Cited by 61NF-κB Signaling PathwaysImmune Response and InflammationSignaling Pathways in Disease

Controlling the Fate of NIK: A Central Stage in Noncanonical NF-κB Signaling

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Sun, Shao-Cong·2010·Science Signaling

Abstract

A component of the IκB kinase complex mediates feedback inhibition of the kinase NIK.

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Crossref · 10.1126/scisignal.3123pe18

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  • There was evidence for noncanonical NF-κB activation in CIN-high cells as revealed by lower levels of p100, a trend toward higher ratios of p52 and phosphorylated p100 relative to total p100, and lower levels of TRAF2.

    “We found evidence for noncanonical NF-κB activation in CIN-high cells as revealed by lower levels of the precursor protein, p100, a trend toward higher ratios of p52 and phosphorylated p100 relative to total p100, as well as lower levels of the noncanonical NF-κB pathway inhibitor, TRAF231”

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Authors
Sun, S.-C.
Affiliations
The University of Texas MD Anderson Cancer Center (US)
Corresponding author
Sun, Shao-Cong
Venue
Science Signaling
Published
2010-05-25
Volume
3
Issue
123
Pages
pe18-pe18
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W2088638587
Cited by
61
References
31
Citations by year
2026: 2 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 9 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 3
FWCI
1.11
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of General Medical Sciences (R01GM084459, GM084459)
  • National Institute of Allergy and Infectious Diseases (AI064639, R01AI057555, R37AI064639, R01AI064639, AI057555)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
NF-κB signaling, non-canonical NF-κB signaling, NIK, IKKα, phosphorylation, feedback regulation, protein stability, immune function
MeSH terms
NF-kappaB-Inducing Kinase, Animals, Humans, Models, Biological, Signal Transduction, NF-kappa B, Protein Serine-Threonine Kinases, Feedback, Physiological, I-kappa B Kinase

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