The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac
Open accessAbstract
Whereas NGF promotes neurite outgrowth, the precursor form proNGF triggers neurite retraction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Pro-BDNF binding to p75NTR has also been shown to induce pruning of axons and dendrites85,88–91 and promote long-term depression (LTD)92–94.”
From Neuronal plasticity and neurotrophic factors in drug responses (2017) · cites this paper as [90]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lifeact: a versatile marker to visualize F-actin
Riedl, J., Crevenna, A. H., Kessenbrock, K., Yu, J. H., Neukirchen, D., Bista, M., Bradke, F., Jenne, D., Holak, T. A., Werb, Z., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1220 · Cited by 2,189
Regulation of Cell Survival by Secreted Proneurotrophins
Lee, R., Kermani, P., Teng, K. K., & Hempstead, B. L. (2001) · Science · doi:10.1126/science.1065057 · Cited by 1,670
Self-citationFunctions of the neurotrophins during nervous system development: What the knockouts are teaching us
Snider, W. D. (1994) · Cell · doi:10.1016/0092-8674(94)90048-5 · Cited by 1,421
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTRand Sortilin
Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-04.2005 · Cited by 1,013
Self-citationSortilin is essential for proNGF-induced neuronal cell death
Nykjaer, A., Lee, R., Teng, K. K., Jansen, P., Madsen, P., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., et al. (2004) · Nature · doi:10.1038/nature02319 · Cited by 962
Self-citationNeurotrophins regulate dendritic growth in developing visual cortex
McAllister, A. K., Lo, D. C., & Katz, L. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90171-x · Cited by 959
AXON RETRACTION AND DEGENERATION IN DEVELOPMENT AND DISEASE
Luo, L., & O’Leary, D. D. M. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135632 · Cited by 859
Brain‐derived neurotrophic factor and the development of structural neuronal connectivity
Cohen‐Cory, S., Kidane, A. H., Shirkey, N. J., & Marshak, S. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20774 · Cited by 611
Neuronal Chemotaxis: Chick Dorsal-Root Axons Turn Toward High Concentrations of Nerve Growth Factor
Gundersen, R. W., & Barrett, J. N. (1979) · Science · doi:10.1126/science.493992 · Cited by 520
Role of fascin in filopodial protrusion
Vignjevic, D. M., Kojima, S.-I., Aratyn-Schaus, Y., Danciu, O. C., Svitkina, T., & Borisy, G. G. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200603013 · Cited by 485
Debant, A., Serra‐Pages, C., Seipel, K., O'Brien, S., Tang, M. H. Y., Park, S. H., & Streuli, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5466 · Cited by 467
Shutes, A., Onesto, C., Picard, V., Leblond, B., Schweighoffer, F., & Der, C. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703571200 · Cited by 336
Migrastatin analogues target fascin to block tumour metastasis
Chen, L., Yang, S., Jakoncic, J., Zhang, J. J., & Huang, X.-Y. (2010) · Nature · doi:10.1038/nature08978 · Cited by 270
Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury
Harrington, A. W., Leiner, B., Blechschmitt, C., Arevalo, J. C., Lee, R., Mörl, K., Meyer, M., Hempstead, B. L., Yoon, S. O., & Giehl, K. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305755101 · Cited by 269
Self-citationRegulating actin dynamics in neuronal growth cones by ADF/cofilin and Rho family GTPases
Kuhn, T. B., Meberg, P. J., Brown, M. D., Bernstein, B. W., Minamide, L. S., Jensen, J. R., Okada, K., Soda, E. A., & Bamburg, J. R. (2000) · Journal of Neurobiology · doi:10.1002/1097-4695(200008)44:2 · Cited by 189
Ono, S., Yamakita, Y., Yamashiro, S., Matsudaira, P. T., Gnarra, J. R., Obinata, T., & Matsumura, F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.4.2527 · Cited by 185
Domeniconi, M., Zampieri, N., Spencer, T., Hilaire, M., Mellado, W., Chao, M. V., & Filbin, M. T. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.029 · Cited by 180
Self-citationAssay of Cdc42, Rac, and Rho GTPase Activation by Affinity Methods
Planat‐Benard, V., & Bokoch, G. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)45028-8 · Cited by 173
Suter, U., Heymach, J. V., & Shooter, E. M. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07778.x · Cited by 162
Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning
Xu, N., & Henkemeyer, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2254 · Cited by 158
Estrach, S., Schmidt, S., Diriong, S., Penna, A., Blangy, A., Fort, P., & Debant, A. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00658-9 · Cited by 152
Trio Mediates Netrin-1-Induced Rac1 Activation in Axon Outgrowth and Guidance
Briançon‐Marjollet, A., Ghogha, A., Nawabi, H., Triki, I., Auziol, C., Fromont, S., Piché, C., Enslen, H., Chébli, K., Cloutier, J., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00998-07 · Cited by 152
Volosin, M., Trotter, C., Cragnolini, A., Kenchappa, R. S., Light, M., Hempstead, B. L., Carter, B. D., & Friedman, W. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2841-08.2008 · Cited by 149
Self-citationNeurotrophin receptors: Old friends with new partners
Schecterson, L. C., & Bothwell, M. A. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20767 · Cited by 132
Chattopadhyay, M., Mata, M. M., & Fink, D. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5530-07.2008 · Cited by 126
Huber, L. J., & Chao, M. V. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1019 · Cited by 117
Self-citationNeurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin
Shonukan, T., Bagayogo, I., McCrea, P., Chao, M. V., & Hempstead, B. L. (2003) · Oncogene · doi:10.1038/sj.onc.1206561 · Cited by 107
Self-citationA Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway
Bouquier, N., Vignal, E., Charrasse, S., Weill, M., Schmidt, S., Léonetti, J., Blangy, A., & Fort, P. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.04.012 · Cited by 106
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
Feng, D., Kim, T., Özkan, E., Light, M. P., Torkin, R., Teng, K. K., Hempstead, B. L., & García, K. C. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.12.030 · Cited by 106
Self-citationKantor, D. B., & Kolodkin, A. L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00364-7 · Cited by 80
Analysis of G-protein-coupled receptor dimerization following chemokine signaling
Mellado, M., Martínez‐A, C., & Rodrı́guez-Frade, J. M. (2002) · Methods · doi:10.1016/s1046-2023(02)00093-2 · Cited by 67
Seipel, K., Medley, Q. G., Kedersha, N., Zhang, X. A., O’Brien, S. P., Serra‐Pages, C., Hemler, M. E., & Streuli, M. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.12.1825 · Cited by 67
Kidins220/ARMS regulates Rac1-dependent neurite outgrowth by direct interaction with the RhoGEF Trio
Neubrand, V. E., Thomas, C., Schmidt, S., Debant, A., & Schiavo, G. (2010) · Journal of Cell Science · doi:10.1242/jcs.064055 · Cited by 64
Multiple novel isoforms of Trio are expressed in the developing rat brain
McPherson, C. E., Eipper, B. A., & Mains, R. E. (2005) · Gene · doi:10.1016/j.gene.2004.12.028 · Cited by 60
Self-citationKim, T., & Hempstead, B. L. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.118 · Cited by 59
Self-citationFerraro, F., Ma, X., Sobota, J. A., Eipper, B. A., & Mains, R. E. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0503 · Cited by 49
Self-citationSong, J. K., & Giniger, E. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22525 · Cited by 39
Naska, S., Lin, D. C. C., Miller, F. D., & Kaplan, D. R. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.05.015 · Cited by 36
Kichev, A., Ilieva, E. V., Piñol‐Ripoll, G., Podlesniy, P., Ferrer, I., Portero‐Otín, M., Pamplona, R., & Espinet, C. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090018 · Cited by 30
Axon Pruning in the Developing Vertebrate Hippocampus
Faulkner, R. L., Low, L. K., & Cheng, H.-J. (2006) · Developmental Neuroscience · doi:10.1159/000096207 · Cited by 29
Rossol, M., Quandt, D., & Hauschildt, S. (2001) · Cell Motility and the Cytoskeleton · doi:10.1002/1097-0169(200102)48:2 · Cited by 14
da Costa, S. R., Wang, Y., Vilalta, P. M., Schönthal, A. H., & Hamm‐Alvarez, S. F. (2000) · Cell Motility and the Cytoskeleton · doi:10.1002/1097-0169(200012)47:4 · Cited by 11
Cited by
Sorted by citations
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7260130 · Cited by 480
The Role of BDNF on Neural Plasticity in Depression
Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., & Liu, H. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00082 · Cited by 435
BDNF and Hippocampal Synaptic Plasticity
Leal, G., Bramham, C. R., & Duarte, C. B. (2017) · Vitamins and Hormones · doi:10.1016/bs.vh.2016.10.004 · Cited by 425
Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
Castrén, E., & Kojima, M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.010 · Cited by 337
Yang, J., Harte‐Hargrove, L. C., Siao, C.-J., Marinic, T. E., Clarke, R., Ma, Q., Jing, D., LaFrancois, J. J., Bath, K. G., Mark, W. H., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.040 · Cited by 333
Self-citation
Metadata
- Authors
- Deinhardt, K., Kim, T., Spellman, D. S., Mains, R. E., Eipper, B. A., Neubert, T. A., Chao, M. V., & Hempstead, B. L.
- Affiliations
- New York University (US)
- Weill Cornell Medicine (US)
- UConn Health (US)
- Corresponding author
- Kim, Taeho
- Hempstead, Barbara L.
- ORCID
- Venue
- Science Signaling
- Published
- 2011-12-06
- Volume
- 4
- Issue
- 202
- Pages
- ra82-ra82
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC3360552
- OpenAlex
- W2046114399
- Cited by
- 183
- References
- 42
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 7 · 2023: 28 · 2022: 13 · 2021: 9 · 2020: 15 · 2019: 16 · 2018: 7 · 2017: 11 · 2016: 14 · 2015: 11 · 2014: 20 · 2013: 7 · 2012: 9
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Funders
- National Institutes of Health (1s10rr017990-01)
- National Institute on Drug Abuse (R01DA015464, DA-15464)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-32948, R01DK032948, R56DK032948)
- National Institute of Neurological Disorders and Stroke (R01NS021072, R01NS064114, NS30687, NS-21072, R01NS030687, NS050276, P30NS050276, R56NS021072, NS64114)
- National Center for Research Resources (RR017990)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-23315, P01HD023315)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- proNGF, p75 neurotrophin receptor, SorCS2, sortilin, trios, Rac, fascin, actin dynamics, neuronal morphology, hippocampal neurons, axon guidance
- MeSH terms
- Actins, Animals, Carrier Proteins, Cell Line, Cells, Cultured, Humans, Microfilament Proteins, Models, Neurological, Nerve Tissue Proteins, Receptors, Cell Surface, Signal Transduction, Growth Cones, Guanine Nucleotide Exchange Factors, rac GTP-Binding Proteins, Receptor, Nerve Growth Factor, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review