Cited by 263T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesSingle-cell and spatial transcriptomics

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Precursors of human CD4 + cytotoxic T lymphocytes identified by single-cell transcriptome analysis

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Patil, Veena S., Madrigal, Ariel, Schmiedel, Benjamin J., Clarke, James, O’Rourke, Patrick, de Silva, Aruna D., Harris, Eva, Peters, Bjoern, Seumois, Gregory, Weiskopf, Daniela, Sette, Alessandro, Vijayanand, Pandurangan·2018·Science Immunology

DOI 10.1126/sciimmunol.aan8664PMC PMC5931334

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Abstract

Human CD4 + cytotoxic T lymphocytes that play a vital role in antiviral immunity are highly heterogeneous.

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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Massively parallel digital transcriptional profiling of single cells
Zheng, G. X. Y., Terry, J. M., Belgrader, P., Ryvkin, P., Bent, Z. W., Wilson, R., Ziraldo, S. B., Wheeler, T. D., McDermott, G. P., Zhu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14049 · Cited by 7,353
Spatial reconstruction of single-cell gene expression data
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055
Full-length RNA-seq from single cells using Smart-seq2
Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
Finak, G., McDavid, A., Yajima, M., Deng, J., Gersuk, V., Shalek, A. K., Slichter, C. K., Miller, H. W., McElrath, M. J., Prlic, M., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0844-5 · Cited by 3,159
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing
Zheng, C., Zheng, L., Yoo, J.-K., Guo, H., Zhang, Y., Guo, X., Kang, B., Hu, R., Huang, J. Y., Zhang, Q., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.035 · Cited by 2,152
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · cited 1×
“The opposing expression pattern of KLRG1 and IL7R transcripts in clusters 3 and 4 is similar to that observed in memory precursor effector cells (IL-7Rhigh and KLRG1−) described in murine models of resolving acute infections (52, 56).”
Result
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Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
Appay, V., Dunbar, P. R., Callan, M. F. C., Klenerman, P., Gillespie, G. M. A., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., et al. (2002) · Nature Medicine · doi:10.1038/nm0402-379 · Cited by 1,556
Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 + T Cells
O’Shea, J. J., & Paul, W. E. (2010) · Science · doi:10.1126/science.1178334 · Cited by 1,401
Bayesian approach to single-cell differential expression analysis
Kharchenko, P. V., Silberstein, L., & Scadden, D. T. (2014) · Nature Methods · doi:10.1038/nmeth.2967 · Cited by 1,348
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,293
Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin
Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., et al. (2003) · Science · doi:10.1126/science.1090148 · Cited by 1,014
Expanding roles for CD4+ T cells in immunity to viruses
Swain, S. L., McKinstry, K. K., & Strutt, T. M. (2012) · Nature reviews. Immunology · doi:10.1038/nri3152 · Cited by 1,011
The who's who of T ‐cell differentiation: Human memory T ‐cell subsets
Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817
Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1
Zhou, X.-Y., Yu, S.-Y., Zhao, D.-M., Harty, J., Badovinac, V., & Xue, H.-H. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.002 · Cited by 689
Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8 + T cells
Weiskopf, D., Angelo, M. A., de Azeredo, E. L., Sidney, J., Greenbaum, J., Fernando, A. N., Broadwater, A. H., Kolla, R. V., Silva, A. D. D., de Silva, A. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305227110 · Cited by 625
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VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires
Shugay, M., Bagaev, D. V., Turchaninova, M. A., Bolotin, D. A., Britanova, O. V., Putintseva, E. V., Pogorelyy, M. V., Nazarov, V. I., Zvyagin, I. V., Kirgizova, V., et al. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004503 · Cited by 608
Single-cell genomics unveils critical regulators of Th17 cell pathogenicity
Gaublomme, J. T., Yosef, N., Lee, Y., Gertner, R. S., Yang, L. V., Wu, C., Pandolfi, P. P., Mak, T., Satija, R., Shalek, A. K., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.009 · Cited by 575
Characterization of CD4+ CTLs Ex Vivo
Appay, V., Zaunders, J. J., Papagno, L., Sutton, J., Jaramillo, A., Waters, A., Easterbrook, P., Grey, P., Smith, D. E., McMichael, A. J., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5954 · Cited by 545
The role of profilin complexes in cell motility and other cellular processes
Witke, W. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.07.003 · Cited by 529
Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer
Ganesan, A.-P., Clarke, J., Wood, O., Garrido-Martin, E. M., Chee, S. J., Mellows, T., Samaniego-Castruita, D., Singh, D., Seumois, G., Alzetani, A., et al. (2017) · Nature Immunology · doi:10.1038/ni.3775 · Cited by 528
Self-citation
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(2016) · doi:10.1038/nmeth.3800 · Cited by 434
Towards error-free profiling of immune repertoires
Shugay, M., Britanova, O. V., Merzlyak, E. M., Turchaninova, M. A., Mamedov, I. Z., Tuganbaev, T., Bolotin, D. A., Staroverov, D. B., Putintseva, E. V., Plevová, K., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2960 · Cited by 428
Emergence of a CD4+CD28− Granzyme B+, Cytomegalovirus-Specific T Cell Subset after Recovery of Primary Cytomegalovirus Infection
van Leeuwen, E. M. M., Remmerswaal, E. B. M., Vossen, M. T. M., Rowshani, A. T., Dillen, P. M. E. W., van Lier, R. A. W., & ten Berge, I. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1834 · Cited by 369
Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
Jeannet, G., Boudousquié, C., Gardiol, N., Kang, J., Huelsken, J., & Held, W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914127107 · Cited by 360
Regulatory T cell memory
Rosenblum, M. D., Way, S. S., & Abbas, A. K. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.1 · Cited by 358
Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)
Voehringer, D., Koschella, M., & Pircher, H. (2002) · Blood · doi:10.1182/blood-2002-02-0657 · Cited by 352
Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation
Takemoto, N., Intlekofer, A. M., Northrup, J. T., Wherry, E. J., & Reiner, S. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7515 · Cited by 339
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Weiskopf, D., Bangs, D. J., Sidney, J., Kolla, R. V., Silva, A. D. D., de Silva, A. M., Crotty, S., Peters, B., & Sette, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505956112 · Cited by 312
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Engel, I., Seumois, G., Chávez, L., Samaniego‐Castruita, D., White, B. M., Chawla, A., Mock, D. C., Vijayanand, P., & Kronenberg, M. (2016) · Nature Immunology · doi:10.1038/ni.3437 · Cited by 304
Self-citation
Functional classification of memory CD8+ T cells by CX3CR1 expression
Böttcher, J. P., Beyer, M., Meissner, F., Abdullah, Z., Sander, J., Höchst, B., Eickhoff, S., Rieckmann, J. C., Russo, C., Bauer, T., et al. (2015) · Nature Communications · doi:10.1038/ncomms9306 · Cited by 292
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Brown, D. M., Lee, S., García-Hernández, M. D. L. L., & Swain, S. L. (2012) · Journal of Virology · doi:10.1128/jvi.07172-11 · Cited by 245
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Swanstrom, J., Plante, J. A., Plante, K. S., Young, E., McGowan, E., Gallichotte, E. N., Widman, D. G., Heise, M. T., de Silva, A. M., & Baric, R. S. (2016) · mBio · doi:10.1128/mbio.01123-16 · Cited by 237
Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms
McKinstry, K. K., Strutt, T. M., Kuang, Y., Brown, D. M., Sell, S., Dutton, R. W., & Swain, S. L. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63689 · Cited by 223
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage
Takeuchi, A., Badr, M. E. S. G., Miyauchi, K., Ishihara, C., Onishi, R. M., Guo, Z., Sasaki, Y., Ike, H., Takumi, A., Tsuji, N. M., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150519 · Cited by 220
Expression of the Interleukin-7 Receptor Alpha Chain (CD127) on Virus-Specific CD8+ T Cells Identifies Functionally and Phenotypically Defined Memory T Cells during Acute Resolving Hepatitis B Virus Infection
Boettler, T., Panther, E., Bengsch, B., Nazarova, N., Spangenberg, H., Blum, H., & Thimme, R. (2006) · Journal of Virology · doi:10.1128/jvi.80.7.3532-3540.2006 · Cited by 207
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Juno, J. A., van Bockel, D., Kent, S. J., Kelleher, A. D., Zaunders, J. J., & Munier, C. M. L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00019 · Cited by 195
Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection
Zaunders, J. J. (2003) · Blood · doi:10.1182/blood-2003-08-2765 · Cited by 187
Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans
Derhovanessian, E., Maier, A. B., Hähnel, K., Beck, R., de Craen, A. J. M., Slagboom, P. E., Westendorp, R. G. J., & Pawelec, G. (2011) · Journal of General Virology · doi:10.1099/vir.0.036004-0 · Cited by 186
Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice
Siegrist, C., Barrios, C. S., Martínez, X., Brandt, C., Berney, M., Córdova, M., Kovařík, J., & Lambert, P. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199812)28:12 · Cited by 184
Expression of Killer Cell Lectin-Like Receptor G1 on Antigen-Specific Human CD8+ T Lymphocytes during Active, Latent, and Resolved Infection and its Relation with CD57
Ibegbu, C., Xu, Y., Harris, W. B., Maggio, D. M., Miller, J. D., & Kourtis, A. P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6088 · Cited by 183
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Lang, K. S., Recher, M., Navarini, A. A., Harris, N. L., Löhning, M., Junt, T., Probst, H. C., Hengartner, H., & Zinkernagel, R. M. (2005) · European Journal of Immunology · doi:10.1002/eji.200425828 · Cited by 176
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Cohen, D. M., Kutscher, B., Chen, H. A., Murphy, D. B., & Craig, S. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600738200 · Cited by 160
Cytotoxic CD4 + T cells in viral hepatitis
Aslan, N., Yurdaydın, C., Wiegand, J., Greten, T. F., Ciner, A., Meyer, M., Heiken, H., Kuhlmann, B., Kaiser, T., Bozkaya, H., et al. (2006) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2006.00723.x · Cited by 153
Coincidence of Actin Filaments and Talin Is Required to Activate Vinculin
Chen, H. A., Choudhury, D. M., & Craig, S. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607324200 · Cited by 151
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Kraus, A., Messer, W. B., Haymore, L. B., & de Silva, A. M. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.00827-07 · Cited by 148
Cutting Edge: Emergence of CD127high Functionally Competent Memory T Cells Is Compromised by High Viral Loads and Inadequate T Cell Help
Fuller, M. J., Hildeman, D. A., Sabbaj, S., Gaddis, D. E., Tebo, A. E., Shang, L., Goepfert, P., & Zajac, A. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.5926 · Cited by 140
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Kanakaratne, N., Wahala, W. M. P. B., Messer, W. B., Tissera, H. A., Shahani, A., Abeysinghe, N., de Silva, A. M., & Gunasekera, M. B. (2009) · Emerging infectious diseases · doi:10.3201/eid1502.080926 · Cited by 138
Lessons from the study of T-cell differentiation in persistent human virus infection
Appay, V., & Rowland‐Jones, S. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2004.02.007 · Cited by 136
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Hidalgo, L. G., Einecke, G., Allanach, K., & Halloran, P. F. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.02128.x · Cited by 106
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Arlehamn, C. S. L., Seumois, G., Gerasimova, A. V., Huang, C. C., Fu, Z., Yue, X., Sette, A., Vijayanand, P., & Peters, B. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401151 · Cited by 104
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Norris, P. J., Moffett, H. F., Yang, O. O., Kaufmann, D., Clark, M. J., Addo, M. M., & Rosenberg, E. S. (2004) · Journal of Virology · doi:10.1128/jvi.78.16.8844-8851.2004 · Cited by 95
Serological diagnosis of dengue by an Elisa inhibition method (EIM)
Fernandez, R., & Vázquez, S. (1990) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02761990000300012 · Cited by 92
Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma
Seumois, G., Zapardiel‐Gonzalo, J., White, B. M., Singh, D. K., Schulten, V. M. J., Dillon, M., Hinz, D., Broide, D. H., Sette, A., Peters, B., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600397 · Cited by 91
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Weiskopf, D., Angelo, M. A., Grifoni, A., O’Rourke, P., Sidney, J., Paul, S., Silva, A. D. D., Phillips, E. J., Mallal, S. A., Premawansa, S., et al. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw309 · Cited by 89
Self-citation
Virus-activated CD8 T cells and lymphokine-activated NK cells express the mast cell function-associated antigen, an inhibitory C-type lectin.
Blaser, C., Kaufmann, M., & Pircher, H. (1998) · PubMed · Cited by 73
The Transcription Factor Hobit Identifies Human Cytotoxic CD4+ T Cells
Oja, A. E., Braga, F. A. V., Remmerswaal, E. B. M., Kragten, N. A. M., Hertoghs, K. M. L., Zuo, J., Moss, P. A. H., van Lier, R. A. W., van Gisbergen, K. P. J. M., & Hombrink, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00325 · Cited by 73
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Cutting Edge: Virus-Activated CD8 T Cells and Lymphokine-Activated NK Cells Express the Mast Cell Function-Associated Antigen, An Inhibitory C-Type Lectin
Blaser, C., Kaufmann, M., & Pircher, H. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6451 · Cited by 71
Differential Regulation of Killer Cell Lectin-Like Receptor G1 Expression on T Cells
Robbins, S. H., Terrizzi, S. C., Sydora, B. C., Mikayama, T., & Brossay, L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.12.5876 · Cited by 70
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Hoppmann, N., Graetz, C., Paterka, M., Poisa-Beiro, L., Larochelle, C., Hasan, M., Lill, C. M., Zipp, F., & Siffrin, V. (2015) · Brain · doi:10.1093/brain/awu408 · Cited by 66
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Eshima, K., Chiba, S., Suzuki, H., Kokubo, K., Kobayashi, H., Iizuka, M., Iwabuchi, K., & Shinohara, N. (2012) · Immunology Letters · doi:10.1016/j.imlet.2012.02.013 · Cited by 66
Sincell : an R/Bioconductor package for statistical assessment of cell-state hierarchies from single-cell RNA-seq
Juliá, M., Telenti, A., & Rausell, A. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv368 · Cited by 57
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Hau-Shien, C., Chang, S., Wang, T., Ko, H.-J., Lin, Y.-C., Lin, K.-T., Chang, K.-M., & Chuang, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030397 · Cited by 55
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Terahara, K., Ishii, H., Nomura, T., Takahashi, N., Takeda, A., Shiino, T., Tsunetsugu‐Yokota, Y., & Matano, T. (2014) · Journal of Virology · doi:10.1128/jvi.02032-14 · Cited by 37
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Theodoris, C. V., Xiao, L., Chopra, A., Chaffin, M. D., Al Sayed, Z. R., Hill, M. C., Mantineo, H., Brydon, E. M., Zeng, Z., Liu, X. S., et al. (2023) · Nature · doi:10.1038/s41586-023-06139-9 · Cited by 1,193
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Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,119
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See all 263

Authors: Patil, V. S., Madrigal, A., Schmiedel, B. J., Clarke, J., O’Rourke, P., de Silva, A. D., Harris, E., Peters, B., Seumois, G., Weiskopf, D., Sette, A., & Vijayanand, P.
Affiliations: La Jolla Institute for Immunology (US)
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
University of California, Berkeley (US)
Corresponding author: Vijayanand, Pandurangan
ORCID: Patil, Veena S.
Madrigal, Ariel
Schmiedel, Benjamin J.
Clarke, James
O’Rourke, Patrick
de Silva, Aruna D.
Harris, Eva
Peters, Bjoern
Seumois, Gregory
Weiskopf, Daniela
Sette, Alessandro
Vijayanand, Pandurangan
Venue: Science Immunology
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2018-01-26
Volume: 3
Issue: 19
ISSN: 2470-9468 (ISSN-L)
DOI: 10.1126/sciimmunol.aan8664
PMC: PMC5931334
OpenAlex: W2783929588
Cited by: 262
References: 74
Citations by year: 2026: 23 · 2025: 26 · 2024: 25 · 2023: 21 · 2022: 37 · 2021: 42 · 2020: 46 · 2019: 24 · 2018: 18
FWCI: 13.96
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Science Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ePrints Soton (University of Southampton) (acceptedVersion)
Funders: NIH Office of the Director (award317527, U19AI118626, award317529, U19AI118610, award360682, R01HL114093, award360683, R24AI108564)
William K. Bowes Jr Foundation (award317531)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
Keywords: cytotoxic CD4+ T cells, T cell differentiation, TCR clonotypes, CD127, single-cell transcriptomics, T cell subsets
MeSH terms: Humans, Immunologic Memory, Leukocytes, Mononuclear, Lymphocyte Activation, Receptors, Antigen, T-Cell, T-Lymphocytes, Cytotoxic, CD4-Positive T-Lymphocytes, Gene Expression Profiling, Single-Cell Analysis, Transcriptome

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Precursors of human CD4 + cytotoxic T lymphocytes identified by single-cell transcriptome analysis

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