Cited by 124T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

Armed and Ready: Transcriptional Regulation of Tissue-Resident Memory CD8 T Cells

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Behr, Felix M., Chuwonpad, Ammarina, Stark, Regina, van Gisbergen, Klaas P. J. M.·2018·Frontiers in Immunology

Abstract

A fundamental benefit of immunological memory is the ability to respond in an enhanced manner upon secondary encounter with the same pathogen. Tissue-resident memory CD8 T (TRM) cells contribute to improved protection against reinfection through the generation of immediate effector responses at the site of pathogen entry. Key to the potential of TRM cells to develop rapid recall responses is their location within the epithelia of the skin, lungs and intestines at prime entry sites of pathogens. TRM cells are among the first immune cells to respond to pathogens that have been previously encountered in an antigen-specific manner. Upon recognition of invading pathogens, TRM cells release IFN-γ and other pro-inflammatory cytokines and chemokines. These effector molecules activate the surrounding epithelial tissue and recruit other immune cells including Natural Killer (NK) cells, B cells and circulating memory CD8 T cells to the site of infection. The repertoire of TRM effector functions also includes the direct lysis of infected cells through the release of cytotoxic molecules such as perforin and granzymes. The mechanisms enabling TRM cells to respond in such a rapid manner are gradually being uncovered. In this review, we will address the signals that instruct TRM generation and maintenance as well as the underlying transcriptional network that keeps TRM cells in a deployment-ready modus. Furthermore, we will discuss how TRM cells respond to reinfection of the tissue and how transcription factors may control immediate and proliferative TRM responses.

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Authors
Behr, F. M., Chuwonpad, A., Stark, R., & van Gisbergen, K. P. J. M.
Affiliations
Amsterdam UMC Location University of Amsterdam (NL)
Venue
Frontiers in Immunology
Published
2018-07-30
Volume
9
Pages
1770-1770
ISSN
1664-3224 (ISSN-L)
OpenAlex
W2885490686
Cited by
124
References
147
Citations by year
2026: 4 · 2025: 13 · 2024: 13 · 2023: 23 · 2022: 20 · 2021: 19 · 2020: 24 · 2019: 8
FWCI
1.54
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • ZonMw
  • Landsteiner Foundation for Blood Transfusion Research
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
tissue-resident memory T cells, CD8+ T cells, transcriptional regulation, immunological memory, reinfection, interferon-gamma, cytokines and chemokines, cytotoxicity, epithelial barrier function, transcription factors, memory T cell maintenance, recall response
MeSH terms
Animals, Cell Differentiation, Gene Expression Regulation, Humans, Immunologic Memory, Lymphocyte Activation, Organ Specificity, Phenotype, Transcription, Genetic, Signal Transduction, Biomarkers, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes

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