Determinants of resident tissue macrophage identity and function
Open accessAbstract
Resident tissue macrophages (RTMs) have a broad spectrum of immune- and non-immune-related tissue-supporting activities. The roots of this heterogeneity and versatility are only beginning to be understood. Here, we propose a conceptual framework for considering the RTM heterogeneity that organizes the factors shaping RTM identity within four cardinal points: (1) ontogeny and the view that adult RTM populations comprise a defined mixture of cells that arise from either embryonic precursors or adult monocytes; (2) local factors unique to the niche of residence, evolving during development and aging; (3) inflammation status; and (4) the cumulative effect of time spent in a specific tissue that contributes to the resilient adaptation of macrophages to their dynamic environment. We review recent findings within this context and discuss the technological advances that are revolutionizing the study of macrophage biology.
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In other mouse tissues, including brain, lung, and epidermis, macrophages are exclusively derived from embryonic precursors.
“However, other mouse studies have observed that in other tissues, such as in the brain, lung and epidermis, macrophages are exclusively embryonically derived (36).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [36]
Macrophage heterogeneity within specific tissues is greater than previously recognised.
“Furthermore, we have to acknowledge that macrophage heterogeneity, even within specific tissues, is greater than previously appreciated (36).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [36]
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Determinants, mechanisms, and functional outcomes of myeloid cell diversity in cancer
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- Authors
- Blériot, C., Chakarov, S., & Ginhoux, F.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Corresponding author
- Ginhoux, Florent
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 52
- Issue
- 6
- Pages
- 957-970
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W3036265910
- Cited by
- 507
- References
- 159
- Citations by year
- 2026: 73 · 2025: 73 · 2024: 91 · 2023: 106 · 2022: 97 · 2021: 51 · 2020: 16
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- macrophage heterogeneity, macrophage identity, macrophage ontogeny, tissue niche, aging, inflammation, macrophage function
- MeSH terms
- Cell Plasticity, Animals, Disease Susceptibility, Humans, Inflammation, Macrophage Activation, Macrophages, Monocytes, Organ Specificity, Phenotype, Biomarkers, Cellular Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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