Cited by 507Immune cells in cancerPhagocytosis and Immune RegulationImmune responses and vaccinations

Determinants of resident tissue macrophage identity and function

Open access
Blériot, Camille, Chakarov, Svetoslav, Ginhoux, Florent·2020·Immunity

Abstract

Resident tissue macrophages (RTMs) have a broad spectrum of immune- and non-immune-related tissue-supporting activities. The roots of this heterogeneity and versatility are only beginning to be understood. Here, we propose a conceptual framework for considering the RTM heterogeneity that organizes the factors shaping RTM identity within four cardinal points: (1) ontogeny and the view that adult RTM populations comprise a defined mixture of cells that arise from either embryonic precursors or adult monocytes; (2) local factors unique to the niche of residence, evolving during development and aging; (3) inflammation status; and (4) the cumulative effect of time spent in a specific tissue that contributes to the resilient adaptation of macrophages to their dynamic environment. We review recent findings within this context and discuss the technological advances that are revolutionizing the study of macrophage biology.

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Crossref · 10.1016/j.immuni.2020.05.014

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159 of 159 references verified0 citation errors · 0 not checkable

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  • In other mouse tissues, including brain, lung, and epidermis, macrophages are exclusively derived from embryonic precursors.

    “However, other mouse studies have observed that in other tissues, such as in the brain, lung and epidermis, macrophages are exclusively embryonically derived (36).”

    From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [36]

  • Macrophage heterogeneity within specific tissues is greater than previously recognised.

    “Furthermore, we have to acknowledge that macrophage heterogeneity, even within specific tissues, is greater than previously appreciated (36).”

    From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [36]

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Authors
Blériot, C., Chakarov, S., & Ginhoux, F.
Affiliations
Agency for Science, Technology and Research (SG)
Corresponding author
Ginhoux, Florent
Venue
Immunity
Publisher
Elsevier BV
Published
2020-06
Volume
52
Issue
6
Pages
957-970
ISSN
1074-7613 (ISSN-L)
OpenAlex
W3036265910
Cited by
507
References
159
Citations by year
2026: 73 · 2025: 73 · 2024: 91 · 2023: 106 · 2022: 97 · 2021: 51 · 2020: 16
FWCI
6.59
Type
journal article
Language
en
Open access
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
macrophage heterogeneity, macrophage identity, macrophage ontogeny, tissue niche, aging, inflammation, macrophage function
MeSH terms
Cell Plasticity, Animals, Disease Susceptibility, Humans, Inflammation, Macrophage Activation, Macrophages, Monocytes, Organ Specificity, Phenotype, Biomarkers, Cellular Microenvironment

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