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Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor

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A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration

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PTEN: Local and Global Modulation of Neuronal Function in Health and Disease

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Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes

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Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

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Altered translation elongation contributes to key hallmarks of aging in the killifish brain

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Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

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Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration

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Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease

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Protein kinase Cα gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation

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Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

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Sex-specific DNA methylation: impact on human health and development

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REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment

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Protein Kinase C: Targets to Regenerate Brain Injuries?

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Network-based identification of genetic factors in ageing, lifestyle and type 2 diabetes that influence to the progression of Alzheimer's disease

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Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer

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Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology

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The key genes, phosphoproteins, processes, and pathways affected by efavirenz‐activated CYP46A1 in the amyloid‐decreasing paradigm of efavirenz treatment

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HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology

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PKCα and PKCδ: Friends and Rivals

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Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes

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Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?

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Direct and Systemic Administration of a CNS-Permeant Tamoxifen Analog Reduces Amphetamine-Induced Dopamine Release and Reinforcing Effects

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A Calcium- and Diacylglycerol-Stimulated Protein Kinase C (PKC), Caenorhabditis elegans PKC-2, Links Thermal Signals to Learned Behavior by Acting in Sensory Neurons and Intestinal Cells

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The role of PKC/PKR in aging, Alzheimer's disease, and perioperative neurocognitive disorders

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Profiling of Alzheimer’s disease related genes in mild to moderate vitamin D hypovitaminosis

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Small-molecule drug screening identifies drug Ro 31-8220 that reduces toxic phosphorylated tau in Drosophila melanogaster

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Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition

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Regulation of spermatid polarity by the actin- and microtubule (MT)-based cytoskeletons

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TASK channels: channelopathies, trafficking, and receptor-mediated inhibition

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AhR/miR-23a-3p/PKCα axis contributes to memory deficits in ovariectomized and normal aging female mice

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Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes

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Putative role of natural products as Protein Kinase C modulator in different disease conditions

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Heat shock proteins function as signaling molecules to mediate neuron–glia communication in C. elegans during aging

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Mechanistic insight of the potential of geraniol against Alzheimer’s disease

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Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

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Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brainPreprint

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FAK-mediated signaling controls amyloid beta overload, learning and memory deficits in a mouse model of Alzheimer’s disease

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PKCα Isoform Inhibits Insulin Signaling and Aggravates Neuronal Insulin Resistance

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Cancer-associated mutations in protein kinase C theta are loss-of-function

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Amyloid-β-Driven Synaptic Deficits Are Mediated by Synaptic Removal of GluA3-Containing AMPA Receptors

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Exploring the efficient natural products for Alzheimer’s disease therapy via Drosophila melanogaster (fruit fly) models

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The α1-adrenergic receptors in the amygdala regulate the induction of learned despair through protein kinase C-beta signaling

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Brain phosphoproteomic analysis identifies diabetes‐related substrates in Alzheimer's disease pathology in older adults

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Amyloid‐β Dysregulates Oligodendroglial Lineage Cell Dynamics and Myelination via PKC in the Zebrafish Spinal Cord

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PKCα: Prospects in Regulating Insulin Resistance and AD

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PKC in Regenerative Therapy: New Insights for Old Targets

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Rapid screening of active ingredients and action mechanisms of Ecliptae Herba for treating Alzheimer's disease by UPLC-Q-TOF/MS and “component-target-pathway” network

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The KLDpT activation loop motif is critical for MARK kinase activity

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TDP‐43 Phosphorylation: Pathological Modification or Protective Factor Antagonizing TDP‐43 Aggregation in Neurodegenerative Diseases?

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Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

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Network-based analysis on the genes and their interactions reveals link between schizophrenia and Alzheimer's disease

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Gene co-expression changes underlying the functional connectomic alterations in Alzheimer’s disease

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Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice

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Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis

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Uncovering active ingredients and mechanisms of Pholiota adiposa in the treatment of Alzheimer’s disease based on network pharmacology and bioinformatics

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A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease

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A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation

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CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex‐specific alteration of multiple proteins involved in Alzheimer's disease

Do, A. N., Song, S., Ali, M., Timsina, J., Wang, L., Western, D., Liu, M., Sanford, J., Rosende-Roca, M., Boada, M., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71063 · Cited by 4

Elevated CSF GAP-43 in Mild Cognitive Impairment Linked to Cognitive Impairment Through Increased Amyloid-β Accumulation, with a Shift to Reduced Amyloid-β Accumulation in Alzheimer’s Disease

Azargoonjahromi, A., Eivazi, M., Nasiri, H., Tarhriz, V., Payandeh, Z., & Initiative, A. D. N. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02333-8 · Cited by 2

C-spine mutations of protein kinase C and Akt as a novel generalizable approach to create stable pseudokinases

Hodapp, S. J., Kao, T. H., Wu, J., Balasuriya, N., Antal, C. E., Taylor, S. S., & Newton, A. C. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110921 · Cited by 2

Lithium chloride alters Tau phosphorylation, kinase activity, and Rho GTPase signaling in cell models

Hoffmann, D. B., Ahola, V., Huber, N., Natunen, T., Leskelä, S., Takalo, M., Martiskainen, H., Ballweg, S., Vorontsov, E. A., Selzer, S., et al. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119347 · Cited by 1

Synapse engineering: A new level of brain modulation

Chen, Y., & Geng, Y. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.10.003 · Cited by 1

How can cancer research be illuminated by brain research (and vice versa)?

Mentis, A. A., Papavassiliou, K. A., Piperi, C., & Papavassiliou, A. G. (2023) · International Journal of Cancer · doi:10.1002/ijc.34682 · Cited by 1

Paul Greengard, Ph.D. (1925‐2019)

Gandy, S., & Suzuki, T. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.08.001 · Cited by 1

Atypical Protein Kinase C Hyperactivity in Insulin-Resistant and Insulin-Sensitive Forms of Alzheimer’s Disease: A Potential Therapeutic Target

Farese, R. V., Kindy, M. S., & Sajan, M. P. (2020) · Exon Publications eBooks · doi:10.36255/exonpublications.alzheimersdisease.2020.ch6 · Cited by 1

Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer’s disease

Newton, A. C., Tanzi, R. E., & VanHook, A. M. (2016) · Science Signaling · doi:10.1126/scisignal.aaf9436

FRETting over postsynaptic PKC signaling

Dell’Acqua, M. L., & Woolfrey, K. M. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0190-5

Protein Kinase Cγ Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing AutoinhibitionPreprint

Pilo, C. A., Baffi, T. R., Kornev, A. P., Kunkel, M. T., Malfavon, M., Chen, D., Huang, L., Longman, C., Kannan, N., Raskind, W. H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.24.449810

Protein Kinase C (Prkc)

Newton, A. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101822

Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts

Mira, H., Díez del Corral, R., & Morales, A. V. (2020) · Frontiers research topics · doi:10.3389/978-2-88963-988-5

Protein Kinase C (Prkc)

Newton, A. C. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101822-1

Editorial expression of concern

Foley, J. F. (2022) · Science Signaling · doi:10.1126/scisignal.add4323

PRKCA and TCF4 Genetic Variants in Anxiety Symptoms and Generalized Anxiety Disorder in a Sample of Colombian Subjects Selected on the Basis of High Anxiety Scores

Rodríguez, D., Montes, L. U., Quiñones, B. J., Zamora, S., Moreno, L., Villamil, W., González‐Giraldo, Y., Báez, S., Forero, D. A., & Trujillo‐Güiza, M. L. (2023) · The Open Psychology Journal · doi:10.2174/0118743501266432231122062610 · Cited by 1

Additional file 1 of Mechanistic insight of the potential of geraniol against Alzheimer’s disease

Liu, Y., Zhou, S., Huang, X., & Rehman, H. M. (2022) · Figshare · doi:10.6084/m9.figshare.20070019

Additional file 2 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology

Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Figshare · doi:10.6084/m9.figshare.14490464

Amyloid β oligomers dysregulate oligodendrocyte differentiation and myelination via PKC in the zebrafish spinal cordPreprint

Balantzategi, U., Gaminde‐Blasco, A., Bayón‐Cordero, L., Sánchez‐Gómez, M. V., Zugaza, J. L., Appel, B., & Alberdi, E. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.10.598246

Screening of a kinase inhibitor library in human Huntington’s disease iPSC-derived striatal precursor neurons reveals a neuroprotective effect of PKC-α/β1 inhibitionPreprint

Jiang, M., Shi, T., Miryala, R., Rodriguez, M., Wang, R. S., Sultania, R., Guttman, L. C., Johnston, J., Mulligan, L., Li, Y., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.18.677178

Gene-Exercise Interactions in Amyloid Metabolism and Clearance: Implications for Alzheimer’s Disease

Astorino, M. F., Cipriano, G. L., Anchesi, I., Lui, M., Raffaele, I., Calabrò, M., & Crisafulli, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199816

Additional file 1 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology

Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Figshare · doi:10.6084/m9.figshare.14490461

Additional file 2 of Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice

Yang, J., Yang, N., Zhao, H., Qiao, Y., Li, Y., Wang, C., Lim, K., Zhang, C., Yang, W., & Lu, L. (2023) · Figshare · doi:10.6084/m9.figshare.24098424

Additional file 1 of Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice

Yang, J., Yang, N., Zhao, H., Qiao, Y., Li, Y., Wang, C., Lim, K., Zhang, C., Yang, W., & Lu, L. (2023) · Figshare · doi:10.6084/m9.figshare.24098421

Additional file 3 of Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice

Yang, J., Yang, N., Zhao, H., Qiao, Y., Li, Y., Wang, C., Lim, K., Zhang, C., Yang, W., & Lu, L. (2023) · Figshare · doi:10.6084/m9.figshare.24098427

A role for PKC in Alzheimer's disease

Ferrarelli, L. K. (2016) · Science · doi:10.1126/science.352.6287.783-r

The Role of PICK1 and PKC alpha in Alzheimer’s Disease

Alfonso, S. (2016) · eScholarship (California Digital Library)

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

Lordén, G., Wozniak, J. M., Doré, K., Dozier, L. E., Cates‐Gatto, C., Patrick, G. N., Gonzalez, D. J., Roberts, A. J., Tanzi, R. E., & Newton, A. C. (2022) · Nature Communications · doi:10.1038/s41467-022-34679-7 · Cited by 45

Amplified Protein Kinase C Signaling in Alzheimer's Disease

Lordén, G., Wosniak, J. M., Dozier, L. E., Patrick, G. N., Gonzalez, D. J., Roberts, A. J., & Newton, A. C. (2020) · The FASEB Journal · doi:10.1096/fasebj.2020.34.s1.06842 · Cited by 2

Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer’s disease

Newton, A. C., Tanzi, R. E., & VanHook, A. M. (2016) · Science Signaling · doi:10.1126/scisignal.aaf9436