Armed and Ready: Transcriptional Regulation of Tissue-Resident Memory CD8 T Cells
Open accessAbstract
A fundamental benefit of immunological memory is the ability to respond in an enhanced manner upon secondary encounter with the same pathogen. Tissue-resident memory CD8 T (TRM) cells contribute to improved protection against reinfection through the generation of immediate effector responses at the site of pathogen entry. Key to the potential of TRM cells to develop rapid recall responses is their location within the epithelia of the skin, lungs and intestines at prime entry sites of pathogens. TRM cells are among the first immune cells to respond to pathogens that have been previously encountered in an antigen-specific manner. Upon recognition of invading pathogens, TRM cells release IFN-γ and other pro-inflammatory cytokines and chemokines. These effector molecules activate the surrounding epithelial tissue and recruit other immune cells including Natural Killer (NK) cells, B cells and circulating memory CD8 T cells to the site of infection. The repertoire of TRM effector functions also includes the direct lysis of infected cells through the release of cytotoxic molecules such as perforin and granzymes. The mechanisms enabling TRM cells to respond in such a rapid manner are gradually being uncovered. In this review, we will address the signals that instruct TRM generation and maintenance as well as the underlying transcriptional network that keeps TRM cells in a deployment-ready modus. Furthermore, we will discuss how TRM cells respond to reinfection of the tissue and how transcription factors may control immediate and proliferative TRM responses.
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Trm cells are non-circulating T cells that form the first line of defence against reinfection in tissues.
“tissue resident memory T cells (Trm) cells are non-circulating T cells that form the first line of defence against reinfection in tissues [281-283].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [282]
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works
Self-citationTissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses
Behr, F. M., Parga-Vidal, L., Kragten, N. A. M., van Dam, T. J. P., Wesselink, T. H., Sheridan, B. S., Arens, R., van Lier, R. A. W., Stark, R., & van Gisbergen, K. P. J. M. (2020) · Nature Immunology · doi:10.1038/s41590-020-0723-4 · Cited by 184 · see citing works
Self-citationBehr, F. M., Beumer‐Chuwonpad, A., Kragten, N. A. M., Wesselink, T. H., Stark, R., & van Gisbergen, K. P. J. M. (2021) · European Journal of Immunology · doi:10.1002/eji.202048737 · Cited by 30 · see citing works
Self-citationTissue-resident and innate-like T cells in patients with advanced chronic liver disease
Ibidapo-Obe, O., & Bruns, T. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100812 · Cited by 25 · see citing works
Maccioni, L., Loriot, A., Dewulf, J., Bommer, G., Horsmans, Y., Lanthier, N., Leclercq, I., Schnabl, B., & Stärkel, P. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17177 · Cited by 23 · see citing works
- Authors
- Behr, F. M., Chuwonpad, A., Stark, R., & van Gisbergen, K. P. J. M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2018-07-30
- Volume
- 9
- Pages
- 1770-1770
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC6090154
- OpenAlex
- W2885490686
- Cited by
- 124
- References
- 147
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 13 · 2023: 23 · 2022: 20 · 2021: 19 · 2020: 24 · 2019: 8
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- ZonMw
- Landsteiner Foundation for Blood Transfusion Research
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- tissue-resident memory T cells, CD8+ T cells, transcriptional regulation, immunological memory, reinfection, interferon-gamma, cytokines and chemokines, cytotoxicity, epithelial barrier function, transcription factors, memory T cell maintenance, recall response
- MeSH terms
- Animals, Cell Differentiation, Gene Expression Regulation, Humans, Immunologic Memory, Lymphocyte Activation, Organ Specificity, Phenotype, Transcription, Genetic, Signal Transduction, Biomarkers, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes
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