg, N., McCaughan, G. W., & Hamann, A. (2005) · Hepatology · doi:10.1002/hep.20885 · Cited by 57 · see citing works
Self-citationOhteki, T., Maki, C., Koyasu, S., et al. (1999) · PubMed · Cited by 53 · see citing works
CD8+T Cells Eliminate Liver-Stage Plasmodium berghei Parasites without Detectable Bystander Effect
Cockburn, I. A., Tse, S., & Zavala, F. P. (2014) · Infection and Immunity · doi:10.1128/iai.01500-13 · Cited by 49 · see citing works
Self-citationBose, T. O., Pham, Q.-M., Jellison, E. R., Mouriès, J., Ballantyne, C. M., & Lefrançois, L. (2013) · Infection and Immunity · doi:10.1128/iai.00749-12 · Cited by 48 · see citing works
Sela, U., Mauermann, N., Hershkoviz, R., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7255 · Cited by 37 · see citing works
Virus-Specific CD8+ T Cells in the Liver: Armed and Ready to Kill
Keating, R., Yue, W. W., Rutigliano, J. A., So, J., Olivas, E., Thomas, P. G., & Doherty, P. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2737 · Cited by 30 · see citing works
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Pallett, L. J., Davies, J., Colbeck, E. J., Robertson, F., Hansi, N., Easom, N. J. W., Burton, A. R., Stegmann, K. A., Schurich, A., Swadling, L., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162115 · Cited by 347 · see citing works
Koda, Y., Teratani, T., Chu, P.-S., Hagihara, Y., Mikami, Y., Harada, Y., Tsujikawa, H., Miyamoto, K., Suzuki, T., Taniki, N., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24734-0 · Cited by 219 · see citing works
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Inverso, D., Shi, J., Lee, K. H., Jakab, M., Ben-Moshe, S., Kulkarni, S. R., Schneider, M., Wang, G., Komeili, M., Vélez, P. A., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.05.001 · Cited by 114 · see citing works
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van Gisbergen, K. P. J. M., Zens, K. D., & Münz, C. (2021) · European Journal of Immunology · doi:10.1002/eji.202049062 · Cited by 39 · see citing works
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Pallett, L. J., & Maini, M. K. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00932-w · Cited by 28 · see citing works
Kremer, K. N., Khammash, H. A., Miranda, A. M., Rutt, L. N., Twardy, S. M., Anton, P. E., Campbell, M. L., Garza-Ortiz, C., Orlicky, D. J., Pelanda, R., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1497788 · Cited by 19 · see citing works
- Authors
- McNamara, H. A., Cai, Y., Wagle, M. V., Sontani, Y., Roots, C. M., Miosge, L. A., O’Connor, J. H., Sutton, H. J., Ganusov, V. V., Heath, W. R., Bertolino, P., Goodnow, C. G., Parish, I. A., Enders, A., & Cockburn, I. A.
- Affiliations
- Australian National University (AU)
- University of Tennessee at Knoxville (US)
- The University of Melbourne (AU)
- The University of Sydney (AU)
- Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 2601, Australia.
- Corresponding author
- Cockburn, I. A.
- ORCID
- Venue
- Science Immunology
- Published
- 2017-03-31
- Volume
- 2
- Issue
- 9
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC5505664
- OpenAlex
- W2595908170
- Cited by
- 181
- References
- 39
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 18 · 2023: 14 · 2022: 18 · 2021: 28 · 2020: 27 · 2019: 18 · 2018: 21 · 2017: 5
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Funders
- National Institutes of Health (award288585)
- Ramaciotti Foundations (award288586)
- National Health and Medical Research Council (award288587)
- Ian Potter Foundation (award288588)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- LFA-1, ICAM-1, CD8+ T cells, hepatic sinusoids, adhesion molecules, T cell homing, Plasmodium, lymphocytic choriomeningitis virus, effector memory T cells
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