The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Precursors of human CD4 + cytotoxic T lymphocytes identified by single-cell transcriptome analysis
Open accessAbstract
Human CD4 + cytotoxic T lymphocytes that play a vital role in antiviral immunity are highly heterogeneous.
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“cells overexpressing genes such as Eomes, Gzmk, and Ctla2a, which are commonly associated with CD8 T cells (denoted cytotoxic) and were previously described in the context of viral infection and cancer as CD4 cytotoxic T cells (32–34).”
From Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes (2019) · cites this paper as [32]
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Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Massively parallel digital transcriptional profiling of single cells
Zheng, G. X. Y., Terry, J. M., Belgrader, P., Ryvkin, P., Bent, Z. W., Wilson, R., Ziraldo, S. B., Wheeler, T. D., McDermott, G. P., Zhu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14049 · Cited by 7,353
Spatial reconstruction of single-cell gene expression data
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055
Full-length RNA-seq from single cells using Smart-seq2
Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137
Finak, G., McDavid, A., Yajima, M., Deng, J., Gersuk, V., Shalek, A. K., Slichter, C. K., Miller, H. W., McElrath, M. J., Prlic, M., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0844-5 · Cited by 3,159
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing
Zheng, C., Zheng, L., Yoo, J.-K., Guo, H., Zhang, Y., Guo, X., Kang, B., Hu, R., Huang, J. Y., Zhang, Q., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.035 · Cited by 2,152
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · cited 1×
“The opposing expression pattern of KLRG1 and IL7R transcripts in clusters 3 and 4 is similar to that observed in memory precursor effector cells (IL-7Rhigh and KLRG1−) described in murine models of resolving acute infections (52, 56).”
ResultTranscriptional control of effector and memory CD8+ T cell differentiation
Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628
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Peng, J., Sun, B.-F., Chen, C.-Y., Zhou, J.-Y., Chen, Y.-S., Chen, H., Liu, L., Huang, D., Jiang, J., Cui, G.-S., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0195-y · Cited by 1,321
Transfer learning enables predictions in network biology
Theodoris, C. V., Xiao, L., Chopra, A., Chaffin, M. D., Al Sayed, Z. R., Hill, M. C., Mantineo, H., Brydon, E. M., Zeng, Z., Liu, X. S., et al. (2023) · Nature · doi:10.1038/s41586-023-06139-9 · Cited by 1,193
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,119
A cell atlas of human thymic development defines T cell repertoire formation
Park, J.-E., Botting, R. A., Conde, C. D., Popescu, D.-M., Lavaert, M., Kunz, D. J., Goh, I., Stephenson, E., Ragazzini, R., Tuck, E. J., et al. (2020) · Science · doi:10.1126/science.aay3224 · Cited by 746
Metadata
- Authors
- Patil, V. S., Madrigal, A., Schmiedel, B. J., Clarke, J., O’Rourke, P., de Silva, A. D., Harris, E., Peters, B., Seumois, G., Weiskopf, D., Sette, A., & Vijayanand, P.
- Affiliations
- La Jolla Institute for Immunology (US)
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
- University of California, Berkeley (US)
- Corresponding author
- Vijayanand, Pandurangan
- ORCID
- Venue
- Science Immunology
- Published
- 2018-01-26
- Volume
- 3
- Issue
- 19
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC5931334
- OpenAlex
- W2783929588
- Cited by
- 262
- References
- 74
- Citations by year
- 2026: 23 · 2025: 26 · 2024: 25 · 2023: 21 · 2022: 37 · 2021: 42 · 2020: 46 · 2019: 24 · 2018: 18
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Funders
- NIH Office of the Director (award317527, U19AI118626, award317529, U19AI118610, award360682, R01HL114093, award360683, R24AI108564)
- William K. Bowes Jr Foundation (award317531)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- cytotoxic CD4+ T cells, T cell differentiation, TCR clonotypes, CD127, single-cell transcriptomics, T cell subsets
- MeSH terms
- Humans, Immunologic Memory, Leukocytes, Mononuclear, Lymphocyte Activation, Receptors, Antigen, T-Cell, T-Lymphocytes, Cytotoxic, CD4-Positive T-Lymphocytes, Gene Expression Profiling, Single-Cell Analysis, Transcriptome
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