Hempstead, Barbara L.

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

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Regulation of Cell Survival by Secreted Proneurotrophins

Lee, R., Kermani, P., Teng, K. K., & Hempstead, B. L. (2001) · Science

Nerve injury and regenerationCell death mechanisms and regulation

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The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor

Kaplan, D. R., Hempstead, B. L., Martin-Zanca, D., Chao, M. V., & Parada, L. F. (1991) · Science

Nerve injury and regenerationHereditary Neurological Disorders

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Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science

Neurotransmitter Receptor Influence on BehaviorNerve injury and regeneration

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Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W.-H., Hempstead, B. L., & Lu, B. (2004) · Science

Neuroscience and Neuropharmacology ResearchNerve injury and regeneration

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ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTRand Sortilin

Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience

Nerve injury and regenerationCell death mechanisms and regulation

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Sortilin is essential for proNGF-induced neuronal cell death

Nykjaer, A., Lee, R., Teng, K. K., Jansen, P., Madsen, P., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., et al. (2004) · Nature

Nerve injury and regenerationCell death mechanisms and regulation

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In vitro microvessels for the study of angiogenesis and thrombosis

Zheng, Y., Chen, J., Craven, M., Choi, N. W., Totorica, S., Diaz-Santana, A., Kermani, P., Hempstead, B., Fischbach-Teschl, C., López, J. A., et al. (2012) · Proceedings of the National Academy of Sciences

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

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Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

Chen, Z.-Y., Patel, P. D., Sant, G., Meng, C.-X., Teng, K. K., Hempstead, B. L., & Lee, F. S. (2004) · The Journal of Neuroscience

Nerve injury and regenerationCellular transport and secretion

Cited by 874

p75 and Trk: A two-receptor system

Chao, M. V., & Hempstead, B. L. (1995) · Trends in Neurosciences

Nerve injury and regenerationNuclear Receptors and Signaling

Cited by 857

Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience

Neuroscience and Neuropharmacology ResearchNerve injury and regeneration

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New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

Greenberg, M. E., Xu, B., Lu, B., & Hempstead, B. L. (2009) · The Journal of Neuroscience

Nerve injury and regenerationNeuroscience and Neuropharmacology Research

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Neuronal release of proBDNF

Yang, J., Siao, C.-J., Nagappan, G., Marinic, T., Jing, D., McGrath, K., Chen, Z.-Y., Mark, W., Tessarollo, L., Lee, F. S., et al. (2009) · Nature Neuroscience

Nerve injury and regenerationNeuroscience and Neuropharmacology Research

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Autocrine BDNF-TrkB signalling within a single dendritic spine

Harward, S. C., Hedrick, N. G., Hall, C. E., Parra-Bueno, P., Milner, T. A., Pan, E., Laviv, T., Hempstead, B. L., Yasuda, R., & McNamara, J. O. (2016) · Nature

Neuroscience and Neuropharmacology ResearchNerve injury and regeneration

Cited by 325

The many faces of p75NTR

Hempstead, B. (2002) · Current Opinion in Neurobiology

Nerve injury and regenerationCell death mechanisms and regulation

Cited by 321

Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury

Harrington, A. W., Leiner, B., Blechschmitt, C., Arevalo, J. C., Lee, R., Mörl, K., Meyer, M., Hempstead, B. L., Yoon, S. O., & Giehl, K. M. (2004) · Proceedings of the National Academy of Sciences

Nerve injury and regenerationCell death mechanisms and regulation

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Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

Anastasia, A., Deinhardt, K., Chao, M. V., Will, N. E., Irmady, K., Lee, F. S., Hempstead, B. L., & Bracken, C. (2013) · Nature Communications

Nerve injury and regenerationAxon Guidance and Neuronal Signaling

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Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses

Je, H. S., Yang, F., Ji, Y., Nagappan, G., Hempstead, B. L., & Lu, B. (2012) · Proceedings of the National Academy of Sciences

Nerve injury and regenerationAxon Guidance and Neuronal Signaling

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Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

Deinhardt, K., Kim, T., Spellman, D. S., Mains, R. E., Eipper, B. A., Neubert, T. A., Chao, M. V., & Hempstead, B. L. (2011) · Science Signaling

Axon Guidance and Neuronal SignalingNerve injury and regeneration

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Induction of Proneurotrophins and Activation of p75NTR-Mediated Apoptosis via Neurotrophin Receptor-Interacting Factor in Hippocampal Neurons after Seizures

Volosin, M., Trotter, C., Cragnolini, A., Kenchappa, R. S., Light, M., Hempstead, B. L., Carter, B. D., & Friedman, W. J. (2008) · The Journal of Neuroscience

Nerve injury and regenerationEpilepsy research and treatment

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Pro-BDNF–induced synaptic depression and retraction at developing neuromuscular synapses

Yang, F., Je, H.-S., Ji, Y., Nagappan, G., Hempstead, B., & Lu, B. (2009) · Journal of Cell Biology

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Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development

Casey, B. J., Glatt, C. E., Tottenham, N., Soliman, F., Bath, K., Amso, D., Altemus, M., Pattwell, S., Jones, R., Levita, L., et al. (2009) · Neuroscience

Neurotransmitter Receptor Influence on BehaviorGenetics and Neurodevelopmental Disorders

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ProBDNF and Mature BDNF as Punishment and Reward Signals for Synapse Elimination at Mouse Neuromuscular Junctions

Je, H. S., Yang, F., Ji, Y., Potluri, S., Fu, X.-Q., Luo, Z.-G., Nagappan, G., Chan, J. P., Hempstead, B., Son, Y.-J., et al. (2013) · Journal of Neuroscience

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Impact of Genetic Variant BDNF (Val66Met) on Brain Structure and Function

Chen, Z., Bath, K., McEwen, B., Hempstead, B., & Lee, F. (2008) · Novartis Foundation Symposia

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