Organelle-specific initiation of cell death

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Mitochondrial membrane permeabilization in cell death

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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Apoptosis: controlled demolition at the cellular level

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Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

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Mitochondria and cell death: outer membrane permeabilization and beyond

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

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p53 Has a Direct Apoptogenic Role at the Mitochondria

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Regulated necrosis: the expanding network of non-apoptotic cell death pathways

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

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Organelle-specific initiation of cell death pathways

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ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

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A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

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Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

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BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for Apoptosis

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DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis

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TNF-α Induces Two Distinct Caspase-8 Activation Pathways

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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsPreprint

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

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PARP inhibition: PARP1 and beyond

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Mechanism of Toxicity in Rotenone Models of Parkinson's Disease

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JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

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The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

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A role for ATR in the DNA damage-induced phosphorylation of p53

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A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

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Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

Nargund, A. M., Pellegrino, M., Fiorese, C. J., Baker, B. M., & Haynes, C. M. (2012) · Science · doi:10.1126/science.1223560 · Cited by 1,027 · see citing works

Many cuts to ruin: a comprehensive update of caspase substrates

Fischer, U., Jänicke, R. U., & Schulze‐Osthoff, K. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401160 · Cited by 1,025 · see citing works

Endoplasmic reticulum-mitochondria contacts: Function of the junction

Rowland, A. A., & Voeltz, G. K. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3440 · Cited by 1,018 · see citing works

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

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Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

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PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

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Mitotic catastrophe: a mechanism for avoiding genomic instability

Vitale, I., Galluzzi, L., Castedo, M., & Kroemer, G. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3115 · Cited by 834 · see citing works

CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells

Yamaguchi, H., & Wang, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406933200 · Cited by 825 · see citing works

Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis

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Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

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p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

Vaseva, A. V., Marchenko, N. D., Ji, K., Tsirka, S. E., Holzmann, S., & Moll, U. M. (2012) · Cell · doi:10.1016/j.cell.2012.05.014 · Cited by 740 · see citing works

Mitochondria: master regulators of danger signalling

Galluzzi, L., Kepp, O., & Kroemer, G. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3479 · Cited by 733 · see citing works

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

Lassus, P., Opitz-Araya, X., & Lazebnik, Y. A. (2002) · Science · doi:10.1126/science.1074721 · Cited by 719 · see citing works

G protein-coupled receptors: novel targets for drug discovery in cancer

Lappano, R., & Maggiolini, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3320 · Cited by 717 · see citing works

Lysosomal cell death at a glance

Aits, S., & Jäättelä, M. (2013) · Journal of Cell Science · doi:10.1242/jcs.091181 · Cited by 667 · see citing works

The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

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Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis

Puthalakath, H., Villunger, A., O'Reilly, L. A., Beaumont, J. G., Coultas, L., Cheney, R. E., Huang, D. C. S., & Strasser, A. (2001) · Science · doi:10.1126/science.1062257 · Cited by 656 · see citing works

IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

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Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

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The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance

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Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

Jin, Z., Li, Y., Pitti, R. M., Lawrence, D. A., Pham, V. C., Lill, J. R., & Ashkenazi, A. (2009) · Cell · doi:10.1016/j.cell.2009.03.015 · Cited by 588 · see citing works

Cell death assays for drug discovery

Kepp, O., Galluzzi, L., Lipinski, M. M., Yuan, J., & Kroemer, G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3373 · Cited by 556 · see citing works

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

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Organization of the ER–Golgi interface for membrane traffic control

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Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

Kirkegaard, T., Roth, A. G., Petersen, N. H. T., Mahalka, A. K., Olsen, O. D., Moilanen, I., Zylicz, A., Knudsen, J., Sandhoff, K., Arenz, C., et al. (2010) · Nature · doi:10.1038/nature08710 · Cited by 519 · see citing works

The mitochondrial UPR – protecting organelle protein homeostasis

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Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion

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XIAP discriminates between type I and type II FAS-induced apoptosis

Jost, P. J., Grabow, S., Gray, D., McKenzie, M. D., Nachbur, U., Huang, D. C. S., Bouillet, P., Thomas, H. E., Borner, C., Silke, J., et al. (2009) · Nature · doi:10.1038/nature08229 · Cited by 482 · see citing works

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

Petrasek, J., Iracheta‐Vellve, A., Csák, T., Satishchandran, A., Kodys, K., Kurt‐Jones, E. A., Fitzgerald, K. A., & Szabó, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308331110 · Cited by 452 · see citing works

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon–independent apoptosis in human melanoma cells

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Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival

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Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis

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PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

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Mitochondrial membrane permeabilization in neuronal injury

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Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

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Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

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CD95 promotes tumour growth

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p53 is associated with cellular microtubules and is transported to the nucleus by dynein

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Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

Young, M. M., Takahashi, Y., Khan, O. A., Park, S., Hori, T., Yun, J. K., Sharma, A. K., Amin, S., Hu, C., Zhang, J., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.309104 · Cited by 372 · see citing works

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

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Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

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BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

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The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

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Mitochondrial translocation of cofilin is an early step in apoptosis induction

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Stat3 controls lysosomal-mediated cell death in vivo

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Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

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Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis

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Regulation of TNFR1 and CD95 signalling by receptor compartmentalization

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Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3

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The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis

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Mediation of Neuronal Apoptosis by Kv2.1-Encoded Potassium Channels

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Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

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Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin

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Crosstalk between ER stress and immunogenic cell death

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Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis

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Vincristine Induces Dramatic Lysosomal Changes and Sensitizes Cancer Cells to Lysosome-Destabilizing Siramesine

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