The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Structure and function of the immune system in the spleen
Open accessAbstract
The spleen is a multitasking secondary lymphoid organ with specialized cells for initiating immunity to blood-borne targets.
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“Human spleens have a different distribution of T cells within germinal centres compared to mice, with humans lacking a clear bridging outer layer.”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [45]
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“The spleen is a peripheral immune organ where adaptive immunity is initiated [62].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [62]
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“The organization of T and B cell zones in the spleen differs significantly between the two species, potentially impacting immune responses(45, 46).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [45]
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In the citing paper
“LPS levels in circulation correlate strongly with severity of ALD in both patients and animal models (45), while mice treated with a broad-spectrum antibiotic cocktail are resistant to alcohol-induced liver injury (46).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [45]
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Citations
Cites
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049
Structure and function of the spleen
Mebius, R. E., & Kraal, G. (2005) · Nature reviews. Immunology · doi:10.1038/nri1669 · Cited by 2,345
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
Guilliams, M., Ginhoux, F., Jakubzick, C., Naik, S. H., Onai, N., Schraml, B. U., Segura, É., Tussiwand, R., & Yona, S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3712 · Cited by 1,923
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
Dudziak, D., Kamphorst, A. O., Heidkamp, G. F., Buchholz, V. R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H., Park, C. G., et al. (2007) · Science · doi:10.1126/science.1136080 · Cited by 1,454
Six-of-the-best: unique contributions of γδ T cells to immunology
Vantourout, P., & Hayday, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3384 · Cited by 1,232
The multifaceted biology of plasmacytoid dendritic cells
Swiecki, M. K., & Colonna, M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3865 · Cited by 1,194
The Spleen in Local and Systemic Regulation of Immunity
Bronte, V., & Pittet, M. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.010 · Cited by 1,132
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B cell depletion therapies in autoimmune disease: advances and mechanistic insights
Lee, D. S. W., Rojas, O. L., & Gommerman, J. L. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00092-2 · Cited by 684
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371
Antigen Cross-Presentation by Macrophages
Muntjewerff, E. M., Meesters, L. D., & van den Bogaart, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01276 · Cited by 262
Jung, E., Romero, R. J., Yeo, L., Primera, R. J. D., Marin‐Concha, J., Para, R., Lopez, A. M., Pacora, P., Gomez‐Lopez, N., Yoon, B. H., et al. (2020) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2020.101146 · Cited by 264
Liu, C.-H., Yang, M.-H., Zhang, G.-Z., Wang, X.-X., Li, B., Li, M., Woelfer, M., Walter, M., & Wang, L. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01732-5 · Cited by 210
Metadata
- Authors
- Lewis, S. M., Williams, A., & Eisenbarth, S. C.
- Affiliations
- Yale University (US)
- The Jackson Laboratory for Genomic Medicine (US)
- Corresponding author
- Eisenbarth, Stephanie C.
- Venue
- Science Immunology
- Published
- 2019-03-22
- Volume
- 4
- Issue
- 33
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC6495537
- OpenAlex
- W2918621261
- Cited by
- 1,301
- References
- 125
- Citations by year
- 2026: 216 · 2025: 266 · 2024: 250 · 2023: 200 · 2022: 164 · 2021: 120 · 2020: 67 · 2019: 17
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR001863)
- National Institute of Allergy and Infectious Diseases (R21AI135221, R01AI108829)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- spleen, secondary lymphoid organs, adaptive immunity, antigen-presenting cells, T cell response, B cell response, hematopoiesis, red blood cell clearance
- MeSH terms
- Animals, Humans, Lymphocytes, Spleen, Adaptive Immunity
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