Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

Vadas, Oscar, Burke, John E., Zhang, Xuxiao, Berndt, Alex, Williams, Roger L.·2011·Science Signaling

Cited by (299)

Items 201–299 of 299

  1. Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity
    Meredith J. Layton, Mirette Saad, Nicole L Church, Richard B. Pearson, Christina Anne Mitchell, Wayne Allen Phillips · 2012 · BMC Biochemistry
  2. Better understanding of phosphoinositide 3-kinase (PI3K) pathways in vasculature: Towards precision therapy targeting angiogenesis and tumor blood supply
    D Tsvetkov, Aliaksei Shymanets, Yü Huang, Kirsten Bucher, Roland P. Piekorz, Emilio Hirsch, Sandra Beer‐Hammer, Christian Harteneck, Maik Gollasch, Bernd Nürnberg · 2016 · Biochemistry (Moscow)
  3. Phosphoinositide 3 Kinase γ Plays a Critical Role in Acute Kidney Injury
    Xiaogao Jin, Qinjun Chu, Liwei Sun, Melanie Tran, Yanlin Wang · 2022 · Cells
  4. Insights into the pathological mechanisms of p85α mutations using a yeast-based phosphatidylinositol 3-kinase model
    María D. Oliver, Teresa Fernández‐Acero, Sandra Luna, Isabel Rodríguez‐Escudero, Marı́a Molina, Rafael Pulido, Vı́ctor J. Cid · 2017 · Bioscience Reports
  5. Dynamic structural biology at the protein membrane interface
    John E. Burke · 2019 · Journal of Biological Chemistry
  6. Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ
    Nicholas Martinez, David F. Thieker, Leiah M. Carey, Juhi A. Rasquinha, Samantha Kistler, Brian A. Kuhlman, Sharon L. Campbell · 2021 · Journal of Molecular Biology
  7. Ligand-Selective Signal Transduction by Two Endogenous GnRH Isoforms Involves Biased Activation of the Class I PI3K Catalytic Subunits p110β, p110γ, and p110δ in Pituitary Gonadotropes and Somatotropes
    Joshua G. Pemberton, James L. Stafford, John Philip Chang · 2014 · Endocrinology
  8. Molecular basis for regulation of the class I phosphoinositide 3-kinases (PI3Ks), and their targeting in human disease
    Alexandria L Shaw, Isobel Barlow-Busch, John E. Burke · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  9. Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
    Duewell, Benjamin R, Wilson, Naomi E, Bailey, Gabriela M, Peabody, Sarah E, Hansen, Scott D · 2024 · eLife
  10. Computational Prediction of Amino Acids Governing Protein-Membrane Interaction for the PIP3 Cell Signaling System
    William A. Irvine, Jack U. Flanagan, Jane R. Allison · 2018 · Structure
  11. Identification of Lectins from Metastatic Cancer Cells through Magnetic Glyconanoparticles
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  12. Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity
    Grace Qun Gong, Jackie D. Kendall, James M. J. J. Dickson, Gordon W. Rewcastle, Christina Maree Buchanan, William Alexander Denny, Peter Robin Shepherd, Jack U. Flanagan · 2017 · Biochemical Journal
  13. Tumor antigen presentation and the associated signal transduction during carcinogenesis
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  14. Dual Systems for Enhancing Control of Protein Activity through Induced Dimerization Approaches
    Sarah Pearce, Chandra L. Tucker · 2021 · Advanced Biology
  15. PIK-24 Inhibits RSV-Induced Syncytium Formation via Direct Interaction with the p85α Subunit of PI3K
    Lifeng Chen, Weibin Xu, Si Xiong, Jun-Xing Cai, Jingjing Zhang, Yao-Lan Li, Man‐Mei Li, Hong Zhang, Zhong Liu · 2022 · Journal of Virology
  16. SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphatase
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  17. Discovery of hydrazide-based PI3K/HDAC dual inhibitors with enhanced pro-apoptotic activity in lymphoma cells
    Baogeng Hou, Geng Jia, Zhongqiang Li, Yuqi Jiang, Yuxin Chen, Xiaoyang Li · 2025 · European Journal of Medicinal Chemistry
  18. Selection on Network Dynamics Drives Differential Rates of Protein Domain Evolution
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  19. Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements
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  20. FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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  21. Structural basis and energy landscape of apigenin-induced cancer cell apoptosis mechanism in PI3K/Akt pathway
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  22. Development of highly sensitive cell-based AKT kinase ELISA for monitoring PI3K beta activity and compound efficacy
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  24. p85α deficiency alleviates ischemia-reperfusion injury by promoting cardiomyocyte survival
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  25. Making PI3K superfamily enzymes run faster
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  26. Control of phosphatidylinositol‐3‐kinase signaling by nanoscale membrane compartmentalization
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  27. PI3Kβ downstream of GPCRs - crucial partners in oncogenesis
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  28. Structures of the PI3Kα/KRas complex on lipid bilayers reveal the molecular mechanism of PI3Kα activation
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  29. Oxidative Stress, Antioxidants, and Chemoprevention: On the Role of Oxidant-Induced Signaling in Cellular Adaptation
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  30. Mechanisms of Resistance to PI3K and AKT Inhibitors
    Pau Castel, Maurizio Scaltriti · 2018 · Resistance to targeted anti-cancer therapeutics
  31. Roles of intrinsically disordered regions in phosphoinositide 3-kinase biocatalysis
    Vrushank Davé, Vladimir Nikolaevich Uversky · 2022 · Elsevier eBooks
  32. PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12
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  33. Activation of the C3a–C3aReceptor-axis is associated with endothelial dysfunction and glycocalyx damage in ST-elevation myocardial infarction
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  34. Structures of the PI3Kα/KRas complex on lipid bilayers reveal molecular mechanisms of PI3Kα activation
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  35. Ras, RhoA, and vascular pharmacology in neurodevelopment and aging
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  36. Diverse activation mechanisms of PI3Ks
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  37. Design and purification of active truncated phosphoinositide 3-kinase gamma protein constructs for structural studies
    Andreja Vujičić Žagar, Léonardo Scapozza, Oscar Vadas · 2017 · Protein Expression and Purification
  38. Functional molecular evolution of a GTP sensing kinase: PI5P4Kβ
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  42. Structural and allosteric effects of the membrane-bound PI3Kα H1047R mutation and opportunities for drug discovery
    Danai Maria Kotzampasi, Zoe Cournia · 2025 · Communications Chemistry
  43. Spatial organization of phosphoinositide signaling
    Siyu Lai, Wenbo Huang, Kangmin He · 2025 · FEBS Letters
  44. A new functional assay reveals that membrane binding is critical for overactivation of the phosphoinositide 3-kinase H1047R mutant
    Alexandra Papafotika, Maria Pavlaki, Vasiliki Lazani, Vasiliki Elpida Karamani, Dimitris Aggelidis, Anna Kapella, Danai Maria Kotzampasi, Bogos Agianian, Argiris Efstratiadis, Zoe Cournia et al. · 2026 · Journal of Biological Chemistry
  45. Understanding the conformational dynamics of PI3Kα due to helical domain mutations: insights from Markov state model analysis
    Vinod Jani, Uddhavesh Sonavane, Sangeeta Sawant · 2025 · Molecular Diversity
  46. Definition and expression in E. coli of large fragments from the human lipid kinase phosphatidylinositol 4-kinase type III alpha, and purification of a 1100-residue N-terminal module
    Cyntia Taveneau, Karine Blondeau, Stéphane Bressanelli · 2015 · Protein Expression and Purification
  47. mTOR in Metabolic and Endocrine Disorders
    Marta M. Swierczynska, Michael N. Hall · 2016 · Elsevier eBooks
  48. Oncogenic PIK3CA corrupts growth factor signaling specificity
    Ralitsa Radostinova Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, S. Yin, Jahangir Sufi, Xiao Qin, Salome Jingchen Zhao, Julia Górczyńska, D. Morelli et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Early phase development of PI3kinase inhibitors for anticancer therapies
    Carlo Caputo, Angela Lombardi, Miryam DEL VICARIO, Domenico Cautela, Raffaele Addeo, Federica Melisi, Anna Grimaldi, Alois Nečas, Evžen Amler, Rossella Sperlongano et al. · 2025 · Expert Opinion on Investigational Drugs
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    Vincenzo Di Lauro, Alessandro Rizzo, Paola Claudia Sacco, Valentina Palma, Francesco Ciccimarra, Gridelli Cesare, Michelino De Laurentiis, Raffaella Massafra · 2026 · Clinical Breast Cancer
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  52. Improved production of class I phosphatidylinositol 4,5-bisphosphate 3-kinase
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  54. Achieving High Levels of Selectivity for Kinase Inhibitors
    Laurent Schio, Hervé Minoux · 2020 · Topics in medicinal chemistry
  55. Focus Issue: Series on Structural Biology
    Wei Wong · 2012 · Science Signaling
  56. Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
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  57. Therapeutics against Cancer Stem Cells: Targeting the Root of Cancer
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  58. Insulin Action in Brain Regulates Systemic Metabolism and Brain
    André Kleinridders, Heather Anne Ferris, Weikang Cai, C. Ronald Kahn · 2014
  59. Phosphatidylinositol 3-Kinase (PI3K) as a therapeutic target in NSCLC
    Christopher W. Stamatkin · 2014 · UKnowledge (University of Kentucky)
  60. Characterizing Osteosarcoma Through PTEN and PI3K: What p53 and Rb1 Can’t Tell Us
    Matthew G. Cable, Robert Lor Randall · 2017 · InTech eBooks
  61. Regulation of EGFR Degradation by Ankyrin105
    Zhubing Li · 2012 · University Library - University of Saskatchewan (University of Saskatchewan)
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  63. Molecular Physiology of Insulin Function
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  64. Ca2+ Controls the Epithelial Cell Quiescence-Proliferation Decision through Regulating IGF Signaling
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  66. The role of thiazolidinedione on adenosine monophosphate-activated protein kinase: Implications on diabetes
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  67. Applications of Constrained Helices
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  68. Phosphoinositide 3-Kinase
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  69. Phosphoinositide 3-Kinase
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