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Cited by 48T-cell and B-cell ImmunologySystemic Lupus Erythematosus ResearchLymphoma Diagnosis and Treatment

The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity

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Salzer, Elisabeth, Zoghi, Samaneh, Kiss, Máté G., Kage, Frieda, Rashkova, Christina, Stahnke, Stephanie, Haimel, Matthias, Platzer, René +21 more·2020·Science Immunology
DOI 10.1126/sciimmunol.abc3979PMC PMC7116756
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Abstract

HEM1 deficiency causes heritable autoimmunity and immunodeficiency.

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  • Most HEM1-deficient patients (six out of nine) displayed increased total B cells.

    “Most patients (six out of nine) displayed increased total B cells [8–10].”

    From HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions (2022) · cites this paper as [9]

    In Results, ‘Aberrant B-cell phenotype in HEM1 deficiency’ (page unavailable), the paper reports that patients’ absolute CD19+ B-cell counts were within the age-matched normal range. It reports increases in particular B-cell subsets, not total B cells, and does not report six of nine patients with increased total B cells. (LLM, conf=0.87)

    Checked by a reasoning model — may be wrong.

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  • Other bacterial infections in HEM1-deficient patients have included cellulitis, septic arthritis, and cholecystitis.

    “Other bacterial infections have included cellulitis, septic arthritis, and cholecystitis [8–10].”

    From HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions (2022) · cites this paper as [9]

    The Results section, “Identification of human HEM1 deficiency” (page unavailable), reports recurrent infections and treatment for assumed or proven bacterial infections in a HEM1-deficient patient. It does not identify cellulitis, septic arthritis, or cholecystitis among those infections. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • HEM1-deficient patients may have systemic lupus erythematosus-like disease with positive anti-nuclear antibodies and double-stranded DNA autoantibodies, and associated immune complex glomerulonephritis.

    “Patients may have systemic lupus erythematosus–like disease with positive anti-nuclear antibodies (ANA) and double-stranded (ds) DNA autoantibodies, and associated immune complex glomerulonephritis [8–10].”

    From HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions (2022) · cites this paper as [9]

    In Results (Identification of human HEM1 deficiency; page unavailable), the paper reports that one HEM1-deficient patient had glomerulonephritis, tested positive for anti-dsDNA antibodies, and was diagnosed with SLE. It does not report a positive ANA test or establish that this patient's glomerulonephritis was immune-complex mediated; the explicit immune-complex glomerulonephritis finding in Results concerns Hem1-deficient mice, not patients. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Increased proportions of naïve B cells and B cell subsets associated with autoimmunity (innate-like memory B CD19+CD21loCD38lo and CD19+CD21−) were observed less consistently in HEM1-deficient patients.

    “Increased proportions of naïve B cells and B cell subsets associated with autoimmunity (innate-like memory B CD19+CD21loCD38lo and CD19+CD21−) were observed less consistently [9, 10].”

    From HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions (2022) · cites this paper as [9]

    The Results section, “Aberrant B-cell phenotype in HEM1 deficiency” (page unavailable), reports increased innate-like CD19+CD38loCD21lo memory B cells associated with autoimmunity. It says naïve B-cell proportions were within the age-matched normal range, however, and does not report an increase in CD19+CD21− cells. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Pathogenic variants in NCKAP1L, a hematopoietically restricted gene encoding the HEM1 protein component of the WRC, define a novel disease involving recurrent bacterial and viral infections, autoimmunity, and excessive inflammation (OMIM 141180).

    “Recently, three reports investigating novel mutations in NCKAP1L, a hematopoietically restricted gene encoding the HEM1 protein component of the WAVE regulatory complex (WRC), established how improper actin networks lead to a clinical syndrome involving recurrent bacterial and viral infections and autoimmunity (OMIM 141180) [8–10].”

    From HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions (2022) · cites this paper as [9]

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Research works printed but not linked: 75

  1. [1]Moulding DA Record J Malinova D Thrasher AJ Actin cytoskeletal defects in immunodeficiency Immunol Rev 2013 256 282 99 24117828 PMC3884764
  2. [2]Kahr WHA Pluthero FG Elkadri A Warner N Drobac M Chen CH Lo RW Li L Li R Li Q Thoeni C Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease Nat Commun 2017 8 14816 28368018 PMC5382316
  3. [3]Lanzi G Moratto D Vairo D Masneri S Delmonte O Paganini T Parolini S Tabellini G Mazza C Savoldi G Montin D A novel primary human immunodeficiency due to deficiency in the WASPinteracting protein WIP J Exp Med 2012 209 29 34 22231303 PMC3260865
  4. [4]Suetsugu S Miki H Takenawa T Identification of Two Human WAVE/SCAR Homologues as General Actin Regulatory Molecules Which Associate with the Arp2/3 Complex Biochem Biophys Research Commun 1999 260 296 302 10381382
  5. [5]Campellone KG Welch MD A nucleator arms race: cellular control of actin assembly Nat Rev Mol Cell Biol 2010 11 237 251 20237478 PMC2929822
  6. [7]Litschko C Linkner J Brühmann S Stradal TEB Reinl T Jänsch L Rottner K Faix J Differential functions of WAVE regulatory complex subunits in the regulation of actin-driven processes Eur J Cell Biol 2017 96 715 727 28889942
  7. [8]Chen B Brinkmann K Chen Z Pak CW Liao Y Shi S Henry L Grishin NV Bogdan S Rosen MK The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton Cell 2014 156 195 207 24439376 PMC4059610
  8. [9]Chen Z Borek D Padrick SB Gomez TS Metlagel Z Ismail AM Umetani J Billadeau DD Otwinowski Z Rosen MK Structure and control of the actin regulatory WAVE complex Nature 2010 468 533 538 21107423 PMC3085272
  9. [10]Yan C WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility EMBO J 2003 22 3602 3612 12853475 PMC165620
  10. [12]Mohan AS Dean KM Isogai T Kasitinon SY Murali VS Roudot P Groisman A Reed DK Welf ES Han SJ Noh J Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells Dev Cell 2019 49 444 460.e9 31063759 PMC6760970
  11. [13]Moujaber O Stochaj U The Cytoskeleton as Regulator of Cell Signaling Pathways Trends Biochem Sci 2019 10.1016/j.tibs.2019.11.003 31812462 · DOI · Paper page
  12. [14]Brunner HI Holland M Beresford MW Ardoin SP Appenzeller S Silva CA Flores F Goilav B Wenderfer SE Levy DM Ravelli A the PRCSG and PRINTO Investigators, American College of Rheumatology Provisional Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus Arthritis Care Res 2018 70 813 822 PMC5980747 29693328
  13. [15]Beutler E G6PD deficiency Blood 1994 84 3613 3636 7949118
  14. [16]Özen S Batu ED Demir S Familial Mediterranean Fever: Recent Developments in Pathogenesis and New Recommendations for Management Front Immunol 2017 8 253 28386255 PMC5362626
  15. [17]Exome Aggregation Consortium Lek M Karczewski KJ Minikel EV Samocha KE Banks E Fennell T O’Donnell-Luria AH Ware JS Hill AJ Cummings BB Tukiainen T Analysis of protein-coding genetic variation in 60,706 humans Nature 2016 536 285 291 27535533 PMC5018207
  16. [18]Karczewski KJ Francioli LC Tiao G Cummings BB Alföldi J Wang Q Collins RL Laricchia KM Ganna A Birnbaum DP Gauthier LD Variation across 141,456 human exomes and genomes reveals the spectrum of loss-of-function intolerance across human protein-coding genes Genomics 2019 10.1101/531210 · DOI · Paper page
  17. [19]Steffen A Rottner K Ehinger J Innocenti M Scita G Wehland J Stradal TEB Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation EMBO J 2004 23 749 759 14765121 PMC380996
  18. [21]Dolati S Kage F Mueller J Müsken M Kirchner M Dittmar G Sixt M Rottner K Falcke M On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility Mol Biol Cell 2018 29 2674 2686 30156465 PMC6249830
  19. [22]Dürre K Keber FC Bleicher P Brauns F Cyron CJ Faix J Bausch AR Capping protein-controlled actin polymerization shapes lipid membranes Nat Commun 2018 9 1630 29691404 PMC5915599
  20. [23]Kage F Winterhoff M Dimchev V Mueller J Thalheim T Freise A Brühmann S Kollasser J Block J Dimchev G Geyer M FMNL formins boost lamellipodial force generation Nat Commun 2017 8 14832 28327544 PMC5364437
  21. [24]Schaks M Singh SP Kage F Thomason P Klünemann T Steffen A Blankenfeldt W Stradal TE Insall RH Rottner K Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo Current Biology 2018 28 3674 3684.e6 30393033 PMC6264382
  22. [25]Leithner A Eichner A Müller J Reversat A Brown M Schwarz J Merrin J de Gorter DJJ Schur F Bayerl J de Vries I Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes Nat Cell Biol 2016 18 1253 1259 27775702
  23. [26]Zhu Z Chai Y Jiang Y Li W Hu H Li W Wu J-W Wang Z-X Huang S Ou G Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration Developmental Cell 2016 39 224 238 27780040
  24. [27]Squarr AJ Brinkmann K Chen B Steinbacher T Ebnet K Rosen MK Bogdan S Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation J Cell Biol 2016 212 591 603 26903538 PMC4772498
  25. [28]Lanzavecchia A Sallusto F Antigen decoding by T lymphocytes: from synapses to fate determination Nat Immunol 2001 2 487 492 11376334
  26. [29]Schatorjé EJH Gemen EFA Driessen GJA Leuvenink J van Hout RWNM de Vries E Paediatric Reference Values for the Peripheral T cell Compartment: T Lymphocyte Subsets in Children Scand J Immunol 2012 75 436 444 22420532
  27. [30]Minton K Innate lymphoid cells: Human ILCs face redundancy Nat Rev Immunol 2016 16 596 597 27640625
  28. [31]Bride K Teachey D Autoimmune lymphoproliferative syndrome: more than a FAScinating disease F1000Res 2017 6 1928 29123652 PMC5668920
  29. [32]Schwab C Gabrysch A Olbrich P Patiño V Warnatz K Wolff D Hoshino A Kobayashi M Imai K Takagi M Dybedal I Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects J Allergy Clin Immunol 2018 142 1932 1946 29729943 PMC6215742
  30. [33]Pernis AB Ivashkiv LB ‘-Omics’ shed light on B cells in lupus Nat Immunol 2019 20 946 948 31285628
  31. [34]Sharabi A Tsokos GC T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy Nat Rev Rheumatol 2020 10.1038/s41584-019-0356-x 31949287 · DOI
  32. [35]Piątosa B Wolska-Kuśnierz B Pac M Siewiera K Gałkowska E Bernatowska E B cell subsets in healthy children: Reference values for evaluation of B cell maturation process in peripheral blood Cytometry 2010 78B 372 381 20533385
  33. [36]Lau D Lan LY-L Andrews SF Henry C Rojas KT Neu KE Huang M Huang Y DeKosky B Palm A-KE Ippolito GC Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation Sci Immunol 2017 2 eaai8153 28783670 PMC5896567
  34. [37]Thorarinsdottir K Camponeschi A Gjertsson I Mårtensson I-L CD21low B cells: A Snapshot of a Unique B Cell Subset in Health and Disease Scand J Immunol 2015 82 254 261 26119182
  35. [38]Shao L Chang J Feng W Wang X Williamson EA Li Y Schajnovitz A Scadden D Mortensen LJ Lin CP Li L The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow Nat Commun 2018 9 2377 29915352 PMC6006146
  36. [39]Shikatani EA Besla R Ensan S Upadhye A Khyzha N Li A Emoto T Chiu F Degousee N Moreau JM Perry HM c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells Cell Reports 2019 27 2304 2312.e6 31116977
  37. [40]Teschendorff AE Enver T Single-cell entropy for accurate estimation of differentiation potency from a cell’s transcriptome Nat Commun 2017 8 15599 28569836 PMC5461595
  38. [41]Teschendorff AE Sollich P Kuehn R Signalling entropy: A novel network-theoretical framework for systems analysis and interpretation of functional omic data Methods 2014 67 282 293 24675401
  39. [42]Park H Staehling-Hampton K Appleby MW Brunkow ME Habib T Zhang Y Ramsdell F Liggitt HD Freie B Tsang M Carlson G A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity J Exp Med 2008 205 2899 2913 19015308 PMC2585840
  40. [43]Chen J Trounstine M Alt FW Young F Kurahara C Loring JF Huszar D Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus Int Immunol 1993 5 647 656 8347558
  41. [44]Shen P Roch T Lampropoulou V O’Connor RA Stervbo U Hilgenberg E Ries S Dang VD Jaimes Y Daridon C Li R IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases Nature 2014 507 366 370 24572363 PMC4260166
  42. [46]De Silva NS Klein U Dynamics of B cells in germinal centres Nat Rev Immunol 2015 15 137 148 25656706 PMC4399774
  43. [47]Li J Yin W Jing Y Kang D Yang L Cheng J Yu Z Peng Z Li X Wen Y Sun X The Coordination Between B Cell Receptor Signaling and the Actin Cytoskeleton During B Cell Activation Front Immunol 2019 9 3096 30687315 PMC6333714
  44. [48]Dominguez-Sola D Kung J Holmes AB Wells VA Mo T Basso K Dalla-Favera R The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program Immunity 2015 43 1064 1074 26620759
  45. [49]Dengler HS Baracho GV Omori SA Bruckner S Arden KC Castrillon DH DePinho RA Rickert RC Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation Nat Immunol 2008 9 1388 1398 18978794 PMC2679692
  46. [50]Zhang X Tang N Hadden TJ Rishi AK Akt, FoxO and regulation of apoptosis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2011 1813 1978 1986 21440011
  47. [51]Serwas NK Hoeger B Ardy RC Stulz SV Sui Z Memaran N Meeths M Krolo A Yüce Petronczki Ö Pfajfer L Hou TZ Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis Nat Commun 2019 10 3106 31308374 PMC6629652
  48. [52]Singh A Joshi V Jindal AK Mathew B Rawat A An updated review on activated PI3 kinase delta syndrome (APDS) Genes & Diseases 2020 7 67 74 32181277 PMC7063426
  49. [53]Leavy O Mediators of central tolerance Nat Rev Immunol 2015 15 404 404 26109131
  50. [54]Stoddart A Jackson AP Brodsky FM Plasticity of B Cell Receptor Internalization upon Conditional Depletion of Clathrin MBoC 2005 16 2339 2348 15716350 PMC1087239
  51. [55]Batista FD Iber D Neuberger MS B cells acquire antigen from target cells after synapse formation Nature 2001 411 489 494 11373683
  52. [56]Janssen E Geha RS Primary immunodeficiencies caused by mutations in actin regulatory proteins Immunol Rev 2019 287 121 134 30565251
  53. [57]Kolhatkar NS Brahmandam A Thouvenel CD Becker-Herman S Jacobs HM Schwartz MA Allenspach EJ Khim S Panigrahi AK Luning Prak ET Thrasher AJ Notarangelo LD Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome J Exp Med 2015 212 1663 1677 26371186 PMC4577851
  54. [58]Becker-Herman S Meyer-Bahlburg A Schwartz MA Jackson SW Hudkins KL Liu C Sather BD Khim S Liggitt D Song W Silverman GJ WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity The Journal of Experimental Medicine 2011 208 2033 2042 21875954 PMC3182055
  55. [59]Janssen E Morbach H Ullas S Bannock JM Massad C Menard L Barlan I Lefranc G Su H Dasouki M Al-Herz W Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells Journal of Allergy and Clinical Immunology 2014 134 1365 1374 PMC4261031 25218284
  56. [60]Keppler SJ Gasparrini F Burbage M Aggarwal S Frederico B Geha RS Way M Bruckbauer A Batista FD Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells Immunity 2015 43 660 673 26453379 PMC4622935
  57. [61]Janssen E Tohme M Hedayat M Leick M Kumari S Ramesh N Massaad MJ Ullas S Azcutia V Goodnow CC Randall KL A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton JCI 2016 126 3837 3851 27599296 PMC5096816
  58. [62]Bolger-Munro M Choi K Scurll JM Abraham L Chappell RS Sheen D Dang-Lawson M Wu X Priatel JJ Coombs D Hammer JA Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation eLife 2019 8 e44574 31157616 PMC6591008
  59. [63]Ozen A Comrie WA Ardy RC Dominguez Conde C Dalgic B Beser OF Morawski AR Karakoc-Aydiner E Tutar E Baris S Ozcay F CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis N Engl J Med 2017 377 52 61 28657829 PMC6690356
  60. [64]Salzer E Cagdas D Hons M Mace EM Garncarz W Petronczki OY Platzer R Pfajfer L Bilic I Ban SA Willmann KL RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics Nat Immunol 2016 17 1352 1360 27776107 PMC6400263
  61. [65]Müller H Jimenez-Heredia R Krolo A Hirschmugl T Dmytrus J Boztug K Bock C VCF.Filter: interactive prioritization of disease-linked genetic variants from sequencing data Nucleic Acids Research 2017 45 W567 W572 28520890 PMC5570181
  62. [66]Zheng GXY Terry JM Belgrader P Ryvkin P Bent ZW Wilson R Ziraldo SB Wheeler TD McDermott GP Zhu J Gregory MT Massively parallel digital transcriptional profiling of single cells Nat Commun 2017 8 14049 28091601 PMC5241818
  63. [67]Wolf FA Angerer P Theis FJ SCANPY: large-scale single-cell gene expression data analysis Genome Biol 2018 19 15 29409532 PMC5802054
  64. [68]McInnes L Healy J Melville J UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction arXiv 2018 available at http://arxiv.org/abs/1802.03426 1802.03426 [cs, stat] · arXiv
  65. [69]Traag V Waltman L van Eck NJ From Louvain to Leiden: guaranteeing well-connected communities Sci Rep 2019 9 5233 30914743 PMC6435756
  66. [70]Wolf FA Hamey FK Plass M Solana J Dahlin JS Göttgens B Rajewsky N Simon L Theis FJ PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells Genome Biol 2019 20 59 30890159 PMC6425583
  67. [72]Kolesnikov N Hastings E Keays M Melnichuk O Tang YA Williams E Dylag M Kurbatova N Brandizi M Burdett T Megy K ArrayExpress update—simplifying data submissions Nucleic Acids Research 2015 43 D1113 D1116 25361974 PMC4383899
  68. [73]Schindelin J Arganda-Carreras I Frise E Kaynig V Longair M Pietzsch T Preibisch S Rueden C Saalfeld S Schmid B Tinevez JY Fiji: an open-source platform for biological-image analysis Nat Methods 2012 9 676 82 22743772 PMC3855844
  69. [74]Li AC Binder CJ Gutierrez A Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma J Clin Invest 2004 114 11 1564 1576 15578089 PMC529277
  70. [75]Ran FA Hsu PD Wright J Agarwala V Scott DA Zhang F Genome engineering using the CRISPR-Cas9 system Nat Protoc 2013 8 2281 308 24157548 PMC3969860
  71. [76]Houmadi R Guipouy D Rey-Barroso J Vasconcelos Z Cornet J Manghi M Destainville N Valitutti S Allart S Dupré L The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse Cell Reports 2018 22 979 991 29386139
  72. [77]Fairhead M Krndija D Lowe ED Howarth M Plug-and-play pairing via defined divalent streptavidins J Mol Biol 2014 426 199 214 24056174 PMC4047826
  73. [78]Howarth M Chinnapen DJ Gerrow K Dorrestein PC Grandy MR Kelleher NL El-Husseini A Ting AY A monovalent streptavidin with a single femtomolar biotin binding site Nat Methods 2006 3 267 73 16554831 PMC2576293
  74. [79]Rossboth BK Platzer R Sevcsik E Baumgart F Stockinger H Schütz GJ Huppa JB Brameshuber M Unscrambling Fluorophore Blinking for Comprehensive Cluster Detection via PALM Biophysics 2019 10.1101/545152 PMC7536177 33020470 · DOI
  75. [80]Gudipati V Rydzek J Perez ID Scharf L Königsberger S Einsele H Stockinger H Hudecek M Huppa JB Inefficient ZAP70-Signaling Blunts Antigen Detection by CAR-T-Cells Immunology 2019 10.1101/720417 · DOI

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Authors
Salzer, E., Zoghi, S., Kiss, M. G., Kage, F., Rashkova, C., Stahnke, S., Haimel, M., Platzer, R., Caldera, M., Ardy, R. C., Hoeger, B., Block, J., Medgyesi, D., Sin, C., Shahkarami, S., Kain, R., Ziaee, V., Hammerl, P., Bock, C., Menche, J., Dupré, L., Huppa, J. B., Sixt, M., Lomakin, A., Rottner, K., Binder, C. J., Stradal, T. E. B., Rezaei, N., & Boztug, K.
Affiliations
  • Austrian Academy of Sciences (AT)
  • Helmholtz Centre for Infection Research (DE)
  • Medical University of Vienna (AT)
  • Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
  • Universal Scientific Education and Research Network (IR)
  • Rheumatology Research Center (IR)
  • University of Salzburg (AT)
  • Institute of Science and Technology Austria (AT)
Corresponding author
  • Salzer, Elisabeth
  • Zoghi, Samaneh
  • Kiss, Máté G.
  • Kage, Frieda
  • Rashkova, Christina
  • Stahnke, Stephanie
  • Haimel, Matthias
  • Hammerl, Peter
ORCID
Venue
Science Immunology
Publisher
American Association for the Advancement of Science (AAAS)
Published
2020-07-03
Volume
5
Issue
49
ISSN
2470-9468 (ISSN-L)
DOI
10.1126/sciimmunol.abc3979
PMC
PMC7116756
OpenAlex
W3040732440
Cited by
48
References
3
Citations by year
2026: 1 · 2025: 3 · 2024: 10 · 2023: 5 · 2022: 12 · 2021: 15 · 2020: 2
FWCI
2.92
Type
journal article
Language
en
Open access
Locations
  • Science Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
  • Institute of Science and Technology Austria (submittedVersion, other-oa)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Keywords
B cell development, autoimmunity, B cell receptor signaling, autoreactive B cells, B cell fate, systemic autoimmunity, mouse model
MeSH terms
Animals, Autoimmune Diseases, B-Lymphocytes, Cell Line, Child, Cytoskeleton, Female, Humans, Infant, Membrane Proteins, Mice, Inbred C57BL, T-Lymphocytes, Autoimmunity, Bone Marrow Transplantation, Mice, Knockout

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