Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases
Vadas, Oscar, Burke, John E., Zhang, Xuxiao, Berndt, Alex, Williams, Roger L.·2011·Science Signaling
Cited by (299)
Items 201–299 of 299
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- Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3KγNicholas Martinez, David F. Thieker, Leiah M. Carey, Juhi A. Rasquinha, Samantha Kistler, Brian A. Kuhlman, Sharon L. Campbell · 2021 · Journal of Molecular Biology
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- Oxidative Stress, Antioxidants, and Chemoprevention: On the Role of Oxidant-Induced Signaling in Cellular AdaptationLars‐Oliver Klotz · 2014 · Springer eBooks
- Mechanisms of Resistance to PI3K and AKT InhibitorsPau Castel, Maurizio Scaltriti · 2018 · Resistance to targeted anti-cancer therapeutics
- Roles of intrinsically disordered regions in phosphoinositide 3-kinase biocatalysisVrushank Davé, Vladimir Nikolaevich Uversky · 2022 · Elsevier eBooks
- PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12Oscar Vadas, Simon Tiede, Maria Chaouki, Laura A. Tesmer, Shanlin Rao, Rémy Visentin, Ulrich Grädler, Martin Augustin, Reiner Kiefersauer, Carola Gößer et al. · 2026 · Nature Communications
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- Structures of the PI3Kα/KRas complex on lipid bilayers reveal molecular mechanisms of PI3Kα activationH. Torosyan, Michael D. Paul, Brigitte G. Meyer, Allison Maker, Natalia Jura, K. Verba · 2026 · Molecules and Cells
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- Design and purification of active truncated phosphoinositide 3-kinase gamma protein constructs for structural studiesAndreja Vujičić Žagar, Léonardo Scapozza, Oscar Vadas · 2017 · Protein Expression and Purification
- Functional molecular evolution of a GTP sensing kinase: PI5P4KβKoh Takeuchi, Miki Senda, Yoshiki Ikeda, Koji Okuwaki, Kaori Fukuzawa, So Nakagawa, Mika Sasaki, Atsuo T. Sasaki, Toshiya Senda · 2023 · FEBS Journal
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- Brain insulin resistance as an early target to attenuate neuroinflammation, oxidative stress and proteinopathies in Alzheimer’s disease: A systematic review of five natural productsReem A. Mohamed, Radwa H. Abdelaziz, Mohamed S. Mohamed, Nayra H. Ahmed, Rouz M. Ahmed · 2025 · Next research.
- Structural and allosteric effects of the membrane-bound PI3Kα H1047R mutation and opportunities for drug discoveryDanai Maria Kotzampasi, Zoe Cournia · 2025 · Communications Chemistry
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- Definition and expression in E. coli of large fragments from the human lipid kinase phosphatidylinositol 4-kinase type III alpha, and purification of a 1100-residue N-terminal moduleCyntia Taveneau, Karine Blondeau, Stéphane Bressanelli · 2015 · Protein Expression and Purification
- mTOR in Metabolic and Endocrine DisordersMarta M. Swierczynska, Michael N. Hall · 2016 · Elsevier eBooks
- Oncogenic PIK3CA corrupts growth factor signaling specificityRalitsa Radostinova Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, S. Yin, Jahangir Sufi, Xiao Qin, Salome Jingchen Zhao, Julia Górczyńska, D. Morelli et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
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- Therapeutics against Cancer Stem Cells: Targeting the Root of CancerKristen M. Smith, Catriona H. M. Jamieson · 2013 · Wiley-VCH eBooks
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