Cited by 183Axon Guidance and Neuronal SignalingNerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

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Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

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Deinhardt, Katrin, Kim, Taeho, Spellman, Daniel S., Mains, Richard E., Eipper, Betty A., Neubert, Thomas A., Chao, Moses V., Hempstead, Barbara L.·2011·Science Signaling

DOI 10.1126/scisignal.2002060PMC PMC3360552

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Whereas NGF promotes neurite outgrowth, the precursor form proNGF triggers neurite retraction.

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Authors: Deinhardt, K., Kim, T., Spellman, D. S., Mains, R. E., Eipper, B. A., Neubert, T. A., Chao, M. V., & Hempstead, B. L.
Affiliations: New York University (US)
Weill Cornell Medicine (US)
UConn Health (US)
Corresponding author: Kim, Taeho
Hempstead, Barbara L.
ORCID: Deinhardt, Katrin
Kim, Taeho
Spellman, Daniel S.
Mains, Richard E.
Eipper, Betty A.
Neubert, Thomas A.
Chao, Moses V.
Hempstead, Barbara L.
Venue: Science Signaling
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2011-12-06
Volume: 4
Issue: 202
Pages: ra82-ra82
ISSN: 1937-9145 (ISSN-L)
1945-0877
DOI: 10.1126/scisignal.2002060
PMC: PMC3360552
OpenAlex: W2046114399
Cited by: 183
References: 42
Citations by year: 2026: 6 · 2025: 10 · 2024: 7 · 2023: 28 · 2022: 13 · 2021: 9 · 2020: 15 · 2019: 16 · 2018: 7 · 2017: 11 · 2016: 14 · 2015: 11 · 2014: 20 · 2013: 7 · 2012: 9
FWCI: 4.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Signaling (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ePrints Soton (University of Southampton) (acceptedVersion)
Funders: National Institutes of Health (1s10rr017990-01)
National Institute on Drug Abuse (R01DA015464, DA-15464)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-32948, R01DK032948, R56DK032948)
National Institute of Neurological Disorders and Stroke (R01NS021072, R01NS064114, NS30687, NS-21072, R01NS030687, NS050276, P30NS050276, R56NS021072, NS64114)
National Center for Research Resources (RR017990)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-23315, P01HD023315)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: proNGF, p75 neurotrophin receptor, SorCS2, sortilin, trios, Rac, fascin, actin dynamics, neuronal morphology, hippocampal neurons, axon guidance
MeSH terms: Actins, Animals, Carrier Proteins, Cell Line, Cells, Cultured, Humans, Microfilament Proteins, Models, Neurological, Nerve Tissue Proteins, Receptors, Cell Surface, Signal Transduction, Growth Cones, Guanine Nucleotide Exchange Factors, rac GTP-Binding Proteins, Receptor, Nerve Growth Factor, Mice, Rats

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