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Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease
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PKCα variants in some patients with Alzheimer’s disease may mediate the pathological effects of amyloid-β.
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“The PRKCA gene encodes protein kinase Cα (PKCα), which participates in synaptic loss resulting from the accumulation of amyloid-β (Aβ) in AD neuropathology [73, 74].”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [73]
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Metadata
- Authors
- Alfonso, S. I., Callender, J. A., Hooli, B., Antal, C. E., Mullin, K., Sherman, M. A., Lesné, S. E., Leitges, M., Newton, A. C., Tanzi, R. E., & Malinow, R.
- Affiliations
- University of California San Diego (US)
- Harvard University (US)
- University of Minnesota (US)
- University of Oslo (NO)
- Corresponding author
- Alfonso, Stephanie I.
- Callender, Julia A.
- Hooli, Basavaraj
- Antal, Corina E.
- Newton, Alexandra C.
- Tanzi, Rudolph E.
- Malinow, Roberto
- ORCID
- Venue
- Science Signaling
- Published
- 2016-05-10
- Volume
- 9
- Issue
- 427
- Pages
- ra47-ra47
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC5154619
- OpenAlex
- W2359021079
- Cited by
- 103
- References
- 54
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 4 · 2023: 12 · 2022: 11 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 7 · 2017: 11 · 2016: 5
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH (GM43154, MH060009, AG032132, GM007752, DGE1144086)
- Cure Alzheimer's Fund
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, protein kinase C alpha, gain-of-function mutations, amyloid-beta, synaptic dysfunction, late-onset Alzheimer's disease, familial Alzheimer's disease, synaptic depression, hippocampus
- MeSH terms
- Protein Domains, Alzheimer Disease, Animals, Chlorocebus aethiops, Family Health, Hippocampus, Humans, Mutation, Neoplasms, Synapses, Genome, Human, Genome, COS Cells, Neurodegenerative Diseases, Mice, Protein Kinase C-alpha
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