SUMOylation of the Transcriptional Co-Repressor KAP1 Is Regulated by the Serine and Threonine Phosphatase PP1
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Two isoforms of protein phosphatase 1 coordinate the recovery of cells from genotoxic stress.
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- Authors
- Li, X., Lin, H. H., Chen, H., Xu, X., Shih, H.-M., & Ann, D. K.
- Affiliations
- University of Southern California (US)
- City Of Hope National Medical Center (US)
- Capital Normal University (CN)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- Corresponding author
- Ann, David K.
- Venue
- Science Signaling
- Published
- 2010-04-27
- Volume
- 3
- Issue
- 119
- Pages
- ra32-ra32
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC3302164
- OpenAlex
- W2160256607
- Cited by
- 59
- References
- 52
- Citations by year
- 2026: 3 · 2025: 3 · 2023: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 6 · 2012: 6
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P30CA033572)
- National Institute of Dental and Craniofacial Research (R01 DE 10742, R01DE010742, R01DE014183, R01-DE-14183)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- KAP1, SUMOylation, protein phosphatase 1, PP1α, ATM, DNA double-strand breaks, genotoxic stress, corepressors, dephosphorylation, transcriptional regulation
- MeSH terms
- Tripartite Motif-Containing Protein 28, Binding Sites, Cell Cycle, DNA Damage, Humans, Kinetics, Phosphoprotein Phosphatases, Phosphorylation, Promoter Regions, Genetic, Repressor Proteins, Small Ubiquitin-Related Modifier Proteins, Cell Line, Tumor, Immunoprecipitation, Gene Knockdown Techniques
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