Dynamic T cell migration program provides resident memory within intestinal epithelium

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067 · see citing works

Lymphocyte Homing and Homeostasis

Butcher, E. C., & Picker, L. J. (1996) · Science · doi:10.1126/science.272.5258.60 · Cited by 2,846 · see citing works

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · see citing works

T-Cell Function and Migration — Two Sides of the Same Coin

von Andrian, U. H., & Mackay, C. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010053431407 · Cited by 1,429 · see citing works

Mucosal vaccines: the promise and the challenge

Neutra, M. R., & Kozlowski, P. A. (2006) · Nature reviews. Immunology · doi:10.1038/nri1777 · Cited by 1,232 · see citing works

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157 · see citing works

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

Mora, J. R., Bono, M. R., Manjunath, N., Weninger, W., Cavanagh, L. L., Rosemblatt, M. S., & von Andrian, U. H. (2003) · Nature · doi:10.1038/nature01726 · Cited by 1,068 · see citing works

Visualizing the generation of memory CD4 T cells in the whole body

Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T., & Jenkins, M. K. (2001) · Nature · doi:10.1038/35065111 · Cited by 1,026 · see citing works

The Vast Majority of CLA+ T Cells Are Resident in Normal Skin

Clark, R. A., Chong, B., Mirchandani, N., Brinster, N. K., Yamanaka, K.-I., Dowgiert, R. K., & Kupper, T. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4431 · Cited by 796 · see citing works

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

Mackay, C. R., Marston, W. L., & Dudler, L. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.3.801 · Cited by 791 · see citing works

Two Sides of the Same Coin

Kelly, S. D., Özyürek, A., & Maris, E. (2009) · Psychological Science · doi:10.1177/0956797609357327 · Cited by 674 · see citing works

Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment

Kunkel, E. J., Campbell, J. J., Haraldsen, G., Pan, J., Boisvert, J., Roberts, A. I., Ebert, E. C., Vierra, M. A., Goodman, S. B., Genovese, M. C., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.5.761 · Cited by 637 · see citing works

Finding a way out: lymphocyte egress from lymphoid organs

Schwab, S. R., & Cyster, J. G. (2007) · Nature Immunology · doi:10.1038/ni1545 · Cited by 607 · see citing works

Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

Miller, J. D., van der Most, R. G., Akondy, R. S., Glidewell, J. T., Albott, S., Masopust, D., Murali-Krishna, K., Mahar, P. L., Edupuganti, S., Lalor, S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.020 · Cited by 601 · see citing works

Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics

Bromley, S. K., Thomas, S. Y., & Luster, A. D. (2005) · Nature Immunology · doi:10.1038/ni1240 · Cited by 509 · see citing works

Intraepithelial lymphocytes: exploring the Third Way in immunology

Hayday, A., Theodoridis, E., Ramsburg, E., & Shires, J. (2001) · Nature Immunology · doi:10.1038/ni1101-997 · Cited by 491 · see citing works

Rapid Acquisition of Tissue-specific Homing Phenotypes by CD4+ T Cells Activated in Cutaneous or Mucosal Lymphoid Tissues

Campbell, D., & Butcher, E. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011502 · Cited by 490 · see citing works

Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine–Mediated Chemotaxis

Zabel, B. A., Agace, W. W., Campbell, J. J., Heath, H., Parent, D., Roberts, A. I., Ebert, E. C., Kassam, N., Qin, S., Zovko, M., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.9.1241 · Cited by 485 · see citing works

Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues

Debes, G. F., Arnold, C. N., Young, A. J., Krautwald, S., Lipp, M., Hay, J. B., & Butcher, E. C. (2005) · Nature Immunology · doi:10.1038/ni1238 · Cited by 478 · see citing works

Perils at mucosal front lines for HIV and SIV and their hosts

Haase, A. T. (2005) · Nature reviews. Immunology · doi:10.1038/nri1706 · Cited by 440 · see citing works

Dynamics of Blood-Borne CD8 Memory T Cell Migration In Vivo

Klonowski, K. D., Williams, K., Marzo, A. L., Blair, D. A., Lingenheld, E. G., & Lefrançois, L. (2004) · Immunity · doi:10.1016/s1074-7613(04)00103-7 · Cited by 383 · see citing works

Organ-Specific Regulation of the CD8 T Cell Response to Listeria monocytogenes Infection

Pope, C. D., Kim, S.-K., Marzo, A. L., Williams, K., Jiang, J. K., Shen, H., & Lefrançois, L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3402 · Cited by 375 · see citing works

Man the barrier! strategic defences in the intestinal mucosa

Nagler‐Anderson, C. (2001) · Nature reviews. Immunology · doi:10.1038/35095573 · Cited by 369 · see citing works

Cutting Edge: Gut Microenvironment Promotes Differentiation of a Unique Memory CD8 T Cell Population

Masopust, D., Vezys, V., Wherry, E. J., Barber, D. L., & Ahmed, R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2079 · Cited by 357 · see citing works

Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues

Mora, J. R., Cheng, G., Picarella, D., Briskin, M., Buchanan, N. M., & von Andrian, U. H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041645 · Cited by 309 · see citing works

Protection from Respiratory Virus Infections Can Be Mediated by Antigen-Specific Cd4+ T Cells That Persist in the Lungs

Hogan, R. J., Zhong, W., Usherwood, E. J., Cookenham, T. S., Roberts, A. D., & Woodland, D. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.8.981 · Cited by 288 · see citing works

Measuring the diaspora for virus-specific CD8 + T cells

Marshall, D. R., Turner, S. J., Belz, G. T., Wingo, S., Andreansky, S. S., Sangster, M. Y., Riberdy, J. M., Liu, T., Tan, M., & Doherty, P. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101132698 · Cited by 285 · see citing works

Activated Primary and Memory CD8 T Cells Migrate to Nonlymphoid Tissues Regardless of Site of Activation or Tissue of Origin

Masopust, D., Vezys, V., Usherwood, E. J., Cauley, L. S., Olson, S., Marzo, A. L., Ward, R. L., Woodland, D. L., & Lefrançois, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4875 · Cited by 281 · see citing works

Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge

Belyakov, I. M., Derby, M. A., Ahlers, J. D., Kelsall, B. L., Earl, P. L., Moss, B., Strober, W., & Berzofsky, J. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1709 · Cited by 258 · see citing works

Generation of gut‐homing T cells and their localization to the small intestinal mucosa

Johansson‐Lindbom, B., & Agace, W. W. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00482.x · Cited by 248 · see citing works

Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization.

Gallichan, W. S., & Rosenthal, K. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.5.1879 · Cited by 238 · see citing works

Chemokine Receptor CCR9 Contributes to the Localization of Plasma Cells to the Small Intestine

Pabst, O., Ohl, L., Wendland, M., Wurbel, M., Kremmer, E., MALISSEN, B., & Förster, R. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20030996 · Cited by 231 · see citing works

Transcutaneous immunization induces mucosal CTLs and protective immunity by migration of primed skin dendritic cells

Belyakov, I. M., Hammond, S. A., Ahlers, J. D., Glenn, G. M., & Berzofsky, J. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20261 · Cited by 202 · see citing works

Memory T Cell Populations in the Lung Airways Are Maintained by Continual Recruitment

Ely, K. H., Cookenham, T. S., Roberts, A. D., & Woodland, D. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.1.537 · Cited by 187 · see citing works

Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells

Stunz, L. L., Lenert, P. S., Peckham, D., Yi, A., Haxhinasto, S. A., Chang, M., Krieg, A. Μ., & Ashman, R. F. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200205)32:5 · Cited by 150 · see citing works

Direct Analysis of the Dynamics of the Intestinal Mucosa CD8 T Cell Response to Systemic Virus Infection

Masopust, D., Jiang, J. K., Shen, H., & Lefrançois, L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2348 · Cited by 148 · see citing works

Induction and Visualization of Mucosal Memory CD8 T Cells Following Systemic Virus Infection

Kim, S.-K., Schluns, K. S., & Lefrançois, L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.8.4125 · Cited by 145 · see citing works

Correlation analysis between frequencies of circulating antigen-specific IgG-bearing memory B cells and serum titers of antigen-specific IgG

Leyendeckers, H., Odendahl, M., Löhndorf, A., Irsch, J., Spangfort, M. D., Miltenyi, S., Hunzelmann, N., Assenmacher, M., Radbruch, A., & Schmitz, J. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199904)29:04 · Cited by 135 · see citing works

Dynamic Programing of CD8+ T Cell Trafficking after Live Viral Immunization

Liu, L., Fuhlbrigge, R. C., Karibian, K., Tian, T., & Kupper, T. S. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.019 · Cited by 132 · see citing works

Immunobiology of Mucosal HIV Infection and the Basis for Development of a New Generation of Mucosal AIDS Vaccines

Belyakov, I. M., & Berzofsky, J. A. (2004) · Immunity · doi:10.1016/s1074-7613(04)00053-6 · Cited by 131 · see citing works

IELs: enforcing law and order in the court of the intestinal epithelium

Cheroutre, H. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00284.x · Cited by 117 · see citing works

Both Mucosal and Systemic Routes of Immunization with the Live, Attenuated NYVAC/Simian Immunodeficiency Virus SIVgpeRecombinant Vaccine Result in Gag-Specific CD8+T-Cell Responses in Mucosal Tissues of Macaques

Stevceva, L., Alvarez, X. A., Lackner, A. A., Tryniszewska, E. A., Kelsall, B. L., Nacsa, J., Tartaglia, J., Strober, W., & Franchini, G. (2002) · Journal of Virology · doi:10.1128/jvi.76.22.11659-11676.2002 · Cited by 75 · see citing works

Immune cell traffic from blood through the normal human skin to lymphatics

Olszewski, W. L. (1995) · Clinics in Dermatology · doi:10.1016/0738-081x(95)00087-v · Cited by 56 · see citing works

Lymphocytes in the bronchoalveolar space reenter the lung tissue by means of the alveolar epithelium, migrate to regional lymph nodes, and subsequently rejoin the systemic immune system

Lehmann, C., Wilkening, A., Leiber, D., Markus, A. M. A., Krug, N., Pabst, R., & Tschernig, T. (2001) · The Anatomical Record · doi:10.1002/ar.1163 · Cited by 52 · see citing works

TREATMENT WITH EITHER ANTI-CD4 OR ANTI-CD8 MONOCLONAL ANTIBODIES BLOCKS ???? T CELL-MEDIATED REJECTION OF INTESTINAL ALLOGRAFTS IN MICE

Newell, K. A., He, G., Hart, J. A. L., & Thistlethwaite, J. R. (1997) · Transplantation · doi:10.1097/00007890-199710150-00004 · Cited by 41 · see citing works

Donor Lymphoid Organs Are a Major Site of Alloreactive T-Cell Priming Following Intestinal Transplantation

Wang, J., Dong, Y., Sun, J., Taylor, R. T., Guo, C., Alegre, M., Williams, I. R., & Newell, K. A. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01516.x · Cited by 38 · see citing works

Immunological memory to Listeria monocytogenes in rodents. IV. Studies on origin and fate of tissue-positioned T memory cells.

Jungi, T. W., & Jungi, R. (1981) · PubMed · Cited by 11 · see citing works

Systemic T cell expansion during localized viral infection

Haanen, J. B., Toebes, M., Cordaro, T. A., Wolkers, M. C., Kruisbeek, A. M., & Schumacher, T. N. (1999) · Data Archiving and Networked Services (DANS) · doi:10.1002/(sici)1521-4141(199904)29:04<1168::aid-immu1168>3.0.co;2-j · Cited by 1 · see citing works

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Im, S. J., Hashimoto, M., Gerner, M. Y., Lee, J., Kissick, H. T., Burger, M. C., Shan, Q., Hale, J. S., Lee, J., Nasti, T. H., et al. (2016) · Nature · doi:10.1038/nature19330 · Cited by 2,070 · see citing works

Transcriptional control of effector and memory CD8+ T cell differentiation

Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628 · see citing works

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

Mackay, L. K., Rahimpour, A., Ma, J. Z., Collins, N., Stock, A. T., Hafon, M.-L., Vega-Ramos, J., Lauzurica, P., Mueller, S. N., Stefanovic, T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2744 · Cited by 1,331 · see citing works

Tissue-Resident Memory T Cells

Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059 · see citing works

Tissue-resident memory T cells: local specialists in immune defence

Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006 · see citing works

Human memory T cells: generation, compartmentalization and homeostasis

Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897 · see citing works

Mechanisms regulating skin immunity and inflammation

Pasparakis, M., Haase, I., & Nestle, F. O. (2014) · Nature reviews. Immunology · doi:10.1038/nri3646 · Cited by 896 · see citing works

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

Jiang, X., Clark, R. A., Liu, L., Wagers, A. J., Fuhlbrigge, R. C., & Kupper, T. S. (2012) · Nature · doi:10.1038/nature10851 · Cited by 883 · see citing works

Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets

Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J. J. C., Bickham, K. L., Lerner, H., Goldstein, M., Sykes, M., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.09.020 · Cited by 848 · see citing works

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

Mueller, S. N., Gebhardt, T., Carbone, F., & Heath, W. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095954 · Cited by 842 · see citing works

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

Skon, C. N., Lee, J.-Y., Anderson, K. G., Masopust, D., Hogquist, K. A., & Jameson, S. C. (2013) · Nature Immunology · doi:10.1038/ni.2745 · Cited by 817 · see citing works

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

Schenkel, J. M., Fraser, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. (2014) · Science · doi:10.1126/science.1254536 · Cited by 731 · see citing works

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

Pan, Y., Tian, T., Park, C. O., Lofftus, S. Y., Mei, S., Liu, X., Luo, C., O’Malley, J. T., Gehad, A. E., Teague, J. E., et al. (2017) · Nature · doi:10.1038/nature21379 · Cited by 718 · see citing works

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

Milner, J. J., Toma, C., Yu, B., Zhang, K., Omilusik, K., Phan, A. T., Wang, D., Getzler, A. J., Nguyen, T., Crotty, S., et al. (2017) · Nature · doi:10.1038/nature24993 · Cited by 677 · see citing works

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D. (2015) · Cell · doi:10.1016/j.cell.2015.03.031 · Cited by 685 · see citing works

Location, location, location: Tissue resident memory T cells in mice and humans

Szabo, P. A., Miron, M., & Farber, D. L. (2019) · Science Immunology · doi:10.1126/sciimmunol.aas9673 · Cited by 651 · see citing works

The immunological anatomy of the skin

Kabashima, K., Honda, T., Ginhoux, F., & Egawa, G. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0084-5 · Cited by 650 · see citing works

A vaccine strategy that protects against genital herpes by establishing local memory T cells

Shin, H., & Iwasaki, A. (2012) · Nature · doi:10.1038/nature11522 · Cited by 646 · see citing works

Sensing and alarm function of resident memory CD8+ T cells

Schenkel, J., Fraser, K. A., Vezys, V., & Masopust, D. (2013) · Nature Immunology · doi:10.1038/ni.2568 · Cited by 648 · see citing works

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A. E., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K. A., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200402 · Cited by 642 · see citing works

From Vaccines to Memory and Back

Sallusto, F., Lanzavecchia, A., Araki, K., & Ahmed, R. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.008 · Cited by 631 · see citing works

Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation

Mackay, L. K., Stock, A. T., Ma, J., Jones, C. M., Kent, S., Mueller, S. N., Heath, W., Carbone, F., & Gebhardt, T. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1202288109 · Cited by 638 · see citing works

The integration of T cell migration, differentiation and function

Masopust, D., & Schenkel, J. M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3442 · Cited by 629 · see citing works

CD8+ T cell metabolism in infection and cancer

Reina-Campos, M., Scharping, N. E., & Goldrath, A. W. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00537-8 · Cited by 574 · see citing works

CD8+CD103+ Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients

Djenidi, F., Adam, J., Goubar, A., Durgeau, A., Meurice, G., de Montpréville, V., Validire, P., Besse, B., & Mami-Chouaib, F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402711 · Cited by 622 · see citing works

The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis

Gerlach, C., Moseman, E. A., Loughhead, S. M., Alvarez, D., Zwijnenburg, A. J., Waanders, L., Garg, R., de la Torre, J. C., & von Andrian, U. H. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.018 · Cited by 567 · see citing works

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

Mackay, L. K., Wynne-Jones, E., Freestone, D., Pellicci, D. G., Mielke, L. A., Newman, D. M., Braun, A., Masson, F., Kallies, A., Belz, G. T., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.008 · Cited by 597 · see citing works

Tissue-Resident T Cells and Other Resident Leukocytes

Masopust, D., & Soerens, A. G. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053214 · Cited by 608 · see citing works

Molecular regulation of effector and memory T cell differentiation

Chang, J. T., Wherry, E. J., & Goldrath, A. W. (2014) · Nature Immunology · doi:10.1038/ni.3031 · Cited by 578 · see citing works

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

Wakim, L. M., Davis, A. S. W., & Bevan, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010201107 · Cited by 577 · see citing works

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

Sojka, D. K., Plougastel-Douglas, B., Yang, L., Pak-Wittel, M. A., Artyomov, M. N., Ivanova, Y., Zhong, C., Chase, J. M., Rothman, P. B., Yu, J. L., et al. (2014) · eLife · doi:10.7554/elife.01659 · Cited by 545 · see citing works

Different patterns of peripheral migration by memory CD4+ and CD8+ T cells

Gebhardt, T., Whitney, P. G., Zaid, A., Mackay, L. K., Brööks, A. G., Heath, W. R., Carbone, F. R., & Mueller, S. N. (2011) · Nature · doi:10.1038/nature10339 · Cited by 529 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works

The emerging role of resident memory T cells in protective immunity and inflammatory disease

Park, C. O., & Kupper, T. S. (2015) · Nature Medicine · doi:10.1038/nm.3883 · Cited by 514 · see citing works

CD8+ T cells in the cancer-immunity cycle

Giles, J. R., Globig, A.-M., Kaech, S. M., & Wherry, E. J. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.005 · Cited by 467 · see citing works

Emerging insights into natural killer cells in human peripheral tissues

Björkström, N. K., Ljunggren, H., & Michaëlsson, J. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.34 · Cited by 451 · see citing works

Resident memory T cells in human health and disease

Clark, R. A. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010641 · Cited by 445 · see citing works

Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention

Zhang, N., & Bevan, M. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.019 · Cited by 403 · see citing works

Lung niches for the generation and maintenance of tissue-resident memory T cells

Turner, D., Bickham, K. L., Thome, J. J. C., Kim, C. Y., D’Ovidio, F., Wherry, E. J., & Färber, D. L. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.67 · Cited by 399 · see citing works

Integrin-based therapeutics: biological basis, clinical use and new drugs

Ley, K. F., Rivera–Nieves, J., Sandborn, W. J., & Shattil, S. J. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.10 · Cited by 404 · see citing works

A mucosal vaccine against <i>Chlamydia trachomatis</i> generates two waves of protective memory T cells

Stary, G., Olive, A., Radovic-Moreno, A. F., Gondek, D., Alvarez, D., Basto, P. A., Perro, M., Vrbanac, V. D., Tager, A. M., Shi, J., et al. (2015) · Science · doi:10.1126/science.aaa8205 · Cited by 379 · see citing works

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

Wakim, L. M., Davis, A. S. W., Liu, R., Hu, Y., Villadangos, J. A., Smyth, G. K., & Bevan, M. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201305 · Cited by 365 · see citing works

The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells

Heath, W. R., & Carbone, F. (2013) · Nature Immunology · doi:10.1038/ni.2680 · Cited by 356 · see citing works

Oral infection drives a distinct population of intestinal resident memory CD8+ T cells with enhanced protective function

Sheridan, B., Pham, Q.-M., Lee, Y.-T., Cauley, L., Puddington, L., & Lefrançois, L. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.007 · Cited by 332 · see citing works

Resident memory T cells, critical components in tumor immunology

Mami‐Chouaib, F., Blanc, C., Corgnac, S., Hans, S., Malenica, I., Granier, C., Tihy, I., & Tartour, É. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0399-6 · Cited by 328 · see citing works

Intravascular staining redefines lung CD8 T cell responses

Anderson, K., Sung, H., Skon, C. N., Lefrançois, L., Deisinger, A., Vezys, V., & Masopust, D. (2012) · Journal of Immunology · doi:10.4049/jimmunol.1201682 · Cited by 309 · see citing works

Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310 · see citing works

Induction of resident memory T cells enhances the efficacy of cancer vaccine

Nizard, M., Roussel, H., Diniz, M. O., Karaki, S., Tran, T., Voron, T., Dransart, E., Sandoval, F., Riquet, M., Rance, B., et al. (2017) · Nature Communications · doi:10.1038/ncomms15221 · Cited by 308 · see citing works

Tissue-resident memory T cells in breast cancer control and immunotherapy responses

Byrne, A., Savas, P., Sant, S., Li, R., Virassamy, B., Luen, S., Beavis, P., Mackay, L. K., Neeson, P., & Loi, S. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0333-y · Cited by 253 · see citing works

Resident memory CD8+ T cells in the upper respiratory tract prevent pulmonary influenza virus infection

Pizzolla, A., Nguyen, T. H. O., Smith, J. M., Brooks, A., Kedzierska, K., Heath, W., Reading, P., & Wakim, L. (2017) · Science immunology · doi:10.1126/sciimmunol.aam6970 · Cited by 284 · see citing works

Generation of effector CD8+ T cells and their conversion to memory T cells

Cui, W., & Kaech, S. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00926.x · Cited by 293 · see citing works

Resident memory T cells in the skin mediate durable immunity to melanoma

Malik, B. T., Byrne, K. T., Vella, J. L., Zhang, P., Shabaneh, T. B., Steinberg, S. M., Molodtsov, A. K., Bowers, J. S., Angeles, C. V., Paulos, C. M., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aam6346 · Cited by 278 · see citing works

Tissue-resident memory T cells at the center of immunity to solid tumors

Amsen, D., van Gisbergen, K. P. J. M., Hombrink, P., & van Lier, R. A. W. (2018) · Nature Immunology · doi:10.1038/s41590-018-0114-2 · Cited by 278 · see citing works

Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection

Sheikh‐Mohamed, S., Isho, B., Chao, G. Y. C., Zuo, M., Cohen, C., Lustig, Y., Nahass, G. R., Salomon, R. E. A., Blacker, G., Fazel‐Zarandi, M., et al. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00511-0 · Cited by 267 · see citing works

Proinflammatory microenvironments within the intestine regulate differentiation of tissue-resident CD8 T cells responding to infection

Bergsbaken, T., & Bevan, M. (2015) · Nature Immunology · doi:10.1038/ni.3108 · Cited by 269 · see citing works

The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance

Schönrich, G., & Raftery, M. J. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00207 · Cited by 272 · see citing works

Tissue-resident memory CD8 + T cells continuously patrol skin epithelia to quickly recognize local antigen

Ariotti, S., Beltman, J. B., Chodaczek, G., Hoekstra, M. E., van Beek, A. E., Gomez, R., Ritsma, L., van Rheenen, J., Marée, A. F. M., Żal, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208927109 · Cited by 274 · see citing works

Airway-Resident Memory CD8 T Cells Provide Antigen-Specific Protection against Respiratory Virus Challenge through Rapid IFN-γ Production

McMaster, S. R., Wilson, J. J., Wang, H., & Kohlmeier, J. E. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402975 · Cited by 260 · see citing works

Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity

Olson, J. A., McDonald-Hyman, C. S., Jameson, S. C., & Hamilton, S. E. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.009 · Cited by 254 · see citing works

Regional and mucosal memory T cells

Sheridan, B., & Lefrançois, L. (2011) · Nature Immunology · doi:10.1038/ni.2029 · Cited by 281 · see citing works

Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier

Olivares-Villagómez, D., & Van Kaer, L. (2018) · Trends in Immunology · doi:10.1016/j.it.2017.11.003 · Cited by 252 · see citing works

Phenotype, Function, and Gene Expression Profiles of Programmed Death-1hi CD8 T Cells in Healthy Human Adults

Duraiswamy, J., Ibegbu, C., Masopust, D., Miller, J. D., Araki, K., Doho, G., Tata, P., Sk, G., Zilliox, M. J., Nakaya, H. I., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001783 · Cited by 246 · see citing works

Quality and quantity

McKinnon, L. R., & Kaul, R. (2012) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e3283504941 · Cited by 245 · see citing works

Quantifying T lymphocyte turnover

de Boer, R. J., & Perelson, A. S. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.12.025 · Cited by 241 · see citing works

Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance

Takamura, S., Yagi, H., Hakata, Y., Motozono, C., McMaster, S. R., Masumoto, T., Fujisawa, M., Chikaishi, T., Komeda, J., Itoh, J., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160938 · Cited by 240 · see citing works

Mucosal Imprinting of Vaccine-Induced CD8 + T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors

Sandoval, F., Terme, M., Nizard, M., Badoual, C., Bureau, M., Freyburger, L., Clémеnt, O., Marcheteau, E., Gey, A., Fraisse, G., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004888 · Cited by 238 · see citing works

Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

Virassamy, B., Caramia, F., Savas, P. S., Sant, S. A., Wang, J., Christo, S. N., Byrne, A., Clarke, K. A., Brown, E., Teo, Z. L., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.01.004 · Cited by 234 · see citing works

Tissue-resident memory T cells in tumor immunity and immunotherapy

Okła, K., Färber, D. L., & Zou, W. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20201605 · Cited by 230 · see citing works

The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues

Kok, L., Masopust, D., & Schumacher, T. N. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00590-3 · Cited by 230 · see citing works

Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus

Slütter, B., Pewe, L. L., Kaech, S. M., & Harty, J. T. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.013 · Cited by 228 · see citing works

T cell homing to epithelial barriers in allergic disease

Islam, S. A., & Luster, A. D. (2012) · Nature Medicine · doi:10.1038/nm.2760 · Cited by 222 · see citing works

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β

Mohammed, J., Beura, L. K., Bobr, A., Astry, B., Chicoine, B., Kashem, S. W., Welty, N. E., Igyártó, B. Z., Wijeyesinghe, S., Thompson, E. A., et al. (2016) · Nature Immunology · doi:10.1038/ni.3396 · Cited by 221 · see citing works

Migratory DCs activate TGF-β to precondition naïve CD8 + T cells for tissue-resident memory fate

Mani, V., Bromley, S. K., Äijö, T., Mora‐Buch, R., Carrizosa, E., Warner, R. D., Hamze, M., Sen, D. R., Chasse, A. Y., Lorant, A. K., et al. (2019) · Science · doi:10.1126/science.aav5728 · Cited by 219 · see citing works

Memory CD8+ T cell responses to cancer

Han, J., Khatwani, N., Searles, T. G., Turk, M. J., & Angeles, C. V. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101435 · Cited by 219 · see citing works

Stem-like exhausted and memory CD8+ T cells in cancer

Gebhardt, T., Park, S. L., & Parish, I. A. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00615-0 · Cited by 216 · see citing works

Optimal Generation of Tissue-Resident but Not Circulating Memory T Cells during Viral Infection Requires Crosspriming by DNGR-1 + Dendritic Cells

Iborra, S., Martínez‐López, M., Khouili, S. C., Enamorado, M., Cueto, F. J., Conde‐Garrosa, R., del Fresno, C., & Sancho, D. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.019 · Cited by 217 · see citing works

Enhanced survival of lung tissue-resident memory CD8+ T cells during infection with influenza virus due to selective expression of IFITM3

Wakim, L. M., Gupta, N., Mintern, J. D., & Villadangos, J. A. (2013) · Nature Immunology · doi:10.1038/ni.2525 · Cited by 214 · see citing works

Cutting Edge: Resident Memory CD8 T Cells Occupy Frontline Niches in Secondary Lymphoid Organs

Schenkel, J. M., Fraser, K. A., & Masopust, D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400003 · Cited by 216 · see citing works

Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection

Khan, T. N., Mooster, J. L., Kilgore, A. M., Osborn, J. F., & Nolz, J. C. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151855 · Cited by 213 · see citing works

A guide to adaptive immune memory

Lam, N., Lee, Y. S., & Färber, D. L. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01040-6 · Cited by 217 · see citing works

Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act

Kalia, V., & Sarkar, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02987 · Cited by 209 · see citing works

Long-lasting stem cell–like memory CD8 ⁺ T cells with a naïve-like profile upon yellow fever vaccination

Fuertes Marraco, S. A., Soneson, C., Cagnon, L., Gannon, P. O., Allard, M., Maillard, S. A., Montandon, N., Rufer, N., Waldvogel, S., Delorenzi, M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3700 · Cited by 206 · see citing works

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life

Schreurs, R., Baumdick, M. E., Sagebiel, A. F., Kaufmann, M., Mokrý, M., Klarenbeek, P. L., Schaltenberg, N., Steinert, F. L., van Rijn, J. M., Drewniak, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.010 · Cited by 206 · see citing works

Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene expression analyses

Arsenio, J., Kakaradov, B., Metz, P. J., Kim, S. H., Yeo, G. W., & Chang, J. T. (2014) · Nature Immunology · doi:10.1038/ni.2842 · Cited by 210 · see citing works

Tissue‐resident memory T cells

Shin, H., & Iwasaki, A. (2013) · Immunological Reviews · doi:10.1111/imr.12087 · Cited by 206 · see citing works

Tissue‐resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance

Gebhardt, T., Palendira, U., Tscharke, D. C., & Bedoui, S. (2018) · Immunological Reviews · doi:10.1111/imr.12650 · Cited by 199 · see citing works

Mucosal Resident Memory CD4 T Cells in Protection and Immunopathology

Turner, D., & Färber, D. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00331 · Cited by 198 · see citing works

Transcriptional Regulation of Tissue-Resident Lymphocytes

Mackay, L. K., & Kallies, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.11.004 · Cited by 196 · see citing works

Tissue resident memory T cells in the respiratory tract

Zheng, M. Z. M., & Wakim, L. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00461-z · Cited by 177 · see citing works

Tissue-Resident Memory T Cells in Cancer Immunosurveillance

Park, S. L., Gebhardt, T., & Mackay, L. K. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.06.002 · Cited by 190 · see citing works

The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival

Howie, D., ten Bokum, A., Necula, A. S., Cobbold, S. P., & Waldmann, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01949 · Cited by 187 · see citing works

Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory

Okhrimenko, A., Grün, J. R., Westendorf, K., Fang, Z., Reinke, S., von Roth, P., Wassilew, G., Kühl, A. A., Kudernatsch, R., Demski, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318731111 · Cited by 188 · see citing works

Prevalence of Anti-Adeno-Associated Virus Immune Responses in International Cohorts of Healthy Donors

Kruzik, A., Fetahagic, D., Hartlieb, B., Dorn, S., Koppensteiner, H., Horling, F. M., Scheiflinger, F., Reipert, B. M., & de la Rosa, M. (2019) · Molecular Therapy - Methods &amp; Clinical Development · doi:10.1016/j.omtm.2019.05.014 · Cited by 182 · see citing works

Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids

McNamara, H. A., Cai, Y., Wagle, M. V., Sontani, Y., Roots, C. M., Miosge, L. A., O’Connor, J. H., Sutton, H. J., Ganusov, V. V., Heath, W. R., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aaj1996 · Cited by 181 · see citing works

Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

Mikhak, Z., Strassner, J. P., & Luster, A. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130091 · Cited by 195 · see citing works

The role of Memory CD8+ T cells in Human Vitiligo

Riding, R., & Harris, J. (2019) · Journal of Immunology · doi:10.4049/jimmunol.1900027 · Cited by 158 · see citing works

E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands

Hofmann, M., & Pircher, H. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1107200108 · Cited by 173 · see citing works

Identification and characterization of HIV-specific resident memory CD8 + T cells in human lymphoid tissue

Buggert, M., Nguyen, S., de Oca, G. S. M., Bengsch, B., Darko, S. W., Ransier, A., Roberts, E. R., Alcazar, D. D., Brody, I. B., Vella, L. A., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aar4526 · Cited by 162 · see citing works

The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location

Walsh, D., da Silva, H. B., Beura, L. K., Peng, C., Hamilton, S. E., Masopust, D., & Jameson, S. C. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900052 · Cited by 163 · see citing works

Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma

McMaster, S. R., Wein, A. N., Dunbar, P. R., Hayward, S. L., Cartwright, E. K., Denning, T. L., & Kohlmeier, J. E. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0003-x · Cited by 161 · see citing works

T cell migration and memory differentiation within the mouse intestinal mucosa in response to infection

Masopust, D., Vezys, V., Wherry, E. J., & Ahmed, R. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.855.6

Generation of gut‐homing T cells and their localization to the small intestinal mucosa

Johansson‐Lindbom, B., & Agace, W. W. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00482.x · Cited by 248 · see citing works

Differential Homing Commitments of Antigen-Specific T Cells After Oral or Parenteral Immunization in Humans

Kantele, A., Zivny, J., Häkkinen, M., Elson, C. O., & Mestecky, J. F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.9.5173 · Cited by 129 · see citing works

Road most traveled: Gut‐specific migration signals and leucocyte entry to the intestine

Grimm, M., & Ng, W. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05682.x · Cited by 3 · see citing works

Specificity and Plasticity of Memory LymphocyteMigration

Mora, J. R., & von Andrian, U. H. (2006) · Current topics in microbiology and immunology · doi:10.1007/3-540-30657-9_4 · Cited by 38 · see citing works