Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis
Open accessAbstract
Transient inflammation in adipose tissue triggers Jak-TGFβ signaling to promote beige adipocyte differentiation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IL-6 signaling through STAT3 controls accelerated loss of white adipose tissue, as shown by inhibition of white adipose tissue lipolysis in mice treated with anti-IL-6R antibody.
“IL-6 signaling through STAT3 has been shown to control this process, as evidenced by inhibition of white adipose tissue lipolysis in mice treated with anti–IL-6R antibody”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Babaei et al., 2018
The section on transient IL-6 family activation reports that lipolytic stimulation raises IL-6 and IL-11, activating Jak/Stat3 in adipocyte progenitors. The Discussion says Stat3 activation depended on lipolysis in this model, rather than showing that IL-6–STAT3 signaling controlled white adipose tissue loss. Our copy does not report inhibition of lipolysis in mice treated with anti–IL-6R antibody. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
Kosteli, A., Sugaru, E., Haemmerle, G., Martin, J. F., Lei, J., Zechner, R., & Ferrante, A. W. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42845 · Cited by 726 · see citing works
Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
Wernstedt Asterholm, I., Tao, C., Morley, T. S., Wang, Q. A., Delgado-Lopez, F., Wang, Z. V., & Scherer, P. E. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.005 · Cited by 668 · see citing works
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity
Jeffery, E., Church, C. D., Holtrup, B., Colman, L., & Rodeheffer, M. S. (2015) · Nature Cell Biology · doi:10.1038/ncb3122 · Cited by 404 · see citing works
Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes
Elabd, C., Chiellini, C., Carmona, M., Galitzky, J., Cochet, O., Petersen, R., Pénicaud, L., Kristiansen, K., Bouloumié, A., Casteilla, L., et al. (2009) · Stem Cells · doi:10.1002/stem.200 · Cited by 252 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 5
- ↵ 1. R. Babaei, 2. I. Bayindir-Buchhalter, 3. I. Meln, 4. A. Vegiopoulos , Immuno-magnetic isolation and thermogenic differentiation of white adipose tissue progenitor cells. Methods Mol. Biol. 1566, 37-48 (2017). Google Scholar 18. ↵ 1. I. Bayindir, 2. R. Babaeikelishomi, 3. S. Kocanova, 4. I. S. Sousa, 5. S. Lerch, 6. O. Hardt, 7. S. Wild, 8. A. Bosio, 9. K. Bystricky, 10. S. Herzig, 11. A. Vegiopoulos , Transcriptional pathways in cPGI2-induced adipocyte progenitor activation for browning. Front Endocrinol. 6, 129 (2015). Google Scholar
- ↵ 1. D. F. Pisani, 2. M. Djedaini, 3. G. E. Beranger, 4. C. Elabd, 5. M. Scheideler, 6. G. Ailhaud, 7. E. Z. Amri , Differentiation of human adipose-derived stem cells into "brite" (brown-in-white) adipocytes. Front. Endocrinol. 2, 87 (2011). Google Scholar
- ↵ 1. H. Nobusue, 2. N. Onishi, 3. T. Shimizu, 4. E. Sugihara, 5. Y. Oki, 6. Y. Sumikawa, 7. T. Chiyoda, 8. K. Akashi, 9. H. Saya, 10. K. Kano , Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation. Nat. Commun. 5, 3368 (2014). CrossRefPubMedGoogle Scholar
- ↵ 1. S. L. Buzelle, 2. R. E. MacPherson, 3. W. T. Peppler, 4. L. Castellani, 5. D. C. Wright , The contribution of IL-6 to beta 3 adrenergic receptor mediated adipose tissue remodeling. Physiol. Rep. 3, e12312 (2015). Abstract/FREE Full TextGoogle Scholar 43.
- ↵ 1. P. Hallenborg, 2. M. Siersbæk, 3. I. Barrio-Hernandez, 4. R. Nielsen, 5. K. Kristiansen, 6. S. Mandrup, 7. L. Grøntved, 8. B. Blagoev , MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3. Cell Death Dis. 7, e2289 (2016). Google Scholar 48. ↵ 1. Y.-H. Tseng, 2. E. Kokkotou, 3. T. J. Schulz, 4. T. L. Huang, 5. J. N. Winnay, 6. C. M. Taniguchi, 7. T. T. Tran, 8. R. Suzuki, 9. D. O. Espinoza, 10. Y. Yamamoto, 11. M. J. Ahrens, 12. A. T. Dudley, 13. A. W. Norris, 14. R. N. Kulkarni, 15. C. R. Kahn , New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454, 1000-1004 (2008). CrossRefPubMedWeb of ScienceGoogle Scholar 49. ↵ 1. H. Yadav, 2. C. Quijano, 3. A. K. Kamaraju, 4. O. Gavrilova, 5. R. Malek, 6. W. Chen, 7. P. Zerfas, 8. D. Zhigang, 9. E. C. Wright, 10. C. Stuelten, 11. P. Sun, 12. S. Lonning, 13. M. Skarulis, 14. A. E. Sumner, 15. T. Finkel, 16. S. G. Rane , Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab. 14, 67-79 (2011). CrossRefPubMedWeb of ScienceGoogle Scholar 50. ↵ 1. A. Vegiopoulos, 2. M. Rohm, 3. S. Herzig , Adipose tissue: Between the extremes. EMBO J. 36, 1999-2017 (2017). Abstract/FREE Full TextGoogle Scholar 51. ↵ 1. M. Ahmadian, 2. M. J. Abbott, 3. T. Tang, 4. C. S. Hudak, 5. Y. Kim, 6. M. Bruss, 7. M. K. Hellerstein, 8. H. Y. Lee, 9. V. T. Samuel, 10. G. I. Shulman, 11. Y. Wang, 12. R. E. Duncan, 13. C. Kang, 14. H. S. Sul , Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab. 13, 739-748 (2011). CrossRefPubMedWeb of ScienceGoogle Scholar 52.
Cited by
Sorted by citations
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works
“IL-6 signaling through STAT3 has been shown to control this process, as evidenced by inhibition of white adipose tissue lipolysis in mice treated with anti–IL-6R antibody (Babaei et al., 2018; Wang et al., 2018a).”
BackgroundInterleukin-6 released from differentiating human beige adipocytes improves browning
Kristóf, E., Klusóczki, Á., Veress, R., Shaw, A., Combi, Z. S., Varga, K., Győry, F., Balajthy, Z., Bai, P., Bacso, Z., et al. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.02.015 · Cited by 77 · see citing works
Adipose tissue aging is regulated by an altered immune system
Zhang, Y.-X., Ou, M.-Y., Yang, Z.-H., Sun, Y., Li, Q.-F., & Zhou, S.-B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125395 · Cited by 62 · see citing works
Gutierrez, A. D., Gao, Z., Hamidi, V., Zhu, L., Saint Andre, K. B., Riggs, K., Ruscheinsky, M., Wang, H., Yu, Y., Miller, C., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100813 · Cited by 44 · see citing works
- Authors
- Babaei, R., Schuster, M., Meln, I., Lerch, S., Ghandour, R. A., Pisani, D. F., Bayindir-Buchhalter, I., Marx, J., Wu, S., Schoiswohl, G., Billeter, A. T., Krunic, D., Mauer, J., Lee, Y.-H., Granneman, J. G., Fischer, L., Müller-Stich, B. P., Amri, E.-Z., Kershaw, E. E., Heikenwälder, M., Herzig, S., & Vegiopoulos, A.
- Affiliations
- DKFZ Junior Group Metabolism and Stem Cell Plasticity (A171), German Cancer Research Center, Heidelberg 69120, Germany.
- German Cancer Research Center (DE)
- Centre National de la Recherche Scientifique (FR)
- University of Pittsburgh (US)
- Heidelberg University (DE)
- Max Planck Institute for Metabolism Research (DE)
- Yonsei University (KR)
- Wayne State University (US)
- Corresponding author
- Herzig, Stephan
- Vegiopoulos, Alexandros
- ORCID
- Babaei, Rohollah
- Schuster, Maximilian
- Meln, Irina
- Ghandour, Rayane A.
- Pisani, Didier F.
- Wu, Shuang
- Schoiswohl, Gabriele
- Billeter, Adrian T.
- Krunic, Damir
- Mauer, Jan
- Lee, Yun-Hee
- Granneman, James G.
- Fischer, Lars
- Müller-Stich, Beat P.
- Amri, Ez-Zoubir
- Kershaw, Erin E.
- Heikenwälder, Mathias
- Herzig, Stephan
- Vegiopoulos, Alexandros
- Venue
- Science Signaling
- Published
- 2018-04-24
- Volume
- 11
- Issue
- 527
- Pages
- eaai7838
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W2801208163
- Cited by
- 53
- References
- 5
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 10 · 2023: 6 · 2022: 5 · 2021: 8 · 2020: 10 · 2019: 9 · 2018: 2
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- HAL (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- National Institutes of Health (R01DK090166)
- Human Frontier Science Program (RGY0082/2014)
- Deutsche Forschungsgemeinschaft (HE 3260/8-1)
- China Scholarship Council
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- beige adipogenesis, adipose tissue inflammation, adipose tissue remodeling, adipocyte lipolysis, adipose triglyceride lipase, IL-6 family cytokines, beta3-adrenergic receptor, adipocyte progenitors, stromal cells
- MeSH terms
- Adipocytes, Beige, Acyltransferases, Adipose Tissue, Animals, Cell Differentiation, Cells, Cultured, Female, Humans, Inflammation, Lipase, Mice, Inbred C57BL, Signal Transduction, Transforming Growth Factor beta, Mice, Knockout, Gene Expression Profiling, Adipogenesis, STAT3 Transcription Factor, Janus Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
