The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease
Open accessAbstract
PKCα variants in some patients with Alzheimer’s disease may mediate the pathological effects of amyloid-β.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The PRKCA gene encodes protein kinase Cα (PKCα), which participates in synaptic loss resulting from the accumulation of amyloid-β (Aβ) in AD neuropathology [73, 74].”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [73]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895
Bootstrap methods: another look at the jackknife
Efron, B. (1979) · The Annals of Statistics · doi:10.1214/aos/1176344552 · Cited by 17,602
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
A simple method for organotypic cultures of nervous tissue
Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,096
TREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–105 of 105
Alzheimer’s pathology enhances excitatory synaptic input and integration in VTA dopamine neurons
Blankenship, H. E., Higgs, M. H., Harold, K. M., Humphries, K. M., & Beckstead, M. J. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.2085-25.2026
Mansour, H. M., & El-Khatib, A. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44173-8.00024-3
Protein kinase C in neurodegenerative disorders
Hekmat, A., & Saboury, A. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44173-8.00013-9
Fang, J., & Wang, X. (2026) · Journal of Proteomics · doi:10.1016/j.jprot.2026.105723
Recent advances in MOF–phosphate interaction-based bioanalysis: from enrichment to sensing
Ding, Z.-D., Lv, Q., Song, X., Chen, J., Yu, B., Fan, H., & Cui, H. (2026) · Microchimica Acta · doi:10.1007/s00604-026-08371-2
Metadata
- Authors
- Alfonso, S. I., Callender, J. A., Hooli, B., Antal, C. E., Mullin, K., Sherman, M. A., Lesné, S. E., Leitges, M., Newton, A. C., Tanzi, R. E., & Malinow, R.
- Affiliations
- University of California San Diego (US)
- Harvard University (US)
- University of Minnesota (US)
- University of Oslo (NO)
- Corresponding author
- Alfonso, Stephanie I.
- Callender, Julia A.
- Hooli, Basavaraj
- Antal, Corina E.
- Newton, Alexandra C.
- Tanzi, Rudolph E.
- Malinow, Roberto
- ORCID
- Venue
- Science Signaling
- Published
- 2016-05-10
- Volume
- 9
- Issue
- 427
- Pages
- ra47-ra47
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC5154619
- OpenAlex
- W2359021079
- Cited by
- 103
- References
- 54
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 4 · 2023: 12 · 2022: 11 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 7 · 2017: 11 · 2016: 5
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH (GM43154, MH060009, AG032132, GM007752, DGE1144086)
- Cure Alzheimer's Fund
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, protein kinase C alpha, gain-of-function mutations, amyloid-beta, synaptic dysfunction, late-onset Alzheimer's disease, familial Alzheimer's disease, synaptic depression, hippocampus
- MeSH terms
- Protein Domains, Alzheimer Disease, Animals, Chlorocebus aethiops, Family Health, Hippocampus, Humans, Mutation, Neoplasms, Synapses, Genome, Human, Genome, COS Cells, Neurodegenerative Diseases, Mice, Protein Kinase C-alpha
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
